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Central Nervous System Venous Angioma

MedGen UID:
156018
•Concept ID:
C0752165
•
Congenital Abnormality
Synonyms: Angioma, CNS Venous; Angioma, Venous, Central Nervous System; Angiomas, CNS Venous; CNS Venous Angioma; CNS Venous Angiomas; Venous Angioma, Central Nervous System; Venous Angioma, CNS; Venous Angiomas, CNS

Definition

A vascular anomaly characterized by a radial or wedge-shaped arrangement of dilated VEINS draining into a larger vein in the brain, spinal cord, or the meninges. Veins in a venous angioma are surrounded by normal nervous tissue, unlike a CENTRAL NERVOUS SYSTEM CAVERNOUS HEMANGIOMA that lacks intervening nervous tissue. Drainage of venous angioma is fully integrated with the body''s venous system, therefore, in most cases there is no clinical signs and rare bleeding. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral Nervous System Venous Angioma

Professional guidelines

PubMed

Management of pediatric cerebral cavernous malformations with gamma knife radiosurgery: a report of 46 cases.
Samanci Y, Ardor GD, Peker S
Childs Nerv Syst 2022 May;38(5):929-938. Epub 2022 Mar 11 doi: 10.1007/s00381-022-05485-9. PMID: 35275282
Concepts and controversies in the management of cerebral developmental venous anomalies.
Cohen JE, Boitsova S, Moscovici S, Itshayek E
Isr Med Assoc J 2010 Nov;12(11):703-6. PMID: 21243874

Recent clinical studies

Etiology

Developmental venous anomalies and brainstem cavernous malformations: a proposed physiological mechanism for haemorrhage.
Maish WN
Neurosurg Rev 2019 Sep;42(3):663-670. Epub 2018 Oct 6 doi: 10.1007/s10143-018-1039-9. PMID: 30291476
Developmental venous anomalies.
Mooney MA, Zabramski JM
Handb Clin Neurol 2017;143:279-282. doi: 10.1016/B978-0-444-63640-9.00026-6. PMID: 28552150
Intracerebral hemorrhage due to developmental venous anomalies.
Li X, Wang Y, Chen W, Wang W, Chen K, Liao H, Lu J, Li Z
J Clin Neurosci 2016 Apr;26:95-100. Epub 2016 Jan 21 doi: 10.1016/j.jocn.2015.06.031. PMID: 26803466
Spinal epidural venous angioma: a case report and review of the literature.
Wu L, Yang T, Deng X, Yang C, Xu Y
Childs Nerv Syst 2014 Sep;30(9):1601-5. Epub 2014 Mar 18 doi: 10.1007/s00381-014-2397-4. PMID: 24639010
Histologically classified venous angiomas of the brain: a controversy.
Abe M, Hagihara N, Tabuchi K, Uchino A, Miyasaka Y
Neurol Med Chir (Tokyo) 2003 Jan;43(1):1-10; discussion 11. doi: 10.2176/nmc.43.1. PMID: 12568316

Diagnosis

Developmental venous anomalies and brainstem cavernous malformations: a proposed physiological mechanism for haemorrhage.
Maish WN
Neurosurg Rev 2019 Sep;42(3):663-670. Epub 2018 Oct 6 doi: 10.1007/s10143-018-1039-9. PMID: 30291476
Developmental Venous Anomaly: Benign or Not Benign.
Aoki R, Srivatanakul K
Neurol Med Chir (Tokyo) 2016 Sep 15;56(9):534-43. Epub 2016 Jun 1 doi: 10.2176/nmc.ra.2016-0030. PMID: 27250700Free PMC Article
Spinal epidural venous angioma: a case report and review of the literature.
Wu L, Yang T, Deng X, Yang C, Xu Y
Childs Nerv Syst 2014 Sep;30(9):1601-5. Epub 2014 Mar 18 doi: 10.1007/s00381-014-2397-4. PMID: 24639010
The association of venous developmental anomalies and cavernous malformations: pathophysiological, diagnostic, and surgical considerations.
Perrini P, Lanzino G
Neurosurg Focus 2006 Jul 15;21(1):e5. doi: 10.3171/foc.2006.21.1.6. PMID: 16859258
Potential complications of segmental hemangiomas of infancy.
Metry DW
Semin Cutan Med Surg 2004 Jun;23(2):107-15. doi: 10.1016/j.sder.2004.01.004. PMID: 15295920

Therapy

Serial imaging and SWAN sequence of developmental venous anomaly thrombosis with hematoma: Diagnosis and follow-up.
Monique B, Sandra C, Marie-Cécile HF, Jean-Pierre L
J Clin Neurosci 2017 Sep;43:148-151. Epub 2017 Jun 16 doi: 10.1016/j.jocn.2017.05.002. PMID: 28624141
Diffuse hemangiomatosis with predominant central nervous system involvement.
Al-Kaabi A, Yanofsky R, Bunge M, Hyman J, Rafay MF
Pediatr Neurol 2009 Jan;40(1):54-7. doi: 10.1016/j.pediatrneurol.2008.09.022. PMID: 19068256
Treatment differences in cases with venous angioma.
Gülşen S, Altinörs N, Atalay B, Benli S, Kaya Y
Turk Neurosurg 2007;17(1):40-4. PMID: 17918678
Sturge-Weber syndrome accompanied with multiple congenital intracranial lesions.
Ergün R, Okten AI, Gezercan Y, Gezici AR
Acta Neurochir (Wien) 2007 Aug;149(8):829-30; discussion 830. Epub 2007 Aug 1 doi: 10.1007/s00701-007-1224-z. PMID: 17660941
Diffuse neonatal haemangiomatosis.
Ho V, Krol A, Bhargava R, Osiovich H
J Paediatr Child Health 2000 Jun;36(3):286-9. doi: 10.1046/j.1440-1754.2000.00491.x. PMID: 10849236

Prognosis

Developmental venous anomalies and brainstem cavernous malformations: a proposed physiological mechanism for haemorrhage.
Maish WN
Neurosurg Rev 2019 Sep;42(3):663-670. Epub 2018 Oct 6 doi: 10.1007/s10143-018-1039-9. PMID: 30291476
Developmental Venous Anomaly: Benign or Not Benign.
Aoki R, Srivatanakul K
Neurol Med Chir (Tokyo) 2016 Sep 15;56(9):534-43. Epub 2016 Jun 1 doi: 10.2176/nmc.ra.2016-0030. PMID: 27250700Free PMC Article
Intracerebral hemorrhage due to developmental venous anomalies.
Li X, Wang Y, Chen W, Wang W, Chen K, Liao H, Lu J, Li Z
J Clin Neurosci 2016 Apr;26:95-100. Epub 2016 Jan 21 doi: 10.1016/j.jocn.2015.06.031. PMID: 26803466
Cerebral developmental venous anomalies.
San Millán Ruíz D, Gailloud P
Childs Nerv Syst 2010 Oct;26(10):1395-406. Epub 2010 Aug 12 doi: 10.1007/s00381-010-1253-4. PMID: 20703485
The association of venous developmental anomalies and cavernous malformations: pathophysiological, diagnostic, and surgical considerations.
Perrini P, Lanzino G
Neurosurg Focus 2006 Jul 15;21(1):e5. doi: 10.3171/foc.2006.21.1.6. PMID: 16859258

Clinical prediction guides

Brainstem cavernous malformations: Natural history versus surgical management.
Walcott BP, Choudhri O, Lawton MT
J Clin Neurosci 2016 Oct;32:164-5. Epub 2016 Jun 16 doi: 10.1016/j.jocn.2016.03.021. PMID: 27320373Free PMC Article
Cerebral developmental venous anomalies.
San Millán Ruíz D, Gailloud P
Childs Nerv Syst 2010 Oct;26(10):1395-406. Epub 2010 Aug 12 doi: 10.1007/s00381-010-1253-4. PMID: 20703485
Non-invasive imaging of intracranial pediatric vascular lesions.
Huisman TA, Singhi S, Pinto PS
Childs Nerv Syst 2010 Oct;26(10):1275-95. Epub 2010 Jul 2 doi: 10.1007/s00381-010-1203-1. PMID: 20596870
The association of venous developmental anomalies and cavernous malformations: pathophysiological, diagnostic, and surgical considerations.
Perrini P, Lanzino G
Neurosurg Focus 2006 Jul 15;21(1):e5. doi: 10.3171/foc.2006.21.1.6. PMID: 16859258
Venous angiomas and epilepsy.
Striano S, Nocerino C, Striano P, Boccella P, Meo R, Bilo L, Cirillo S
Neurol Sci 2000 Jun;21(3):151-5. doi: 10.1007/s100720070090. PMID: 11076003

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