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Clonal Rearrangement, Multiple Peaks

MedGen UID:
1618719
•Concept ID:
C4524439
•
Cell or Molecular Dysfunction

Definition

DNA sequence rearrangements that are detected or characterized by presence of multiple types of protein molecules in a cell population. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClonal Rearrangement, Multiple Peaks

Professional guidelines

PubMed

Resolving T-cell receptor clonality in two and genotype in four multiplex polymerase chain reactions.
Dictor M, Warenholt J, Isinger A
Haematologica 2005 Nov;90(11):1524-32. PMID: 16266900

Recent clinical studies

Etiology

T-cell clonality assessment by next-generation sequencing improves detection sensitivity in mycosis fungoides.
Sufficool KE, Lockwood CM, Abel HJ, Hagemann IS, Schumacher JA, Kelley TW, Duncavage EJ
J Am Acad Dermatol 2015 Aug;73(2):228-36.e2. Epub 2015 Jun 3 doi: 10.1016/j.jaad.2015.04.030. PMID: 26048061
Gene scanning of VDJH-amplified segments is a clinically relevant technique to detect contaminating tumor cells in the apheresis products of multiple myeloma patients undergoing autologous peripheral blood stem cell transplantation.
López-Pérez R, García-Sanz R, González D, Balanzategui A, Chillón MC, Alaejos I, Mateos MV, Caballero MD, Corral M, Orfão A, González M, San Miguel JF
Bone Marrow Transplant 2001 Oct;28(7):665-72. doi: 10.1038/sj.bmt.1703219. PMID: 11704789

Diagnosis

T-cell clonality assessment by next-generation sequencing improves detection sensitivity in mycosis fungoides.
Sufficool KE, Lockwood CM, Abel HJ, Hagemann IS, Schumacher JA, Kelley TW, Duncavage EJ
J Am Acad Dermatol 2015 Aug;73(2):228-36.e2. Epub 2015 Jun 3 doi: 10.1016/j.jaad.2015.04.030. PMID: 26048061
Application of microfluidic technology to the BIOMED-2 protocol for detection of B-cell clonality.
Zamò A, Bertolaso A, van Raaij AW, Mancini F, Scardoni M, Montresor M, Menestrina F, van Krieken JH, Chilosi M, Groenen PJ, Scarpa A
J Mol Diagn 2012 Jan;14(1):30-7. Epub 2011 Oct 24 doi: 10.1016/j.jmoldx.2011.07.007. PMID: 22026958
Resolving T-cell receptor clonality in two and genotype in four multiplex polymerase chain reactions.
Dictor M, Warenholt J, Isinger A
Haematologica 2005 Nov;90(11):1524-32. PMID: 16266900
Delineation of distinct subgroups of multiple myeloma and a model for clonal evolution based on interphase cytogenetics.
Cremer FW, Bila J, Buck I, Kartal M, Hose D, Ittrich C, Benner A, Raab MS, Theil AC, Moos M, Goldschmidt H, Bartram CR, Jauch A
Genes Chromosomes Cancer 2005 Oct;44(2):194-203. doi: 10.1002/gcc.20231. PMID: 16001433
Gene scanning of VDJH-amplified segments is a clinically relevant technique to detect contaminating tumor cells in the apheresis products of multiple myeloma patients undergoing autologous peripheral blood stem cell transplantation.
López-Pérez R, García-Sanz R, González D, Balanzategui A, Chillón MC, Alaejos I, Mateos MV, Caballero MD, Corral M, Orfão A, González M, San Miguel JF
Bone Marrow Transplant 2001 Oct;28(7):665-72. doi: 10.1038/sj.bmt.1703219. PMID: 11704789

Therapy

Gene scanning of VDJH-amplified segments is a clinically relevant technique to detect contaminating tumor cells in the apheresis products of multiple myeloma patients undergoing autologous peripheral blood stem cell transplantation.
López-Pérez R, García-Sanz R, González D, Balanzategui A, Chillón MC, Alaejos I, Mateos MV, Caballero MD, Corral M, Orfão A, González M, San Miguel JF
Bone Marrow Transplant 2001 Oct;28(7):665-72. doi: 10.1038/sj.bmt.1703219. PMID: 11704789

Prognosis

T-cell clonality assessment by next-generation sequencing improves detection sensitivity in mycosis fungoides.
Sufficool KE, Lockwood CM, Abel HJ, Hagemann IS, Schumacher JA, Kelley TW, Duncavage EJ
J Am Acad Dermatol 2015 Aug;73(2):228-36.e2. Epub 2015 Jun 3 doi: 10.1016/j.jaad.2015.04.030. PMID: 26048061
Resolving T-cell receptor clonality in two and genotype in four multiplex polymerase chain reactions.
Dictor M, Warenholt J, Isinger A
Haematologica 2005 Nov;90(11):1524-32. PMID: 16266900
Delineation of distinct subgroups of multiple myeloma and a model for clonal evolution based on interphase cytogenetics.
Cremer FW, Bila J, Buck I, Kartal M, Hose D, Ittrich C, Benner A, Raab MS, Theil AC, Moos M, Goldschmidt H, Bartram CR, Jauch A
Genes Chromosomes Cancer 2005 Oct;44(2):194-203. doi: 10.1002/gcc.20231. PMID: 16001433

Clinical prediction guides

Resolving T-cell receptor clonality in two and genotype in four multiplex polymerase chain reactions.
Dictor M, Warenholt J, Isinger A
Haematologica 2005 Nov;90(11):1524-32. PMID: 16266900
Delineation of distinct subgroups of multiple myeloma and a model for clonal evolution based on interphase cytogenetics.
Cremer FW, Bila J, Buck I, Kartal M, Hose D, Ittrich C, Benner A, Raab MS, Theil AC, Moos M, Goldschmidt H, Bartram CR, Jauch A
Genes Chromosomes Cancer 2005 Oct;44(2):194-203. doi: 10.1002/gcc.20231. PMID: 16001433

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