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Infectious meningitis

MedGen UID:
152668
•Concept ID:
C0729584
•
Disease or Syndrome
Synonyms: Infectious Meningitis; infectious meningitis; Infective meningitis; infective meningitis; meningitis
SNOMED CT: Infective meningitis (312216007)
 
Monarch Initiative: MONDO:0004796

Definition

Inflammation of the meninges of the brain and/or spinal cord caused by an infectious agent (viral, bacterial, or fungal). Symptoms include headache, fever, vomiting, neck stiffness, photophobia, confusion, and seizures. [from NCI]

Professional guidelines

PubMed

Emergency department management of adults with infectious meningitis and encephalitis.
Hogan AN, Brockman II CR, Santa Maria A
Emerg Med Pract 2022 Apr;24(4):1-24. Epub 2022 Apr 2 PMID: 35315604
Impact of a 24/7 multiplex-PCR on the management of patients with confirmed viral meningitis.
Péan de Ponfilly G, Chauvin A, Salmona M, Benmansour H, Bercot B, Camelena F, Courbin V, Eyer X, Lecorche E, Mougari F, Munier AL, Revue E, LeGoff J, Cambau E, Jacquier H
J Infect 2021 Dec;83(6):650-655. Epub 2021 Oct 6 doi: 10.1016/j.jinf.2021.08.050. PMID: 34626699
Aseptic meningitis: diagnosis and management.
Kumar R
Indian J Pediatr 2005 Jan;72(1):57-63. doi: 10.1007/BF02760582. PMID: 15684450

Recent clinical studies

Etiology

Global, regional, and national burden of meningitis and its aetiologies, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.
GBD 2019 Meningitis Antimicrobial Resistance Collaborators
Lancet Neurol 2023 Aug;22(8):685-711. doi: 10.1016/S1474-4422(23)00195-3. PMID: 37479374Free PMC Article
Etiology of Acute Infectious Meningitis and Meningoencephalitis in Karachi, Pakistan: Retrospective Observational Study from a Tertiary Care Center.
Shakoor S, Fatima T, Mir F, Shahid A, Shaheen N, Khan E, Jamil B
Am J Trop Med Hyg 2023 Aug 2;109(2):450-459. Epub 2023 Jul 17 doi: 10.4269/ajtmh.23-0182. PMID: 37460090Free PMC Article
Aseptic meningitis.
Tattevin P, Tchamgoué S, Belem A, Bénézit F, Pronier C, Revest M
Rev Neurol (Paris) 2019 Sep-Oct;175(7-8):475-480. Epub 2019 Jul 30 doi: 10.1016/j.neurol.2019.07.005. PMID: 31375286
Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis.
Wilson MR, Sample HA, Zorn KC, Arevalo S, Yu G, Neuhaus J, Federman S, Stryke D, Briggs B, Langelier C, Berger A, Douglas V, Josephson SA, Chow FC, Fulton BD, DeRisi JL, Gelfand JM, Naccache SN, Bender J, Dien Bard J, Murkey J, Carlson M, Vespa PM, Vijayan T, Allyn PR, Campeau S, Humphries RM, Klausner JD, Ganzon CD, Memar F, Ocampo NA, Zimmermann LL, Cohen SH, Polage CR, DeBiasi RL, Haller B, Dallas R, Maron G, Hayden R, Messacar K, Dominguez SR, Miller S, Chiu CY
N Engl J Med 2019 Jun 13;380(24):2327-2340. doi: 10.1056/NEJMoa1803396. PMID: 31189036Free PMC Article
Multicenter Evaluation of BioFire FilmArray Meningitis/Encephalitis Panel for Detection of Bacteria, Viruses, and Yeast in Cerebrospinal Fluid Specimens.
Leber AL, Everhart K, Balada-Llasat JM, Cullison J, Daly J, Holt S, Lephart P, Salimnia H, Schreckenberger PC, DesJarlais S, Reed SL, Chapin KC, LeBlanc L, Johnson JK, Soliven NL, Carroll KC, Miller JA, Dien Bard J, Mestas J, Bankowski M, Enomoto T, Hemmert AC, Bourzac KM
J Clin Microbiol 2016 Sep;54(9):2251-61. Epub 2016 Jun 22 doi: 10.1128/JCM.00730-16. PMID: 27335149Free PMC Article

Diagnosis

Dural and Leptomeningeal Diseases: Anatomy, Causes, and Neuroimaging Findings.
Kurokawa R, Kurokawa M, Isshiki S, Harada T, Nakaya M, Baba A, Naganawa S, Kim J, Bapuraj J, Srinivasan A, Abe O, Moritani T
Radiographics 2023 Aug;43(9):e230039. doi: 10.1148/rg.230039. PMID: 37535461
Infectious Meningitis and Encephalitis.
Bystritsky RJ, Chow FC
Neurol Clin 2022 Feb;40(1):77-91. doi: 10.1016/j.ncl.2021.08.006. PMID: 34798976
Meningitis.
Aksamit AJ Jr, Berkowitz AL
Continuum (Minneap Minn) 2021 Aug 1;27(4):836-854. doi: 10.1212/CON.0000000000001016. PMID: 34623095
Methods for rapid diagnosis of meningitis etiology in adults.
Poplin V, Boulware DR, Bahr NC
Biomark Med 2020 Apr;14(6):459-479. Epub 2020 Apr 9 doi: 10.2217/bmm-2019-0333. PMID: 32270693Free PMC Article
Aseptic meningitis.
Tattevin P, Tchamgoué S, Belem A, Bénézit F, Pronier C, Revest M
Rev Neurol (Paris) 2019 Sep-Oct;175(7-8):475-480. Epub 2019 Jul 30 doi: 10.1016/j.neurol.2019.07.005. PMID: 31375286

Therapy

Bilateral vocal cord palsy as complication of CNS tuberculosis.
Regner-Nelke L, Labeit B, Nelke C, Schwindt W, Dziewas R, Suntrup-Krueger S
BMC Neurol 2023 Jul 3;23(1):256. doi: 10.1186/s12883-023-03308-1. PMID: 37400784Free PMC Article
Immunoglobulin-induced aseptic meningitis: a case report.
Graça L, Alves J, Nuak J, Sarmento A
BMC Neurol 2018 Jul 17;18(1):97. doi: 10.1186/s12883-018-1102-8. PMID: 30016937Free PMC Article
Nonsteroidal anti-inflammatory drugs exposure and the central nervous system.
Auriel E, Regev K, Korczyn AD
Handb Clin Neurol 2014;119:577-84. doi: 10.1016/B978-0-7020-4086-3.00038-2. PMID: 24365321
The challenge of drug-induced aseptic meningitis.
Moris G, Garcia-Monco JC
Arch Intern Med 1999 Jun 14;159(11):1185-94. doi: 10.1001/archinte.159.11.1185. PMID: 10371226
Central and peripheral nervous complications of dental treatment.
Rossitti EO
Arq Neuropsiquiatr 1995 Sep;53(3-A):513-7. doi: 10.1590/s0004-282x1995000300026. PMID: 8540833

Prognosis

Comparison of endoscopic evacuation, craniotomy, and puncture aspiration for the treatment of spontaneous basal ganglia intracerebral hematoma.
He H, Wang F, Bao D, Niu C
Clin Neurol Neurosurg 2023 Oct;233:107957. Epub 2023 Sep 1 doi: 10.1016/j.clineuro.2023.107957. PMID: 37677859
Reassessing the Value of CSF Protein and Glucose Measurement in Pediatric Infectious Meningitis.
McLaughlin WN, Lamb M, Gaensbauer J
Hosp Pediatr 2022 May 1;12(5):481-490. doi: 10.1542/hpeds.2021-006435. PMID: 35373285
Aseptic meningitis in rheumatoid arthritis after anti-TNF administration: a case-based literature review.
Yıldırım R, Cansu DÜ, Arık D, Saylısoy S, Korkmaz C
Rheumatol Int 2021 Oct;41(10):1845-1853. Epub 2021 Mar 9 doi: 10.1007/s00296-021-04822-6. PMID: 33751192
Cerebrospinal fluid ferritin--unspecific and unsuitable for disease monitoring.
Kolodziej MA, Proemmel P, Quint K, Strik HM
Neurol Neurochir Pol 2014;48(2):116-21. Epub 2014 Jan 23 doi: 10.1016/j.pjnns.2013.09.004. PMID: 24821637
Nonsteroidal anti-inflammatory drugs exposure and the central nervous system.
Auriel E, Regev K, Korczyn AD
Handb Clin Neurol 2014;119:577-84. doi: 10.1016/B978-0-7020-4086-3.00038-2. PMID: 24365321

Clinical prediction guides

Reassessing the Value of CSF Protein and Glucose Measurement in Pediatric Infectious Meningitis.
McLaughlin WN, Lamb M, Gaensbauer J
Hosp Pediatr 2022 May 1;12(5):481-490. doi: 10.1542/hpeds.2021-006435. PMID: 35373285
Usefulness of the FilmArray meningitis/encephalitis (M/E) panel for the diagnosis of infectious meningitis and encephalitis in Taiwan.
Lee SH, Chen SY, Chien JY, Lee TF, Chen JM, Hsueh PR
J Microbiol Immunol Infect 2019 Oct;52(5):760-768. Epub 2019 Apr 30 doi: 10.1016/j.jmii.2019.04.005. PMID: 31085115
Surgical Management of Moderate Basal Ganglia Intracerebral Hemorrhage: Comparison of Safety and Efficacy of Endoscopic Surgery, Minimally Invasive Puncture and Drainage, and Craniotomy.
Fu C, Wang N, Chen B, Wang P, Chen H, Liu W, Liu L
World Neurosurg 2019 Feb;122:e995-e1001. Epub 2018 Nov 4 doi: 10.1016/j.wneu.2018.10.192. PMID: 30404051
Qualitative and Quantitative Comparison of Contrast-Enhanced Fluid-Attenuated Inversion Recovery, Magnetization Transfer Spin Echo, and Fat-Saturation T1-Weighted Sequences in Infectious Meningitis.
Azad R, Tayal M, Azad S, Sharma G, Srivastava RK
Korean J Radiol 2017 Nov-Dec;18(6):973-982. Epub 2017 Sep 21 doi: 10.3348/kjr.2017.18.6.973. PMID: 29089830Free PMC Article
Multicenter Evaluation of BioFire FilmArray Meningitis/Encephalitis Panel for Detection of Bacteria, Viruses, and Yeast in Cerebrospinal Fluid Specimens.
Leber AL, Everhart K, Balada-Llasat JM, Cullison J, Daly J, Holt S, Lephart P, Salimnia H, Schreckenberger PC, DesJarlais S, Reed SL, Chapin KC, LeBlanc L, Johnson JK, Soliven NL, Carroll KC, Miller JA, Dien Bard J, Mestas J, Bankowski M, Enomoto T, Hemmert AC, Bourzac KM
J Clin Microbiol 2016 Sep;54(9):2251-61. Epub 2016 Jun 22 doi: 10.1128/JCM.00730-16. PMID: 27335149Free PMC Article

Recent systematic reviews

Global, regional, and national burden of meningitis and its aetiologies, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.
GBD 2019 Meningitis Antimicrobial Resistance Collaborators
Lancet Neurol 2023 Aug;22(8):685-711. doi: 10.1016/S1474-4422(23)00195-3. PMID: 37479374Free PMC Article

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