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Umbilicated nodule

MedGen UID:
1371045
Concept ID:
C4476593
Acquired Abnormality
HPO: HP:0025103

Definition

A type of skin nodule that has a small depression that resembles a navel (i.e., is umbilicated). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUmbilicated nodule

Professional guidelines

PubMed

Pereira MP, Zeidler C, Nau T, Bobko S, Evers AWM, Garcovich S, Gonçalo M, Halvorsen JA, Lambert J, Legat FJ, Leslie T, Metz M, Misery L, Nordlind K, Reich A, Schneider G, Ständer H, Streit M, Szepietowski JC, Wallengren J, Weisshaar E, Ständer S; EADV Task Force Pruritus
J Eur Acad Dermatol Venereol 2019 Feb;33(2):263-266. Epub 2018 Oct 31 doi: 10.1111/jdv.15275. PMID: 30288812
Bikowski JB Jr
Cutis 2004 Mar;73(3):202-6. PMID: 15074350

Recent clinical studies

Etiology

Zakine E, Schell B, Battistella M, Vignon-Pennamen MD, Chasset F, Mahévas T, Cordoliani F, Adès L, Sébert M, Delaleu J, Jachiet M, Lepelletier C, Lemaire P, Chauvel C, Dhouaieb B, Kim R, Cassius C, Georgin-Lavialle S, Mekinian A, Bagot M, Braun T, Rousset L, Begon E, de Masson A, Fenaux P, Clappier E, Bouaziz JD
JAMA Dermatol 2021 Nov 1;157(11):1349-1354. doi: 10.1001/jamadermatol.2021.3344. PMID: 34495287Free PMC Article
Seddon K, Stringer MD
J Pediatr Surg 2020 Oct;55(10):2154-2158. Epub 2019 Nov 9 doi: 10.1016/j.jpedsurg.2019.10.053. PMID: 31757509
Santiago L, Oliveira D, Cardoso JC, Figueired A
Acta Dermatovenerol Croat 2019 Dec;27(4):280-281. PMID: 31969245
Pereira MP, Steinke S, Zeidler C, Forner C, Riepe C, Augustin M, Bobko S, Dalgard F, Elberling J, Garcovich S, Gieler U, Gonçalo M, Halvorsen JA, Leslie TA, Metz M, Reich A, Şavk E, Schneider G, Serra-Baldrich E, Ständer HF, Streit M, Wallengren J, Weller K, Wollenberg A, Bruland P, Soto-Rey I, Storck M, Dugas M, Weisshaar E, Szepietowski JC, Legat FJ, Ständer S; EADV Task Force Pruritus group members
J Eur Acad Dermatol Venereol 2018 Jul;32(7):1059-1065. Epub 2017 Sep 22 doi: 10.1111/jdv.14570. PMID: 28857299
Murakawa GJ, Kerschmann R, Berger T
Arch Dermatol 1996 May;132(5):545-8. PMID: 8624151

Diagnosis

Bai J, Qiao J
JAMA Dermatol 2024 Jan 1;160(1):103-104. doi: 10.1001/jamadermatol.2023.4162. PMID: 37966830
Zakine E, Schell B, Battistella M, Vignon-Pennamen MD, Chasset F, Mahévas T, Cordoliani F, Adès L, Sébert M, Delaleu J, Jachiet M, Lepelletier C, Lemaire P, Chauvel C, Dhouaieb B, Kim R, Cassius C, Georgin-Lavialle S, Mekinian A, Bagot M, Braun T, Rousset L, Begon E, de Masson A, Fenaux P, Clappier E, Bouaziz JD
JAMA Dermatol 2021 Nov 1;157(11):1349-1354. doi: 10.1001/jamadermatol.2021.3344. PMID: 34495287Free PMC Article
Pereira MP, Zeidler C, Nau T, Bobko S, Evers AWM, Garcovich S, Gonçalo M, Halvorsen JA, Lambert J, Legat FJ, Leslie T, Metz M, Misery L, Nordlind K, Reich A, Schneider G, Ständer H, Streit M, Szepietowski JC, Wallengren J, Weisshaar E, Ständer S; EADV Task Force Pruritus
J Eur Acad Dermatol Venereol 2019 Feb;33(2):263-266. Epub 2018 Oct 31 doi: 10.1111/jdv.15275. PMID: 30288812
Günaştı S, Aksungur VL
Clin Dermatol 2014 Jan-Feb;32(1):47-65. doi: 10.1016/j.clindermatol.2013.05.025. PMID: 24314377
Karpouzis A, Giatromanolaki A, Sivridis E, Kouskoukis C
J Dermatol 2010 Jul;37(7):585-92. doi: 10.1111/j.1346-8138.2010.00918.x. PMID: 20629824

Therapy

Pereira MP, Zeidler C, Nau T, Bobko S, Evers AWM, Garcovich S, Gonçalo M, Halvorsen JA, Lambert J, Legat FJ, Leslie T, Metz M, Misery L, Nordlind K, Reich A, Schneider G, Ständer H, Streit M, Szepietowski JC, Wallengren J, Weisshaar E, Ständer S; EADV Task Force Pruritus
J Eur Acad Dermatol Venereol 2019 Feb;33(2):263-266. Epub 2018 Oct 31 doi: 10.1111/jdv.15275. PMID: 30288812
Sudjaritruk T, Sirisanthana T, Sirisanthana V
BMC Infect Dis 2012 Jan 31;12:28. doi: 10.1186/1471-2334-12-28. PMID: 22289885Free PMC Article
Karpouzis A, Giatromanolaki A, Sivridis E, Kouskoukis C
J Dermatol 2010 Jul;37(7):585-92. doi: 10.1111/j.1346-8138.2010.00918.x. PMID: 20629824
Faver IR, Daoud MS, Su WP
J Am Acad Dermatol 1994 Apr;30(4):575-80. doi: 10.1016/s0190-9622(94)70065-6. PMID: 8157784
Edmondson HA, Peters RL
Semin Roentgenol 1983 Apr;18(2):75-83. doi: 10.1016/0037-198x(83)90005-6. PMID: 6306841

Prognosis

Pereira MP, Steinke S, Zeidler C, Forner C, Riepe C, Augustin M, Bobko S, Dalgard F, Elberling J, Garcovich S, Gieler U, Gonçalo M, Halvorsen JA, Leslie TA, Metz M, Reich A, Şavk E, Schneider G, Serra-Baldrich E, Ständer HF, Streit M, Wallengren J, Weller K, Wollenberg A, Bruland P, Soto-Rey I, Storck M, Dugas M, Weisshaar E, Szepietowski JC, Legat FJ, Ständer S; EADV Task Force Pruritus group members
J Eur Acad Dermatol Venereol 2018 Jul;32(7):1059-1065. Epub 2017 Sep 22 doi: 10.1111/jdv.14570. PMID: 28857299
Sudjaritruk T, Sirisanthana T, Sirisanthana V
BMC Infect Dis 2012 Jan 31;12:28. doi: 10.1186/1471-2334-12-28. PMID: 22289885Free PMC Article
Islam MN, Cohen DM, Bhattacharyya I
Quintessence Int 2011 Jun;42(6):e75-7. PMID: 21519579
Kim JC, Ahn BY, Kim HC, Yu CS, Kang GH, Ha HK, Lee MG
Int J Colorectal Dis 2000 Aug;15(4):236-42. doi: 10.1007/s003840000232. PMID: 11008724
Faver IR, Daoud MS, Su WP
J Am Acad Dermatol 1994 Apr;30(4):575-80. doi: 10.1016/s0190-9622(94)70065-6. PMID: 8157784

Clinical prediction guides

Brusasco M, Kalaja A, Satolli F, Feliciani C, De Felici Del Giudice MB
Acta Dermatovenerol Croat 2024 Mar;32(1):71-72. PMID: 38946190
Brusasco M, Kalaja A, Satolli F, Feliciani C, De Felici Del Giudice MB
Acta Dermatovenerol Croat 2023 Dec;31(3):160-161. PMID: 38439730
Santiago L, Oliveira D, Cardoso JC, Figueired A
Acta Dermatovenerol Croat 2019 Dec;27(4):280-281. PMID: 31969245
Gao F, Li M, Zhang Z, Xiao L, Zhang G, Zheng X, Hua Y, Li J
Eur Radiol 2019 Oct;29(10):5423-5430. Epub 2019 Mar 22 doi: 10.1007/s00330-019-06149-0. PMID: 30903336
Murakawa GJ, Kerschmann R, Berger T
Arch Dermatol 1996 May;132(5):545-8. PMID: 8624151

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