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Abnormal large intestinal mucosa morphology

MedGen UID:
1369183
•Concept ID:
C4476585
•
Anatomical Abnormality
HPO: HP:0025090

Definition

A structural anomaly of the mucous lining of the large intestine. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal large intestinal mucosa morphology

Professional guidelines

PubMed

Microscopic colitis: pathophysiology and clinical management.
Miehlke S, Verhaegh B, Tontini GE, Madisch A, Langner C, Münch A
Lancet Gastroenterol Hepatol 2019 Apr;4(4):305-314. doi: 10.1016/S2468-1253(19)30048-2. PMID: 30860066
Solitary rectal ulcer syndrome: clinical features, pathophysiology, diagnosis and treatment strategies.
Zhu QC, Shen RR, Qin HL, Wang Y
World J Gastroenterol 2014 Jan 21;20(3):738-44. doi: 10.3748/wjg.v20.i3.738. PMID: 24574747Free PMC Article
New frontiers in the treatment of Hirschsprung disease.
Thapar N
J Pediatr Gastroenterol Nutr 2009 Apr;48 Suppl 2:S92-4. doi: 10.1097/MPG.0b013e3181a15d62. PMID: 19300137

Recent clinical studies

Etiology

Morphology of inflammatory bowel diseases (IBD).
Fabián O, Kamaradová K
Cesk Patol 2022 Spring;58(1):27-37. PMID: 35387455
Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis.
van der Post S, Jabbar KS, Birchenough G, Arike L, Akhtar N, Sjovall H, Johansson MEV, Hansson GC
Gut 2019 Dec;68(12):2142-2151. Epub 2019 Mar 26 doi: 10.1136/gutjnl-2018-317571. PMID: 30914450Free PMC Article
Microscopic colitis: pathophysiology and clinical management.
Miehlke S, Verhaegh B, Tontini GE, Madisch A, Langner C, Münch A
Lancet Gastroenterol Hepatol 2019 Apr;4(4):305-314. doi: 10.1016/S2468-1253(19)30048-2. PMID: 30860066
Field cancerisation in colorectal cancer: a new frontier or pastures past?
Patel A, Tripathi G, Gopalakrishnan K, Williams N, Arasaradnam RP
World J Gastroenterol 2015 Apr 7;21(13):3763-72. doi: 10.3748/wjg.v21.i13.3763. PMID: 25852261Free PMC Article
Is irritable bowel syndrome an organic disorder?
El-Salhy M, Gundersen D, Gilja OH, Hatlebakk JG, Hausken T
World J Gastroenterol 2014 Jan 14;20(2):384-400. doi: 10.3748/wjg.v20.i2.384. PMID: 24574708Free PMC Article

Diagnosis

Morphology of inflammatory bowel diseases (IBD).
Fabián O, Kamaradová K
Cesk Patol 2022 Spring;58(1):27-37. PMID: 35387455
Microscopic colitis: pathophysiology and clinical management.
Miehlke S, Verhaegh B, Tontini GE, Madisch A, Langner C, Münch A
Lancet Gastroenterol Hepatol 2019 Apr;4(4):305-314. doi: 10.1016/S2468-1253(19)30048-2. PMID: 30860066
Colonic Dieulafoy's lesion.
Kumar S
Gastrointest Endosc 2015 Mar;81(3):761. doi: 10.1016/j.gie.2014.12.001. PMID: 25708764
Is irritable bowel syndrome an organic disorder?
El-Salhy M, Gundersen D, Gilja OH, Hatlebakk JG, Hausken T
World J Gastroenterol 2014 Jan 14;20(2):384-400. doi: 10.3748/wjg.v20.i2.384. PMID: 24574708Free PMC Article
Newer diarrheal syndromes.
Sawczenko A, Sandhu BK
Indian J Pediatr 1999;66(1 Suppl):S46-51. PMID: 11132469

Therapy

Cholinergic Signaling Attenuates Pro-Inflammatory Interleukin-8 Response in Colonic Epithelial Cells.
Müller I, Kym U, Galati V, Tharakan S, Subotic U, Krebs T, Stathopoulos E, Schmittenbecher P, Cholewa D, Romero P, Reingruber B; NIGStudy Group, Holland-Cunz S, Keck S
Front Immunol 2021;12:781147. Epub 2022 Jan 6 doi: 10.3389/fimmu.2021.781147. PMID: 35069554Free PMC Article
An intestinal organoid-based platform that recreates susceptibility to T-cell-mediated tissue injury.
Matsuzawa-Ishimoto Y, Hine A, Shono Y, Rudensky E, Lazrak A, Yeung F, Neil JA, Yao X, Chen YH, Heaney T, Schuster SL, Zwack EE, Axelrad JE, Hudesman D, Tsai JJ, Nichols K, Dewan MZ, Cammer M, Beal A, Hoffman S, Geddes B, Bertin J, Liu C, Torres VJ, Loke P, van den Brink MRM, Cadwell K
Blood 2020 Jun 25;135(26):2388-2401. doi: 10.1182/blood.2019004116. PMID: 32232483Free PMC Article
Pathogenesis of Diverticulosis and Diverticular Disease.
Kupcinskas J, Strate LL, Bassotti G, Torti G, Herszènyi L, Malfertheiner P, Cassieri C, Walker MM, Tursi A
J Gastrointestin Liver Dis 2019 Dec 19;28(suppl. 4):7-10. doi: 10.15403/jgld-551. PMID: 31930230
Microscopic colitis: pathophysiology and clinical management.
Miehlke S, Verhaegh B, Tontini GE, Madisch A, Langner C, Münch A
Lancet Gastroenterol Hepatol 2019 Apr;4(4):305-314. doi: 10.1016/S2468-1253(19)30048-2. PMID: 30860066
Pathogenesis and pathophysiology of duodenal ulcer.
Lam SK
Clin Gastroenterol 1984 May;13(2):447-72. PMID: 6378445

Prognosis

An intestinal organoid-based platform that recreates susceptibility to T-cell-mediated tissue injury.
Matsuzawa-Ishimoto Y, Hine A, Shono Y, Rudensky E, Lazrak A, Yeung F, Neil JA, Yao X, Chen YH, Heaney T, Schuster SL, Zwack EE, Axelrad JE, Hudesman D, Tsai JJ, Nichols K, Dewan MZ, Cammer M, Beal A, Hoffman S, Geddes B, Bertin J, Liu C, Torres VJ, Loke P, van den Brink MRM, Cadwell K
Blood 2020 Jun 25;135(26):2388-2401. doi: 10.1182/blood.2019004116. PMID: 32232483Free PMC Article
Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis.
van der Post S, Jabbar KS, Birchenough G, Arike L, Akhtar N, Sjovall H, Johansson MEV, Hansson GC
Gut 2019 Dec;68(12):2142-2151. Epub 2019 Mar 26 doi: 10.1136/gutjnl-2018-317571. PMID: 30914450Free PMC Article
Microscopic colitis: pathophysiology and clinical management.
Miehlke S, Verhaegh B, Tontini GE, Madisch A, Langner C, Münch A
Lancet Gastroenterol Hepatol 2019 Apr;4(4):305-314. doi: 10.1016/S2468-1253(19)30048-2. PMID: 30860066
Field cancerisation in colorectal cancer: a new frontier or pastures past?
Patel A, Tripathi G, Gopalakrishnan K, Williams N, Arasaradnam RP
World J Gastroenterol 2015 Apr 7;21(13):3763-72. doi: 10.3748/wjg.v21.i13.3763. PMID: 25852261Free PMC Article
Newer diarrheal syndromes.
Sawczenko A, Sandhu BK
Indian J Pediatr 1999;66(1 Suppl):S46-51. PMID: 11132469

Clinical prediction guides

An intestinal organoid-based platform that recreates susceptibility to T-cell-mediated tissue injury.
Matsuzawa-Ishimoto Y, Hine A, Shono Y, Rudensky E, Lazrak A, Yeung F, Neil JA, Yao X, Chen YH, Heaney T, Schuster SL, Zwack EE, Axelrad JE, Hudesman D, Tsai JJ, Nichols K, Dewan MZ, Cammer M, Beal A, Hoffman S, Geddes B, Bertin J, Liu C, Torres VJ, Loke P, van den Brink MRM, Cadwell K
Blood 2020 Jun 25;135(26):2388-2401. doi: 10.1182/blood.2019004116. PMID: 32232483Free PMC Article
Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis.
van der Post S, Jabbar KS, Birchenough G, Arike L, Akhtar N, Sjovall H, Johansson MEV, Hansson GC
Gut 2019 Dec;68(12):2142-2151. Epub 2019 Mar 26 doi: 10.1136/gutjnl-2018-317571. PMID: 30914450Free PMC Article
Changes in the Gastric Mucosa With Aging.
Sonnenberg A, Genta RM
Clin Gastroenterol Hepatol 2015 Dec;13(13):2276-81. Epub 2015 Feb 24 doi: 10.1016/j.cgh.2015.02.020. PMID: 25724703
Is irritable bowel syndrome an organic disorder?
El-Salhy M, Gundersen D, Gilja OH, Hatlebakk JG, Hausken T
World J Gastroenterol 2014 Jan 14;20(2):384-400. doi: 10.3748/wjg.v20.i2.384. PMID: 24574708Free PMC Article
Chlamydia trachomatis proctitis.
Quinn TC, Goodell SE, Mkrtichian E, Schuffler MD, Wang SP, Stamm WE, Holmes KK
N Engl J Med 1981 Jul 23;305(4):195-200. doi: 10.1056/NEJM198107233050404. PMID: 7017409

Recent systematic reviews

Endoscopic findings and colonic perforation in microscopic colitis: A systematic review.
Marlicz W, Skonieczna-Żydecka K, Yung DE, Loniewski I, Koulaouzidis A
Dig Liver Dis 2017 Oct;49(10):1073-1085. Epub 2017 Aug 9 doi: 10.1016/j.dld.2017.07.015. PMID: 28847471
Local Excision Techniques for Rectal Cancer After Neoadjuvant Chemoradiotherapy: What Are We Doing?
Smith FM, Ahad A, Perez RO, Marks J, Bujko K, Heald RJ
Dis Colon Rectum 2017 Feb;60(2):228-239. doi: 10.1097/DCR.0000000000000749. PMID: 28059920

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