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Tumor Initiation

MedGen UID:
154615
Concept ID:
C0598935
Neoplastic Process

Definition

The first stage of tumor induction by a carcinogen, consisting of subtle alteration of cells by exposure to a carcinogenic agent so that they are likely to form a tumor upon subsequent exposure to a promoting agent. (NCI) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTumor Initiation

Professional guidelines

PubMed

Alzahrani SM, Al Doghaither HA, Al-Ghafari AB, Pushparaj PN
Oncol Rep 2023 Oct;50(4) Epub 2023 Aug 18 doi: 10.3892/or.2023.8612. PMID: 37594133
Yu L, Wei J, Liu P
Semin Cancer Biol 2022 Oct;85:69-94. Epub 2021 Jun 25 doi: 10.1016/j.semcancer.2021.06.019. PMID: 34175443
Bansal A, Simon MC
J Cell Biol 2018 Jul 2;217(7):2291-2298. Epub 2018 Jun 18 doi: 10.1083/jcb.201804161. PMID: 29915025Free PMC Article

Recent clinical studies

Etiology

Reed AD, Pensa S, Steif A, Stenning J, Kunz DJ, Porter LJ, Hua K, He P, Twigger AJ, Siu AJQ, Kania K, Barrow-McGee R, Goulding I, Gomm JJ, Speirs V, Jones JL, Marioni JC, Khaled WT
Nat Genet 2024 Apr;56(4):652-662. Epub 2024 Mar 28 doi: 10.1038/s41588-024-01688-9. PMID: 38548988Free PMC Article
Chen R, Zou J, Zhong X, Li J, Kang R, Tang D
Cancer Lett 2024 Jan 28;581:216494. Epub 2023 Nov 24 doi: 10.1016/j.canlet.2023.216494. PMID: 38007142
Weeden CE, Hill W, Lim EL, Grönroos E, Swanton C
Cell 2023 Apr 13;186(8):1541-1563. doi: 10.1016/j.cell.2023.03.013. PMID: 37059064
Walcher L, Kistenmacher AK, Suo H, Kitte R, Dluczek S, Strauß A, Blaudszun AR, Yevsa T, Fricke S, Kossatz-Boehlert U
Front Immunol 2020;11:1280. Epub 2020 Aug 7 doi: 10.3389/fimmu.2020.01280. PMID: 32849491Free PMC Article
Hopkins BD, Goncalves MD, Cantley LC
J Clin Oncol 2016 Dec 10;34(35):4277-4283. Epub 2016 Nov 7 doi: 10.1200/JCO.2016.67.9712. PMID: 27903152Free PMC Article

Diagnosis

Decourtye-Espiard L, Guilford P
Gastroenterology 2023 Apr;164(5):719-735. Epub 2023 Feb 4 doi: 10.1053/j.gastro.2023.01.038. PMID: 36740198
Lian X, Yang K, Li R, Li M, Zuo J, Zheng B, Wang W, Wang P, Zhou S
Mol Cancer 2022 Jan 21;21(1):27. doi: 10.1186/s12943-021-01486-5. PMID: 35062950Free PMC Article
Tan YT, Lin JF, Li T, Li JJ, Xu RH, Ju HQ
Cancer Commun (Lond) 2021 Feb;41(2):109-120. Epub 2020 Oct 29 doi: 10.1002/cac2.12108. PMID: 33119215Free PMC Article
Walcher L, Kistenmacher AK, Suo H, Kitte R, Dluczek S, Strauß A, Blaudszun AR, Yevsa T, Fricke S, Kossatz-Boehlert U
Front Immunol 2020;11:1280. Epub 2020 Aug 7 doi: 10.3389/fimmu.2020.01280. PMID: 32849491Free PMC Article
Lowe SW, Lin AW
Carcinogenesis 2000 Mar;21(3):485-95. doi: 10.1093/carcin/21.3.485. PMID: 10688869

Therapy

Wang DR, Wu XL, Sun YL
Signal Transduct Target Ther 2022 Sep 19;7(1):331. doi: 10.1038/s41392-022-01136-2. PMID: 36123348Free PMC Article
Llombart V, Mansour MR
EBioMedicine 2022 Jan;75:103756. Epub 2021 Dec 20 doi: 10.1016/j.ebiom.2021.103756. PMID: 34942444Free PMC Article
Ramaiah MJ, Tangutur AD, Manyam RR
Life Sci 2021 Jul 15;277:119504. Epub 2021 Apr 16 doi: 10.1016/j.lfs.2021.119504. PMID: 33872660
Xiao Y, Yu D
Pharmacol Ther 2021 May;221:107753. Epub 2020 Nov 28 doi: 10.1016/j.pharmthera.2020.107753. PMID: 33259885Free PMC Article
Jin MZ, Jin WL
Signal Transduct Target Ther 2020 Aug 25;5(1):166. doi: 10.1038/s41392-020-00280-x. PMID: 32843638Free PMC Article

Prognosis

Zhang S, Xiao X, Yi Y, Wang X, Zhu L, Shen Y, Lin D, Wu C
Signal Transduct Target Ther 2024 Jun 19;9(1):149. doi: 10.1038/s41392-024-01848-7. PMID: 38890350Free PMC Article
Qin R, Ren W, Ya G, Wang B, He J, Ren S, Jiang L, Zhao S
Clin Exp Med 2023 Sep;23(5):1359-1373. Epub 2022 Sep 29 doi: 10.1007/s10238-022-00888-z. PMID: 36173487Free PMC Article
Walcher L, Kistenmacher AK, Suo H, Kitte R, Dluczek S, Strauß A, Blaudszun AR, Yevsa T, Fricke S, Kossatz-Boehlert U
Front Immunol 2020;11:1280. Epub 2020 Aug 7 doi: 10.3389/fimmu.2020.01280. PMID: 32849491Free PMC Article
Hopkins BD, Goncalves MD, Cantley LC
J Clin Oncol 2016 Dec 10;34(35):4277-4283. Epub 2016 Nov 7 doi: 10.1200/JCO.2016.67.9712. PMID: 27903152Free PMC Article
Grant TJ, Hua K, Singh A
Prog Mol Biol Transl Sci 2016;144:241-275. Epub 2016 Oct 15 doi: 10.1016/bs.pmbts.2016.09.008. PMID: 27865459Free PMC Article

Clinical prediction guides

Zhang S, Xiao X, Yi Y, Wang X, Zhu L, Shen Y, Lin D, Wu C
Signal Transduct Target Ther 2024 Jun 19;9(1):149. doi: 10.1038/s41392-024-01848-7. PMID: 38890350Free PMC Article
Ogawa J, Pao GM, Shokhirev MN, Verma IM
Cell Rep 2018 Apr 24;23(4):1220-1229. doi: 10.1016/j.celrep.2018.03.105. PMID: 29694897Free PMC Article
Binnewies M, Roberts EW, Kersten K, Chan V, Fearon DF, Merad M, Coussens LM, Gabrilovich DI, Ostrand-Rosenberg S, Hedrick CC, Vonderheide RH, Pittet MJ, Jain RK, Zou W, Howcroft TK, Woodhouse EC, Weinberg RA, Krummel MF
Nat Med 2018 May;24(5):541-550. Epub 2018 Apr 23 doi: 10.1038/s41591-018-0014-x. PMID: 29686425Free PMC Article
Senft D, Leiserson MDM, Ruppin E, Ronai ZA
Trends Mol Med 2017 Oct;23(10):874-898. Epub 2017 Sep 5 doi: 10.1016/j.molmed.2017.08.003. PMID: 28887051Free PMC Article
Lin VTG, Pruitt HC, Samant RS, Shevde LA
Trends Cancer 2017 Feb;3(2):126-136. Epub 2017 Jan 27 doi: 10.1016/j.trecan.2016.12.007. PMID: 28718443Free PMC Article

Recent systematic reviews

Liu W, Zhong B, Wagner RW, Garcia MK, McQuade JL, Huang W, Li Y, Gonzalez GMN, R Spano M, Cohen A, Geng Y, Cohen L
Integr Cancer Ther 2024 Jan-Dec;23:15347354241302072. doi: 10.1177/15347354241302072. PMID: 39663880Free PMC Article
Akinyemi AO, Simpson KE, Oyelere SF, Nur M, Ngule CM, Owoyemi BCD, Ayarick VA, Oyelami FF, Obaleye O, Esoe DP, Liu X, Li Z
Mol Med 2023 Aug 21;29(1):112. doi: 10.1186/s10020-023-00706-6. PMID: 37605113Free PMC Article
Lucidi D, Cantaffa C, Miglio M, Spina F, Alicandri Ciufelli M, Marchioni A, Marchioni D
Int J Mol Sci 2023 Jan 31;24(3) doi: 10.3390/ijms24032670. PMID: 36768990Free PMC Article
Zhao M, Zhang Y, Shen S
Clin Transl Oncol 2023 Jun;25(6):1512-1521. Epub 2022 Dec 31 doi: 10.1007/s12094-022-03060-x. PMID: 36586065
Araújo-Filho HG, Dos Santos JF, Carvalho MTB, Picot L, Fruitier-Arnaudin I, Groult H, Quintans-Júnior LJ, Quintans JSS
Phytother Res 2021 Sep;35(9):4957-4970. Epub 2021 Apr 17 doi: 10.1002/ptr.7125. PMID: 33864293

Supplemental Content

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    Practice guidelines

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

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