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Delayed fracture healing

MedGen UID:
137672
•Concept ID:
C0332743
•
Pathologic Function
Synonyms: Delayed Union Fracture; Delayed union of fracture; Fracture, delayed union
SNOMED CT: Delayed union of fracture (134194006); Delayed union of fracture (28087009); Fracture, delayed union (28087009)
 
HPO: HP:0032537

Definition

A delay in healing of a fracture past the expected duration. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDelayed fracture healing

Professional guidelines

PubMed

The Treatment of Closed Finger and Metacarpal Fractures.
Cavalcanti Kussmaul A, Kuehlein T, Langer MF, Ayache A, Unglaub F
Dtsch Arztebl Int 2023 Dec 15;120(50):855-862. doi: 10.3238/arztebl.m2023.0226. PMID: 37963039Free PMC Article
Pulsed electromagnetic fields: promising treatment for osteoporosis.
Wang T, Yang L, Jiang J, Liu Y, Fan Z, Zhong C, He C
Osteoporos Int 2019 Feb;30(2):267-276. Epub 2019 Jan 2 doi: 10.1007/s00198-018-04822-6. PMID: 30603841
Adverse reactions and drug-drug interactions in the management of women with postmenopausal osteoporosis.
Rizzoli R, Reginster JY, Boonen S, Bréart G, Diez-Perez A, Felsenberg D, Kaufman JM, Kanis JA, Cooper C
Calcif Tissue Int 2011 Aug;89(2):91-104. Epub 2011 Jun 3 doi: 10.1007/s00223-011-9499-8. PMID: 21637997Free PMC Article

Recent clinical studies

Etiology

Diabetes and the Microvasculature of the Bone and Marrow.
Le T, Salas Sanchez A, Nashawi D, Kulkarni S, Prisby RD
Curr Osteoporos Rep 2024 Feb;22(1):11-27. Epub 2024 Jan 10 doi: 10.1007/s11914-023-00841-3. PMID: 38198033
Delayed Fracture Healing.
Mick P, Fischer C
Semin Musculoskelet Radiol 2022 Jun;26(3):329-337. Epub 2022 Jun 2 doi: 10.1055/s-0041-1740380. PMID: 35654098
The intersection of fracture healing and infection: Orthopaedics research society workshop 2021.
Hellwinkel JE, Working ZM, Certain L, García AJ, Wenke JC, Bahney CS
J Orthop Res 2022 Mar;40(3):541-552. Epub 2022 Jan 25 doi: 10.1002/jor.25261. PMID: 35076097Free PMC Article
NSAIDs and fracture healing.
Geusens P, Emans PJ, de Jong JJ, van den Bergh J
Curr Opin Rheumatol 2013 Jul;25(4):524-31. doi: 10.1097/BOR.0b013e32836200b8. PMID: 23680778
Denosumab for prevention of fractures in postmenopausal women with osteoporosis.
Cummings SR, San Martin J, McClung MR, Siris ES, Eastell R, Reid IR, Delmas P, Zoog HB, Austin M, Wang A, Kutilek S, Adami S, Zanchetta J, Libanati C, Siddhanti S, Christiansen C; FREEDOM Trial
N Engl J Med 2009 Aug 20;361(8):756-65. Epub 2009 Aug 11 doi: 10.1056/NEJMoa0809493. PMID: 19671655

Diagnosis

Diabetes and the Microvasculature of the Bone and Marrow.
Le T, Salas Sanchez A, Nashawi D, Kulkarni S, Prisby RD
Curr Osteoporos Rep 2024 Feb;22(1):11-27. Epub 2024 Jan 10 doi: 10.1007/s11914-023-00841-3. PMID: 38198033
Effect of Bushen Tiansui Decoction on Delayed Fracture Healing: A Systematic Review and Meta-analysis.
Cheng L, Wang G, Lu H, Li S, Xiong W, Wang J
J Musculoskelet Neuronal Interact 2023 Dec 1;23(4):471-488. PMID: 38037365Free PMC Article
Delayed Fracture Healing.
Mick P, Fischer C
Semin Musculoskelet Radiol 2022 Jun;26(3):329-337. Epub 2022 Jun 2 doi: 10.1055/s-0041-1740380. PMID: 35654098
The intersection of fracture healing and infection: Orthopaedics research society workshop 2021.
Hellwinkel JE, Working ZM, Certain L, García AJ, Wenke JC, Bahney CS
J Orthop Res 2022 Mar;40(3):541-552. Epub 2022 Jan 25 doi: 10.1002/jor.25261. PMID: 35076097Free PMC Article
Pulsed electromagnetic fields: promising treatment for osteoporosis.
Wang T, Yang L, Jiang J, Liu Y, Fan Z, Zhong C, He C
Osteoporos Int 2019 Feb;30(2):267-276. Epub 2019 Jan 2 doi: 10.1007/s00198-018-04822-6. PMID: 30603841

Therapy

Effect of Bushen Tiansui Decoction on Delayed Fracture Healing: A Systematic Review and Meta-analysis.
Cheng L, Wang G, Lu H, Li S, Xiong W, Wang J
J Musculoskelet Neuronal Interact 2023 Dec 1;23(4):471-488. PMID: 38037365Free PMC Article
Anabolic Therapies in Osteoporosis and Bone Regeneration.
Russow G, Jahn D, Appelt J, Märdian S, Tsitsilonis S, Keller J
Int J Mol Sci 2018 Dec 26;20(1) doi: 10.3390/ijms20010083. PMID: 30587780Free PMC Article
Continuous infusion of PTH(1-34) delayed fracture healing in mice.
Yukata K, Kanchiku T, Egawa H, Nakamura M, Nishida N, Hashimoto T, Ogasa H, Taguchi T, Yasui N
Sci Rep 2018 Sep 4;8(1):13175. doi: 10.1038/s41598-018-31345-1. PMID: 30181648Free PMC Article
NSAIDs and fracture healing.
Geusens P, Emans PJ, de Jong JJ, van den Bergh J
Curr Opin Rheumatol 2013 Jul;25(4):524-31. doi: 10.1097/BOR.0b013e32836200b8. PMID: 23680778
Denosumab for prevention of fractures in postmenopausal women with osteoporosis.
Cummings SR, San Martin J, McClung MR, Siris ES, Eastell R, Reid IR, Delmas P, Zoog HB, Austin M, Wang A, Kutilek S, Adami S, Zanchetta J, Libanati C, Siddhanti S, Christiansen C; FREEDOM Trial
N Engl J Med 2009 Aug 20;361(8):756-65. Epub 2009 Aug 11 doi: 10.1056/NEJMoa0809493. PMID: 19671655

Prognosis

Prognostic and therapeutic potential of microRNAs for fracture healing processes and non-union fractures: A systematic review.
Breulmann FL, Hatt LP, Schmitz B, Wehrle E, Richards RG, Della Bella E, Stoddart MJ
Clin Transl Med 2023 Jan;13(1):e1161. doi: 10.1002/ctm2.1161. PMID: 36629031Free PMC Article
LncRNA SNHG1 Delayed Fracture Healing via Modulating miR-181a-5p/PTEN Axis.
Guo X, Zhang J, Han X, Wang G
J Invest Surg 2022 Jun;35(6):1304-1312. Epub 2022 Mar 9 doi: 10.1080/08941939.2022.2048926. PMID: 35263556
Time Course of Immune Response and Immunomodulation During Normal and Delayed Healing of Musculoskeletal Wounds.
Muire PJ, Mangum LH, Wenke JC
Front Immunol 2020;11:1056. Epub 2020 Jun 4 doi: 10.3389/fimmu.2020.01056. PMID: 32582170Free PMC Article
Biological perspectives of delayed fracture healing.
Hankenson KD, Zimmerman G, Marcucio R
Injury 2014 Jun;45 Suppl 2(0 2):S8-S15. doi: 10.1016/j.injury.2014.04.003. PMID: 24857030Free PMC Article
Denosumab for prevention of fractures in postmenopausal women with osteoporosis.
Cummings SR, San Martin J, McClung MR, Siris ES, Eastell R, Reid IR, Delmas P, Zoog HB, Austin M, Wang A, Kutilek S, Adami S, Zanchetta J, Libanati C, Siddhanti S, Christiansen C; FREEDOM Trial
N Engl J Med 2009 Aug 20;361(8):756-65. Epub 2009 Aug 11 doi: 10.1056/NEJMoa0809493. PMID: 19671655

Clinical prediction guides

Effect of Bushen Tiansui Decoction on Delayed Fracture Healing: A Systematic Review and Meta-analysis.
Cheng L, Wang G, Lu H, Li S, Xiong W, Wang J
J Musculoskelet Neuronal Interact 2023 Dec 1;23(4):471-488. PMID: 38037365Free PMC Article
LncRNA SNHG1 Delayed Fracture Healing via Modulating miR-181a-5p/PTEN Axis.
Guo X, Zhang J, Han X, Wang G
J Invest Surg 2022 Jun;35(6):1304-1312. Epub 2022 Mar 9 doi: 10.1080/08941939.2022.2048926. PMID: 35263556
LncRNA KCNQ1OT1 delayed fracture healing through the Wnt/β-catenin pathway.
Gu H, Li Z, Lv XF, Zhao AB, Zhu MY, Zhang Y
Eur Rev Med Pharmacol Sci 2019 Jun;23(11):4575-4583. doi: 10.26355/eurrev_201906_18034. PMID: 31210283
Biological perspectives of delayed fracture healing.
Hankenson KD, Zimmerman G, Marcucio R
Injury 2014 Jun;45 Suppl 2(0 2):S8-S15. doi: 10.1016/j.injury.2014.04.003. PMID: 24857030Free PMC Article
Denosumab for prevention of fractures in postmenopausal women with osteoporosis.
Cummings SR, San Martin J, McClung MR, Siris ES, Eastell R, Reid IR, Delmas P, Zoog HB, Austin M, Wang A, Kutilek S, Adami S, Zanchetta J, Libanati C, Siddhanti S, Christiansen C; FREEDOM Trial
N Engl J Med 2009 Aug 20;361(8):756-65. Epub 2009 Aug 11 doi: 10.1056/NEJMoa0809493. PMID: 19671655

Recent systematic reviews

Effect of Bushen Tiansui Decoction on Delayed Fracture Healing: A Systematic Review and Meta-analysis.
Cheng L, Wang G, Lu H, Li S, Xiong W, Wang J
J Musculoskelet Neuronal Interact 2023 Dec 1;23(4):471-488. PMID: 38037365Free PMC Article
Prognostic and therapeutic potential of microRNAs for fracture healing processes and non-union fractures: A systematic review.
Breulmann FL, Hatt LP, Schmitz B, Wehrle E, Richards RG, Della Bella E, Stoddart MJ
Clin Transl Med 2023 Jan;13(1):e1161. doi: 10.1002/ctm2.1161. PMID: 36629031Free PMC Article
Synergistic use of biomaterials and licensed therapeutics to manipulate bone remodelling and promote non-union fracture repair.
Simpson CR, Kelly HM, Murphy CM
Adv Drug Deliv Rev 2020;160:212-233. Epub 2020 Oct 27 doi: 10.1016/j.addr.2020.10.011. PMID: 33122088
The Use of Growth Factors and Mesenchymal Stem Cells in Orthopaedics: In particular, their use in Fractures and Non-Unions: A Systematic Review.
Sinclair KL, Mafi P, Mafi R, Khan WS
Curr Stem Cell Res Ther 2017;12(4):312-325. doi: 10.2174/1574888X11666160614104500. PMID: 27306399
Bisphosphonates and nonhealing femoral fractures: analysis of the FDA Adverse Event Reporting System (FAERS) and international safety efforts: a systematic review from the Research on Adverse Drug Events And Reports (RADAR) project.
Edwards BJ, Bunta AD, Lane J, Odvina C, Rao DS, Raisch DW, McKoy JM, Omar I, Belknap SM, Garg V, Hahr AJ, Samaras AT, Fisher MJ, West DP, Langman CB, Stern PH
J Bone Joint Surg Am 2013 Feb 20;95(4):297-307. doi: 10.2106/JBJS.K.01181. PMID: 23426763Free PMC Article

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