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Nevus sebaceus

MedGen UID:
1372214
•Concept ID:
C4476818
•
Neoplastic Process
HPO: HP:0025511

Definition

A solitary yellow-orange slightly raised plaque typically on scalp or face. The plaque typically thickens and becomes more verrucous or pebbly during childhood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNevus sebaceus

Professional guidelines

PubMed

S2k guideline: Laser therapy of the skin.
Paasch U, Zidane M, Baron JM, Bund T, Cappius HJ, Drosner M, Feise K, Fischer T, Gauglitz G, Gerber PA, Grunewald S, Herberger K, Jung A, Karsai S, Kautz G, Philipp C, Schädel D, Seitz AT, Nast A
J Dtsch Dermatol Ges 2022 Sep;20(9):1248-1267. Epub 2022 Sep 13 doi: 10.1111/ddg.14879. PMID: 36098675
Sebaceus and Becker's Nevus: Overview of Their Presentation, Pathogenesis, Associations, and Treatment.
Patel P, Malik K, Khachemoune A
Am J Clin Dermatol 2015 Jun;16(3):197-204. doi: 10.1007/s40257-015-0123-y. PMID: 25782676
Diagnosis and management of benign lumps and bumps in childhood.
Price HN, Zaenglein AL
Curr Opin Pediatr 2007 Aug;19(4):420-4. doi: 10.1097/MOP.0b013e328224b8ee. PMID: 17630606

Recent clinical studies

Therapy

Topical sirolimus therapy for nevus sebaceus and epidermal nevus: A case series.
Zhou AG, Antaya RJ
J Am Acad Dermatol 2022 Aug;87(2):407-409. Epub 2021 Aug 21 doi: 10.1016/j.jaad.2021.08.029. PMID: 34428533
Topical photodynamic therapy for nevus sebaceous on the face.
In SI, Lee JY, Kim YC
Eur J Dermatol 2010 Sep-Oct;20(5):590-2. Epub 2010 Aug 16 doi: 10.1684/ejd.2010.1048. PMID: 20709645
Cutaneous lesions: benign and malignant.
Padgett JK
Facial Plast Surg Clin North Am 2005 May;13(2):195-202, v. doi: 10.1016/j.fsc.2004.11.006. PMID: 15817400
Photodynamic therapy for nevus sebaceus with topical delta-aminolevulinic acid.
Dierickx CC, Goldenhersh M, Dwyer P, Stratigos A, Mihm M, Anderson RR
Arch Dermatol 1999 Jun;135(6):637-40. doi: 10.1001/archderm.135.6.637. PMID: 10376688
Basal cell carcinoma in a girl after cobalt irradiation to the cranium for acute lymphoblastic leukemia: case report and literature review.
Garcia-Silva J, Velasco-Benito JA, Pena-Penabad C, Armijo M
Pediatr Dermatol 1996 Jan-Feb;13(1):54-7. doi: 10.1111/j.1525-1470.1996.tb01190.x. PMID: 8919528

Prognosis

Syringocystadenocarcinoma papilliferum with locoregional metastases.
Satter E, Grady D, Schlocker CT
Dermatol Online J 2014 Apr 16;20(4):22335. PMID: 24746298
Diagnosis and management of benign lumps and bumps in childhood.
Price HN, Zaenglein AL
Curr Opin Pediatr 2007 Aug;19(4):420-4. doi: 10.1097/MOP.0b013e328224b8ee. PMID: 17630606
Mucoepidermoid carcinoma arising within nevus sebaceus of Jadassohn.
Diwan AH, Smith KJ, Brown R, Skelton HG
J Cutan Pathol 2003 Nov;30(10):652-5. doi: 10.1034/j.1600-0560.2003.00124.x. PMID: 14744092
Spiradenoma arising in a nevus sebaceus of Jadassohn: case report and literature review.
Shapiro M, Johnson B Jr, Witmer W, Elenitsas R
Am J Dermatopathol 1999 Oct;21(5):462-7. doi: 10.1097/00000372-199910000-00011. PMID: 10535577
Organoid nevus.
Pinkus H
Mod Probl Paediatr 1976 Oct 20-23;20:50-7. PMID: 1032522

Clinical prediction guides

Nevus sebaceus: a clinicopathological study of 168 cases and review of the literature.
Kamyab-Hesari K, Seirafi H, Jahan S, Aghazadeh N, Hejazi P, Azizpour A, Goodarzi A
Int J Dermatol 2016 Feb;55(2):193-200. Epub 2015 Sep 17 doi: 10.1111/ijd.12845. PMID: 26381137
Alteration of the β-catenin pathway in spiradenoma.
Im M, Kim DH, Park JS, Chung H, Lee Y, Kim CD, Seo YJ, Lee JH
J Cutan Pathol 2011 Aug;38(8):657-62. Epub 2011 Apr 26 doi: 10.1111/j.1600-0560.2011.01706.x. PMID: 21518380
Spiradenoma arising in a nevus sebaceus of Jadassohn: case report and literature review.
Shapiro M, Johnson B Jr, Witmer W, Elenitsas R
Am J Dermatopathol 1999 Oct;21(5):462-7. doi: 10.1097/00000372-199910000-00011. PMID: 10535577
Sebomatricoma: a unifying term that encompasses all benign neoplasms with sebaceous differentiation.
Sáchez Yus E, Requena L, Simón P, del Río E
Am J Dermatopathol 1995 Jun;17(3):213-21. doi: 10.1097/00000372-199506000-00001. PMID: 8599428
Organoid nevus.
Pinkus H
Mod Probl Paediatr 1976 Oct 20-23;20:50-7. PMID: 1032522

Recent systematic reviews

Syringocystadenocarcinoma papilliferum: a systematic review of clinical characteristics, reappraisal of associations, diagnostic pitfalls and management challenges.
Wan L, Park A, Khachemoune A
Arch Dermatol Res 2024 Jun 21;316(7):421. doi: 10.1007/s00403-024-03176-w. PMID: 38904691

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