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Nevus sebaceus

MedGen UID:: 1372214
•Concept ID:: C4476818
•: Neoplastic Process

HPO:	HP:0025511

Definition

A solitary yellow-orange slightly raised plaque typically on scalp or face. The plaque typically thickens and becomes more verrucous or pebbly during childhood. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNevus sebaceus

Phenotypic abnormality
- Abnormality of the integument
  - Abnormality of the skin
    - Abnormal skin morphology
      - Localized skin lesion
        Nevus
        Nevus sebaceus

Professional guidelines

PubMed

S2k guideline: Laser therapy of the skin.

Paasch U, Zidane M, Baron JM, Bund T, Cappius HJ, Drosner M, Feise K, Fischer T, Gauglitz G, Gerber PA, Grunewald S, Herberger K, Jung A, Karsai S, Kautz G, Philipp C, Schädel D, Seitz AT, Nast A
J Dtsch Dermatol Ges 2022 Sep;20(9):1248-1267. Epub 2022 Sep 13 doi: 10.1111/ddg.14879. PMID: 36098675

Sebaceus and Becker's Nevus: Overview of Their Presentation, Pathogenesis, Associations, and Treatment.

Patel P, Malik K, Khachemoune A
Am J Clin Dermatol 2015 Jun;16(3):197-204. doi: 10.1007/s40257-015-0123-y. PMID: 25782676

Diagnosis and management of benign lumps and bumps in childhood.

Price HN, Zaenglein AL
Curr Opin Pediatr 2007 Aug;19(4):420-4. doi: 10.1097/MOP.0b013e328224b8ee. PMID: 17630606

See all (4)

Recent clinical studies

Etiology

Secondary Tumors Arising from Nevus Sebaceus: A Multicenter Collaborative Study and Literature Review.

Ye Q, Wu Q, Jia M, Li FZ, Fang S
Dermatology 2023;239(1):140-147. Epub 2022 Sep 9 doi: 10.1159/000526143. PMID: 36088908

Sebaceous Neoplasms.

Flux K
Surg Pathol Clin 2017 Jun;10(2):367-382. doi: 10.1016/j.path.2017.01.009. PMID: 28477886

Epidermal nevus syndromes.

Asch S, Sugarman JL
Handb Clin Neurol 2015;132:291-316. doi: 10.1016/B978-0-444-62702-5.00022-6. PMID: 26564089

Giant nevus sebaceus: definition, surgical techniques, and rationale for treatment.

Chepla KJ, Gosain AK
Plast Reconstr Surg 2012 Aug;130(2):296e-304e. doi: 10.1097/PRS.0b013e3182589df2. PMID: 22842426

Nevus sebaceus of Jadassohn.

Terenzi V, Indrizzi E, Buonaccorsi S, Leonardi A, Pellacchia V, Fini G
J Craniofac Surg 2006 Nov;17(6):1234-9. doi: 10.1097/01.scs.0000221531.56529.cc. PMID: 17119437

See all (37)

Diagnosis

Hamartomas of skin and soft tissue.

Tjarks BJ, Gardner JM, Riddle ND
Semin Diagn Pathol 2019 Jan;36(1):48-61. Epub 2018 Dec 11 doi: 10.1053/j.semdp.2018.12.001. PMID: 30573326

Sebaceous Neoplasms.

Flux K
Surg Pathol Clin 2017 Jun;10(2):367-382. doi: 10.1016/j.path.2017.01.009. PMID: 28477886

Sebaceus and Becker's Nevus: Overview of Their Presentation, Pathogenesis, Associations, and Treatment.

Patel P, Malik K, Khachemoune A
Am J Clin Dermatol 2015 Jun;16(3):197-204. doi: 10.1007/s40257-015-0123-y. PMID: 25782676

Syringocystadenoma.

Mundi JP, Rose AE, Boyd KP, Patel RR, Lipkin G
Dermatol Online J 2013 Dec 16;19(12):20722. PMID: 24365013

Sebaceous gland neoplasia.

Prioleau PG, Santa Cruz DJ
J Cutan Pathol 1984 Oct;11(5):396-414. doi: 10.1111/j.1600-0560.1984.tb00397.x. PMID: 6392373

See all (85)

Therapy

Topical sirolimus therapy for nevus sebaceus and epidermal nevus: A case series.

Zhou AG, Antaya RJ
J Am Acad Dermatol 2022 Aug;87(2):407-409. Epub 2021 Aug 21 doi: 10.1016/j.jaad.2021.08.029. PMID: 34428533

Topical photodynamic therapy for nevus sebaceous on the face.

In SI, Lee JY, Kim YC
Eur J Dermatol 2010 Sep-Oct;20(5):590-2. Epub 2010 Aug 16 doi: 10.1684/ejd.2010.1048. PMID: 20709645

Cutaneous lesions: benign and malignant.

Padgett JK
Facial Plast Surg Clin North Am 2005 May;13(2):195-202, v. doi: 10.1016/j.fsc.2004.11.006. PMID: 15817400

Photodynamic therapy for nevus sebaceus with topical delta-aminolevulinic acid.

Dierickx CC, Goldenhersh M, Dwyer P, Stratigos A, Mihm M, Anderson RR
Arch Dermatol 1999 Jun;135(6):637-40. doi: 10.1001/archderm.135.6.637. PMID: 10376688

Basal cell carcinoma in a girl after cobalt irradiation to the cranium for acute lymphoblastic leukemia: case report and literature review.

Garcia-Silva J, Velasco-Benito JA, Pena-Penabad C, Armijo M
Pediatr Dermatol 1996 Jan-Feb;13(1):54-7. doi: 10.1111/j.1525-1470.1996.tb01190.x. PMID: 8919528

See all (5)

Prognosis

Diagnosis and management of benign lumps and bumps in childhood.

Price HN, Zaenglein AL
Curr Opin Pediatr 2007 Aug;19(4):420-4. doi: 10.1097/MOP.0b013e328224b8ee. PMID: 17630606

Mucoepidermoid carcinoma arising within nevus sebaceus of Jadassohn.

Diwan AH, Smith KJ, Brown R, Skelton HG
J Cutan Pathol 2003 Nov;30(10):652-5. doi: 10.1034/j.1600-0560.2003.00124.x. PMID: 14744092

Spiradenoma arising in a nevus sebaceus of Jadassohn: case report and literature review.

Shapiro M, Johnson B Jr, Witmer W, Elenitsas R
Am J Dermatopathol 1999 Oct;21(5):462-7. doi: 10.1097/00000372-199910000-00011. PMID: 10535577

The Muir-Torre syndrome: a 25-year retrospect.

Schwartz RA, Torre DP
J Am Acad Dermatol 1995 Jul;33(1):90-104. doi: 10.1016/0190-9622(95)90017-9. PMID: 7601953

Organoid nevus.

Pinkus H
Mod Probl Paediatr 1976 Oct 20-23;20:50-7. PMID: 1032522

See all (21)

Clinical prediction guides

Nevus sebaceus: a clinicopathological study of 168 cases and review of the literature.

Kamyab-Hesari K, Seirafi H, Jahan S, Aghazadeh N, Hejazi P, Azizpour A, Goodarzi A
Int J Dermatol 2016 Feb;55(2):193-200. Epub 2015 Sep 17 doi: 10.1111/ijd.12845. PMID: 26381137

Didymosis aplasticosebacea: coexistence of aplasia cutis congenita and nevus sebaceus may be explained as a twin spot phenomenon.

Happle R, König A
Dermatology 2001;202(3):246-8. doi: 10.1159/000051645. PMID: 11385232

Spiradenoma arising in a nevus sebaceus of Jadassohn: case report and literature review.

Shapiro M, Johnson B Jr, Witmer W, Elenitsas R
Am J Dermatopathol 1999 Oct;21(5):462-7. doi: 10.1097/00000372-199910000-00011. PMID: 10535577

Linear epidermal nevus and nevus sebaceus syndromes: a clinicopathologic study of 3 patients.

Prayson RA, Kotagal P, Wyllie E, Bingaman W
Arch Pathol Lab Med 1999 Apr;123(4):301-5. doi: 10.5858/1999-123-0301-LENANS. PMID: 10320141

Organoid nevus.

Pinkus H
Mod Probl Paediatr 1976 Oct 20-23;20:50-7. PMID: 1032522

See all (31)