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Neurenteric cyst

MedGen UID:
14343
•Concept ID:
C0027806
•
Congenital Abnormality
Synonyms: Cyst, Neurenteric; Cyst, Neuroenteric; Cysts, Neurenteric; Cysts, Neuroenteric; Neurenteric Cyst; Neurenteric Cysts; Neuroenteric Cyst; Neuroenteric Cysts
SNOMED CT: Neurenteric cyst (789120001); Neurenteric cyst (41353005)
 
HPO: HP:0030725
Monarch Initiative: MONDO:0017087
Orphanet: ORPHA268865

Definition

The neurenteric cyst is a rare lesion composed of heterotopic endodermal tissue. During the third week of human embryogenesis, the neurenteric canal unites the yolk sac and the amniotic cavity as it traverses the primitive notochordal plate. Persistence of the normally transient neurenteric canal prevents appropriate separation of endoderm and notochord. This results in a variable degree of communication between neural and enteric epithelium. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeurenteric cyst
Follow this link to review classifications for Neurenteric cyst in Orphanet.

Professional guidelines

PubMed

Update on prenatal diagnosis and fetal surgery for myelomeningocele.
Meller C, Covini D, Aiello H, Izbizky G, Portillo Medina S, Otaño L
Arch Argent Pediatr 2021 Jun;119(3):e215-e228. doi: 10.5546/aap.2021.eng.e215. PMID: 34033426
Spina Bifida Management.
Phillips LA, Burton JM, Evans SH
Curr Probl Pediatr Adolesc Health Care 2017 Jul;47(7):173-177. Epub 2017 Jul 19 doi: 10.1016/j.cppeds.2017.06.007. PMID: 28734746
MTHFR: Addressing Genetic Counseling Dilemmas Using Evidence-Based Literature.
Levin BL, Varga E
J Genet Couns 2016 Oct;25(5):901-11. Epub 2016 Apr 30 doi: 10.1007/s10897-016-9956-7. PMID: 27130656

Recent clinical studies

Etiology

Supratentorial Neurenteric Cysts: Systematic Literature Review and Case Report.
Stopa BM, Cuoco JA, Stump MS, Rogers CM
World Neurosurg 2022 Aug;164:8-24. Epub 2022 Apr 20 doi: 10.1016/j.wneu.2022.04.057. PMID: 35460907
Endoscopic Endonasal Approaches to the Clival Region.
Ravnik J, Hribernik B, Lanišnik B
Acta Med Acad 2020;49 Suppl 1:45-53. doi: 10.5644/ama2006-124.306. PMID: 33543630
Neurenteric cysts, incidence and surgical treatment.
Kozak J, Bizik I, Surkala J, Steno J, Steno A
Bratisl Lek Listy 2019;120(9):680-685. doi: 10.4149/BLL_2019_114. PMID: 31475554
Complex forms of spinal dysraphism.
Patnaik A, Mahapatra AK
Childs Nerv Syst 2013 Sep;29(9):1527-32. Epub 2013 Sep 7 doi: 10.1007/s00381-013-2161-1. PMID: 24013322
Spectrum of nonterminal myelocystoceles.
Rossi A, Piatelli G, Gandolfo C, Pavanello M, Hoffmann C, Van Goethem JW, Cama A, Tortori-Donati P
Neurosurgery 2006 Mar;58(3):509-15; discussion 509-15. doi: 10.1227/01.NEU.0000197122.92954.82. PMID: 16528191

Diagnosis

Meningeal carcinomatosis secondary to neurenteric cysts with malignant transformation: a case report.
Chu M, Wang L, Ye H, Li J, Lu D, Piao Y, Wu L
BMC Neurol 2022 Nov 16;22(1):433. doi: 10.1186/s12883-022-02978-7. PMID: 36384561Free PMC Article
Endoscopic Endonasal Approaches to the Clival Region.
Ravnik J, Hribernik B, Lanišnik B
Acta Med Acad 2020;49 Suppl 1:45-53. doi: 10.5644/ama2006-124.306. PMID: 33543630
Neurosurgical pathology of limited dorsal myeloschisis.
Morioka T, Suzuki SO, Murakami N, Shimogawa T, Mukae N, Inoha S, Sasaguri T, Iihara K
Childs Nerv Syst 2018 Feb;34(2):293-303. Epub 2017 Oct 23 doi: 10.1007/s00381-017-3625-5. PMID: 29063264
Complex forms of spinal dysraphism.
Patnaik A, Mahapatra AK
Childs Nerv Syst 2013 Sep;29(9):1527-32. Epub 2013 Sep 7 doi: 10.1007/s00381-013-2161-1. PMID: 24013322
Long-term follow-up and pregnancy in a patient with neurenteric cyst: case report.
Ramos-Zúñiga R, Casillas-Espinosa PM, Sánchez-Prieto JA, Encarnación-Ibarra O, López-Hernández Mdel S
Cir Cir 2011 Jul-Aug;79(4):334-7. PMID: 21951888

Therapy

Risk Factors in a Pediatric Population for Postoperative Intracranial Infection Following Endoscopic Endonasal Skull Base Surgery and the Role of Antibiotic Prophylaxis.
Palmieri D, Champagne PO, Valappil B, McDowell MM, Gardner PA, Snyderman CH
Am J Rhinol Allergy 2023 Jan;37(1):13-18. Epub 2022 Sep 1 doi: 10.1177/19458924221123113. PMID: 36050937
Supratentorial Neurenteric Cysts: Systematic Literature Review and Case Report.
Stopa BM, Cuoco JA, Stump MS, Rogers CM
World Neurosurg 2022 Aug;164:8-24. Epub 2022 Apr 20 doi: 10.1016/j.wneu.2022.04.057. PMID: 35460907
Management of an unusual, recurrent neurenteric cyst in an infant: case report and review of the literature.
Esfahani DR, Burokas L, Brown HG, Hahn YS, Nikas D
Childs Nerv Syst 2017 Sep;33(9):1603-1607. Epub 2017 Jun 22 doi: 10.1007/s00381-017-3487-x. PMID: 28643040
Neurenteric cyst: an unusual cause of third nerve palsy.
Wait SD, Choi LS, Teo C
Childs Nerv Syst 2011 Apr;27(4):639-41. Epub 2010 Nov 25 doi: 10.1007/s00381-010-1332-6. PMID: 21107583
Surgical approaches: postoperative care and complications "posterolateral-far lateral transcondylar approach to the ventral foramen magnum and upper cervical spinal canal".
Menezes AH
Childs Nerv Syst 2008 Oct;24(10):1203-7. Epub 2008 Mar 26 doi: 10.1007/s00381-008-0597-5. PMID: 18365213

Prognosis

Neurenteric cysts, incidence and surgical treatment.
Kozak J, Bizik I, Surkala J, Steno J, Steno A
Bratisl Lek Listy 2019;120(9):680-685. doi: 10.4149/BLL_2019_114. PMID: 31475554
Ventral foramen magnum neurenteric cysts: a case series and review of literature.
Prasad GL, Sharma BS, Mahapatra AK
Neurosurg Rev 2016 Oct;39(4):535-44. Epub 2015 Dec 10 doi: 10.1007/s10143-015-0687-2. PMID: 26662045
Complex forms of spinal dysraphism.
Patnaik A, Mahapatra AK
Childs Nerv Syst 2013 Sep;29(9):1527-32. Epub 2013 Sep 7 doi: 10.1007/s00381-013-2161-1. PMID: 24013322
Tethered cord syndrome in adults.
Klekamp J
J Neurosurg Spine 2011 Sep;15(3):258-70. Epub 2011 May 20 doi: 10.3171/2011.4.SPINE10504. PMID: 21599446
Spectrum of nonterminal myelocystoceles.
Rossi A, Piatelli G, Gandolfo C, Pavanello M, Hoffmann C, Van Goethem JW, Cama A, Tortori-Donati P
Neurosurgery 2006 Mar;58(3):509-15; discussion 509-15. doi: 10.1227/01.NEU.0000197122.92954.82. PMID: 16528191

Clinical prediction guides

Imaging alterations due to squamous metaplasia in intracranial neurenteric cysts: A report of two cases.
Watanabe N, Akasaki Y, Fujigasaki J, Mori R, Aizawa D, Ikeuchi S, Murayama Y
Neuroradiol J 2016 Jun;29(3):187-92. Epub 2016 Mar 23 doi: 10.1177/1971400916638356. PMID: 27009777Free PMC Article
Clinical presentation and surgical outcomes of intramedullary neurenteric cysts.
Yang T, Wu L, Fang J, Yang C, Deng X, Xu Y
J Neurosurg Spine 2015 Jul;23(1):99-110. Epub 2015 Apr 24 doi: 10.3171/2014.11.SPINE14352. PMID: 25909275
Diagnostic and surgical implications of ventral vertebrobasilar displacement by posterior fossa neurenteric cysts.
Uschold T, Xu DS, Wilson DA, Abla AA, Nakaji P, Spetzler RF, Chang SW
World Neurosurg 2014 Sep-Oct;82(3-4):480-4. Epub 2013 Oct 16 doi: 10.1016/j.wneu.2013.10.037. PMID: 24141002
Spectrum of nonterminal myelocystoceles.
Rossi A, Piatelli G, Gandolfo C, Pavanello M, Hoffmann C, Van Goethem JW, Cama A, Tortori-Donati P
Neurosurgery 2006 Mar;58(3):509-15; discussion 509-15. doi: 10.1227/01.NEU.0000197122.92954.82. PMID: 16528191
Intramedullary neurenteric cyst without any associated malformation. One case evaluated by RMI and electron microscopic study.
Riviérez M, Buisson G, Kujas M, Ridarch A, Mignon E, Jouannelle A, René-Corail P
Acta Neurochir (Wien) 1997;139(9):887-90. doi: 10.1007/BF01411408. PMID: 9351995

Recent systematic reviews

Resection of intradural spinal lesions with concomitant instrumented fusion in children: a systematic review and representative cases.
Prather KY, Baier MP, Coulibaly NJ, Stephens ME, Chen S, Omini ME, Jea A
J Neurosurg Pediatr 2024 Jul 1;34(1):99-110. Epub 2024 Apr 5 doi: 10.3171/2024.1.PEDS23444. PMID: 38579345
Supratentorial Neurenteric Cysts: Systematic Literature Review and Case Report.
Stopa BM, Cuoco JA, Stump MS, Rogers CM
World Neurosurg 2022 Aug;164:8-24. Epub 2022 Apr 20 doi: 10.1016/j.wneu.2022.04.057. PMID: 35460907

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