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Cutaneous sclerotic plaque

MedGen UID:
1612942
•Concept ID:
C4531175
•
Finding
HPO: HP:0031359

Definition

A solid, raised, plateau-like (flat-topped) lesion greater than 1 cm in diameter that is characterized by hardening (sclerosis) of the affected skin area (related to collagen thickening). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCutaneous sclerotic plaque

Professional guidelines

PubMed

Long-term treatment of cutaneous manifestations of tuberous sclerosis complex with topical 1% sirolimus cream: A prospective study of 25 patients.
Malissen N, Vergely L, Simon M, Roubertie A, Malinge MC, Bessis D
J Am Acad Dermatol 2017 Sep;77(3):464-472.e3. Epub 2017 May 11 doi: 10.1016/j.jaad.2017.04.005. PMID: 28502378
The efficacy of pulsed dye laser treatment for inflammatory skin diseases: a systematic review.
Erceg A, de Jong EM, van de Kerkhof PC, Seyger MM
J Am Acad Dermatol 2013 Oct;69(4):609-615.e8. Epub 2013 May 24 doi: 10.1016/j.jaad.2013.03.029. PMID: 23711766

Recent clinical studies

Etiology

Superficial fibromas with CTNNB1 mutation.
Kuntze A, Meliß RR, Ermert L, Falkenberg KD, Puller AC, Trautmann M, Hartmann W, Wardelmann E
Genes Chromosomes Cancer 2024 May;63(5):e23247. doi: 10.1002/gcc.23247. PMID: 38757718
Cutaneous mucinosis of infancy: report of a rare case and review of the literature.
Chan C, Mann JA, Mihm MC Jr, Yan S, Momtahen S
Dermatol Online J 2018 Oct 15;24(10) PMID: 30677812
Post-stripping sclerodermiform dermatitis.
French LE, Braun R, Masouyé I, Ramelet AA, Humbert PG, Saurat JH
Arch Dermatol 1999 Nov;135(11):1387-91. doi: 10.1001/archderm.135.11.1387. PMID: 10566839
Classification of morphea (localized scleroderma).
Peterson LS, Nelson AM, Su WP
Mayo Clin Proc 1995 Nov;70(11):1068-76. doi: 10.4065/70.11.1068. PMID: 7475336
Tuberous sclerosis.
Kwiatkowski DJ, Short MP
Arch Dermatol 1994 Mar;130(3):348-54. PMID: 8129414

Diagnosis

Tuberous Sclerosis.
Amorim BDB, Azulay D, Ramos-E-Silva M
Skinmed 2021;19(3):179-185. Epub 2021 Jun 1 PMID: 34303387
Squamoid eccrine ductal carcinoma.
Jacob J, Kugelman L
Cutis 2018 May;101(5):378;380;385. PMID: 29894529
Localized and systemic scleroderma.
Hawk A, English JC 3rd
Semin Cutan Med Surg 2001 Mar;20(1):27-37. doi: 10.1053/sder.2001.23093. PMID: 11308134
Classification of morphea (localized scleroderma).
Peterson LS, Nelson AM, Su WP
Mayo Clin Proc 1995 Nov;70(11):1068-76. doi: 10.4065/70.11.1068. PMID: 7475336
Tuberous sclerosis.
Kwiatkowski DJ, Short MP
Arch Dermatol 1994 Mar;130(3):348-54. PMID: 8129414

Therapy

Chromoblastomycosis in a Diabetic Patient Without a History of Trauma.
Zarei M, Schneider S, Villasante A, Villada G, Patel T, Hu S, Romanelli P
Am J Dermatopathol 2015 Sep;37(9):e112-5. doi: 10.1097/DAD.0000000000000273. PMID: 25830721
Intravenous immunoglobulin therapy for scleromyxedema: a case report and review of literature.
Sroa N, Campbell S, Bechtel M
J Drugs Dermatol 2010 Mar;9(3):263-5. PMID: 20232589
The medical uses and side effects of etanercept with a focus on cutaneous disease.
Scheinfeld N
J Drugs Dermatol 2004 Nov-Dec;3(6):653-9. PMID: 15624748
Localized and systemic scleroderma.
Hawk A, English JC 3rd
Semin Cutan Med Surg 2001 Mar;20(1):27-37. doi: 10.1053/sder.2001.23093. PMID: 11308134
Post-stripping sclerodermiform dermatitis.
French LE, Braun R, Masouyé I, Ramelet AA, Humbert PG, Saurat JH
Arch Dermatol 1999 Nov;135(11):1387-91. doi: 10.1001/archderm.135.11.1387. PMID: 10566839

Prognosis

Superficial fibromas with CTNNB1 mutation.
Kuntze A, Meliß RR, Ermert L, Falkenberg KD, Puller AC, Trautmann M, Hartmann W, Wardelmann E
Genes Chromosomes Cancer 2024 May;63(5):e23247. doi: 10.1002/gcc.23247. PMID: 38757718
Eczematous graft-vs-host disease: A report of three cases and review of the literature.
Chan SL, Wood BA, Mesbah Ardakani N
J Cutan Pathol 2020 Nov;47(11):1085-1095. Epub 2020 Aug 28 doi: 10.1111/cup.13836. PMID: 32767402
The efficacy of pulsed dye laser treatment for inflammatory skin diseases: a systematic review.
Erceg A, de Jong EM, van de Kerkhof PC, Seyger MM
J Am Acad Dermatol 2013 Oct;69(4):609-615.e8. Epub 2013 May 24 doi: 10.1016/j.jaad.2013.03.029. PMID: 23711766
Localized and systemic scleroderma.
Hawk A, English JC 3rd
Semin Cutan Med Surg 2001 Mar;20(1):27-37. doi: 10.1053/sder.2001.23093. PMID: 11308134
Diagnosis of Lyme disease based on dermatologic manifestations.
Malane MS, Grant-Kels JM, Feder HM Jr, Luger SW
Ann Intern Med 1991 Mar 15;114(6):490-8. doi: 10.7326/0003-4819-114-6-490. PMID: 1994797

Clinical prediction guides

Periodontal disease and its association to endothelial dysfunction and clinical changes in limited systemic sclerosis: A case-control study.
Jud P, Wimmer G, Meinitzer A, Strohmaier H, Schwantzer G, Moazedi-Fürst F, Schweiger L, Brodmann M, Hafner F, Arefnia B
J Periodontal Res 2023 Jun;58(3):621-633. Epub 2023 Mar 15 doi: 10.1111/jre.13111. PMID: 36919705
Clinical characteristics of sarcoidosis patients with systemic sclerosis-specific autoantibody: Possible involvement of thymus and activation-regulated chemokine and a review of the published works.
Ueda-Hayakawa I, Nguyen CTH, Kishimoto I, Ly NTM, Okamoto H
J Dermatol 2019 Jul;46(7):577-583. Epub 2019 May 27 doi: 10.1111/1346-8138.14932. PMID: 31131913
Forehead plaque: a cutaneous marker of CNS involvement in tuberous sclerosis.
Rama Rao GR, Krishna Rao PV, Gopal KV, Kumar YH, Ramachandra BV
Indian J Dermatol Venereol Leprol 2008 Jan-Feb;74(1):28-31. doi: 10.4103/0378-6323.38403. PMID: 18187819
Post-stripping sclerodermiform dermatitis.
French LE, Braun R, Masouyé I, Ramelet AA, Humbert PG, Saurat JH
Arch Dermatol 1999 Nov;135(11):1387-91. doi: 10.1001/archderm.135.11.1387. PMID: 10566839
Tuberous sclerosis.
Kwiatkowski DJ, Short MP
Arch Dermatol 1994 Mar;130(3):348-54. PMID: 8129414

Recent systematic reviews

The efficacy of pulsed dye laser treatment for inflammatory skin diseases: a systematic review.
Erceg A, de Jong EM, van de Kerkhof PC, Seyger MM
J Am Acad Dermatol 2013 Oct;69(4):609-615.e8. Epub 2013 May 24 doi: 10.1016/j.jaad.2013.03.029. PMID: 23711766

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