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Abnormal sex hormone-binding globulin level

MedGen UID:
1613168
•Concept ID:
C4531027
•
Finding
HPO: HP:0031438

Definition

A deviation from the normal concentration in the circulation of sex hormone-binding globulin, a circulating glycoprotein that transports testosterone and other steroids in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal sex hormone-binding globulin level

Professional guidelines

PubMed

AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ANDROGEN EXCESS AND PCOS SOCIETY DISEASE STATE CLINICAL REVIEW: GUIDE TO THE BEST PRACTICES IN THE EVALUATION AND TREATMENT OF POLYCYSTIC OVARY SYNDROME--PART 1.
Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E; American Association of Clinical Endocrinologists (AACE); American College of Endocrinology (ACE); Androgen Excess and PCOS Society (AES)
Endocr Pract 2015 Nov;21(11):1291-300. doi: 10.4158/EP15748.DSC. PMID: 26509855
Evolving utility of sex hormone-binding globulin measurements in clinical medicine.
Hammond GL, Wu TS, Simard M
Curr Opin Endocrinol Diabetes Obes 2012 Jun;19(3):183-9. doi: 10.1097/MED.0b013e328353732f. PMID: 22531107
Clinical utility of sex hormone-binding globulin measurement.
Pugeat M, Crave JC, Tourniaire J, Forest MG
Horm Res 1996;45(3-5):148-55. doi: 10.1159/000184778. PMID: 8964574

Recent clinical studies

Etiology

Sex hormone-binding globulin and polycystic ovary syndrome.
Zhu JL, Chen Z, Feng WJ, Long SL, Mo ZC
Clin Chim Acta 2019 Dec;499:142-148. Epub 2019 Sep 13 doi: 10.1016/j.cca.2019.09.010. PMID: 31525346
Hepatic manifestations of women with polycystic ovary syndrome.
Chen MJ, Ho HN
Best Pract Res Clin Obstet Gynaecol 2016 Nov;37:119-128. Epub 2016 Apr 6 doi: 10.1016/j.bpobgyn.2016.03.003. PMID: 27107966
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ANDROGEN EXCESS AND PCOS SOCIETY DISEASE STATE CLINICAL REVIEW: GUIDE TO THE BEST PRACTICES IN THE EVALUATION AND TREATMENT OF POLYCYSTIC OVARY SYNDROME--PART 1.
Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E; American Association of Clinical Endocrinologists (AACE); American College of Endocrinology (ACE); Androgen Excess and PCOS Society (AES)
Endocr Pract 2015 Nov;21(11):1291-300. doi: 10.4158/EP15748.DSC. PMID: 26509855
Evolving utility of sex hormone-binding globulin measurements in clinical medicine.
Hammond GL, Wu TS, Simard M
Curr Opin Endocrinol Diabetes Obes 2012 Jun;19(3):183-9. doi: 10.1097/MED.0b013e328353732f. PMID: 22531107
Hypopituitarism.
Ascoli P, Cavagnini F
Pituitary 2006;9(4):335-42. doi: 10.1007/s11102-006-0416-5. PMID: 17077946

Diagnosis

The endocrinology of male breast cancer.
Fentiman IS
Endocr Relat Cancer 2018 Jun;25(6):R365-R373. doi: 10.1530/ERC-18-0117. PMID: 29752333
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ANDROGEN EXCESS AND PCOS SOCIETY DISEASE STATE CLINICAL REVIEW: GUIDE TO THE BEST PRACTICES IN THE EVALUATION AND TREATMENT OF POLYCYSTIC OVARY SYNDROME--PART 1.
Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E; American Association of Clinical Endocrinologists (AACE); American College of Endocrinology (ACE); Androgen Excess and PCOS Society (AES)
Endocr Pract 2015 Nov;21(11):1291-300. doi: 10.4158/EP15748.DSC. PMID: 26509855
Evolving utility of sex hormone-binding globulin measurements in clinical medicine.
Hammond GL, Wu TS, Simard M
Curr Opin Endocrinol Diabetes Obes 2012 Jun;19(3):183-9. doi: 10.1097/MED.0b013e328353732f. PMID: 22531107
Hypopituitarism.
Ascoli P, Cavagnini F
Pituitary 2006;9(4):335-42. doi: 10.1007/s11102-006-0416-5. PMID: 17077946
Clinical utility of sex hormone-binding globulin measurement.
Pugeat M, Crave JC, Tourniaire J, Forest MG
Horm Res 1996;45(3-5):148-55. doi: 10.1159/000184778. PMID: 8964574

Therapy

The endocrinology of male breast cancer.
Fentiman IS
Endocr Relat Cancer 2018 Jun;25(6):R365-R373. doi: 10.1530/ERC-18-0117. PMID: 29752333
Hepatic manifestations of women with polycystic ovary syndrome.
Chen MJ, Ho HN
Best Pract Res Clin Obstet Gynaecol 2016 Nov;37:119-128. Epub 2016 Apr 6 doi: 10.1016/j.bpobgyn.2016.03.003. PMID: 27107966
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ANDROGEN EXCESS AND PCOS SOCIETY DISEASE STATE CLINICAL REVIEW: GUIDE TO THE BEST PRACTICES IN THE EVALUATION AND TREATMENT OF POLYCYSTIC OVARY SYNDROME--PART 1.
Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E; American Association of Clinical Endocrinologists (AACE); American College of Endocrinology (ACE); Androgen Excess and PCOS Society (AES)
Endocr Pract 2015 Nov;21(11):1291-300. doi: 10.4158/EP15748.DSC. PMID: 26509855
Hypopituitarism.
Ascoli P, Cavagnini F
Pituitary 2006;9(4):335-42. doi: 10.1007/s11102-006-0416-5. PMID: 17077946
Clinical utility of sex hormone-binding globulin measurement.
Pugeat M, Crave JC, Tourniaire J, Forest MG
Horm Res 1996;45(3-5):148-55. doi: 10.1159/000184778. PMID: 8964574

Prognosis

Pioglitazone can improve liver sex hormone-binding globulin levels and lipid metabolism in polycystic ovary syndrome by regulating hepatocyte nuclear factor-4α.
Zhao H, Wang D, Xing C, Lv B, Wang X, He B
J Steroid Biochem Mol Biol 2023 May;229:106265. Epub 2023 Feb 1 doi: 10.1016/j.jsbmb.2023.106265. PMID: 36737028
Sex hormone-binding globulin and polycystic ovary syndrome.
Zhu JL, Chen Z, Feng WJ, Long SL, Mo ZC
Clin Chim Acta 2019 Dec;499:142-148. Epub 2019 Sep 13 doi: 10.1016/j.cca.2019.09.010. PMID: 31525346
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ANDROGEN EXCESS AND PCOS SOCIETY DISEASE STATE CLINICAL REVIEW: GUIDE TO THE BEST PRACTICES IN THE EVALUATION AND TREATMENT OF POLYCYSTIC OVARY SYNDROME--PART 1.
Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E; American Association of Clinical Endocrinologists (AACE); American College of Endocrinology (ACE); Androgen Excess and PCOS Society (AES)
Endocr Pract 2015 Nov;21(11):1291-300. doi: 10.4158/EP15748.DSC. PMID: 26509855
Sex hormones and breast cancer risk and prognosis.
Folkerd E, Dowsett M
Breast 2013 Aug;22 Suppl 2:S38-43. doi: 10.1016/j.breast.2013.07.007. PMID: 24074790
Evolving utility of sex hormone-binding globulin measurements in clinical medicine.
Hammond GL, Wu TS, Simard M
Curr Opin Endocrinol Diabetes Obes 2012 Jun;19(3):183-9. doi: 10.1097/MED.0b013e328353732f. PMID: 22531107

Clinical prediction guides

Oxidative stress promotes hyperandrogenism by reducing sex hormone-binding globulin in polycystic ovary syndrome.
Sun Y, Li S, Liu H, Bai H, Hu K, Zhang R, Liu Q, Fan P
Fertil Steril 2021 Dec;116(6):1641-1650. Epub 2021 Aug 22 doi: 10.1016/j.fertnstert.2021.07.1203. PMID: 34433519
New Biomarkers to Evaluate Hyperandrogenemic Women and Hypogonadal Men.
Karakas SE, Surampudi P
Adv Clin Chem 2018;86:71-125. Epub 2018 Aug 18 doi: 10.1016/bs.acc.2018.06.001. PMID: 30144842
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ANDROGEN EXCESS AND PCOS SOCIETY DISEASE STATE CLINICAL REVIEW: GUIDE TO THE BEST PRACTICES IN THE EVALUATION AND TREATMENT OF POLYCYSTIC OVARY SYNDROME--PART 1.
Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E; American Association of Clinical Endocrinologists (AACE); American College of Endocrinology (ACE); Androgen Excess and PCOS Society (AES)
Endocr Pract 2015 Nov;21(11):1291-300. doi: 10.4158/EP15748.DSC. PMID: 26509855
Evolving utility of sex hormone-binding globulin measurements in clinical medicine.
Hammond GL, Wu TS, Simard M
Curr Opin Endocrinol Diabetes Obes 2012 Jun;19(3):183-9. doi: 10.1097/MED.0b013e328353732f. PMID: 22531107
Clinical utility of sex hormone-binding globulin measurement.
Pugeat M, Crave JC, Tourniaire J, Forest MG
Horm Res 1996;45(3-5):148-55. doi: 10.1159/000184778. PMID: 8964574

Recent systematic reviews

Impact of pharmacological interventions on biochemical hyperandrogenemia in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials.
Abdalla MA, Shah N, Deshmukh H, Sahebkar A, Östlundh L, Al-Rifai RH, Atkin SL, Sathyapalan T
Arch Gynecol Obstet 2023 May;307(5):1347-1376. Epub 2022 Apr 18 doi: 10.1007/s00404-022-06549-6. PMID: 35434762
Metabolic Surgery on Patients With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis.
Yue W, Huang X, Zhang W, Li S, Liu X, Zhao Y, Shu J, Liu T, Li W, Liu S
Front Endocrinol (Lausanne) 2022;13:848947. Epub 2022 Mar 10 doi: 10.3389/fendo.2022.848947. PMID: 35360056Free PMC Article
Effects of bariatric surgery on the menstruation- and reproductive-related hormones of women with obesity without polycystic ovary syndrome: a systematic review and meta-analysis.
Lv B, Xing C, He B
Surg Obes Relat Dis 2022 Jan;18(1):148-160. Epub 2021 Sep 10 doi: 10.1016/j.soard.2021.09.008. PMID: 34756568
Effects of combined oral contraceptives on the clinical and biochemical parameters of hyperandrogenism in patients with polycystic ovary syndrome: a systematic review and meta-analysis.
Amiri M, Kabir A, Nahidi F, Shekofteh M, Ramezani Tehrani F
Eur J Contracept Reprod Health Care 2018 Feb;23(1):64-77. Epub 2018 Feb 19 doi: 10.1080/13625187.2018.1435779. PMID: 29457756
MANAGEMENT OF ENDOCRINE DISEASE: The impact of subclinical hypothyroidism on anthropometric characteristics, lipid, glucose and hormonal profile of PCOS patients: a systematic review and meta-analysis.
Pergialiotis V, Konstantopoulos P, Prodromidou A, Florou V, Papantoniou N, Perrea DN
Eur J Endocrinol 2017 Mar;176(3):R159-R166. Epub 2016 Dec 22 doi: 10.1530/EJE-16-0611. PMID: 28007842

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