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Abnormal CSF/serum albumin ratio

MedGen UID:: 1381163
•Concept ID:: C4476894
•: Finding

HPO:	HP:0030981

Definition

A deviation from the normal range of the ratio of the albumin concentration in the cerebrospinal fluid (CSF) to the concentration in serum (which may be defined as 3.2-9.0). This is an index of blood-brain barrier (BBB) integrity, adjusted for the serum albumin concentration, and an increased ratio is taken as a sign of a loss of integrity of the BBB with leakage of albumin into the CSF. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal CSF/serum albumin ratio

Fetal anomaly
- Congenital Systemic Disorder
  - Abnormality of the nervous system
    - Abnormal nervous system morphology
      - Morphological central nervous system abnormality
        Abnormal cerebrospinal fluid morphology
        Abnormal CSF/serum albumin ratio
        Decreased CSF/serum albumin ratio
        Increased CSF/serum albumin ratio

Recent clinical studies

Etiology

Cerebrospinal fluid abnormalities in first- and multi-episode schizophrenia-spectrum disorders: impact of clinical and demographical variables.

Oviedo-Salcedo T, Wagner E, Campana M, Gagsteiger A, Strube W, Eichhorn P, Louiset ML, Luykx J, de Witte LD, Kahn RS, Benros ME, Falkai P, Hasan A
Transl Psychiatry 2021 Dec 8;11(1):621. doi: 10.1038/s41398-021-01751-7. PMID: 34880213 Free PMC Article

CSF Findings in Acute NMDAR and LGI1 Antibody-Associated Autoimmune Encephalitis.

Dürr M, Nissen G, Sühs KW, Schwenkenbecher P, Geis C, Ringelstein M, Hartung HP, Friese MA, Kaufmann M, Malter MP, Madlener M, Thaler FS, Kümpfel T, Senel M, Häusler MG, Schneider H, Bergh FT, Kellinghaus C, Zettl UK, Wandinger KP, Melzer N, Gross CC, Lange P, Dreyhaupt J, Tumani H, Leypoldt F, Lewerenz J; German Network for Research on Autoimmune Encephalitis
Neurol Neuroimmunol Neuroinflamm 2021 Nov;8(6) Epub 2021 Oct 25 doi: 10.1212/NXI.0000000000001086. PMID: 34697224 Free PMC Article

Cerebrospinal fluid test results and associations with subsequent mental disorders, neurological diseases, and CNS infections: A population-based cohort study.

Orlovska-Waast S, Petersen LV, Gasse C, Nordentoft M, Mortensen PB, Kondziella D, Benros ME
Brain Behav Immun 2021 Nov;98:210-218. Epub 2021 Aug 12 doi: 10.1016/j.bbi.2021.08.006. PMID: 34390802

Cerebrospinal fluid abnormalities in meningeosis neoplastica: a retrospective 12-year analysis.

Djukic M, Trimmel R, Nagel I, Spreer A, Lange P, Stadelmann C, Nau R
Fluids Barriers CNS 2017 Mar 28;14(1):7. doi: 10.1186/s12987-017-0057-2. PMID: 28351400 Free PMC Article

The effect of systemic inflammation on human brain barrier function.

Elwood E, Lim Z, Naveed H, Galea I
Brain Behav Immun 2017 May;62:35-40. Epub 2016 Nov 1 doi: 10.1016/j.bbi.2016.10.020. PMID: 27810376 Free PMC Article

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Diagnosis

Cerebrospinal fluid test results and associations with subsequent mental disorders, neurological diseases, and CNS infections: A population-based cohort study.

Orlovska-Waast S, Petersen LV, Gasse C, Nordentoft M, Mortensen PB, Kondziella D, Benros ME
Brain Behav Immun 2021 Nov;98:210-218. Epub 2021 Aug 12 doi: 10.1016/j.bbi.2021.08.006. PMID: 34390802

Cerebrospinal fluid markers of inflammation and infections in schizophrenia and affective disorders: a systematic review and meta-analysis.

Orlovska-Waast S, Köhler-Forsberg O, Brix SW, Nordentoft M, Kondziella D, Krogh J, Benros ME
Mol Psychiatry 2019 Jun;24(6):869-887. Epub 2018 Aug 16 doi: 10.1038/s41380-018-0220-4. PMID: 30116031 Free PMC Article

Cerebrospinal fluid abnormalities in meningeosis neoplastica: a retrospective 12-year analysis.

Djukic M, Trimmel R, Nagel I, Spreer A, Lange P, Stadelmann C, Nau R
Fluids Barriers CNS 2017 Mar 28;14(1):7. doi: 10.1186/s12987-017-0057-2. PMID: 28351400 Free PMC Article

Isolated blood-cerebrospinal fluid barrier dysfunction: prevalence and associated diseases.

Brettschneider J, Claus A, Kassubek J, Tumani H
J Neurol 2005 Sep;252(9):1067-73. Epub 2005 Apr 1 doi: 10.1007/s00415-005-0817-9. PMID: 15789126

IgG production within the central nervous system: a critical review of proposed formulae.

Lefvert AK, Link H
Ann Neurol 1985 Jan;17(1):13-20. doi: 10.1002/ana.410170105. PMID: 3985580

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Therapy

Comparison of Clinical Features and Prognostic Factors of Cryptococcal Meningitis Caused by Cryptococcus neoformans in Patients With and Without Pulmonary Nodules.

Cao W, Jian C, Zhang H, Xu S
Mycopathologia 2019 Feb;184(1):73-80. Epub 2018 May 8 doi: 10.1007/s11046-018-0263-8. PMID: 29737452

Cerebrospinal fluid protein concentrations related to clinical findings in patients with sciatica caused by disk herniation.

Skouen JS, Larsen JL, Vollset SE
J Spinal Disord 1994 Feb;7(1):12-8. doi: 10.1097/00002517-199407010-00002. PMID: 8186584

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Prognosis

Cerebrospinal fluid abnormalities in first- and multi-episode schizophrenia-spectrum disorders: impact of clinical and demographical variables.

Comparison of Clinical Features and Prognostic Factors of Cryptococcal Meningitis Caused by Cryptococcus neoformans in Patients With and Without Pulmonary Nodules.

Cao W, Jian C, Zhang H, Xu S
Mycopathologia 2019 Feb;184(1):73-80. Epub 2018 May 8 doi: 10.1007/s11046-018-0263-8. PMID: 29737452

Procarboxypeptidase U (proCPU, TAFI, proCPB2) in cerebrospinal fluid during ischemic stroke is associated with stroke progression, outcome and blood-brain barrier dysfunction.

Mertens JC, Leenaerts D, Brouns R, Engelborghs S, Ieven M, De Deyn PP, Lambeir AM, Hendriks D
J Thromb Haemost 2018 Feb;16(2):342-348. Epub 2017 Dec 26 doi: 10.1111/jth.13914. PMID: 29194929

The effect of systemic inflammation on human brain barrier function.

Elwood E, Lim Z, Naveed H, Galea I
Brain Behav Immun 2017 May;62:35-40. Epub 2016 Nov 1 doi: 10.1016/j.bbi.2016.10.020. PMID: 27810376 Free PMC Article

Childhood encephalopathy: viruses, immune response, and outcome.

Clarke M, Newton RW, Klapper PE, Sutcliffe H, Laing I, Wallace G
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Clinical prediction guides

Cerebrospinal fluid abnormalities in first- and multi-episode schizophrenia-spectrum disorders: impact of clinical and demographical variables.

CSF Findings in Acute NMDAR and LGI1 Antibody-Associated Autoimmune Encephalitis.

Procarboxypeptidase U (proCPU, TAFI, proCPB2) in cerebrospinal fluid during ischemic stroke is associated with stroke progression, outcome and blood-brain barrier dysfunction.

Mertens JC, Leenaerts D, Brouns R, Engelborghs S, Ieven M, De Deyn PP, Lambeir AM, Hendriks D
J Thromb Haemost 2018 Feb;16(2):342-348. Epub 2017 Dec 26 doi: 10.1111/jth.13914. PMID: 29194929

The effect of systemic inflammation on human brain barrier function.

Elwood E, Lim Z, Naveed H, Galea I
Brain Behav Immun 2017 May;62:35-40. Epub 2016 Nov 1 doi: 10.1016/j.bbi.2016.10.020. PMID: 27810376 Free PMC Article

Interleukin-6 levels in the cerebrospinal fluid and serum of patients with Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy.

Maimone D, Annunziata P, Simone IL, Livrea P, Guazzi GC
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