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Genital blistering

MedGen UID:
1616961
•Concept ID:
C3854369
•
Finding
HPO: HP:0031464

Definition

The presence of one or more bullae on the skin of the genital region, defined as fluid-filled blisters more than 5 mm in diameter with thin walls. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGenital blistering

Professional guidelines

PubMed

European Guidelines (S3) on diagnosis and management of mucous membrane pemphigoid, initiated by the European Academy of Dermatology and Venereology - Part II.
Schmidt E, Rashid H, Marzano AV, Lamberts A, Di Zenzo G, Diercks GFH, Alberti-Violetti S, Barry RJ, Borradori L, Caproni M, Carey B, Carrozzo M, Cianchini G, Corrà A, Dikkers FG, Feliciani C, Geerling G, Genovese G, Hertl M, Joly P, Meijer JM, Mercadante V, Murrell DF, Ormond M, Pas HH, Patsatsi A, Rauz S, van Rhijn BD, Roth M, Setterfield J, Zillikens D, C Prost, Zambruno G, Horváth B, Caux F
J Eur Acad Dermatol Venereol 2021 Oct;35(10):1926-1948. Epub 2021 Jul 26 doi: 10.1111/jdv.17395. PMID: 34309078Free PMC Article
Acyclovir in the Treatment of Herpes Viruses - A Review.
Kłysik K, Pietraszek A, Karewicz A, Nowakowska M
Curr Med Chem 2020;27(24):4118-4137. doi: 10.2174/0929867325666180309105519. PMID: 29521211
Oral lichen planus and lichenoid reactions: etiopathogenesis, diagnosis, management and malignant transformation.
Ismail SB, Kumar SK, Zain RB
J Oral Sci 2007 Jun;49(2):89-106. doi: 10.2334/josnusd.49.89. PMID: 17634721

Recent clinical studies

Therapy

European Guidelines (S3) on diagnosis and management of mucous membrane pemphigoid, initiated by the European Academy of Dermatology and Venereology - Part II.
Schmidt E, Rashid H, Marzano AV, Lamberts A, Di Zenzo G, Diercks GFH, Alberti-Violetti S, Barry RJ, Borradori L, Caproni M, Carey B, Carrozzo M, Cianchini G, Corrà A, Dikkers FG, Feliciani C, Geerling G, Genovese G, Hertl M, Joly P, Meijer JM, Mercadante V, Murrell DF, Ormond M, Pas HH, Patsatsi A, Rauz S, van Rhijn BD, Roth M, Setterfield J, Zillikens D, C Prost, Zambruno G, Horváth B, Caux F
J Eur Acad Dermatol Venereol 2021 Oct;35(10):1926-1948. Epub 2021 Jul 26 doi: 10.1111/jdv.17395. PMID: 34309078Free PMC Article
Mycoplasma pneumoniae-associated mucositis.
Gonçalves R, Gata L, Brett A
BMJ Case Rep 2021 Apr 15;14(4) doi: 10.1136/bcr-2020-239086. PMID: 33858884Free PMC Article
Current Perspectives on Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
Lerch M, Mainetti C, Terziroli Beretta-Piccoli B, Harr T
Clin Rev Allergy Immunol 2018 Feb;54(1):147-176. doi: 10.1007/s12016-017-8654-z. PMID: 29188475
Topical treatments for cutaneous warts.
Kwok CS, Gibbs S, Bennett C, Holland R, Abbott R
Cochrane Database Syst Rev 2012 Sep 12;2012(9):CD001781. doi: 10.1002/14651858.CD001781.pub3. PMID: 22972052Free PMC Article
Oral lichen planus and lichenoid reactions: etiopathogenesis, diagnosis, management and malignant transformation.
Ismail SB, Kumar SK, Zain RB
J Oral Sci 2007 Jun;49(2):89-106. doi: 10.2334/josnusd.49.89. PMID: 17634721

Prognosis

Ocular manifestations in Kindler syndrome.
Maharana PK, Sahay P, Mandal S, Nagpal R, Sharma N
Indian J Ophthalmol 2022 Jul;70(7):2585-2587. doi: 10.4103/ijo.IJO_791_22. PMID: 35791162Free PMC Article
Small-volume detection: platform developments for clinically-relevant applications.
Sung WH, Tsao YT, Shen CJ, Tsai CY, Cheng CM
J Nanobiotechnology 2021 Apr 21;19(1):114. doi: 10.1186/s12951-021-00852-1. PMID: 33882955Free PMC Article
Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: An Update.
Dodiuk-Gad RP, Chung WH, Valeyrie-Allanore L, Shear NH
Am J Clin Dermatol 2015 Dec;16(6):475-93. doi: 10.1007/s40257-015-0158-0. PMID: 26481651
Atypical presentations of bullous pemphigoid: Clinical and immunopathological aspects.
Cozzani E, Gasparini G, Burlando M, Drago F, Parodi A
Autoimmun Rev 2015 May;14(5):438-45. Epub 2015 Jan 21 doi: 10.1016/j.autrev.2015.01.006. PMID: 25617817
Management of pemphigus in pediatric patients.
Gürcan H, Mabrouk D, Razzaque Ahmed A
Minerva Pediatr 2011 Aug;63(4):279-91. PMID: 21909064

Clinical prediction guides

Feasibility of 5-fluorouracil and imiquimod for the topical treatment of cervical intraepithelial neoplasias (CIN) 2/3.
Desravines N, Hsu CH, Mohnot S, Sahasrabuddhe V, House M, Sauter E, O'Connor S, Bauman JE, Chow HS, Rahangdale L
Int J Gynaecol Obstet 2023 Dec;163(3):862-867. Epub 2023 Jul 11 doi: 10.1002/ijgo.14983. PMID: 37431689Free PMC Article
Current Perspectives on Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
Lerch M, Mainetti C, Terziroli Beretta-Piccoli B, Harr T
Clin Rev Allergy Immunol 2018 Feb;54(1):147-176. doi: 10.1007/s12016-017-8654-z. PMID: 29188475
Nav Channels in Damaged Membranes.
Morris CE, Joos B
Curr Top Membr 2016;78:561-97. Epub 2016 Aug 2 doi: 10.1016/bs.ctm.2016.06.001. PMID: 27586295
Sulfur mustard-induced poikiloderma: a case report.
Emadi SN, Kaffashi M, Poursaleh Z, Akhavan-Moghaddam J, Soroush MR, Emadi SE, Taghavi NO
Cutan Ocul Toxicol 2011 Jun;30(2):170-4. Epub 2010 Dec 10 doi: 10.3109/15569527.2010.539585. PMID: 21142708
Cervicovaginal involvement in pemphigus vulgaris: a clinical study of 77 cases.
Akhyani M, Chams-Davatchi C, Naraghi Z, Daneshpazhooh M, Toosi S, Asgari M, Malekhami F
Br J Dermatol 2008 Mar;158(3):478-82. Epub 2007 Dec 6 doi: 10.1111/j.1365-2133.2007.08356.x. PMID: 18070212

Recent systematic reviews

Clinical features of chronic bullous dermatosis of childhood.
Wilson A, Murrell DF
Clin Exp Dermatol 2022 May;47(5):873-881. Epub 2022 Jan 2 doi: 10.1111/ced.15059. PMID: 34919291
Bee products and the treatment of blister-like lesions around the mouth, skin and genitalia caused by herpes viruses-A systematic review.
Münstedt K
Complement Ther Med 2019 Apr;43:81-84. Epub 2019 Jan 22 doi: 10.1016/j.ctim.2019.01.014. PMID: 30935560
Topical treatments for cutaneous warts.
Kwok CS, Gibbs S, Bennett C, Holland R, Abbott R
Cochrane Database Syst Rev 2012 Sep 12;2012(9):CD001781. doi: 10.1002/14651858.CD001781.pub3. PMID: 22972052Free PMC Article

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