U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tetraploidy

MedGen UID:
137689
•Concept ID:
C0333694
•
Cell or Molecular Dysfunction
Synonyms: Tetraploid; Tetraploidies; Tetraploids
SNOMED CT: Tetraploidy (62749002); Tetraploidy (726363000)

Definition

A numerical chromosomal abnormality characterized by the presence of four complete sets of chromosomes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTetraploidy
Follow this link to review classifications for Tetraploidy in Orphanet.

Professional guidelines

PubMed

Exploring the molecular pathogenesis, diagnosis and treatment of fibrolamellar hepatocellular carcinoma: A state of art review of the current literature.
Alshareefy Y, Shen CY, Prekash RJ
Pathol Res Pract 2023 Aug;248:154655. Epub 2023 Jun 26 doi: 10.1016/j.prp.2023.154655. PMID: 37429175
Image analysis and flow cytometric DNA studies of benign and malignant body cavity fluids: reappraisal of the role of current methods in the differential diagnosis of reactive versus malignant conditions.
Lazcano O, Chen LM, Tsai C, Li CY, Katzmann JA, Sebo TJ, Kimlinger TK, Baker J
Mod Pathol 2000 Jul;13(7):788-96. doi: 10.1038/modpathol.3880137. PMID: 10912939
The role of deoxyribonucleic acid image cytometric and interphase cytogenetic analyses in the differential diagnosis, prognosis, and clinical follow-up of hydatidiform moles. A report from the Central Molar Registration in The Netherlands.
van de Kaa CA, Schijf CP, de Wilde PC, Hanselaar AG, Vooijs PG
Am J Obstet Gynecol 1997 Nov;177(5):1219-29. doi: 10.1016/s0002-9378(97)70043-7. PMID: 9396922

Recent clinical studies

Etiology

Polyploidy is widespread in Microsporidia.
Khalaf A, Lawniczak MKN, Blaxter ML, Jaron KS
Microbiol Spectr 2024 Feb 6;12(2):e0366923. Epub 2024 Jan 12 doi: 10.1128/spectrum.03669-23. PMID: 38214524Free PMC Article
The prognostic implications of tetraploidy/near-Tetraploidy in acute myeloid leukemia: a case series and systematic review of the literature.
Xie J, Nachabe A, Hathaway LJ, Farah B, Berbari B, Li Y, Brown TC, Schmid JL, Socola F, Saba NS, Safah H
Leuk Lymphoma 2021 Jan;62(1):203-210. Epub 2020 Sep 29 doi: 10.1080/10428194.2020.1817435. PMID: 32993375
Tetraploidy/near-tetraploidy acute myeloid leukemia.
Huang L, Wang SA, DiNardo C, Li S, Hu S, Xu J, Zhou W, Goswami M, Medeiros LJ, Tang G
Leuk Res 2017 Feb;53:20-27. Epub 2016 Dec 2 doi: 10.1016/j.leukres.2016.11.016. PMID: 27951415
Biomarkers in Barrett's esophagus.
Reid BJ, Blount PL, Rabinovitch PS
Gastrointest Endosc Clin N Am 2003 Apr;13(2):369-97. doi: 10.1016/s1052-5157(03)00006-0. PMID: 12916666
Linear hypopigmentation and hyperpigmentation, including mosaicism.
Loomis CA
Semin Cutan Med Surg 1997 Mar;16(1):44-53. doi: 10.1016/s1085-5629(97)80035-1. PMID: 9125765

Diagnosis

Exploring the molecular pathogenesis, diagnosis and treatment of fibrolamellar hepatocellular carcinoma: A state of art review of the current literature.
Alshareefy Y, Shen CY, Prekash RJ
Pathol Res Pract 2023 Aug;248:154655. Epub 2023 Jun 26 doi: 10.1016/j.prp.2023.154655. PMID: 37429175
The prognostic implications of tetraploidy/near-Tetraploidy in acute myeloid leukemia: a case series and systematic review of the literature.
Xie J, Nachabe A, Hathaway LJ, Farah B, Berbari B, Li Y, Brown TC, Schmid JL, Socola F, Saba NS, Safah H
Leuk Lymphoma 2021 Jan;62(1):203-210. Epub 2020 Sep 29 doi: 10.1080/10428194.2020.1817435. PMID: 32993375
Tetraploidy/near-tetraploidy acute myeloid leukemia.
Huang L, Wang SA, DiNardo C, Li S, Hu S, Xu J, Zhou W, Goswami M, Medeiros LJ, Tang G
Leuk Res 2017 Feb;53:20-27. Epub 2016 Dec 2 doi: 10.1016/j.leukres.2016.11.016. PMID: 27951415
Medulloblastomics: the end of the beginning.
Northcott PA, Jones DT, Kool M, Robinson GW, Gilbertson RJ, Cho YJ, Pomeroy SL, Korshunov A, Lichter P, Taylor MD, Pfister SM
Nat Rev Cancer 2012 Dec;12(12):818-34. doi: 10.1038/nrc3410. PMID: 23175120Free PMC Article
Current topic: confined placental mosaicism and intrauterine fetal development.
Kalousek DK
Placenta 1994 Apr;15(3):219-30. doi: 10.1016/0143-4004(94)90014-0. PMID: 8066047

Therapy

Near-tetraploid T-cell acute lymphoblastic leukaemia in childhood: Results of the AIEOP-BFM ALL studies.
Ceppi F, Gotti G, Möricke A, Silvestri D, Poyer F, Lentes J, Bergmann A, Trka J, Alten J, Elitzur S, Barbaric D, Buldini B, Dell'Acqua F, Schumacher F, Casazza G, Tchinda J, Nebral K, Conter V, Attarbaschi A, Schrappe M
Eur J Cancer 2022 Nov;175:120-124. Epub 2022 Sep 13 doi: 10.1016/j.ejca.2022.08.013. PMID: 36113241
Janus Face of Drug-Induced Tetraploidy in Non-Hodgkin Lymphoma.
Mahadevan D, Rogers GC
Trends Cancer 2020 Aug;6(8):627-630. Epub 2020 Apr 11 doi: 10.1016/j.trecan.2020.03.009. PMID: 32291237
NSAID use and somatic exomic mutations in Barrett's esophagus.
Galipeau PC, Oman KM, Paulson TG, Sanchez CA, Zhang Q, Marty JA, Delrow JJ, Kuhner MK, Vaughan TL, Reid BJ, Li X
Genome Med 2018 Feb 27;10(1):17. doi: 10.1186/s13073-018-0520-y. PMID: 29486792Free PMC Article
UroVysion® multiprobe FISH in the triage of equivocal urinary cytology cases.
Bubendorf L, Piaton E
Ann Pathol 2012 Dec;32(6):e52-6, 438-43. Epub 2012 Nov 24 doi: 10.1016/j.annpat.2012.09.207. PMID: 23244486
Biomarkers in Barrett's esophagus.
Reid BJ, Blount PL, Rabinovitch PS
Gastrointest Endosc Clin N Am 2003 Apr;13(2):369-97. doi: 10.1016/s1052-5157(03)00006-0. PMID: 12916666

Prognosis

The prognostic implications of tetraploidy/near-Tetraploidy in acute myeloid leukemia: a case series and systematic review of the literature.
Xie J, Nachabe A, Hathaway LJ, Farah B, Berbari B, Li Y, Brown TC, Schmid JL, Socola F, Saba NS, Safah H
Leuk Lymphoma 2021 Jan;62(1):203-210. Epub 2020 Sep 29 doi: 10.1080/10428194.2020.1817435. PMID: 32993375
Cytogenetic complexity and heterogeneity in intravascular lymphoma.
Fujikura K, Yamashita D, Yoshida M, Ishikawa T, Itoh T, Imai Y
J Clin Pathol 2021 Apr;74(4):244-250. Epub 2020 Aug 6 doi: 10.1136/jclinpath-2020-206573. PMID: 32763919
Tetraploidy/near-tetraploidy acute myeloid leukemia.
Huang L, Wang SA, DiNardo C, Li S, Hu S, Xu J, Zhou W, Goswami M, Medeiros LJ, Tang G
Leuk Res 2017 Feb;53:20-27. Epub 2016 Dec 2 doi: 10.1016/j.leukres.2016.11.016. PMID: 27951415
Biomarkers in Barrett's esophagus.
Reid BJ, Blount PL, Rabinovitch PS
Gastrointest Endosc Clin N Am 2003 Apr;13(2):369-97. doi: 10.1016/s1052-5157(03)00006-0. PMID: 12916666
Linear hypopigmentation and hyperpigmentation, including mosaicism.
Loomis CA
Semin Cutan Med Surg 1997 Mar;16(1):44-53. doi: 10.1016/s1085-5629(97)80035-1. PMID: 9125765

Clinical prediction guides

Exploring the molecular pathogenesis, diagnosis and treatment of fibrolamellar hepatocellular carcinoma: A state of art review of the current literature.
Alshareefy Y, Shen CY, Prekash RJ
Pathol Res Pract 2023 Aug;248:154655. Epub 2023 Jun 26 doi: 10.1016/j.prp.2023.154655. PMID: 37429175
Cytogenetic complexity and heterogeneity in intravascular lymphoma.
Fujikura K, Yamashita D, Yoshida M, Ishikawa T, Itoh T, Imai Y
J Clin Pathol 2021 Apr;74(4):244-250. Epub 2020 Aug 6 doi: 10.1136/jclinpath-2020-206573. PMID: 32763919
Cytokinesis Failure Leading to Chromosome Instability in v-Src-Induced Oncogenesis.
Nakayama Y, Soeda S, Ikeuchi M, Kakae K, Yamaguchi N
Int J Mol Sci 2017 Apr 12;18(4) doi: 10.3390/ijms18040811. PMID: 28417908Free PMC Article
Immunoglobulin isotypes in Atlantic salmon, Salmo salar.
Hordvik I
Biomolecules 2015 Feb 27;5(1):166-77. doi: 10.3390/biom5010166. PMID: 25734583Free PMC Article
Tetraploidy in hydatidiform moles.
Sundvall L, Lund H, Niemann I, Jensen UB, Bolund L, Sunde L
Hum Reprod 2013 Jul;28(7):2010-20. Epub 2013 Apr 30 doi: 10.1093/humrep/det132. PMID: 23633551

Recent systematic reviews

The prognostic implications of tetraploidy/near-Tetraploidy in acute myeloid leukemia: a case series and systematic review of the literature.
Xie J, Nachabe A, Hathaway LJ, Farah B, Berbari B, Li Y, Brown TC, Schmid JL, Socola F, Saba NS, Safah H
Leuk Lymphoma 2021 Jan;62(1):203-210. Epub 2020 Sep 29 doi: 10.1080/10428194.2020.1817435. PMID: 32993375

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...