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Malignant Hypothalamic Neoplasm

MedGen UID:
148264
•Concept ID:
C0751238
•
Neoplastic Process
Synonyms: Cancer, Hypothalamic; Cancers, Hypothalamic; Hypothalamic Cancer; Hypothalamic Cancers; Hypothalamic Neoplasm, Malignant; Hypothalamic Neoplasms, Malignant; Malignant Hypothalamic Neoplasms; Neoplasm, Malignant Hypothalamic; Neoplasms, Hypothalamic, Malignant; Neoplasms, Malignant Hypothalamic

Definition

A primary or metastatic malignant neoplasm that affects the hypothalamus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Hypothalamic Neoplasm

Professional guidelines

PubMed

Diagnosis and Management of Pituitary Adenomas: A Review.
Tritos NA, Miller KK
JAMA 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444. PMID: 37097352
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483
Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline.
Melmed S, Casanueva FF, Hoffman AR, Kleinberg DL, Montori VM, Schlechte JA, Wass JA; Endocrine Society
J Clin Endocrinol Metab 2011 Feb;96(2):273-88. doi: 10.1210/jc.2010-1692. PMID: 21296991

Recent clinical studies

Etiology

A proposed clinical classification for pituitary neoplasms to guide therapy and prognosis.
Ho KKY, Fleseriu M, Wass J, Katznelson L, Raverot G, Little AS, Castaño JP, Reincke M, Lopes MB, Kaiser UB, Chanson P, Gadelha M, Melmed S
Lancet Diabetes Endocrinol 2024 Mar;12(3):209-214. Epub 2024 Jan 29 doi: 10.1016/S2213-8587(23)00382-0. PMID: 38301678
National UK guidelines for the management of paediatric craniopharyngioma.
Gan HW, Morillon P, Albanese A, Aquilina K, Chandler C, Chang YC, Drimtzias E, Farndon S, Jacques TS, Korbonits M, Kuczynski A, Limond J, Robinson L, Simmons I, Thomas N, Thomas S, Thorp N, Vargha-Khadem F, Warren D, Zebian B, Mallucci C, Spoudeas HA
Lancet Diabetes Endocrinol 2023 Sep;11(9):694-706. Epub 2023 Aug 4 doi: 10.1016/S2213-8587(23)00162-6. PMID: 37549682
Overview of the 2022 WHO Classification of Pituitary Tumors.
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Clinically non-functioning pituitary adenomas.
Chanson P, Wolf P
Presse Med 2021 Dec;50(4):104086. Epub 2021 Oct 28 doi: 10.1016/j.lpm.2021.104086. PMID: 34718111
Pituitary in the Spotlight.
Reincke M, Honegger J
Exp Clin Endocrinol Diabetes 2021 Mar;129(3):143-145. Epub 2021 Mar 9 doi: 10.1055/a-1369-8898. PMID: 33690869

Diagnosis

National UK guidelines for the management of paediatric craniopharyngioma.
Gan HW, Morillon P, Albanese A, Aquilina K, Chandler C, Chang YC, Drimtzias E, Farndon S, Jacques TS, Korbonits M, Kuczynski A, Limond J, Robinson L, Simmons I, Thomas N, Thomas S, Thorp N, Vargha-Khadem F, Warren D, Zebian B, Mallucci C, Spoudeas HA
Lancet Diabetes Endocrinol 2023 Sep;11(9):694-706. Epub 2023 Aug 4 doi: 10.1016/S2213-8587(23)00162-6. PMID: 37549682
Overview of the 2022 WHO Classification of Pituitary Tumors.
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Childhood-onset Craniopharyngioma.
Otte A, Müller HL
J Clin Endocrinol Metab 2021 Sep 27;106(10):e3820-e3836. doi: 10.1210/clinem/dgab397. PMID: 34086900
The Diagnosis and Treatment of Craniopharyngioma.
Müller HL
Neuroendocrinology 2020;110(9-10):753-766. Epub 2019 Nov 4 doi: 10.1159/000504512. PMID: 31678973
Craniopharyngioma.
Müller HL
Handb Clin Neurol 2014;124:235-53. doi: 10.1016/B978-0-444-59602-4.00016-2. PMID: 25248591

Therapy

Diagnosis and management of prolactin-secreting pituitary adenomas: a Pituitary Society international Consensus Statement.
Petersenn S, Fleseriu M, Casanueva FF, Giustina A, Biermasz N, Biller BMK, Bronstein M, Chanson P, Fukuoka H, Gadelha M, Greenman Y, Gurnell M, Ho KKY, Honegger J, Ioachimescu AG, Kaiser UB, Karavitaki N, Katznelson L, Lodish M, Maiter D, Marcus HJ, McCormack A, Molitch M, Muir CA, Neggers S, Pereira AM, Pivonello R, Post K, Raverot G, Salvatori R, Samson SL, Shimon I, Spencer-Segal J, Vila G, Wass J, Melmed S
Nat Rev Endocrinol 2023 Dec;19(12):722-740. Epub 2023 Sep 5 doi: 10.1038/s41574-023-00886-5. PMID: 37670148
Aggressive pituitary tumours and pituitary carcinomas.
Raverot G, Ilie MD, Lasolle H, Amodru V, Trouillas J, Castinetti F, Brue T
Nat Rev Endocrinol 2021 Nov;17(11):671-684. Epub 2021 Sep 7 doi: 10.1038/s41574-021-00550-w. PMID: 34493834
Craniopharyngioma.
Müller HL
Handb Clin Neurol 2014;124:235-53. doi: 10.1016/B978-0-444-59602-4.00016-2. PMID: 25248591
Craniopharyngioma.
Müller HL
Endocr Rev 2014 Jun;35(3):513-43. Epub 2014 Jan 27 doi: 10.1210/er.2013-1115. PMID: 24467716
Pituitary incidentaloma.
Orija IB, Weil RJ, Hamrahian AH
Best Pract Res Clin Endocrinol Metab 2012 Feb;26(1):47-68. doi: 10.1016/j.beem.2011.07.003. PMID: 22305452

Prognosis

Craniopharyngiomas.
Hamblin R, Tsermoulas G, Karavitaki N
Presse Med 2021 Dec;50(4):104078. Epub 2021 Oct 22 doi: 10.1016/j.lpm.2021.104078. PMID: 34688870
Childhood-onset Craniopharyngioma.
Otte A, Müller HL
J Clin Endocrinol Metab 2021 Sep 27;106(10):e3820-e3836. doi: 10.1210/clinem/dgab397. PMID: 34086900
The Epidemiology of Pituitary Adenomas.
Daly AF, Beckers A
Endocrinol Metab Clin North Am 2020 Sep;49(3):347-355. Epub 2020 Jun 10 doi: 10.1016/j.ecl.2020.04.002. PMID: 32741475
Craniopharyngioma.
Müller HL
Endocr Rev 2014 Jun;35(3):513-43. Epub 2014 Jan 27 doi: 10.1210/er.2013-1115. PMID: 24467716
Pituitary incidentaloma: an endocrine society clinical practice guideline.
Freda PU, Beckers AM, Katznelson L, Molitch ME, Montori VM, Post KD, Vance ML; Endocrine Society
J Clin Endocrinol Metab 2011 Apr;96(4):894-904. doi: 10.1210/jc.2010-1048. PMID: 21474686Free PMC Article

Clinical prediction guides

A proposed clinical classification for pituitary neoplasms to guide therapy and prognosis.
Ho KKY, Fleseriu M, Wass J, Katznelson L, Raverot G, Little AS, Castaño JP, Reincke M, Lopes MB, Kaiser UB, Chanson P, Gadelha M, Melmed S
Lancet Diabetes Endocrinol 2024 Mar;12(3):209-214. Epub 2024 Jan 29 doi: 10.1016/S2213-8587(23)00382-0. PMID: 38301678
Diagnostic challenges in cyclic Cushing's syndrome: a systematic review.
Nowak E, Vogel F, Albani A, Braun L, Rubinstein G, Zopp S, Ritzel K, Beuschlein F, Theodoropoulou M, Reincke M
Lancet Diabetes Endocrinol 2023 Aug;11(8):593-606. Epub 2023 Jul 7 doi: 10.1016/S2213-8587(23)00150-X. PMID: 37429301
Childhood-onset Craniopharyngioma.
Otte A, Müller HL
J Clin Endocrinol Metab 2021 Sep 27;106(10):e3820-e3836. doi: 10.1210/clinem/dgab397. PMID: 34086900
Pituitary adenomas: an overview.
Lake MG, Krook LS, Cruz SV
Am Fam Physician 2013 Sep 1;88(5):319-27. PMID: 24010395
Craniopharyngiomas.
Karavitaki N, Cudlip S, Adams CB, Wass JA
Endocr Rev 2006 Jun;27(4):371-97. Epub 2006 Mar 16 doi: 10.1210/er.2006-0002. PMID: 16543382

Recent systematic reviews

Giant prolactinomas, a detailed analysis of 196 adult cases.
Lisa B, Arno V, Christophe B, Heyning Paul V, Carlien H
Pituitary 2023 Oct;26(5):529-537. Epub 2023 Aug 7 doi: 10.1007/s11102-023-01337-0. PMID: 37544978
Diagnostic challenges in cyclic Cushing's syndrome: a systematic review.
Nowak E, Vogel F, Albani A, Braun L, Rubinstein G, Zopp S, Ritzel K, Beuschlein F, Theodoropoulou M, Reincke M
Lancet Diabetes Endocrinol 2023 Aug;11(8):593-606. Epub 2023 Jul 7 doi: 10.1016/S2213-8587(23)00150-X. PMID: 37429301
The effects of physical activity on cortisol and sleep: A systematic review and meta-analysis.
De Nys L, Anderson K, Ofosu EF, Ryde GC, Connelly J, Whittaker AC
Psychoneuroendocrinology 2022 Sep;143:105843. Epub 2022 Jun 24 doi: 10.1016/j.psyneuen.2022.105843. PMID: 35777076
ROHHAD(NET) Syndrome: Systematic Review of the Clinical Timeline and Recommendations for Diagnosis and Prognosis.
Harvengt J, Gernay C, Mastouri M, Farhat N, Lebrethon MC, Seghaye MC, Bours V
J Clin Endocrinol Metab 2020 Jul 1;105(7) doi: 10.1210/clinem/dgaa247. PMID: 32407531
Pituitary incidentalomas.
Scangas GA, Laws ER Jr
Pituitary 2014 Oct;17(5):486-91. doi: 10.1007/s11102-013-0517-x. PMID: 24052242

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