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Acromegaly

MedGen UID:
1304
•Concept ID:
C0001206
•
Disease or Syndrome
Synonym: Pituitary giant
SNOMED CT: Acromegaly (74107003); Growth hormone hypersecretion syndrome (74107003); STH hypersecretion syndrome (74107003); Marie disease (74107003); Anterior pituitary adenoma syndrome (74107003); Acromegalia (74107003)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0019933
Orphanet: ORPHA963

Definition

A rare acquired endocrine disease related to excessive production of growth hormone (GH) and characterized by progressive somatic disfigurement (mainly involving the face and extremities) and systemic manifestations. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcromegaly
Follow this link to review classifications for Acromegaly in Orphanet.

Professional guidelines

PubMed

Diagnosis and Management of Pituitary Adenomas: A Review.
Tritos NA, Miller KK
JAMA 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444. PMID: 37097352
Acromegaly: pathogenesis, diagnosis, and management.
Fleseriu M, Langlois F, Lim DST, Varlamov EV, Melmed S
Lancet Diabetes Endocrinol 2022 Nov;10(11):804-826. Epub 2022 Oct 6 doi: 10.1016/S2213-8587(22)00244-3. PMID: 36209758
Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696

Recent clinical studies

Etiology

Pegvisomant in the treatment of acromegaly.
Ságová I, Mokáň M, Payer J, Vaňuga P
Vnitr Lek 2022 Fall;68(E-7):17-22. doi: 10.36290/vnl.2022.101. PMID: 36402555
Acromegaly and bone.
Maffezzoni F, Formenti AM
Minerva Endocrinol 2018 Jun;43(2):168-182. Epub 2017 Sep 7 doi: 10.23736/S0391-1977.17.02733-X. PMID: 28880058
Acromegalic osteopathy.
Mazziotti G, Maffezzoni F, Frara S, Giustina A
Pituitary 2017 Feb;20(1):63-69. doi: 10.1007/s11102-016-0758-6. PMID: 27709412
Pegvisomant Treatment in Acromegaly.
Neggers SJ, Muhammad A, van der Lely AJ
Neuroendocrinology 2016;103(1):59-65. Epub 2015 Mar 19 doi: 10.1159/000381644. PMID: 25792221
Acromegaly: an endocrine society clinical practice guideline.
Katznelson L, Laws ER Jr, Melmed S, Molitch ME, Murad MH, Utz A, Wass JA; Endocrine Society
J Clin Endocrinol Metab 2014 Nov;99(11):3933-51. Epub 2014 Oct 30 doi: 10.1210/jc.2014-2700. PMID: 25356808

Diagnosis

Acromegaly.
Weinreb J, Arora S
N Engl J Med 2023 Jan 5;388(1):70. doi: 10.1056/NEJMicm2205570. PMID: 36599064
Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
Acromegaly and bone.
Maffezzoni F, Formenti AM
Minerva Endocrinol 2018 Jun;43(2):168-182. Epub 2017 Sep 7 doi: 10.23736/S0391-1977.17.02733-X. PMID: 28880058
Acromegaly: an endocrine society clinical practice guideline.
Katznelson L, Laws ER Jr, Melmed S, Molitch ME, Murad MH, Utz A, Wass JA; Endocrine Society
J Clin Endocrinol Metab 2014 Nov;99(11):3933-51. Epub 2014 Oct 30 doi: 10.1210/jc.2014-2700. PMID: 25356808
Acromegaly pathogenesis and treatment.
Melmed S
J Clin Invest 2009 Nov;119(11):3189-202. Epub 2009 Nov 2 doi: 10.1172/JCI39375. PMID: 19884662Free PMC Article

Therapy

ACROBAT Edge: Safety and Efficacy of Switching Injected SRLs to Oral Paltusotine in Patients With Acromegaly.
Gadelha MR, Gordon MB, Doknic M, Mezősi E, Tóth M, Randeva H, Marmon T, Jochelson T, Luo R, Monahan M, Madan A, Ferrara-Cook C, Struthers RS, Krasner A
J Clin Endocrinol Metab 2023 Apr 13;108(5):e148-e159. doi: 10.1210/clinem/dgac643. PMID: 36353760Free PMC Article
The Future of Somatostatin Receptor Ligands in Acromegaly.
Gadelha MR, Wildemberg LE, Kasuki L
J Clin Endocrinol Metab 2022 Jan 18;107(2):297-308. doi: 10.1210/clinem/dgab726. PMID: 34618894Free PMC Article
Somatostatin and its Analogs.
Sun L, Coy DH
Curr Drug Targets 2016;17(5):529-37. doi: 10.2174/1389450116666141205163548. PMID: 26951062
Pasireotide for the treatment of acromegaly.
Wildemberg LE, Gadelha MR
Expert Opin Pharmacother 2016;17(4):579-88. Epub 2016 Feb 17 doi: 10.1517/14656566.2016.1146688. PMID: 26808354
New therapeutic agents for acromegaly.
Melmed S
Nat Rev Endocrinol 2016 Feb;12(2):90-8. Epub 2015 Nov 27 doi: 10.1038/nrendo.2015.196. PMID: 26610414

Prognosis

The changing landscape of acromegaly - an epidemiological perspective.
Rosendal C, Arlien-Søborg MC, Nielsen EH, Andersen MS, Feltoft CL, Kistorp C, Dekkers OM, Jørgensen JOL, Dal J
Rev Endocr Metab Disord 2024 Aug;25(4):691-705. Epub 2024 Feb 10 doi: 10.1007/s11154-024-09875-z. PMID: 38337125
Risk Factors for Colorectal Polyps and Cancer.
Sninsky JA, Shore BM, Lupu GV, Crockett SD
Gastrointest Endosc Clin N Am 2022 Apr;32(2):195-213. Epub 2022 Feb 22 doi: 10.1016/j.giec.2021.12.008. PMID: 35361331
The Epidemiology of Pituitary Adenomas.
Daly AF, Beckers A
Endocrinol Metab Clin North Am 2020 Sep;49(3):347-355. Epub 2020 Jun 10 doi: 10.1016/j.ecl.2020.04.002. PMID: 32741475
Determinants of morbidities and mortality in acromegaly.
Kasuki L, Rocha PDS, Lamback EB, Gadelha MR
Arch Endocrinol Metab 2019 Nov-Dec;63(6):630-637. doi: 10.20945/2359-3997000000193. PMID: 31939488Free PMC Article
Acromegaly.
Colao A, Grasso LFS, Giustina A, Melmed S, Chanson P, Pereira AM, Pivonello R
Nat Rev Dis Primers 2019 Mar 21;5(1):20. doi: 10.1038/s41572-019-0071-6. PMID: 30899019

Clinical prediction guides

Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
Acromegaly and bone.
Maffezzoni F, Formenti AM
Minerva Endocrinol 2018 Jun;43(2):168-182. Epub 2017 Sep 7 doi: 10.23736/S0391-1977.17.02733-X. PMID: 28880058
Auditory changes in acromegaly.
Tabur S, Korkmaz H, Baysal E, Hatipoglu E, Aytac I, Akarsu E
J Endocrinol Invest 2017 Jun;40(6):621-626. Epub 2016 Dec 29 doi: 10.1007/s40618-016-0602-x. PMID: 28035526
Endocrine Hypertension: A Practical Approach.
Pappachan JM, Buch HN
Adv Exp Med Biol 2017;956:215-237. doi: 10.1007/5584_2016_26. PMID: 27864805
Acromegaly.
Nabarro JD
Clin Endocrinol (Oxf) 1987 Apr;26(4):481-512. doi: 10.1111/j.1365-2265.1987.tb00805.x. PMID: 3308190

Recent systematic reviews

Metabolomics in acromegaly: a systematic review.
Pînzariu O, Georgescu CE
J Investig Med 2023 Aug;71(6):634-645. Epub 2023 May 4 doi: 10.1177/10815589231169452. PMID: 37139720
Determinants of skeletal fragility in acromegaly: a systematic review and meta-analysis.
Ribeiro de Moura C, Campos Lopes S, Monteiro AM
Pituitary 2022 Dec;25(6):780-794. Epub 2022 Jul 22 doi: 10.1007/s11102-022-01256-6. PMID: 35867180
Cost-effectiveness of acromegaly treatments: a systematic review.
Leonart LP, Borba HHL, Ferreira VL, Riveros BS, Pontarolo R
Pituitary 2018 Dec;21(6):642-652. doi: 10.1007/s11102-018-0908-0. PMID: 30159696
Medical Treatments for Acromegaly: A Systematic Review and Network Meta-Analysis.
Leonart LP, Ferreira VL, Tonin FS, Fernandez-Llimos F, Pontarolo R
Value Health 2018 Jul;21(7):874-880. Epub 2018 Feb 8 doi: 10.1016/j.jval.2017.12.014. PMID: 30005760
Mortality in acromegaly decreased in the last decade: a systematic review and meta-analysis.
Bolfi F, Neves AF, Boguszewski CL, Nunes-Nogueira VS
Eur J Endocrinol 2018 Jul;179(1):59-71. Epub 2018 May 15 doi: 10.1530/EJE-18-0255. PMID: 29764907

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