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Medulloblastoma, Not Otherwise Specified

MedGen UID:
1371227
•Concept ID:
C4330668
•
Neoplastic Process
Synonym: Medulloblastoma, NOS

Definition

A medulloblastoma which has not been further characterized. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMedulloblastoma, Not Otherwise Specified

Professional guidelines

PubMed

Differentiation of Outcomes by Treatment Regimen and Histology in Central Nervous System Primary Embryonal Tumors.
Bhimani AD, Ryoo JS, Reddy AK, Denyer S, McGuire LS, Alonso M, Mehta AI
World Neurosurg 2020 Sep;141:e289-e306. Epub 2020 May 17 doi: 10.1016/j.wneu.2020.05.103. PMID: 32434022

Recent clinical studies

Etiology

Changes in Peripheral Blood Regulatory T Cells and IL-6 and IL-10 Levels Predict Response of Pediatric Medulloblastoma and Germ Cell Tumors With Residual or Disseminated Disease to Craniospinal Irradiation.
Song L, Wang S, Fang T, Qiu X, Wang X, Zhou X, Morse MA, Hobeika A, Wu W, Yang H, Ren J, Lyerly HK
Int J Radiat Oncol Biol Phys 2021 Oct 1;111(2):479-490. Epub 2021 May 8 doi: 10.1016/j.ijrobp.2021.04.041. PMID: 33974888
C19MC amplification and expression of Lin28A and Olig2 in the classification of embryonal tumors of the central nervous system: A 14-year retrospective study from a tertiary care center.
Nambirajan A, Gurung N, Suri V, Sarkar C, Kumar A, Singh M, Sharma MC
Childs Nerv Syst 2021 Apr;37(4):1067-1075. Epub 2020 Nov 24 doi: 10.1007/s00381-020-04973-0. PMID: 33236184
Medulloblastoma of the adult: results from a multicenter retrospective study by AINO (Italian Association of Neuro-Oncology) and SIN (Italian Society of Neurology).
Gaviani P, Simonetti G, Rudà R, Franchino F, Lombardi G, Possanzini M, Squintu S, Villani V, Teriaca M, Cavallieri F, Caffo M, Salmaggi A, Bianco A, Anghileri E, Farinotti M, Tramacere I, Silvani A
Neurol Sci 2021 Feb;42(2):665-671. Epub 2020 Jul 11 doi: 10.1007/s10072-020-04556-6. PMID: 32654010
Differentiation of Outcomes by Treatment Regimen and Histology in Central Nervous System Primary Embryonal Tumors.
Bhimani AD, Ryoo JS, Reddy AK, Denyer S, McGuire LS, Alonso M, Mehta AI
World Neurosurg 2020 Sep;141:e289-e306. Epub 2020 May 17 doi: 10.1016/j.wneu.2020.05.103. PMID: 32434022
Treatment of pediatric high-grade central nervous system tumors with high-dose methotrexate in combination with multiagent chemotherapy: A single-institution experience.
Bernstock JD, Alva E, Cohen JL, Lobbous M, Chagoya G, Elsayed GA, Orr BA, Rozzelle C, Rocque B, Blount J, Johnston JM, Li R, Fiveash JB, Dhall G, Reddy AT, Friedman GK
Pediatr Blood Cancer 2020 Mar;67(3):e28119. Epub 2019 Dec 18 doi: 10.1002/pbc.28119. PMID: 31850678

Diagnosis

Changes in Peripheral Blood Regulatory T Cells and IL-6 and IL-10 Levels Predict Response of Pediatric Medulloblastoma and Germ Cell Tumors With Residual or Disseminated Disease to Craniospinal Irradiation.
Song L, Wang S, Fang T, Qiu X, Wang X, Zhou X, Morse MA, Hobeika A, Wu W, Yang H, Ren J, Lyerly HK
Int J Radiat Oncol Biol Phys 2021 Oct 1;111(2):479-490. Epub 2021 May 8 doi: 10.1016/j.ijrobp.2021.04.041. PMID: 33974888
C19MC amplification and expression of Lin28A and Olig2 in the classification of embryonal tumors of the central nervous system: A 14-year retrospective study from a tertiary care center.
Nambirajan A, Gurung N, Suri V, Sarkar C, Kumar A, Singh M, Sharma MC
Childs Nerv Syst 2021 Apr;37(4):1067-1075. Epub 2020 Nov 24 doi: 10.1007/s00381-020-04973-0. PMID: 33236184
Medulloblastoma of the adult: results from a multicenter retrospective study by AINO (Italian Association of Neuro-Oncology) and SIN (Italian Society of Neurology).
Gaviani P, Simonetti G, Rudà R, Franchino F, Lombardi G, Possanzini M, Squintu S, Villani V, Teriaca M, Cavallieri F, Caffo M, Salmaggi A, Bianco A, Anghileri E, Farinotti M, Tramacere I, Silvani A
Neurol Sci 2021 Feb;42(2):665-671. Epub 2020 Jul 11 doi: 10.1007/s10072-020-04556-6. PMID: 32654010
Embryonal Tumors of the Central Nervous System: An Update.
Blessing MM, Alexandrescu S
Surg Pathol Clin 2020 Jun;13(2):235-247. Epub 2020 Apr 7 doi: 10.1016/j.path.2020.01.003. PMID: 32389264
Brain, other central nervous system, and eye cancer.
Polednak AP, Flannery JT
Cancer 1995 Jan 1;75(1 Suppl):330-7. doi: 10.1002/1097-0142(19950101)75:1+<330::aid-cncr2820751315>3.0.co;2-5. PMID: 8001004

Therapy

Clinical and Neuroimaging Features of Magnetic Resonance-Guided Stereotactic Laser Ablation for Newly Diagnosed and Recurrent Pediatric Brain Tumors: A Single Institutional Series.
Pehlivan KC, Khanna PC, Elster JD, Paul MR, Levy ML, Crawford JR, Gonda DD
World Neurosurg 2021 Jun;150:e378-e387. Epub 2021 Mar 17 doi: 10.1016/j.wneu.2021.03.027. PMID: 33722713
Embryonal Tumors of the Central Nervous System: An Update.
Blessing MM, Alexandrescu S
Surg Pathol Clin 2020 Jun;13(2):235-247. Epub 2020 Apr 7 doi: 10.1016/j.path.2020.01.003. PMID: 32389264
Treatment of pediatric high-grade central nervous system tumors with high-dose methotrexate in combination with multiagent chemotherapy: A single-institution experience.
Bernstock JD, Alva E, Cohen JL, Lobbous M, Chagoya G, Elsayed GA, Orr BA, Rozzelle C, Rocque B, Blount J, Johnston JM, Li R, Fiveash JB, Dhall G, Reddy AT, Friedman GK
Pediatr Blood Cancer 2020 Mar;67(3):e28119. Epub 2019 Dec 18 doi: 10.1002/pbc.28119. PMID: 31850678
Primitive neuroectodermal tumors of the brainstem in children treated according to the HIT trials: clinical findings of a rare disease.
Friedrich C, Warmuth-Metz M, von Bueren AO, Nowak J, Bison B, von Hoff K, Pietsch T, Kortmann RD, Rutkowski S
J Neurosurg Pediatr 2015 Mar;15(3):227-35. Epub 2015 Jan 2 doi: 10.3171/2014.9.PEDS14213. PMID: 25555122

Prognosis

Pediatric brain tumors in sub-Saharan Africa: a systematic review and meta-analysis.
Nyalundja AD, Kanmounye US, Karekezi C, Laeke T, Thango N, Balogun JA
J Neurosurg Pediatr 2024 Jun 1;33(6):524-535. Epub 2024 Mar 15 doi: 10.3171/2024.1.PEDS23282. PMID: 38489811
Changes in Peripheral Blood Regulatory T Cells and IL-6 and IL-10 Levels Predict Response of Pediatric Medulloblastoma and Germ Cell Tumors With Residual or Disseminated Disease to Craniospinal Irradiation.
Song L, Wang S, Fang T, Qiu X, Wang X, Zhou X, Morse MA, Hobeika A, Wu W, Yang H, Ren J, Lyerly HK
Int J Radiat Oncol Biol Phys 2021 Oct 1;111(2):479-490. Epub 2021 May 8 doi: 10.1016/j.ijrobp.2021.04.041. PMID: 33974888
Embryonal Tumors of the Central Nervous System: An Update.
Blessing MM, Alexandrescu S
Surg Pathol Clin 2020 Jun;13(2):235-247. Epub 2020 Apr 7 doi: 10.1016/j.path.2020.01.003. PMID: 32389264
Treatment of pediatric high-grade central nervous system tumors with high-dose methotrexate in combination with multiagent chemotherapy: A single-institution experience.
Bernstock JD, Alva E, Cohen JL, Lobbous M, Chagoya G, Elsayed GA, Orr BA, Rozzelle C, Rocque B, Blount J, Johnston JM, Li R, Fiveash JB, Dhall G, Reddy AT, Friedman GK
Pediatr Blood Cancer 2020 Mar;67(3):e28119. Epub 2019 Dec 18 doi: 10.1002/pbc.28119. PMID: 31850678
Biological aspects of brain tumors in infancy and childhood.
Giuffrè R
Childs Nerv Syst 1989 Apr;5(2):55-9. doi: 10.1007/BF00571110. PMID: 2660986

Clinical prediction guides

Pediatric brain tumors in sub-Saharan Africa: a systematic review and meta-analysis.
Nyalundja AD, Kanmounye US, Karekezi C, Laeke T, Thango N, Balogun JA
J Neurosurg Pediatr 2024 Jun 1;33(6):524-535. Epub 2024 Mar 15 doi: 10.3171/2024.1.PEDS23282. PMID: 38489811
Changes in Peripheral Blood Regulatory T Cells and IL-6 and IL-10 Levels Predict Response of Pediatric Medulloblastoma and Germ Cell Tumors With Residual or Disseminated Disease to Craniospinal Irradiation.
Song L, Wang S, Fang T, Qiu X, Wang X, Zhou X, Morse MA, Hobeika A, Wu W, Yang H, Ren J, Lyerly HK
Int J Radiat Oncol Biol Phys 2021 Oct 1;111(2):479-490. Epub 2021 May 8 doi: 10.1016/j.ijrobp.2021.04.041. PMID: 33974888
Trends in brain cancer incidence and survival in the United States: Surveillance, Epidemiology, and End Results Program, 1973 to 2001.
Deorah S, Lynch CF, Sibenaller ZA, Ryken TC
Neurosurg Focus 2006 Apr 15;20(4):E1. doi: 10.3171/foc.2006.20.4.E1. PMID: 16709014
Descriptive epidemiology of primary brain and CNS tumors: results from the Central Brain Tumor Registry of the United States, 1990-1994.
Surawicz TS, McCarthy BJ, Kupelian V, Jukich PJ, Bruner JM, Davis FG
Neuro Oncol 1999 Jan;1(1):14-25. doi: 10.1093/neuonc/1.1.14. PMID: 11554386Free PMC Article
Intraobserver reproducibility in assigning brain tumors to classes in the World Health Organization diagnostic scheme. The Childhood Brain Tumor Consortium.
J Neurooncol 1989 Sep;7(3):211-24. doi: 10.1007/BF00172914. PMID: 2795117

Recent systematic reviews

Pediatric brain tumors in sub-Saharan Africa: a systematic review and meta-analysis.
Nyalundja AD, Kanmounye US, Karekezi C, Laeke T, Thango N, Balogun JA
J Neurosurg Pediatr 2024 Jun 1;33(6):524-535. Epub 2024 Mar 15 doi: 10.3171/2024.1.PEDS23282. PMID: 38489811

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