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Malignant struma ovarii

MedGen UID:
137777
•Concept ID:
C0334525
•
Neoplastic Process
Synonyms: Malignant Struma Ovarii; malignant struma ovarii; Struma ovarii, malignant; struma ovarii, malignant; struma ovarii, malignant (morphologic abnormality); Thyroid Carcinoma Arising in Struma Ovarii
SNOMED CT: Malignant struma ovarii (18854008); Struma ovarii, malignant (18854008)
 
Monarch Initiative: MONDO:0003332

Definition

A carcinoma with histological features identical to thyroid carcinoma, arising in ovarian mature teratoma with aberrant thyroid tissue (struma ovarii). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant struma ovarii

Recent clinical studies

Etiology

Incidence, clinical characteristics, and survival outcomes of ovarian strumal diseases: a retrospective cohort study.
Li S, Hong R, Yin M, Zhang T, Zhang X, Yang J
BMC Womens Health 2023 Sep 19;23(1):497. doi: 10.1186/s12905-023-02624-5. PMID: 37726744Free PMC Article
Metastatic malignant struma ovarii: a case report and review of the literature on the management of malignant struma ovarii.
Taelman V, Boer M, Taelman P
Acta Clin Belg 2022 Jun;77(3):721-725. Epub 2021 Jun 30 doi: 10.1080/17843286.2021.1944583. PMID: 34191687
Malignant struma ovarii: surgical, histopathological and survival outcomes for thyroid-type carcinoma of struma ovarii with recommendations for standardising multi-modal management. A retrospective case series sharing the experience of a single institution over 10 years.
Addley S, Mihai R, Alazzam M, Dhar S, Soleymani Majd H
Arch Gynecol Obstet 2021 Apr;303(4):863-870. Epub 2021 Jan 29 doi: 10.1007/s00404-021-05969-0. PMID: 33512594
Laparoscopic excision of malignant struma ovarii and 1 year follow-up without further treatment.
Kraemer B, Grischke EM, Staebler A, Hirides P, Rothmund R
Fertil Steril 2011 May;95(6):2124.e9-12. Epub 2011 Jan 26 doi: 10.1016/j.fertnstert.2010.12.047. PMID: 21269611
Struma ovarii.
Ayhan A, Yanik F, Tuncer R, Tuncer ZS, Ruacan S
Int J Gynaecol Obstet 1993 Aug;42(2):143-6. doi: 10.1016/0020-7292(93)90628-a. PMID: 7901063

Diagnosis

Incidence, clinical characteristics, and survival outcomes of ovarian strumal diseases: a retrospective cohort study.
Li S, Hong R, Yin M, Zhang T, Zhang X, Yang J
BMC Womens Health 2023 Sep 19;23(1):497. doi: 10.1186/s12905-023-02624-5. PMID: 37726744Free PMC Article
Malignant struma ovarii: From case to analysis.
Ayhan S, Kilic F, Ersak B, Aytekin O, Akar S, Turkmen O, Akgul G, Toyran A, Turan T, Kimyon Comert G
J Obstet Gynaecol Res 2021 Sep;47(9):3339-3351. Epub 2021 Jul 4 doi: 10.1111/jog.14902. PMID: 34219334
Malignant struma ovarii: surgical, histopathological and survival outcomes for thyroid-type carcinoma of struma ovarii with recommendations for standardising multi-modal management. A retrospective case series sharing the experience of a single institution over 10 years.
Addley S, Mihai R, Alazzam M, Dhar S, Soleymani Majd H
Arch Gynecol Obstet 2021 Apr;303(4):863-870. Epub 2021 Jan 29 doi: 10.1007/s00404-021-05969-0. PMID: 33512594
Malignant struma ovarii.
Yassa L, Sadow P, Marqusee E
Nat Clin Pract Endocrinol Metab 2008 Aug;4(8):469-72. Epub 2008 Jun 17 doi: 10.1038/ncpendmet0887. PMID: 18560398
Struma ovarii.
Ayhan A, Yanik F, Tuncer R, Tuncer ZS, Ruacan S
Int J Gynaecol Obstet 1993 Aug;42(2):143-6. doi: 10.1016/0020-7292(93)90628-a. PMID: 7901063

Therapy

Metastatic malignant struma ovarii: a case report and review of the literature on the management of malignant struma ovarii.
Taelman V, Boer M, Taelman P
Acta Clin Belg 2022 Jun;77(3):721-725. Epub 2021 Jun 30 doi: 10.1080/17843286.2021.1944583. PMID: 34191687
Malignant struma ovarii: From case to analysis.
Ayhan S, Kilic F, Ersak B, Aytekin O, Akar S, Turkmen O, Akgul G, Toyran A, Turan T, Kimyon Comert G
J Obstet Gynaecol Res 2021 Sep;47(9):3339-3351. Epub 2021 Jul 4 doi: 10.1111/jog.14902. PMID: 34219334
Sincronous malignant struma ovarii and papillary thyroid carcinoma.
Fernández Catalina P, Rego Iraeta A, Lorenzo Solar M, Sánchez Sobrino P
Endocrinol Nutr 2016 Aug-Sep;63(7):366-7. Epub 2016 Jun 11 doi: 10.1016/j.endonu.2016.05.002. PMID: 27297016
Struma ovarii maligna.
Matysiak-Grzes M, Fischbach J, Gut P, Klimowicz A, Gryczynska M, Wasko R, Ruchala M
Neuro Endocrinol Lett 2013;34(2):97-101. PMID: 23645304
Malignant struma ovarii.
Yassa L, Sadow P, Marqusee E
Nat Clin Pract Endocrinol Metab 2008 Aug;4(8):469-72. Epub 2008 Jun 17 doi: 10.1038/ncpendmet0887. PMID: 18560398

Prognosis

Incidence, clinical characteristics, and survival outcomes of ovarian strumal diseases: a retrospective cohort study.
Li S, Hong R, Yin M, Zhang T, Zhang X, Yang J
BMC Womens Health 2023 Sep 19;23(1):497. doi: 10.1186/s12905-023-02624-5. PMID: 37726744Free PMC Article
Malignant struma ovarii: From case to analysis.
Ayhan S, Kilic F, Ersak B, Aytekin O, Akar S, Turkmen O, Akgul G, Toyran A, Turan T, Kimyon Comert G
J Obstet Gynaecol Res 2021 Sep;47(9):3339-3351. Epub 2021 Jul 4 doi: 10.1111/jog.14902. PMID: 34219334
Clinical characteristics and survival outcomes of malignant struma ovarii confined to the ovary.
Li S, Yang T, Xiang Y, Li X, Zhang L, Deng S
BMC Cancer 2021 Apr 9;21(1):383. doi: 10.1186/s12885-021-08118-7. PMID: 33836675Free PMC Article
Malignant struma ovarii: surgical, histopathological and survival outcomes for thyroid-type carcinoma of struma ovarii with recommendations for standardising multi-modal management. A retrospective case series sharing the experience of a single institution over 10 years.
Addley S, Mihai R, Alazzam M, Dhar S, Soleymani Majd H
Arch Gynecol Obstet 2021 Apr;303(4):863-870. Epub 2021 Jan 29 doi: 10.1007/s00404-021-05969-0. PMID: 33512594
Laparoscopic excision of malignant struma ovarii and 1 year follow-up without further treatment.
Kraemer B, Grischke EM, Staebler A, Hirides P, Rothmund R
Fertil Steril 2011 May;95(6):2124.e9-12. Epub 2011 Jan 26 doi: 10.1016/j.fertnstert.2010.12.047. PMID: 21269611

Clinical prediction guides

Clinical Manifestations of Malignant Struma Ovarii: A Retrospective Case Series in a Tertiary Hospital in Korea.
Ryu HJ, Leem DE, Yoo JH, Kim TH, Kim SW, Chung JH
Endocrinol Metab (Seoul) 2024 Jun;39(3):461-467. Epub 2024 May 9 doi: 10.3803/EnM.2023.1863. PMID: 38721636Free PMC Article
Role of gene sequencing in classifying struma ovarii: BRAF p.G469A mutation and TERT promoter alterations favour malignant struma ovarii.
Neyrand S, Trecourt A, Lopez J, Just PA, Descotes F, Borson-Chazot F, Ray-Coquard I, Decaussin-Petrucci M, Devouassoux-Shisheboran M
Histopathology 2024 Jan;84(2):291-300. Epub 2023 Sep 28 doi: 10.1111/his.15052. PMID: 37771077
Malignant struma ovarii: a population-level analysis of a large series of 68 patients.
Goffredo P, Sawka AM, Pura J, Adam MA, Roman SA, Sosa JA
Thyroid 2015 Feb;25(2):211-5. Epub 2014 Dec 5 doi: 10.1089/thy.2014.0328. PMID: 25375817
Monodermal teratomas (struma ovarii). Clinicopathological characteristics of 11 cases and literature review.
Kondi-Pafiti A, Mavrigiannaki P, Grigoriadis Ch, Kontogianni-Katsarou K, Mellou A, Kleanthis CK, Liapis A
Eur J Gynaecol Oncol 2011;32(6):657-9. PMID: 22335029
Natural history of biologically malignant struma ovarii: analysis of 27 cases with extraovarian spread.
Shaco-Levy R, Bean SM, Bentley RC, Robboy SJ
Int J Gynecol Pathol 2010 May;29(3):212-27. doi: 10.1097/PGP.0b013e3181bfb133. PMID: 20407319

Recent systematic reviews

Malignant struma ovarii: From case to analysis.
Ayhan S, Kilic F, Ersak B, Aytekin O, Akar S, Turkmen O, Akgul G, Toyran A, Turan T, Kimyon Comert G
J Obstet Gynaecol Res 2021 Sep;47(9):3339-3351. Epub 2021 Jul 4 doi: 10.1111/jog.14902. PMID: 34219334

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