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Phagocyte bactericidal dysfunction

MedGen UID:: 14713
•Concept ID:: C0031306
•: Disease or Syndrome

Synonyms:	Bactericidal Dysfunction, Phagocyte; Bactericidal Dysfunctions, Phagocyte; Dysfunction, Phagocyte Bactericidal; Dysfunctions, Phagocyte Bactericidal; Phagocyte Bactericidal Dysfunction; Phagocyte Bactericidal Dysfunctions

Monarch Initiative:	MONDO:0005910

Definition

Disorders in which phagocytic cells cannot kill ingested bacteria; characterized by frequent recurring infection with formulation of granulomas. [from MONDO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVPhagocyte bactericidal dysfunction

Phenotypic abnormality
- Abnormality of the immune system
  - Abnormality of immune system physiology
    - Immunodeficiency
      - Phagocyte bactericidal dysfunction
        Chronic granulomatous disease
        Granulomatous disease, chronic, autosomal recessive, cytochrome b-negative
        Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type 1
        Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type 2
        Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type 3
        Granulomatous disease, chronic, X-linked
        Chédiak-Higashi syndrome
        Aleutian disease
        Hyper-IgE syndrome
        CADINS disease
        Hyper-IgE recurrent infection syndrome 1, autosomal dominant
        Immunodeficiency 23
        Netherton syndrome
        Severe dermatitis-multiple allergies-metabolic wasting syndrome

Professional guidelines

PubMed

Germline Mosaicism in STAT3: A Pitfall for Genetic Diagnosis, Counseling, and Therapy of Hyper-IgE Syndrome.

Sabbagh Q, Cohen JD, Mortreux J, Raymond L, Geromel V, Boursier G, Jeziorski E, Le Moing V, Bessis D, Geneviève D
Dermatitis 2023 Nov-Dec;34(6):561-563. Epub 2023 Jan 19 doi: 10.1089/derm.2022.0057. PMID: 36917542

Modern management of phagocyte defects.

Lanini LL, Prader S, Siler U, Reichenbach J
Pediatr Allergy Immunol 2017 Mar;28(2):124-134. Epub 2016 Oct 13 doi: 10.1111/pai.12654. PMID: 27612320

Practice parameter for the diagnosis and management of primary immunodeficiency.

Bonilla FA, Bernstein IL, Khan DA, Ballas ZK, Chinen J, Frank MM, Kobrynski LJ, Levinson AI, Mazer B, Nelson RP Jr, Orange JS, Routes JM, Shearer WT, Sorensen RU; American Academy of Allergy, Asthma and Immunology; American College of Allergy, Asthma and Immunology; Joint Council of Allergy, Asthma and Immunology
Ann Allergy Asthma Immunol 2005 May;94(5 Suppl 1):S1-63. doi: 10.1016/s1081-1206(10)61142-8. PMID: 15945566

See all (131)

Recent clinical studies

Etiology

Oral manifestations of primary immune deficiencies in children.

Szczawinska-Poplonyk A, Gerreth K, Breborowicz A, Borysewicz-Lewicka M
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009 Sep;108(3):e9-20. Epub 2009 Jul 12 doi: 10.1016/j.tripleo.2009.03.049. PMID: 19596208

The acridine orange fluorochrome microassay: a new technique for quantitation of neutrophil function in burned patients.

Carpenter AB, Boykin JV Jr, Crute SL, Haynes BW
J Trauma 1986 Apr;26(4):389-92. doi: 10.1097/00005373-198604000-00014. PMID: 3959145

Recurrent infection in the child.

Regelmann WE
Postgrad Med 1982 Jan;71(1):157-66, 171-4. doi: 10.1080/00325481.1982.11715967. PMID: 7054773

Kx antigen, the McLeod phenotype, and chronic granulomatous disease: further studies.

Marsh WL, Oyen R, Nichols ME
Vox Sang 1976 Nov;31(5):356-62. doi: 10.1111/j.1423-0410.1976.tb04659.x. PMID: 1007158

Chronic granulomatous disease and the Kell blood groups.

Marsh WL, Oyen R, Nichols ME, Allen FH Jr
Br J Haematol 1975 Feb;29(2):247-62. doi: 10.1111/j.1365-2141.1975.tb01819.x. PMID: 1191546

See all (35)

Diagnosis

Inflammation and repeated infections in CGD: two sides of a coin.

Kuijpers T, Lutter R
Cell Mol Life Sci 2012 Jan;69(1):7-15. Epub 2011 Nov 15 doi: 10.1007/s00018-011-0834-z. PMID: 22083605 Free PMC Article

Functional leukocyte disorders.

Miller ME
Pediatr Ann 1979 Jun;8(6):10-24. doi: 10.3928/0090-4481-19790601-05. PMID: 471548

Chronic granulomatous disease.

Johnston RB, Newman SL
Pediatr Clin North Am 1977 May;24(2):365-76. doi: 10.1016/s0031-3955(16)33424-1. PMID: 323805

Nitroblue-tetrazolium tests.

Segal AW
Lancet 1974 Nov 23;2(7891):1248-52. doi: 10.1016/s0140-6736(74)90758-2. PMID: 4139481

Granuloma formation.

James DG
Trans Med Soc Lond 1972;88:116-49. PMID: 4353228

See all (105)

Therapy

Phagocytic cell dysfunction.

Quie PG
J Allergy Clin Immunol 1986 Mar;77(3):387-98. doi: 10.1016/0091-6749(86)90169-7. PMID: 3512661

Chronic granulomatous disease.

Johnston RB, Newman SL
Pediatr Clin North Am 1977 May;24(2):365-76. doi: 10.1016/s0031-3955(16)33424-1. PMID: 323805

Aggressive cancer treatment and its role in predisposing to infection.

Tattersall MH
Eur J Cancer (1965) 1975 Aug;11suppl:9-19. doi: 10.1016/b978-0-08-019964-1.50006-3. PMID: 815094

The skin as a reflector of immunologic change.

Sams WM Jr, Logan WS
Rheumatology 1973;4(0):98-143. PMID: 4151990

Granuloma formation.

James DG
Trans Med Soc Lond 1972;88:116-49. PMID: 4353228

See all (66)

Prognosis

Malacoplakia of the skin: overview of a rare clinical entity.

Kyriakou G, Gialeli E, Vryzaki E, Koumoundourou D, Glentis A, Georgiou S
Dermatol Online J 2019 Jun 15;25(6) PMID: 31329385

Granulocyte function disorders: aspects of development, genetics and management.

Yang KD, Hill HR
Pediatr Infect Dis J 2001 Sep;20(9):889-900. doi: 10.1097/00006454-200109000-00014. PMID: 11734771

Primary immunodeficiency diseases in Norway.

Stray-Pedersen A, Abrahamsen TG, Frøland SS
J Clin Immunol 2000 Nov;20(6):477-85. doi: 10.1023/a:1026416017763. PMID: 11202238

The CD11/CD18 leukocyte glycoprotein deficiency.

Todd RF 3rd, Freyer DR
Hematol Oncol Clin North Am 1988 Mar;2(1):13-31. PMID: 3279017

Phagocyte defects.

White CJ, Gallin JI
Clin Immunol Immunopathol 1986 Jul;40(1):50-61. doi: 10.1016/0090-1229(86)90068-1. PMID: 2941193

See all (17)

Clinical prediction guides

Oral manifestations of primary immune deficiencies in children.

Systemic lupus erythematosus in Staphylococcus aureus hyperimmunoglobulinaemia E syndrome.

Schopfer K, Feldges A, Baerlocher K, Parisot RF, Wilhelm JA, Matter L
Br Med J (Clin Res Ed) 1983 Aug 20;287(6391):524-6. doi: 10.1136/bmj.287.6391.524. PMID: 6411204 Free PMC Article

Chorioretinal lesions, sea-blue histiocytes and other manifestations in familial chronic granulomatous disease.

Lischner HW, Martyn LJ
Birth Defects Orig Artic Ser 1975;11(1):73-6. PMID: 1148391

Phagocytosis in patients and carriers of chronic granulomatous disease.

Biggar WD
Lancet 1975 May 3;1(7914):991-5. doi: 10.1016/s0140-6736(75)91943-1. PMID: 48723

Pathogenesis of lipoid nephrosis: a disorder of T-cell function.

Shalhoub RJ
Lancet 1974 Sep 7;2(7880):556-60. doi: 10.1016/s0140-6736(74)91880-7. PMID: 4140273

See all (26)

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Phagocyte bactericidal dysfunction

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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