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Linear earlobe crease

MedGen UID:
1612311
•Concept ID:
C4531075
•
Anatomical Abnormality
HPO: HP:0031510

Definition

A transverse linear fissure (crease) in the lobule of the ear. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLinear earlobe crease

Recent clinical studies

Etiology

The association between earlobe crease (Frank's sign) and cognitive performance is related to age. Results from the Atahualpa Project.
Del Brutto OH, Mera RM, Zambrano M, Costa AF
Arch Gerontol Geriatr 2018 Nov-Dec;79:104-107. Epub 2018 Aug 27 doi: 10.1016/j.archger.2018.08.008. PMID: 30179743
Diagonal earlobe crease associated with increased epicardial adipose tissue and carotid intima media thickness in subjects free of clinical cardiovascular disease.
Ziyrek M, Şahin S, Özdemir E, Acar Z, Kahraman S
Turk Kardiyol Dern Ars 2016 Sep;44(6):474-80. doi: 10.5543/tkda.2016.37806. PMID: 27665328
Association between diagonal earlobe crease and cardio-ankle vascular index in asymptomatic hypertensive patients.
Korkmaz L, Ağaç MT, Erkan H, Acar Z, Gurbak I, Bektas H, Kurt D, Celik S
Med Princ Pract 2013;22(6):530-4. Epub 2013 Aug 12 doi: 10.1159/000351886. PMID: 23941731Free PMC Article

Diagnosis

Cutaneous Mucinosis Associated with Beckwith-Wiedemann Syndrome.
Lacey R, Shalabi D, Nikbakht N
Skinmed 2020;18(1):42-44. Epub 2020 Jan 1 PMID: 32167456

Prognosis

Association between diagonal earlobe crease and cardio-ankle vascular index in asymptomatic hypertensive patients.
Korkmaz L, Ağaç MT, Erkan H, Acar Z, Gurbak I, Bektas H, Kurt D, Celik S
Med Princ Pract 2013;22(6):530-4. Epub 2013 Aug 12 doi: 10.1159/000351886. PMID: 23941731Free PMC Article

Clinical prediction guides

The association between earlobe crease (Frank's sign) and cognitive performance is related to age. Results from the Atahualpa Project.
Del Brutto OH, Mera RM, Zambrano M, Costa AF
Arch Gerontol Geriatr 2018 Nov-Dec;79:104-107. Epub 2018 Aug 27 doi: 10.1016/j.archger.2018.08.008. PMID: 30179743
Association between diagonal earlobe crease and cardio-ankle vascular index in asymptomatic hypertensive patients.
Korkmaz L, Ağaç MT, Erkan H, Acar Z, Gurbak I, Bektas H, Kurt D, Celik S
Med Princ Pract 2013;22(6):530-4. Epub 2013 Aug 12 doi: 10.1159/000351886. PMID: 23941731Free PMC Article

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