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Myelophthisic anemia

MedGen UID:
1529
•Concept ID:
C0002890
•
Disease or Syndrome
Synonyms: Anemia, Leukoerythroblastic; Anemia, Myelophthisic; Anemias, Leukoerythroblastic; Anemias, Myelophthisic; Leukoerythroblastic Anemia; Leukoerythroblastic Anemias; Myelophthisic Anemia; Myelophthisic Anemias
SNOMED CT: Myelophthisic anemia (2694001); Anemia associated with marrow infiltration (2694001); Leukoerythroblastic anemia (2694001); Leukoerythroblastosis (2694001)
 
Monarch Initiative: MONDO:0005868

Definition

A laboratory test result indicating an abnormal amount of circulating nucleated red blood cells and immature red blood cells. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyelophthisic anemia

Professional guidelines

PubMed

Myelophthisic anemia as terminal stage of polycythemia vera; protracted x-ray treatment followed by a myelosclerotic syndrome.
ROSELSEN E, OHLSEN S
Acta Med Scand 1952 Mar 19;142(4):239-48. doi: 10.1111/j.0954-6820.1952.tb13861.x. PMID: 14932790

Recent clinical studies

Etiology

Access to Palliative Care Services and Clinical Outcomes of Patients With Solid Malignancy-Associated Myelophthisis in a Resource-Limited Setting.
Vargas-Serafin C, Acosta-Medina AA, Teran-De-la-Sancha K, Delgado-de-la-Mora J, Bourlon MT, Bourlon C
Am J Hosp Palliat Care 2021 Aug;38(8):932-937. Epub 2020 Nov 9 doi: 10.1177/1049909120969963. PMID: 33161730
Clinical, histopathologic, and genetic features of pediatric primary myelofibrosis--an entity different from adults.
DeLario MR, Sheehan AM, Ataya R, Bertuch AA, Vega C 2nd, Webb CR, Lopez-Terrada D, Venkateswaran L
Am J Hematol 2012 May;87(5):461-4. Epub 2012 Mar 3 doi: 10.1002/ajh.23140. PMID: 22389089
Leukoerythroblastic anemia in metastatic prostate cancer. Clinical and prognostic significance in patients with hormone-refractory disease.
Shamdas GJ, Ahmann FR, Matzner MB, Ritchie JM
Cancer 1993 Jun 1;71(11):3594-600. doi: 10.1002/1097-0142(19930601)71:11<3594::aid-cncr2820711121>3.0.co;2-o. PMID: 8490908
Osteopetrosis. Current clinical considerations.
Shapiro F
Clin Orthop Relat Res 1993 Sep;(294):34-44. PMID: 8358940
Leukoerythroblastosis. Diagnostic and prognostic significance.
Weick JK, Hagedorn AB, Linman JW
Mayo Clin Proc 1974 Feb;49(2):110-3. PMID: 4544259

Diagnosis

Access to Palliative Care Services and Clinical Outcomes of Patients With Solid Malignancy-Associated Myelophthisis in a Resource-Limited Setting.
Vargas-Serafin C, Acosta-Medina AA, Teran-De-la-Sancha K, Delgado-de-la-Mora J, Bourlon MT, Bourlon C
Am J Hosp Palliat Care 2021 Aug;38(8):932-937. Epub 2020 Nov 9 doi: 10.1177/1049909120969963. PMID: 33161730
Osteopetrosis. Current clinical considerations.
Shapiro F
Clin Orthop Relat Res 1993 Sep;(294):34-44. PMID: 8358940
Anemia and cancer.
Steinberg D
CA Cancer J Clin 1989 Sep-Oct;39(5):296-304. doi: 10.3322/canjclin.39.5.296. PMID: 2513101
Anemia in cancer.
Zucker S
Cancer Invest 1985;3(3):249-60. doi: 10.3109/07357908509039786. PMID: 3891030
ACUTE PROMYELOCYTIC LEUKAEMIA.
WOODLIFF HJ, KAKULAS BA
Med J Aust 1964 Jul 11;2:62-4. doi: 10.5694/j.1326-5377.1964.tb114970.x. PMID: 14177131

Therapy

Leukoerythroblastosis in a Young Child with Severe Malaria and Superimposed Gram Negative Infection.
Varo R, Sitoe A, Cossa A, Ordi J, Rozman M, Bassat Q
J Trop Pediatr 2018 Dec 1;64(6):553-556. doi: 10.1093/tropej/fmx101. PMID: 29272534
An elderly man with hemolysis and myelophthisic anemia.
Horn R, Maiti A, Cherian SV
Eur J Intern Med 2018 Feb;48:e7-e8. Epub 2017 Jul 8 doi: 10.1016/j.ejim.2017.07.004. PMID: 28697949
An aggressive presentation of colorectal cancer with an atypical lymphoproliferative pattern of metastatic disease: a case report and review of the literature.
Shah SM, Rosenthal MH, Griffin GK, Jacobsen ED, McCleary NJ
Clin Colorectal Cancer 2014 Sep;13(3):e5-e11. Epub 2014 Jun 23 doi: 10.1016/j.clcc.2014.05.002. PMID: 25065654
Lenalidomide therapy in myelofibrosis with myeloid metaplasia.
Tefferi A, Cortes J, Verstovsek S, Mesa RA, Thomas D, Lasho TL, Hogan WJ, Litzow MR, Allred JB, Jones D, Byrne C, Zeldis JB, Ketterling RP, McClure RF, Giles F, Kantarjian HM
Blood 2006 Aug 15;108(4):1158-64. Epub 2006 Apr 11 doi: 10.1182/blood-2006-02-004572. PMID: 16609064
Osteopetrosis. Current clinical considerations.
Shapiro F
Clin Orthop Relat Res 1993 Sep;(294):34-44. PMID: 8358940

Prognosis

Access to Palliative Care Services and Clinical Outcomes of Patients With Solid Malignancy-Associated Myelophthisis in a Resource-Limited Setting.
Vargas-Serafin C, Acosta-Medina AA, Teran-De-la-Sancha K, Delgado-de-la-Mora J, Bourlon MT, Bourlon C
Am J Hosp Palliat Care 2021 Aug;38(8):932-937. Epub 2020 Nov 9 doi: 10.1177/1049909120969963. PMID: 33161730
Clinical, histopathologic, and genetic features of pediatric primary myelofibrosis--an entity different from adults.
DeLario MR, Sheehan AM, Ataya R, Bertuch AA, Vega C 2nd, Webb CR, Lopez-Terrada D, Venkateswaran L
Am J Hematol 2012 May;87(5):461-4. Epub 2012 Mar 3 doi: 10.1002/ajh.23140. PMID: 22389089
Osteopetrosis. Current clinical considerations.
Shapiro F
Clin Orthop Relat Res 1993 Sep;(294):34-44. PMID: 8358940
Anemia in cancer.
Zucker S
Cancer Invest 1985;3(3):249-60. doi: 10.3109/07357908509039786. PMID: 3891030
Leukoerythroblastosis. Diagnostic and prognostic significance.
Weick JK, Hagedorn AB, Linman JW
Mayo Clin Proc 1974 Feb;49(2):110-3. PMID: 4544259

Clinical prediction guides

Osteopetrosis: a rare cause of anemia--review of literature.
Saluja S, Bhandari S, Aggarwal S, Kapoor S
Indian J Pathol Microbiol 2009 Jul-Sep;52(3):363-7. doi: 10.4103/0377-4929.54995. PMID: 19679962
Effects of weiganli on the hemopoietic function of the myelosuppressed anemic mice.
Chen Y, Zhu B, Yan S, Zhang L, Li J
J Tradit Chin Med 2007 Jun;27(2):143-7. PMID: 17710815
Premature labor and leukoerythroblastosis in a newborn with parvovirus B19 infection.
Gulen H, Basarir F, Hakan N, Ciftdogan DY, Tansug N, Onag A
Haematologica 2005 Nov;90 Suppl:ECR38. PMID: 16266929
Myelophthisis as a solitary manifestation of failure from rectal carcinoma. A Batson phenomenon?
Mathew P, Fleming D, Adegboyega PA
Arch Pathol Lab Med 2000 Aug;124(8):1228-30. doi: 10.5858/2000-124-1228-MAASMO. PMID: 10923090
Granulocytic fragments in sepsis.
Krauss JS, Dover RK, Khankhanian NK, Tom GD
Mod Pathol 1989 Jul;2(4):301-5. PMID: 2762286

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