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Yellow nodule

MedGen UID:
1628196
•Concept ID:
C2153623
•
Finding
HPO: HP:0025554

Definition

A type of skin nodule (a lesions that is greater than either 10mm in both width and depth, and most frequently centered in the dermis or subcutaneous fat) with a yellowish coloration (that reflects a high lipid content of the lesion). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVYellow nodule

Professional guidelines

PubMed

A Multicenter Cross-Sectional Study and Systematic Review of Necrobiotic Xanthogranuloma With Proposed Diagnostic Criteria.
Nelson CA, Zhong CS, Hashemi DA, Ashchyan HJ, Brown-Joel Z, Noe MH, Imadojemu S, Micheletti RG, Vleugels RA, Wanat KA, Rosenbach M, Mostaghimi A
JAMA Dermatol 2020 Mar 1;156(3):270-279. doi: 10.1001/jamadermatol.2019.4221. PMID: 31940000Free PMC Article
Childhood Solitary Cutaneous Mastocytoma: Clinical Manifestations, Diagnosis, Evaluation, and Management.
Leung AKC, Lam JM, Leong KF
Curr Pediatr Rev 2019;15(1):42-46. doi: 10.2174/1573396315666181120163952. PMID: 30465511Free PMC Article
Computer-Aided Nodule Assessment and Risk Yield (CANARY) may facilitate non-invasive prediction of EGFR mutation status in lung adenocarcinomas.
Clay R, Kipp BR, Jenkins S, Karwoski RA, Maldonado F, Rajagopalan S, Voss JS, Bartholmai BJ, Aubry MC, Peikert T
Sci Rep 2017 Dec 15;7(1):17620. doi: 10.1038/s41598-017-17659-6. PMID: 29247171Free PMC Article

Recent clinical studies

Etiology

The Many Faces of Endometriosis-Related Neoplasms in the Same Patient: A Brief Report.
Santoro A, Angelico G, Inzani F, Spadola S, Arciuolo D, Valente M, Fiorentino V, Mulè A, Scambia G, Zannoni GF
Gynecol Obstet Invest 2020;85(4):371-376. Epub 2020 Jun 22 doi: 10.1159/000508225. PMID: 32570258
Clinical features of intratarsal keratinous cysts.
Kim JA, Kim N, Choung HK, Lee MJ, Lee C, Khwarg SI
Eye (Lond) 2016 Jan;30(1):59-63. Epub 2015 Oct 2 doi: 10.1038/eye.2015.184. PMID: 26427989Free PMC Article
Arthroscopic management of intra-articular pigmented villonodular synovitis of temporomandibular joint.
Cai XY, Yang C, Chen MJ, Jiang B, Yun B, Fang B
Int J Oral Maxillofac Surg 2011 Feb;40(2):150-4. Epub 2010 Oct 18 doi: 10.1016/j.ijom.2010.09.010. PMID: 20961736

Diagnosis

Yellow Nodule on the Scalp.
Martin TM, Tapia-Centola B, Loo DS
Cutis 2022 Nov;110(5):E18-E19. doi: 10.12788/cutis.0671. PMID: 36638375
The Many Faces of Endometriosis-Related Neoplasms in the Same Patient: A Brief Report.
Santoro A, Angelico G, Inzani F, Spadola S, Arciuolo D, Valente M, Fiorentino V, Mulè A, Scambia G, Zannoni GF
Gynecol Obstet Invest 2020;85(4):371-376. Epub 2020 Jun 22 doi: 10.1159/000508225. PMID: 32570258
Sebaceous carcinoma: review of the literature.
Kyllo RL, Brady KL, Hurst EA
Dermatol Surg 2015 Jan;41(1):1-15. doi: 10.1097/DSS.0000000000000152. PMID: 25521100
Arthroscopic management of intra-articular pigmented villonodular synovitis of temporomandibular joint.
Cai XY, Yang C, Chen MJ, Jiang B, Yun B, Fang B
Int J Oral Maxillofac Surg 2011 Feb;40(2):150-4. Epub 2010 Oct 18 doi: 10.1016/j.ijom.2010.09.010. PMID: 20961736
Peripheral odontogenic keratocyst.
Preston RD, Narayana N
J Periodontol 2005 Dec;76(12):2312-5. doi: 10.1902/jop.2005.76.12.2312. PMID: 16332245

Therapy

Sebaceous carcinoma: review of the literature.
Kyllo RL, Brady KL, Hurst EA
Dermatol Surg 2015 Jan;41(1):1-15. doi: 10.1097/DSS.0000000000000152. PMID: 25521100
Yellow nodule in vestibule.
Pullon PA, Miller AS
Gen Dent 1981 Sep-Oct;29(5):396, 399. PMID: 6955234

Prognosis

Aggressively progressing primary undifferentiated pleomorphic sarcoma in the eyelid: A case report and review of the literature.
Choi W, Hwang JH, Kim GE, Yoon KC
Medicine (Baltimore) 2017 May;96(18):e6616. doi: 10.1097/MD.0000000000006616. PMID: 28471957Free PMC Article
Sebaceous carcinoma: review of the literature.
Kyllo RL, Brady KL, Hurst EA
Dermatol Surg 2015 Jan;41(1):1-15. doi: 10.1097/DSS.0000000000000152. PMID: 25521100
Arthroscopic management of intra-articular pigmented villonodular synovitis of temporomandibular joint.
Cai XY, Yang C, Chen MJ, Jiang B, Yun B, Fang B
Int J Oral Maxillofac Surg 2011 Feb;40(2):150-4. Epub 2010 Oct 18 doi: 10.1016/j.ijom.2010.09.010. PMID: 20961736
Peripheral odontogenic keratocyst.
Preston RD, Narayana N
J Periodontol 2005 Dec;76(12):2312-5. doi: 10.1902/jop.2005.76.12.2312. PMID: 16332245
Lipoma of the adrenal gland.
Büttner A
Pathol Int 1999 Nov;49(11):1007-9. doi: 10.1046/j.1440-1827.1999.00966.x. PMID: 10594848

Clinical prediction guides

Aggressively progressing primary undifferentiated pleomorphic sarcoma in the eyelid: A case report and review of the literature.
Choi W, Hwang JH, Kim GE, Yoon KC
Medicine (Baltimore) 2017 May;96(18):e6616. doi: 10.1097/MD.0000000000006616. PMID: 28471957Free PMC Article
Report of rare case of dermatofibrosarcoma protuberans in the buccal mucosa: review of diagnostic, histopathological and immunohistochemical criteria.
Katarinny Goes Gonzaga A, Lopes Cordeiro Mandú A, Oliveira Sales A, Miryam Costa Medeiros A, Rodrigues Rodrigues R, Teixeira Oliveira P, Rocha Germano A, Janine Dantas Silveira É
Dermatol Online J 2016 Oct 15;22(10) PMID: 28329585
Ectopic intrathyroidal thymus accompanied by intrathyroidal parathyroid as a cause of a solitary thyroid nodule in adult.
Kim A, Kang SH, Bae YK
Int J Clin Exp Pathol 2014;7(9):6375-8. Epub 2014 Aug 15 PMID: 25337294Free PMC Article

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