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Invasive Lung Mucinous Adenocarcinoma

MedGen UID:
1626367
•Concept ID:
C4522160
•
Neoplastic Process
Synonym: Mucinous Invasive Lung Adenocarcinoma

Definition

An invasive adenocarcinoma that arises from the lung. It is characterized by the presence of tall columnar cells and mucin production. This category refers to cases formerly classified as mucinous bronchioloalveolar carcinoma, excluding cases that meet the criteria for adenocarcinoma in situ or mucinous minimally invasive adenocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInvasive Lung Mucinous Adenocarcinoma

Professional guidelines

PubMed

Inclusion of multiple high-risk histopathological criteria improves the prediction of adjuvant chemotherapy efficacy in lung adenocarcinoma.
Sereno M, He Z, Smith CR, Baena J, Das M, Hastings RK, Rake G, Fennell DA, Nakas A, Moore DA, Le Quesne J
Histopathology 2021 May;78(6):838-848. Epub 2021 Feb 7 doi: 10.1111/his.14301. PMID: 33155719Free PMC Article
Invasive mucinous adenocarcinoma of the lung: Serial CT findings, clinical features, and treatment and survival outcomes.
Beck KS, Sung YE, Lee KY, Han DH
Thorac Cancer 2020 Dec;11(12):3463-3472. Epub 2020 Oct 5 doi: 10.1111/1759-7714.13674. PMID: 33021074Free PMC Article
About thymic carcinomas: challenges in diagnosis and management.
Mlika M, Boudaya S, Braham E, Chermiti F, Sayi A, Marghli A, El Mezni F
Asian Cardiovasc Thorac Ann 2016 May;24(4):350-4. Epub 2016 Mar 21 doi: 10.1177/0218492316640129. PMID: 27002097

Recent clinical studies

Etiology

Radiological and clinical features of large consolidative-type pulmonary invasive mucinous adenocarcinoma.
Chen J, Qi L, Wang J, Xue L, Xue Q, Jia J, Zhang G, Liu J, Li F, Cui S
Clin Respir J 2024 Mar;18(3):e13743. doi: 10.1111/crj.13743. PMID: 38529681Free PMC Article
Stepwise progression of invasive mucinous adenocarcinoma based on radiological and biological characteristics.
Goto E, Takamochi K, Kishikawa S, Hayashi T, Ueda T, Hattori A, Fukui M, Matsunaga T, Suzuki K; Tokyo Metropolitan Innovative Oncology Research Group (TMIG)
Lung Cancer 2023 Oct;184:107348. Epub 2023 Aug 20 doi: 10.1016/j.lungcan.2023.107348. PMID: 37619407
Cytological features of stromal spindle cells and their prognostic significance in lung adenocarcinoma.
Miyata-Morita K, Morita S, Dejima H, Saito K, Sakao Y, Mochizuki M, Sasajima Y
Cytopathology 2023 Jul;34(4):337-345. Epub 2023 Mar 22 doi: 10.1111/cyt.13232. PMID: 36946097
Presence of non-Newtonian fluid in invasive pulmonary mucinous adenocarcinomas impacts fluorescence during intraoperative molecular imaging of lung cancer.
Azari F, Kennedy G, Chang A, Nadeem B, Sullivan N, Marfatia I, Din A, Desphande C, Kucharczuk J, Delikatny EJ, Singhal S
Eur J Nucl Med Mol Imaging 2022 Nov;49(13):4406-4418. Epub 2022 Jul 25 doi: 10.1007/s00259-022-05912-8. PMID: 35876868Free PMC Article
Invasive IPMN relapse later and more often in lungs in comparison to pancreatic ductal adenocarcinoma.
Capretti G, Nebbia M, Gavazzi F, Nappo G, Ridolfi C, Sollai M, Spaggiari P, Bozzarelli S, Carrara S, Luberto A, Zerbi A
Pancreatology 2022 Sep;22(6):782-788. Epub 2022 Jun 3 doi: 10.1016/j.pan.2022.05.006. PMID: 35701318

Diagnosis

Radiological and clinical features of large consolidative-type pulmonary invasive mucinous adenocarcinoma.
Chen J, Qi L, Wang J, Xue L, Xue Q, Jia J, Zhang G, Liu J, Li F, Cui S
Clin Respir J 2024 Mar;18(3):e13743. doi: 10.1111/crj.13743. PMID: 38529681Free PMC Article
Mucous Gland Adenoma of the Lung: A Neoplastic Counterpart of Mucinous Bronchial Glands.
Sasaki E, Masago K, Kogure Y, Fujita S, Iwakoshi A, Kuroda H, Tsuzuki T, Tsuta K, Matsushita H, Oki M
Mod Pathol 2023 Jun;36(6):100182. Epub 2023 Apr 5 doi: 10.1016/j.modpat.2023.100182. PMID: 37028599
Adenocarcinoma classification: patterns and prognosis.
Kuhn E, Morbini P, Cancellieri A, Damiani S, Cavazza A, Comin CE
Pathologica 2018 Mar;110(1):5-11. PMID: 30259909
The IASLC Lung Cancer Staging Project: Proposals for Coding T Categories for Subsolid Nodules and Assessment of Tumor Size in Part-Solid Tumors in the Forthcoming Eighth Edition of the TNM Classification of Lung Cancer.
Travis WD, Asamura H, Bankier AA, Beasley MB, Detterbeck F, Flieder DB, Goo JM, MacMahon H, Naidich D, Nicholson AG, Powell CA, Prokop M, Rami-Porta R, Rusch V, van Schil P, Yatabe Y; International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee and Advisory Board Members
J Thorac Oncol 2016 Aug;11(8):1204-1223. Epub 2016 Apr 21 doi: 10.1016/j.jtho.2016.03.025. PMID: 27107787
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

Therapy

International Association for the Study of Lung Cancer Study of Reproducibility in Assessment of Pathologic Response in Resected Lung Cancers After Neoadjuvant Therapy.
Dacic S, Travis W, Redman M, Saqi A, Cooper WA, Borczuk A, Chung JH, Glass C, Lopez JM, Roden AC, Sholl L, Weissferdt A, Posadas J, Walker A, Zhu H, Wijeratne MT, Connolly C, Wynes M, Bota-Rabassedas N, Sanchez-Espiridion B, Lee JJ, Berezowska S, Chou TY, Kerr K, Nicholson A, Poleri C, Schalper KA, Tsao MS, Carbone DP, Ready N, Cascone T, Heymach J, Sepesi B, Shu C, Rizvi N, Sonett J, Altorki N, Provencio M, Bunn PA Jr, Kris MG, Belani CP, Kelly K, Wistuba I; IASLC Pathology Committee
J Thorac Oncol 2023 Oct;18(10):1290-1302. Epub 2023 Sep 12 doi: 10.1016/j.jtho.2023.07.017. PMID: 37702631
Identification of a novel RSRC1-ALK (R6: A20) fusion using next-generation sequencing technique.
Xia J, Chen S, Zhang Z, Wang J
Cancer Genet 2023 Nov;278-279:18-23. Epub 2023 Aug 9 doi: 10.1016/j.cancergen.2023.08.003. PMID: 37572583
Comparison of the immunotherapy efficacy between invasive mucinous and non-mucinous adenocarcinoma in advanced lung cancer patients with KRAS mutation: a retrospective study.
Xu M, Hao Y, Zhou H, Shi Z, Si J, Song Z
Med Oncol 2023 Jun 9;40(7):198. doi: 10.1007/s12032-023-02059-w. PMID: 37294384
Clinical features, treatment, and prognosis of different histological types of primary small bowel adenocarcinoma: A propensity score matching analysis based on the SEER database.
Zhou YW, Xia RL, Chen YY, Ma XL, Liu JY
Eur J Surg Oncol 2021 Aug;47(8):2108-2118. Epub 2021 Apr 2 doi: 10.1016/j.ejso.2021.03.260. PMID: 33849741
NRG1 fusion-driven tumors: biology, detection, and the therapeutic role of afatinib and other ErbB-targeting agents.
Laskin J, Liu SV, Tolba K, Heining C, Schlenk RF, Cheema P, Cadranel J, Jones MR, Drilon A, Cseh A, Gyorffy S, Solca F, Duruisseaux M
Ann Oncol 2020 Dec;31(12):1693-1703. Epub 2020 Sep 9 doi: 10.1016/j.annonc.2020.08.2335. PMID: 32916265Free PMC Article

Prognosis

Radiological and clinical features of large consolidative-type pulmonary invasive mucinous adenocarcinoma.
Chen J, Qi L, Wang J, Xue L, Xue Q, Jia J, Zhang G, Liu J, Li F, Cui S
Clin Respir J 2024 Mar;18(3):e13743. doi: 10.1111/crj.13743. PMID: 38529681Free PMC Article
Diffuse expression of MUC6 defines a distinct clinicopathological subset of pulmonary invasive mucinous adenocarcinoma.
Kishikawa S, Hayashi T, Saito T, Takamochi K, Kohsaka S, Sano K, Sasahara N, Sasa K, Kurihara T, Hara K, Suehara Y, Takahashi F, Suzuki K, Yao T
Mod Pathol 2021 Apr;34(4):786-797. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00690-w. PMID: 33024306
Adenocarcinoma classification: patterns and prognosis.
Kuhn E, Morbini P, Cancellieri A, Damiani S, Cavazza A, Comin CE
Pathologica 2018 Mar;110(1):5-11. PMID: 30259909
The IASLC Lung Cancer Staging Project: Proposals for Coding T Categories for Subsolid Nodules and Assessment of Tumor Size in Part-Solid Tumors in the Forthcoming Eighth Edition of the TNM Classification of Lung Cancer.
Travis WD, Asamura H, Bankier AA, Beasley MB, Detterbeck F, Flieder DB, Goo JM, MacMahon H, Naidich D, Nicholson AG, Powell CA, Prokop M, Rami-Porta R, Rusch V, van Schil P, Yatabe Y; International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee and Advisory Board Members
J Thorac Oncol 2016 Aug;11(8):1204-1223. Epub 2016 Apr 21 doi: 10.1016/j.jtho.2016.03.025. PMID: 27107787
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

Clinical prediction guides

Radiological and clinical features of large consolidative-type pulmonary invasive mucinous adenocarcinoma.
Chen J, Qi L, Wang J, Xue L, Xue Q, Jia J, Zhang G, Liu J, Li F, Cui S
Clin Respir J 2024 Mar;18(3):e13743. doi: 10.1111/crj.13743. PMID: 38529681Free PMC Article
International Association for the Study of Lung Cancer Study of Reproducibility in Assessment of Pathologic Response in Resected Lung Cancers After Neoadjuvant Therapy.
Dacic S, Travis W, Redman M, Saqi A, Cooper WA, Borczuk A, Chung JH, Glass C, Lopez JM, Roden AC, Sholl L, Weissferdt A, Posadas J, Walker A, Zhu H, Wijeratne MT, Connolly C, Wynes M, Bota-Rabassedas N, Sanchez-Espiridion B, Lee JJ, Berezowska S, Chou TY, Kerr K, Nicholson A, Poleri C, Schalper KA, Tsao MS, Carbone DP, Ready N, Cascone T, Heymach J, Sepesi B, Shu C, Rizvi N, Sonett J, Altorki N, Provencio M, Bunn PA Jr, Kris MG, Belani CP, Kelly K, Wistuba I; IASLC Pathology Committee
J Thorac Oncol 2023 Oct;18(10):1290-1302. Epub 2023 Sep 12 doi: 10.1016/j.jtho.2023.07.017. PMID: 37702631
Invasive IPMN relapse later and more often in lungs in comparison to pancreatic ductal adenocarcinoma.
Capretti G, Nebbia M, Gavazzi F, Nappo G, Ridolfi C, Sollai M, Spaggiari P, Bozzarelli S, Carrara S, Luberto A, Zerbi A
Pancreatology 2022 Sep;22(6):782-788. Epub 2022 Jun 3 doi: 10.1016/j.pan.2022.05.006. PMID: 35701318
The IASLC Lung Cancer Staging Project: Proposals for Coding T Categories for Subsolid Nodules and Assessment of Tumor Size in Part-Solid Tumors in the Forthcoming Eighth Edition of the TNM Classification of Lung Cancer.
Travis WD, Asamura H, Bankier AA, Beasley MB, Detterbeck F, Flieder DB, Goo JM, MacMahon H, Naidich D, Nicholson AG, Powell CA, Prokop M, Rami-Porta R, Rusch V, van Schil P, Yatabe Y; International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee and Advisory Board Members
J Thorac Oncol 2016 Aug;11(8):1204-1223. Epub 2016 Apr 21 doi: 10.1016/j.jtho.2016.03.025. PMID: 27107787
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

Recent systematic reviews

Prognostic factors for invasive mucinous adenocarcinoma of the lung: systematic review and meta-analysis.
Zhao T, Yi J, Luo D, Liu J, Fan X, Wu Q, Wang W
World J Surg Oncol 2024 Feb 2;22(1):41. doi: 10.1186/s12957-024-03326-4. PMID: 38303008Free PMC Article
Association between the novel classification of lung adenocarcinoma subtypes and EGFR/KRAS mutation status: A systematic literature review and pooled-data analysis.
Jiang L, Mino-Kenudson M, Roden AC, Rosell R, Molina MÁ, Flores RM, Pilz LR, Brunelli A, Venuta F, He J; AME Lung Cancer Collaborative Group
Eur J Surg Oncol 2019 May;45(5):870-876. Epub 2019 Feb 16 doi: 10.1016/j.ejso.2019.02.006. PMID: 30833014
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

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