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Middle cerebral artery infarction

MedGen UID:
152845
•Concept ID:
C0740392
•
Disease or Syndrome
Synonyms: Cerebral Infarction, Middle Cerebral Artery; Infarct, MCA; Infarction, Middle Cerebral Artery; Infarcts, MCA; MCA Infarct; MCA Infarction; MCA Infarcts; Middle Cerebral Artery Circulation Infarction; Middle Cerebral Artery Infarction; Middle Cerebral Artery Stroke; Stroke, Middle Cerebral Artery
 
HPO: HP:0033762
Monarch Initiative: MONDO:0006857

Definition

Acute onset neurological deficits such as weakness, dizziness, numbness, issues with speech, or visual changes related to sudden impairment of blood flow to a part of the brain due to occlusion or rupture of the middle cerebral artery to the brain. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMiddle cerebral artery infarction

Professional guidelines

PubMed

Malignant Middle Cerebral Artery Infarction during Early versus Late Endovascular Treatment in Acute Ischemic Stroke.
Guo W, Li N, Xu J, Ma J, Li S, Ren C, Chen J, Duan J, Ma Q, Song H, Zhao W, Ji X
Curr Neurovasc Res 2023;20(2):254-260. doi: 10.2174/1567202620666230710114443. PMID: 37431897
Decompressive craniectomy for the treatment of malignant middle cerebral artery infarction.
Mohan Rajwani K, Crocker M, Moynihan B
Br J Neurosurg 2017 Aug;31(4):401-409. Epub 2017 Jun 12 doi: 10.1080/02688697.2017.1329518. PMID: 28604106
Malignant MCA Infarction: Pathophysiology and Imaging for Early Diagnosis and Management Decisions.
Heiss WD
Cerebrovasc Dis 2016;41(1-2):1-7. Epub 2015 Nov 19 doi: 10.1159/000441627. PMID: 26581023

Recent clinical studies

Etiology

Prediction of midline shift after media ischemia using computed tomography perfusion.
Müller SJ, Khadhraoui E, Ernst MS, Riedel CH
BMC Med Imaging 2022 Mar 12;22(1):42. doi: 10.1186/s12880-022-00762-0. PMID: 35279071Free PMC Article
Normothermia after decompressive surgery for space-occupying middle cerebral artery infarction: a protocol-based approach.
Rahmig J, Kuhn M, Neugebauer H, Jüttler E, Reichmann H, Schneider H
BMC Neurol 2017 Dec 4;17(1):205. doi: 10.1186/s12883-017-0988-x. PMID: 29202815Free PMC Article
Twin-twin transfusion and laser therapy.
Behrendt N, Galan HL
Curr Opin Obstet Gynecol 2016 Apr;28(2):79-85. doi: 10.1097/GCO.0000000000000247. PMID: 26871537
Prediction of malignant middle cerebral artery infarction using computed tomography-based intracranial volume reserve measurements.
Minnerup J, Wersching H, Ringelstein EB, Heindel W, Niederstadt T, Schilling M, Schäbitz WR, Kemmling A
Stroke 2011 Dec;42(12):3403-9. Epub 2011 Sep 8 doi: 10.1161/STROKEAHA.111.619734. PMID: 21903965
Surgical decompression for space-occupying cerebral infarction (the Hemicraniectomy After Middle Cerebral Artery infarction with Life-threatening Edema Trial [HAMLET]): a multicentre, open, randomised trial.
Hofmeijer J, Kappelle LJ, Algra A, Amelink GJ, van Gijn J, van der Worp HB; HAMLET investigators
Lancet Neurol 2009 Apr;8(4):326-33. Epub 2009 Mar 5 doi: 10.1016/S1474-4422(09)70047-X. PMID: 19269254

Diagnosis

Prediction of midline shift after media ischemia using computed tomography perfusion.
Müller SJ, Khadhraoui E, Ernst MS, Riedel CH
BMC Med Imaging 2022 Mar 12;22(1):42. doi: 10.1186/s12880-022-00762-0. PMID: 35279071Free PMC Article
Prediction of malignant middle cerebral artery infarction using computed tomography-based intracranial volume reserve measurements.
Minnerup J, Wersching H, Ringelstein EB, Heindel W, Niederstadt T, Schilling M, Schäbitz WR, Kemmling A
Stroke 2011 Dec;42(12):3403-9. Epub 2011 Sep 8 doi: 10.1161/STROKEAHA.111.619734. PMID: 21903965
Malignant middle cerebral artery (MCA) infarction: pathophysiology, diagnosis and management.
Treadwell SD, Thanvi B
Postgrad Med J 2010 Apr;86(1014):235-42. doi: 10.1136/pgmj.2009.094292. PMID: 20354047
Imaging of acute stroke.
Muir KW, Buchan A, von Kummer R, Rother J, Baron JC
Lancet Neurol 2006 Sep;5(9):755-68. doi: 10.1016/S1474-4422(06)70545-2. PMID: 16914404
Treatment options for large hemispheric stroke.
Steiner T, Ringleb P, Hacke W
Neurology 2001;57(5 Suppl 2):S61-8. doi: 10.1212/wnl.57.suppl_2.s61. PMID: 11552058

Therapy

Tenecteplase for Stroke at 4.5 to 24 Hours with Perfusion-Imaging Selection.
Albers GW, Jumaa M, Purdon B, Zaidi SF, Streib C, Shuaib A, Sangha N, Kim M, Froehler MT, Schwartz NE, Clark WM, Kircher CE, Yang M, Massaro L, Lu XY, Rippon GA, Broderick JP, Butcher K, Lansberg MG, Liebeskind DS, Nouh A, Schwamm LH, Campbell BCV; TIMELESS Investigators
N Engl J Med 2024 Feb 22;390(8):701-711. Epub 2024 Feb 8 doi: 10.1056/NEJMoa2310392. PMID: 38329148
Extracranial-Intracranial Bypass and Risk of Stroke and Death in Patients With Symptomatic Artery Occlusion: The CMOSS Randomized Clinical Trial.
Ma Y, Wang T, Wang H, Amin-Hanjani S, Tong X, Wang J, Tong Z, Kuai D, Cai Y, Ren J, Wang D, Duan L, Maimaitili A, Hang C, Yu J, Bai X, Powers WJ, Derdeyn CP, Wu Y, Ling F, Gu Y, Jiao L; CMOSS Investigators
JAMA 2023 Aug 22;330(8):704-714. doi: 10.1001/jama.2023.13390. PMID: 37606672Free PMC Article
Malignant middle cerebral artery (MCA) infarction: pathophysiology, diagnosis and management.
Treadwell SD, Thanvi B
Postgrad Med J 2010 Apr;86(1014):235-42. doi: 10.1136/pgmj.2009.094292. PMID: 20354047
Music listening enhances cognitive recovery and mood after middle cerebral artery stroke.
Särkämö T, Tervaniemi M, Laitinen S, Forsblom A, Soinila S, Mikkonen M, Autti T, Silvennoinen HM, Erkkilä J, Laine M, Peretz I, Hietanen M
Brain 2008 Mar;131(Pt 3):866-76. doi: 10.1093/brain/awn013. PMID: 18287122
Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials.
Vahedi K, Hofmeijer J, Juettler E, Vicaut E, George B, Algra A, Amelink GJ, Schmiedeck P, Schwab S, Rothwell PM, Bousser MG, van der Worp HB, Hacke W; DECIMAL, DESTINY, and HAMLET investigators
Lancet Neurol 2007 Mar;6(3):215-22. doi: 10.1016/S1474-4422(07)70036-4. PMID: 17303527

Prognosis

Outcome After Decompressive Craniectomy for Middle Cerebral Artery Infarction: Timing of the Intervention.
Goedemans T, Verbaan D, Coert BA, Kerklaan B, van den Berg R, Coutinho JM, van Middelaar T, Nederkoorn PJ, Vandertop WP, van den Munckhof P
Neurosurgery 2020 Mar 1;86(3):E318-E325. doi: 10.1093/neuros/nyz522. PMID: 31943069Free PMC Article
Malignant MCA Infarction: Pathophysiology and Imaging for Early Diagnosis and Management Decisions.
Heiss WD
Cerebrovasc Dis 2016;41(1-2):1-7. Epub 2015 Nov 19 doi: 10.1159/000441627. PMID: 26581023
Prediction of malignant middle cerebral artery infarction using computed tomography-based intracranial volume reserve measurements.
Minnerup J, Wersching H, Ringelstein EB, Heindel W, Niederstadt T, Schilling M, Schäbitz WR, Kemmling A
Stroke 2011 Dec;42(12):3403-9. Epub 2011 Sep 8 doi: 10.1161/STROKEAHA.111.619734. PMID: 21903965
Hemodynamic factors and perfusion abnormalities in early neurological deterioration.
Alawneh JA, Moustafa RR, Baron JC
Stroke 2009 Jun;40(6):e443-50. Epub 2009 Apr 23 doi: 10.1161/STROKEAHA.108.532465. PMID: 19390076
Applicability of biomarkers in ischemic stroke.
Castellanos M, Serena J
Cerebrovasc Dis 2007;24 Suppl 1:7-15. Epub 2007 Nov 1 doi: 10.1159/000107374. PMID: 17971634

Clinical prediction guides

Machine learning prediction of malignant middle cerebral artery infarction after mechanical thrombectomy for anterior circulation large vessel occlusion.
Hoffman H, Wood JS, Cote JR, Jalal MS, Masoud HE, Gould GC
J Stroke Cerebrovasc Dis 2023 Mar;32(3):106989. Epub 2023 Jan 16 doi: 10.1016/j.jstrokecerebrovasdis.2023.106989. PMID: 36652789
Stereotactic Aspiration Acts as an Effective Treatment for Malignant Middle Cerebral Artery Infarction.
Wang Z, Chen M, Wang C, Luo J, Sun S, Lu X
J Healthc Eng 2022;2022:4373404. Epub 2022 Apr 16 doi: 10.1155/2022/4373404. PMID: 35469230Free PMC Article
Normothermia after decompressive surgery for space-occupying middle cerebral artery infarction: a protocol-based approach.
Rahmig J, Kuhn M, Neugebauer H, Jüttler E, Reichmann H, Schneider H
BMC Neurol 2017 Dec 4;17(1):205. doi: 10.1186/s12883-017-0988-x. PMID: 29202815Free PMC Article
Surgical decompression for space-occupying cerebral infarction (the Hemicraniectomy After Middle Cerebral Artery infarction with Life-threatening Edema Trial [HAMLET]): a multicentre, open, randomised trial.
Hofmeijer J, Kappelle LJ, Algra A, Amelink GJ, van Gijn J, van der Worp HB; HAMLET investigators
Lancet Neurol 2009 Apr;8(4):326-33. Epub 2009 Mar 5 doi: 10.1016/S1474-4422(09)70047-X. PMID: 19269254
Applicability of biomarkers in ischemic stroke.
Castellanos M, Serena J
Cerebrovasc Dis 2007;24 Suppl 1:7-15. Epub 2007 Nov 1 doi: 10.1159/000107374. PMID: 17971634

Recent systematic reviews

Concurrent Cardio-Cerebral Infarctions in COVID-19: A Systematic Review of Published Case Reports/Series.
Desai R, Mondal A, Prasad A, Vyas A, Jain A, Rupareliya C, Shah M, Paul T, Kumar G, Sachdeva R
Curr Probl Cardiol 2023 Oct;48(10):101814. Epub 2023 May 18 doi: 10.1016/j.cpcardiol.2023.101814. PMID: 37209804Free PMC Article
Angiographic Systems for Classifying Distal Arterial Occlusions.
Pillai P, Mitchell PJ, Phan TG, Ma H, Yan B
Cerebrovasc Dis 2023;52(3):353-362. Epub 2022 Nov 24 doi: 10.1159/000526873. PMID: 36423598Free PMC Article
Surgical decompression for malignant cerebral oedema after ischaemic stroke.
Dower A, Mulcahy M, Maharaj M, Chen H, Lim CED, Li Y, Sheridan M
Cochrane Database Syst Rev 2022 Nov 16;11(11):CD014989. doi: 10.1002/14651858.CD014989.pub2. PMID: 36385224Free PMC Article
Early Prediction of Malignant Brain Edema After Ischemic Stroke.
Wu S, Yuan R, Wang Y, Wei C, Zhang S, Yang X, Wu B, Liu M
Stroke 2018 Dec;49(12):2918-2927. doi: 10.1161/STROKEAHA.118.022001. PMID: 30571414
Evidence for the efficacy of statins in animal stroke models: a meta-analysis.
García-Bonilla L, Campos M, Giralt D, Salat D, Chacón P, Hernández-Guillamon M, Rosell A, Montaner J
J Neurochem 2012 Jul;122(2):233-43. Epub 2012 May 21 doi: 10.1111/j.1471-4159.2012.07773.x. PMID: 22548274

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