U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Decreased male libido

MedGen UID:
1378453
•Concept ID:
C4477042
•
Anatomical Abnormality
HPO: HP:0040306

Definition

Reduced desire for sexual activity on the part of a male. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased male libido

Professional guidelines

PubMed

Medical Treatment of Hypogonadism in Men.
Mani SB, Clavijo RI
Urol Clin North Am 2022 May;49(2):197-207. doi: 10.1016/j.ucl.2021.12.008. PMID: 35428426
EMAS position statement: Testosterone replacement therapy in the aging male‏.
Dimopoulou C, Ceausu I, Depypere H, Lambrinoudaki I, Mueck A, Pérez-López FR, Rees M, van der Schouw YT, Senturk LM, Simonsini T, Stevenson JC, Stute P, Goulis DG
Maturitas 2016 Feb;84:94-9. Epub 2015 Nov 10 doi: 10.1016/j.maturitas.2015.11.003. PMID: 26614257
Male acquired hypogonadotropic hypogonadism: diagnosis and treatment.
Salenave S, Trabado S, Maione L, Brailly-Tabard S, Young J
Ann Endocrinol (Paris) 2012 Apr;73(2):141-6. Epub 2012 Apr 25 doi: 10.1016/j.ando.2012.03.040. PMID: 22541999

Recent clinical studies

Etiology

Symptoms and risk factors for long COVID in non-hospitalized adults.
Subramanian A, Nirantharakumar K, Hughes S, Myles P, Williams T, Gokhale KM, Taverner T, Chandan JS, Brown K, Simms-Williams N, Shah AD, Singh M, Kidy F, Okoth K, Hotham R, Bashir N, Cockburn N, Lee SI, Turner GM, Gkoutos GV, Aiyegbusi OL, McMullan C, Denniston AK, Sapey E, Lord JM, Wraith DC, Leggett E, Iles C, Marshall T, Price MJ, Marwaha S, Davies EH, Jackson LJ, Matthews KL, Camaradou J, Calvert M, Haroon S
Nat Med 2022 Aug;28(8):1706-1714. Epub 2022 Jul 25 doi: 10.1038/s41591-022-01909-w. PMID: 35879616Free PMC Article
The Role of Testosterone in the Elderly: What Do We Know?
Barone B, Napolitano L, Abate M, Cirillo L, Reccia P, Passaro F, Turco C, Morra S, Mastrangelo F, Scarpato A, Amicuzi U, Morgera V, Romano L, Calace FP, Pandolfo SD, De Luca L, Aveta A, Sicignano E, Trivellato M, Spena G, D'Alterio C, Fusco GM, Vitale R, Arcaniolo D, Crocetto F
Int J Mol Sci 2022 Mar 24;23(7) doi: 10.3390/ijms23073535. PMID: 35408895Free PMC Article
Finasteride for hair loss: a review.
Gupta AK, Venkataraman M, Talukder M, Bamimore MA
J Dermatolog Treat 2022 Jun;33(4):1938-1946. Epub 2021 Aug 2 doi: 10.1080/09546634.2021.1959506. PMID: 34291720
Testosterone replacement therapy.
Barbonetti A, D'Andrea S, Francavilla S
Andrology 2020 Nov;8(6):1551-1566. Epub 2020 Mar 9 doi: 10.1111/andr.12774. PMID: 32068334
Adverse effects of androgen deprivation therapy and strategies to mitigate them.
Nguyen PL, Alibhai SM, Basaria S, D'Amico AV, Kantoff PW, Keating NL, Penson DF, Rosario DJ, Tombal B, Smith MR
Eur Urol 2015 May;67(5):825-36. Epub 2014 Aug 2 doi: 10.1016/j.eururo.2014.07.010. PMID: 25097095

Diagnosis

Male Reproductive Endocrine Disorders.
McCoskey M, Vernon N
Prim Care 2024 Sep;51(3):455-466. Epub 2024 May 23 doi: 10.1016/j.pop.2024.04.003. PMID: 39067971
Medical Treatment of Hypogonadism in Men.
Mani SB, Clavijo RI
Urol Clin North Am 2022 May;49(2):197-207. doi: 10.1016/j.ucl.2021.12.008. PMID: 35428426
Testosterone replacement therapy.
Barbonetti A, D'Andrea S, Francavilla S
Andrology 2020 Nov;8(6):1551-1566. Epub 2020 Mar 9 doi: 10.1111/andr.12774. PMID: 32068334
Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial.
Sletten TL, Magee M, Murray JM, Gordon CJ, Lovato N, Kennaway DJ, Gwini SM, Bartlett DJ, Lockley SW, Lack LC, Grunstein RR, Rajaratnam SMW; Delayed Sleep on Melatonin (DelSoM) Study Group
PLoS Med 2018 Jun;15(6):e1002587. Epub 2018 Jun 18 doi: 10.1371/journal.pmed.1002587. PMID: 29912983Free PMC Article
Late-onset hypogonadism.
Bassil N
Med Clin North Am 2011 May;95(3):507-23, x. doi: 10.1016/j.mcna.2011.03.001. PMID: 21549875

Therapy

The association of hypogonadism with depression and its treatments.
Indirli R, Lanzi V, Arosio M, Mantovani G, Ferrante E
Front Endocrinol (Lausanne) 2023;14:1198437. Epub 2023 Aug 10 doi: 10.3389/fendo.2023.1198437. PMID: 37635965Free PMC Article
The Role of Testosterone in the Elderly: What Do We Know?
Barone B, Napolitano L, Abate M, Cirillo L, Reccia P, Passaro F, Turco C, Morra S, Mastrangelo F, Scarpato A, Amicuzi U, Morgera V, Romano L, Calace FP, Pandolfo SD, De Luca L, Aveta A, Sicignano E, Trivellato M, Spena G, D'Alterio C, Fusco GM, Vitale R, Arcaniolo D, Crocetto F
Int J Mol Sci 2022 Mar 24;23(7) doi: 10.3390/ijms23073535. PMID: 35408895Free PMC Article
Finasteride for hair loss: a review.
Gupta AK, Venkataraman M, Talukder M, Bamimore MA
J Dermatolog Treat 2022 Jun;33(4):1938-1946. Epub 2021 Aug 2 doi: 10.1080/09546634.2021.1959506. PMID: 34291720
Sexual side effects of 5-α-reductase inhibitors finasteride and dutasteride: A comprehensive review.
Fertig RM, Gamret AC, Darwin E, Gaudi S
Dermatol Online J 2017 Nov 11;23(11) PMID: 29447628
Adverse effects of androgen deprivation therapy and strategies to mitigate them.
Nguyen PL, Alibhai SM, Basaria S, D'Amico AV, Kantoff PW, Keating NL, Penson DF, Rosario DJ, Tombal B, Smith MR
Eur Urol 2015 May;67(5):825-36. Epub 2014 Aug 2 doi: 10.1016/j.eururo.2014.07.010. PMID: 25097095

Prognosis

GIANT PROLACTINOMA. A CASE REPORT.
Šulavíková Z, Krásnik V
Cesk Slov Oftalmol 2023 Spring;79(3):143-148. doi: 10.31348/2023/20. PMID: 37344216
Splenectomy is associated with sexual dysfunctions and decreased libido.
Sabino KR, Petroianu A
Sci Rep 2021 Nov 5;11(1):21770. doi: 10.1038/s41598-021-01371-7. PMID: 34741128Free PMC Article
Agitated depression in bipolar disorder.
Serra F, Gordon-Smith K, Perry A, Fraser C, Di Florio A, Craddock N, Jones I, Jones L
Bipolar Disord 2019 Sep;21(6):547-555. Epub 2019 May 6 doi: 10.1111/bdi.12778. PMID: 31004555
Amitriptyline and Sexual Function: A Systematic Review Updated for Sexual Health Practice.
Chen LW, Chen MY, Lian ZP, Lin HS, Chien CC, Yin HL, Chu YH, Chen KY
Am J Mens Health 2018 Mar;12(2):370-379. Epub 2017 Oct 11 doi: 10.1177/1557988317734519. PMID: 29019272Free PMC Article
Safety of estrogen/androgen regimens.
Simon JA
J Reprod Med 2001 Mar;46(3 Suppl):281-90. PMID: 11304876

Clinical prediction guides

Symptoms and risk factors for long COVID in non-hospitalized adults.
Subramanian A, Nirantharakumar K, Hughes S, Myles P, Williams T, Gokhale KM, Taverner T, Chandan JS, Brown K, Simms-Williams N, Shah AD, Singh M, Kidy F, Okoth K, Hotham R, Bashir N, Cockburn N, Lee SI, Turner GM, Gkoutos GV, Aiyegbusi OL, McMullan C, Denniston AK, Sapey E, Lord JM, Wraith DC, Leggett E, Iles C, Marshall T, Price MJ, Marwaha S, Davies EH, Jackson LJ, Matthews KL, Camaradou J, Calvert M, Haroon S
Nat Med 2022 Aug;28(8):1706-1714. Epub 2022 Jul 25 doi: 10.1038/s41591-022-01909-w. PMID: 35879616Free PMC Article
Testosterone replacement therapy.
Barbonetti A, D'Andrea S, Francavilla S
Andrology 2020 Nov;8(6):1551-1566. Epub 2020 Mar 9 doi: 10.1111/andr.12774. PMID: 32068334
Adverse effects of androgen deprivation therapy and strategies to mitigate them.
Nguyen PL, Alibhai SM, Basaria S, D'Amico AV, Kantoff PW, Keating NL, Penson DF, Rosario DJ, Tombal B, Smith MR
Eur Urol 2015 May;67(5):825-36. Epub 2014 Aug 2 doi: 10.1016/j.eururo.2014.07.010. PMID: 25097095
Dehydroepiandrosterone replacement therapy.
Arlt W
Semin Reprod Med 2004 Nov;22(4):379-88. doi: 10.1055/s-2004-861554. PMID: 15635505
Dutasteride.
Evans HC, Goa KL
Drugs Aging 2003;20(12):905-16; discussion 917-8. doi: 10.2165/00002512-200320120-00005. PMID: 14565784

Recent systematic reviews

Comparative effects of finasteride and minoxidil on the male reproductive organs: A systematic review of in vitro and in vivo evidence.
Santana FFV, Lozi AA, Gonçalves RV, Da Silva J, Da Matta SLP
Toxicol Appl Pharmacol 2023 Nov 1;478:116710. Epub 2023 Oct 5 doi: 10.1016/j.taap.2023.116710. PMID: 37805090
Amitriptyline and Sexual Function: A Systematic Review Updated for Sexual Health Practice.
Chen LW, Chen MY, Lian ZP, Lin HS, Chien CC, Yin HL, Chu YH, Chen KY
Am J Mens Health 2018 Mar;12(2):370-379. Epub 2017 Oct 11 doi: 10.1177/1557988317734519. PMID: 29019272Free PMC Article
Determinants of sexual function and dysfunction in men and women with stroke: A systematic review.
Dusenbury W, Palm Johansen P, Mosack V, Steinke EE
Int J Clin Pract 2017 Jul;71(7) Epub 2017 Jun 8 doi: 10.1111/ijcp.12969. PMID: 28594462
Impact of combination therapy 5-alpha reductase inhibitors (5-ARI) plus alpha-blockers (AB) on erectile dysfunction and decrease of libido in patients with LUTS/BPH: a systematic review with meta-analysis.
Favilla V, Russo GI, Privitera S, Castelli T, Giardina R, Calogero AE, Condorelli RA, La Vignera S, Cimino S, Morgia G
Aging Male 2016 Sep;19(3):175-181. Epub 2016 Jun 16 doi: 10.1080/13685538.2016.1195361. PMID: 27310433
A systematic review of sexual concerns reported by gynecological cancer survivors.
Abbott-Anderson K, Kwekkeboom KL
Gynecol Oncol 2012 Mar;124(3):477-89. Epub 2011 Nov 28 doi: 10.1016/j.ygyno.2011.11.030. PMID: 22134375

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...