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Transitional cell papilloma

MedGen UID:
137734
•Concept ID:
C0334266
•
Neoplastic Process
Synonyms: papilloma, transitional cell, benign; Transitional Cell Papilloma; transitional cell papilloma; transitional cell papilloma NOS (morphologic abnormality); Transitional cell papilloma, benign; transitional cell papilloma, benign; transitional cell papilloma, benign (morphologic abnormality); Transitional papilloma; Transitional Papilloma; transitional papilloma
SNOMED CT: Transitional cell papilloma, benign (44342003); Transitional cell papilloma (45083001); Transitional papilloma (44342003)
 
Monarch Initiative: MONDO:0005605

Definition

A benign papillary neoplasm composed of transitional cells which show preservation of the nuclear polarity. [from NCI]

Professional guidelines

PubMed

Management of Wilms tumors in Drash and Frasier syndromes.
Auber F, Jeanpierre C, Denamur E, Jaubert F, Schleiermacher G, Patte C, Cabrol S, Leverger G, Nihoul-Fékété C, Sarnacki S
Pediatr Blood Cancer 2009 Jan;52(1):55-9. doi: 10.1002/pbc.21759. PMID: 18816692

Recent clinical studies

Etiology

Clear evidence of the carcinogenic potential of anthracene: A 2-year feeding study in rats and mice.
Takeda T, Suzuki M, Kano H, Matsumoto M, Umeda Y
Environ Toxicol 2023 Mar;38(4):709-726. Epub 2022 Dec 7 doi: 10.1002/tox.23722. PMID: 36478108
SOX10 is over-expressed in bladder cancer and contributes to the malignant bladder cancer cell behaviors.
Yin H, Qin C, Zhao Y, Du Y, Sheng Z, Wang Q, Song Q, Chen L, Liu C, Xu T
Clin Transl Oncol 2017 Aug;19(8):1035-1044. Epub 2017 Mar 3 doi: 10.1007/s12094-017-1641-2. PMID: 28258492
Management of Wilms tumors in Drash and Frasier syndromes.
Auber F, Jeanpierre C, Denamur E, Jaubert F, Schleiermacher G, Patte C, Cabrol S, Leverger G, Nihoul-Fékété C, Sarnacki S
Pediatr Blood Cancer 2009 Jan;52(1):55-9. doi: 10.1002/pbc.21759. PMID: 18816692
Is routine biopsy of the lacrimal sac wall indicated at dacryocystorhinostomy? A prospective study and literature review.
Merkonidis C, Brewis C, Yung M, Nussbaumer M
Br J Ophthalmol 2005 Dec;89(12):1589-91. doi: 10.1136/bjo.2005.072199. PMID: 16299137Free PMC Article
Urothelial (transitional cell) papilloma of the urinary bladder: a clinicopathologic study of 26 cases.
McKenney JK, Amin MB, Young RH
Mod Pathol 2003 Jul;16(7):623-9. doi: 10.1097/01.MP.0000073973.74228.1E. PMID: 12861056

Diagnosis

P63 Positive Mucoepidermoid Tumor of the Lacrimal Sac with Associated Papilloma.
Iordanous Y, Belrose JC, Cadieux DC, Chakrabarti S, Farmer JP, Allen LH
Orbit 2015;34(4):220-2. Epub 2015 Jun 29 doi: 10.3109/01676830.2015.1049370. PMID: 26121166
Is routine biopsy of the lacrimal sac wall indicated at dacryocystorhinostomy? A prospective study and literature review.
Merkonidis C, Brewis C, Yung M, Nussbaumer M
Br J Ophthalmol 2005 Dec;89(12):1589-91. doi: 10.1136/bjo.2005.072199. PMID: 16299137Free PMC Article
Urothelial (transitional cell) papilloma of the urinary bladder: a clinicopathologic study of 26 cases.
McKenney JK, Amin MB, Young RH
Mod Pathol 2003 Jul;16(7):623-9. doi: 10.1097/01.MP.0000073973.74228.1E. PMID: 12861056
Cytokeratin expression patterns in normal and malignant urothelium: a review of the biological and diagnostic implications.
Southgate J, Harnden P, Trejdosiewicz LK
Histol Histopathol 1999 Apr;14(2):657-64. doi: 10.14670/HH-14.657. PMID: 10212826
Transitional cell neoplasms (carcinomas and inverted papillomas) of the uterine cervix. A report of five cases.
Albores-Saavedra J, Young RH
Am J Surg Pathol 1995 Oct;19(10):1138-45. PMID: 7573672

Therapy

Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin.
Singh RP, Tyagi A, Sharma G, Mohan S, Agarwal R
Clin Cancer Res 2008 Jan 1;14(1):300-8. doi: 10.1158/1078-0432.CCR-07-1565. PMID: 18172282
The Drake Health Registry Study: findings from fifteen years of continuous bladder cancer screening.
Marsh GM, Cassidy LD
Am J Ind Med 2003 Feb;43(2):142-8. doi: 10.1002/ajim.10166. PMID: 12541268

Prognosis

SOX10 is over-expressed in bladder cancer and contributes to the malignant bladder cancer cell behaviors.
Yin H, Qin C, Zhao Y, Du Y, Sheng Z, Wang Q, Song Q, Chen L, Liu C, Xu T
Clin Transl Oncol 2017 Aug;19(8):1035-1044. Epub 2017 Mar 3 doi: 10.1007/s12094-017-1641-2. PMID: 28258492
Urothelial (transitional cell) papilloma of the urinary bladder: a clinicopathologic study of 26 cases.
McKenney JK, Amin MB, Young RH
Mod Pathol 2003 Jul;16(7):623-9. doi: 10.1097/01.MP.0000073973.74228.1E. PMID: 12861056
Cytokeratin expression patterns in normal and malignant urothelium: a review of the biological and diagnostic implications.
Southgate J, Harnden P, Trejdosiewicz LK
Histol Histopathol 1999 Apr;14(2):657-64. doi: 10.14670/HH-14.657. PMID: 10212826
Transitional cell neoplasms (carcinomas and inverted papillomas) of the uterine cervix. A report of five cases.
Albores-Saavedra J, Young RH
Am J Surg Pathol 1995 Oct;19(10):1138-45. PMID: 7573672
Inverted papilloma of the bladder: a distinct urological lesion.
Caro DJ, Tessler A
Cancer 1978 Aug;42(2):708-13. doi: 10.1002/1097-0142(197808)42:2<708::aid-cncr2820420242>3.0.co;2-7. PMID: 354775

Clinical prediction guides

Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin.
Singh RP, Tyagi A, Sharma G, Mohan S, Agarwal R
Clin Cancer Res 2008 Jan 1;14(1):300-8. doi: 10.1158/1078-0432.CCR-07-1565. PMID: 18172282
Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2.
Tyagi A, Singh RP, Agarwal C, Agarwal R
Carcinogenesis 2006 Nov;27(11):2269-80. Epub 2006 Jun 15 doi: 10.1093/carcin/bgl098. PMID: 16777994
Silibinin down-regulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells.
Tyagi AK, Agarwal C, Singh RP, Shroyer KR, Glode LM, Agarwal R
Biochem Biophys Res Commun 2003 Dec 26;312(4):1178-84. doi: 10.1016/j.bbrc.2003.11.038. PMID: 14651997
Cytokeratin expression patterns in normal and malignant urothelium: a review of the biological and diagnostic implications.
Southgate J, Harnden P, Trejdosiewicz LK
Histol Histopathol 1999 Apr;14(2):657-64. doi: 10.14670/HH-14.657. PMID: 10212826
Transitional cell papilloma in the fossa navicularis is positive for human papillomavirus.
Shimizu N, Ichinose Y, Shimo M, Sano T, Nakajima T, Yamanaka H
Int J Urol 1998 May;5(3):296-8. doi: 10.1111/j.1442-2042.1998.tb00608.x. PMID: 9624566

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