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Complex febrile seizure

MedGen UID:
155493
•Concept ID:
C0751057
•
Disease or Syndrome
Synonyms: Complex febrile convulsion; complex febrile convulsions; Complex febrile seizures; Complex fever fit
SNOMED CT: Complex febrile seizure (433083002); Complex febrile convulsion (433083002)
 
HPO: HP:0011172

Definition

A febrile seizure that has any of the following features [from HPO]

Conditions with this feature

CATARACTS, SPASTIC PARAPARESIS, AND SPEECH DELAY
MedGen UID:
1778818
•Concept ID:
C5543440
•
Disease or Syndrome
Cataracts, spastic paraparesis, and speech delay (CSPSD) is an autosomal dominant disorder characterized by spastic paraparesis and bilateral congenital/juvenile cataracts. Speech delay is a common feature (Ferdinandusse et al., 2021).
See: Condition Record
CATARACTS, SPASTIC PARAPARESIS, AND SPEECH DELAY

Professional guidelines

PubMed

Best practices for the management of febrile seizures in children.
Ferretti A, Riva A, Fabrizio A, Bruni O, Capovilla G, Foiadelli T, Orsini A, Raucci U, Romeo A, Striano P, Parisi P
Ital J Pediatr 2024 May 12;50(1):95. doi: 10.1186/s13052-024-01666-1. PMID: 38735928Free PMC Article
Should patients with complex febrile seizure be admitted for further management?
Olson H, Rudloe T, Loddenkemper T, Harper MB, Kimia AA
Am J Emerg Med 2018 Aug;36(8):1386-1390. Epub 2017 Dec 28 doi: 10.1016/j.ajem.2017.12.059. PMID: 29317153
Complex febrile seizures: a practical guide to evaluation and treatment.
Patel AD, Vidaurre J
J Child Neurol 2013 Jun;28(6):762-7. Epub 2013 Apr 10 doi: 10.1177/0883073813483569. PMID: 23576415

Recent clinical studies

Etiology

Cognitive and behavioural development in children presenting with complex febrile seizures: at onset and school age.
Sheppard E, Lalancette E, Thébault-Dagher F, Lafontaine MP, Knoth IS, Gravel J, Lippé S
Epileptic Disord 2021 Apr 1;23(2):325-336. doi: 10.1684/epd.2021.1260. PMID: 33814363
The role of Mean Platelet Volume/platelet count Ratio and Neutrophil to Lymphocyte Ratio on the risk of Febrile Seizure.
Liu Z, Li X, Zhang M, Huang X, Bai J, Pan Z, Lin X, Yu D, Zeng H, Wan R, Ye X
Sci Rep 2018 Oct 11;8(1):15123. doi: 10.1038/s41598-018-33373-3. PMID: 30310107Free PMC Article
Complex febrile seizures: a practical guide to evaluation and treatment.
Patel AD, Vidaurre J
J Child Neurol 2013 Jun;28(6):762-7. Epub 2013 Apr 10 doi: 10.1177/0883073813483569. PMID: 23576415
Febrile seizures.
Srinivasan J, Wallace KA, Scheffer IE
Aust Fam Physician 2005 Dec;34(12):1021-5. PMID: 16333484
Viral infections and recurrences of febrile convulsions.
Rantala H, Uhari M, Tuokko H
J Pediatr 1990 Feb;116(2):195-9. doi: 10.1016/s0022-3476(05)82874-4. PMID: 2299489Free PMC Article

Diagnosis

Best practices for the management of febrile seizures in children.
Ferretti A, Riva A, Fabrizio A, Bruni O, Capovilla G, Foiadelli T, Orsini A, Raucci U, Romeo A, Striano P, Parisi P
Ital J Pediatr 2024 May 12;50(1):95. doi: 10.1186/s13052-024-01666-1. PMID: 38735928Free PMC Article
The role of Mean Platelet Volume/platelet count Ratio and Neutrophil to Lymphocyte Ratio on the risk of Febrile Seizure.
Liu Z, Li X, Zhang M, Huang X, Bai J, Pan Z, Lin X, Yu D, Zeng H, Wan R, Ye X
Sci Rep 2018 Oct 11;8(1):15123. doi: 10.1038/s41598-018-33373-3. PMID: 30310107Free PMC Article
Febrile seizures.
Srinivasan J, Wallace KA, Scheffer IE
Aust Fam Physician 2005 Dec;34(12):1021-5. PMID: 16333484
Role of early EEG and neuroimaging in determination of prognosis in children with complex febrile seizure.
Yücel O, Aka S, Yazicioglu L, Ceran O
Pediatr Int 2004 Aug;46(4):463-7. doi: 10.1111/j.1328-8067.2003.01799.x. PMID: 15310315
Viral infections and recurrences of febrile convulsions.
Rantala H, Uhari M, Tuokko H
J Pediatr 1990 Feb;116(2):195-9. doi: 10.1016/s0022-3476(05)82874-4. PMID: 2299489Free PMC Article

Therapy

Best practices for the management of febrile seizures in children.
Ferretti A, Riva A, Fabrizio A, Bruni O, Capovilla G, Foiadelli T, Orsini A, Raucci U, Romeo A, Striano P, Parisi P
Ital J Pediatr 2024 May 12;50(1):95. doi: 10.1186/s13052-024-01666-1. PMID: 38735928Free PMC Article
Simple and complex febrile seizures: is there such a difference? Management and complications in an emergency department.
Rivas-García A, Ferrero-García-Loygorri C, Carrascón González-Pinto L, Mora-Capín AA, Lorente-Romero J, Vázquez-López P
Neurologia (Engl Ed) 2022 Jun;37(5):317-324. Epub 2021 May 27 doi: 10.1016/j.nrleng.2019.05.010. PMID: 35672118
Should patients with complex febrile seizure be admitted for further management?
Olson H, Rudloe T, Loddenkemper T, Harper MB, Kimia AA
Am J Emerg Med 2018 Aug;36(8):1386-1390. Epub 2017 Dec 28 doi: 10.1016/j.ajem.2017.12.059. PMID: 29317153
Complex febrile seizures: a practical guide to evaluation and treatment.
Patel AD, Vidaurre J
J Child Neurol 2013 Jun;28(6):762-7. Epub 2013 Apr 10 doi: 10.1177/0883073813483569. PMID: 23576415
Febrile seizures.
Srinivasan J, Wallace KA, Scheffer IE
Aust Fam Physician 2005 Dec;34(12):1021-5. PMID: 16333484

Prognosis

Best practices for the management of febrile seizures in children.
Ferretti A, Riva A, Fabrizio A, Bruni O, Capovilla G, Foiadelli T, Orsini A, Raucci U, Romeo A, Striano P, Parisi P
Ital J Pediatr 2024 May 12;50(1):95. doi: 10.1186/s13052-024-01666-1. PMID: 38735928Free PMC Article
The role of Mean Platelet Volume/platelet count Ratio and Neutrophil to Lymphocyte Ratio on the risk of Febrile Seizure.
Liu Z, Li X, Zhang M, Huang X, Bai J, Pan Z, Lin X, Yu D, Zeng H, Wan R, Ye X
Sci Rep 2018 Oct 11;8(1):15123. doi: 10.1038/s41598-018-33373-3. PMID: 30310107Free PMC Article
Should patients with complex febrile seizure be admitted for further management?
Olson H, Rudloe T, Loddenkemper T, Harper MB, Kimia AA
Am J Emerg Med 2018 Aug;36(8):1386-1390. Epub 2017 Dec 28 doi: 10.1016/j.ajem.2017.12.059. PMID: 29317153
Febrile seizures.
Srinivasan J, Wallace KA, Scheffer IE
Aust Fam Physician 2005 Dec;34(12):1021-5. PMID: 16333484
Viral infections and recurrences of febrile convulsions.
Rantala H, Uhari M, Tuokko H
J Pediatr 1990 Feb;116(2):195-9. doi: 10.1016/s0022-3476(05)82874-4. PMID: 2299489Free PMC Article

Clinical prediction guides

Children With Complex Febrile Seizures: Is Hospital Admission Necessary?
Kannikeswaran N, Sivaswamy L, Farooqi A, Sethuraman U
Clin Pediatr (Phila) 2021 Jul;60(8):363-369. Epub 2021 May 20 doi: 10.1177/00099228211017702. PMID: 34014115
Cognitive and behavioural development in children presenting with complex febrile seizures: at onset and school age.
Sheppard E, Lalancette E, Thébault-Dagher F, Lafontaine MP, Knoth IS, Gravel J, Lippé S
Epileptic Disord 2021 Apr 1;23(2):325-336. doi: 10.1684/epd.2021.1260. PMID: 33814363
The role of Mean Platelet Volume/platelet count Ratio and Neutrophil to Lymphocyte Ratio on the risk of Febrile Seizure.
Liu Z, Li X, Zhang M, Huang X, Bai J, Pan Z, Lin X, Yu D, Zeng H, Wan R, Ye X
Sci Rep 2018 Oct 11;8(1):15123. doi: 10.1038/s41598-018-33373-3. PMID: 30310107Free PMC Article
Should patients with complex febrile seizure be admitted for further management?
Olson H, Rudloe T, Loddenkemper T, Harper MB, Kimia AA
Am J Emerg Med 2018 Aug;36(8):1386-1390. Epub 2017 Dec 28 doi: 10.1016/j.ajem.2017.12.059. PMID: 29317153
Role of early EEG and neuroimaging in determination of prognosis in children with complex febrile seizure.
Yücel O, Aka S, Yazicioglu L, Ceran O
Pediatr Int 2004 Aug;46(4):463-7. doi: 10.1111/j.1328-8067.2003.01799.x. PMID: 15310315

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