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Oral Intraepithelial Neoplasia

MedGen UID:
1616161
•Concept ID:
C4524462
•
Neoplastic Process

Definition

A precancerous neoplastic process affecting the oral mucosa. It is characterized by the presence of dysplasia in the mucosal epithelium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOral Intraepithelial Neoplasia

Professional guidelines

PubMed

Partial Breast Irradiation for Patients With Early-Stage Invasive Breast Cancer or Ductal Carcinoma In Situ: An ASTRO Clinical Practice Guideline.
Shaitelman SF, Anderson BM, Arthur DW, Bazan JG, Bellon JR, Bradfield L, Coles CE, Gerber NK, Kathpal M, Kim L, Laronga C, Meattini I, Nichols EM, Pierce LJ, Poppe MM, Spears PA, Vinayak S, Whelan T, Lyons JA
Pract Radiat Oncol 2024 Mar-Apr;14(2):112-132. Epub 2023 Nov 15 doi: 10.1016/j.prro.2023.11.001. PMID: 37977261
Management of Endometrial Intraepithelial Neoplasia or Atypical Endometrial Hyperplasia: ACOG Clinical Consensus No. 5.
Obstet Gynecol 2023 Sep 1;142(3):735-744. doi: 10.1097/AOG.0000000000005297. PMID: 37590985
A Physiologically Responsive Nanocomposite Hydrogel for Treatment of Head and Neck Squamous Cell Carcinoma via Proteolysis-Targeting Chimeras Enhanced Immunotherapy.
Wu Y, Chang X, Yang G, Chen L, Wu Q, Gao J, Tian R, Mu W, Gooding JJ, Chen X, Sun S
Adv Mater 2023 Mar;35(12):e2210787. Epub 2023 Feb 10 doi: 10.1002/adma.202210787. PMID: 36656993

Recent clinical studies

Etiology

Population-based utility scores for HPV infection and oropharyngeal squamous cell carcinoma among Indigenous Australians.
Ju X, Canfell K, Howard K, Garvey G, Hedges J, Smith M, Jamieson L
BMC Public Health 2021 Jul 26;21(1):1455. doi: 10.1186/s12889-021-11496-z. PMID: 34311730Free PMC Article
Risk factors of cancer occurrence after surgery of oral intraepithelial neoplasia: A long-term retrospective study.
Ballivet de Régloix S, Badois N, Bernardeschi C, Jouffroy T, Hofmann C
Laryngoscope 2018 Nov;128(11):2546-2551. Epub 2018 May 4 doi: 10.1002/lary.27214. PMID: 29729031
Diagnostic accuracy of oral cancer cytology in a pilot study.
Sekine J, Nakatani E, Hideshima K, Iwahashi T, Sasaki H
Diagn Pathol 2017 Mar 16;12(1):27. doi: 10.1186/s13000-017-0618-3. PMID: 28298213Free PMC Article
Human papillomavirus-associated oral intraepithelial neoplasia.
Woo SB, Cashman EC, Lerman MA
Mod Pathol 2013 Oct;26(10):1288-97. Epub 2013 Apr 19 doi: 10.1038/modpathol.2013.70. PMID: 23599160
Oral premalignant lesions: from the pathological viewpoint.
Izumo T
Int J Clin Oncol 2011 Feb;16(1):15-26. Epub 2011 Jan 14 doi: 10.1007/s10147-010-0169-z. PMID: 21234636

Diagnosis

Oral Epithelial Dysplasia Grading Systems: A Systematic Review & Meta-Analysis.
Khoury ZH, Sultan M, Sultan AS
Int J Surg Pathol 2022 Aug;30(5):499-511. Epub 2022 Jan 7 doi: 10.1177/10668969211070171. PMID: 34994584
Tissue eosinophilia in oral intraepithelial neoplasia as a probable indicator of invasion.
Martinelli-Kläy CP, Lombardi T, Mendis B, Soares EG, Salvado F, Courvoisier DS, Mauricio P
Oral Dis 2018 Mar;24(1-2):103-108. doi: 10.1111/odi.12789. PMID: 29480618
Diagnostic accuracy of oral cancer cytology in a pilot study.
Sekine J, Nakatani E, Hideshima K, Iwahashi T, Sasaki H
Diagn Pathol 2017 Mar 16;12(1):27. doi: 10.1186/s13000-017-0618-3. PMID: 28298213Free PMC Article
Human papillomavirus-associated oral intraepithelial neoplasia.
Woo SB, Cashman EC, Lerman MA
Mod Pathol 2013 Oct;26(10):1288-97. Epub 2013 Apr 19 doi: 10.1038/modpathol.2013.70. PMID: 23599160
Oral premalignant lesions: from the pathological viewpoint.
Izumo T
Int J Clin Oncol 2011 Feb;16(1):15-26. Epub 2011 Jan 14 doi: 10.1007/s10147-010-0169-z. PMID: 21234636

Therapy

Growth modulatory effects of fenretinide encompass keratinocyte terminal differentiation: a favorable outcome for oral squamous cell carcinoma chemoprevention.
Wang D, Pei P, Shea F, Spinney R, Chang A, Lahann J, Mallery SR
Carcinogenesis 2024 Jun 10;45(6):436-449. doi: 10.1093/carcin/bgae022. PMID: 38470060Free PMC Article
Topical application of a mucoadhesive freeze-dried black raspberry gel induces clinical and histologic regression and reduces loss of heterozygosity events in premalignant oral intraepithelial lesions: results from a multicentered, placebo-controlled clinical trial.
Mallery SR, Tong M, Shumway BS, Curran AE, Larsen PE, Ness GM, Kennedy KS, Blakey GH, Kushner GM, Vickers AM, Han B, Pei P, Stoner GD
Clin Cancer Res 2014 Apr 1;20(7):1910-24. Epub 2014 Jan 31 doi: 10.1158/1078-0432.CCR-13-3159. PMID: 24486592Free PMC Article
Reducing the "risk" of chemoprevention: defining and targeting high risk--2005 AACR Cancer Research and Prevention Foundation Award Lecture.
Lippman SM, Lee JJ
Cancer Res 2006 Mar 15;66(6):2893-903. doi: 10.1158/0008-5472.CAN-05-4573. PMID: 16540634

Prognosis

Risk factors of cancer occurrence after surgery of oral intraepithelial neoplasia: A long-term retrospective study.
Ballivet de Régloix S, Badois N, Bernardeschi C, Jouffroy T, Hofmann C
Laryngoscope 2018 Nov;128(11):2546-2551. Epub 2018 May 4 doi: 10.1002/lary.27214. PMID: 29729031
Tissue eosinophilia in oral intraepithelial neoplasia as a probable indicator of invasion.
Martinelli-Kläy CP, Lombardi T, Mendis B, Soares EG, Salvado F, Courvoisier DS, Mauricio P
Oral Dis 2018 Mar;24(1-2):103-108. doi: 10.1111/odi.12789. PMID: 29480618
Diagnostic accuracy of oral cancer cytology in a pilot study.
Sekine J, Nakatani E, Hideshima K, Iwahashi T, Sasaki H
Diagn Pathol 2017 Mar 16;12(1):27. doi: 10.1186/s13000-017-0618-3. PMID: 28298213Free PMC Article
Grading oral epithelial dysplasia: analysis of individual features.
Tilakaratne WM, Sherriff M, Morgan PR, Odell EW
J Oral Pathol Med 2011 Aug;40(7):533-40. Epub 2011 Apr 18 doi: 10.1111/j.1600-0714.2011.01033.x. PMID: 21501232
The impact of liquid-based oral cytology on the diagnosis of oral squamous dysplasia and carcinoma.
Navone R, Burlo P, Pich A, Pentenero M, Broccoletti R, Marsico A, Gandolfo S
Cytopathology 2007 Dec;18(6):356-60. doi: 10.1111/j.1365-2303.2006.00402.x. PMID: 18031448

Clinical prediction guides

Oral Epithelial Dysplasia Grading Systems: A Systematic Review & Meta-Analysis.
Khoury ZH, Sultan M, Sultan AS
Int J Surg Pathol 2022 Aug;30(5):499-511. Epub 2022 Jan 7 doi: 10.1177/10668969211070171. PMID: 34994584
Population-based utility scores for HPV infection and oropharyngeal squamous cell carcinoma among Indigenous Australians.
Ju X, Canfell K, Howard K, Garvey G, Hedges J, Smith M, Jamieson L
BMC Public Health 2021 Jul 26;21(1):1455. doi: 10.1186/s12889-021-11496-z. PMID: 34311730Free PMC Article
Risk factors of cancer occurrence after surgery of oral intraepithelial neoplasia: A long-term retrospective study.
Ballivet de Régloix S, Badois N, Bernardeschi C, Jouffroy T, Hofmann C
Laryngoscope 2018 Nov;128(11):2546-2551. Epub 2018 May 4 doi: 10.1002/lary.27214. PMID: 29729031
Tissue eosinophilia in oral intraepithelial neoplasia as a probable indicator of invasion.
Martinelli-Kläy CP, Lombardi T, Mendis B, Soares EG, Salvado F, Courvoisier DS, Mauricio P
Oral Dis 2018 Mar;24(1-2):103-108. doi: 10.1111/odi.12789. PMID: 29480618
Diagnostic accuracy of oral cancer cytology in a pilot study.
Sekine J, Nakatani E, Hideshima K, Iwahashi T, Sasaki H
Diagn Pathol 2017 Mar 16;12(1):27. doi: 10.1186/s13000-017-0618-3. PMID: 28298213Free PMC Article

Recent systematic reviews

Oral Epithelial Dysplasia Grading Systems: A Systematic Review & Meta-Analysis.
Khoury ZH, Sultan M, Sultan AS
Int J Surg Pathol 2022 Aug;30(5):499-511. Epub 2022 Jan 7 doi: 10.1177/10668969211070171. PMID: 34994584

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