U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Harrod syndrome

MedGen UID:
162895
•Concept ID:
C0795970
•
Disease or Syndrome
Synonyms: Craniofacial digital genital anomalies; Harrod Doman Keele syndrome
SNOMED CT: Cranio-facio-digito-genital syndrome (716089008); Harrod syndrome (716089008); Craniofacial digital and genital anomalies syndrome (716089008)
 
Monarch Initiative: MONDO:0010993
OMIM®: 601095
Orphanet: ORPHA2115

Definition

The association of intellectual deficit, facial dysmorphism (a highly arched palate, pointed chin, and small mouth, hypotelorism, a long nose and large protruding ears), arachnodactyly, hypogenitalism (undescended testes and hypospadias) and failure to thrive. So far, it has been described in three males (including two brothers). An autosomal recessive mode of transmission has been suggested. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHarrod syndrome
Follow this link to review classifications for Harrod syndrome in Orphanet.

Professional guidelines

PubMed

Use of Actigraphy for the Evaluation of Sleep Disorders and Circadian Rhythm Sleep-Wake Disorders: An American Academy of Sleep Medicine Clinical Practice Guideline.
Smith MT, McCrae CS, Cheung J, Martin JL, Harrod CG, Heald JL, Carden KA
J Clin Sleep Med 2018 Jul 15;14(7):1231-1237. doi: 10.5664/jcsm.7230. PMID: 29991437Free PMC Article
Anatomic correlates of ultrasonographic prenatal diagnosis.
Rutledge JC, Weinberg AG, Friedman JM, Harrod MJ, Santos-Ramos R
Prenat Diagn 1986 Jan-Feb;6(1):51-61. doi: 10.1002/pd.1970060108. PMID: 3513152
Genetic counseling for Usher's syndrome patients and their families.
Harrod MJ
Am Ann Deaf 1978 May;123(3):377-80, 419. PMID: 665464

Recent clinical studies

Etiology

Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial.
RECOVERY Collaborative Group
Lancet Child Adolesc Health 2024 Mar;8(3):190-200. Epub 2024 Jan 22 doi: 10.1016/S2352-4642(23)00316-4. PMID: 38272046
Circulating SARS-CoV-2+ megakaryocytes are associated with severe viral infection in COVID-19.
Fortmann SD, Patton MJ, Frey BF, Tipper JL, Reddy SB, Vieira CP, Hanumanthu VS, Sterrett S, Floyd JL, Prasad R, Zucker JD, Crouse AB, Huls F, Chkheidze R, Li P, Erdmann NB, Harrod KS, Gaggar A, Goepfert PA, Grant MB, Might M
Blood Adv 2023 Aug 8;7(15):4200-4214. doi: 10.1182/bloodadvances.2022009022. PMID: 36920790Free PMC Article
Characterization of the Clinical Evidence Supporting Repository Corticotropin Injection for FDA-Approved Indications: A Scoping Review.
Tran KA, Harrod C, Bourdette DN, Cohen DM, Deodhar AA, Hartung DM
JAMA Intern Med 2022 Feb 1;182(2):206-217. doi: 10.1001/jamainternmed.2021.7171. PMID: 34902005
Quality measures for the care of adult patients with restless legs syndrome.
Trotti LM, Goldstein CA, Harrod CG, Koo BB, Sharon D, Zak R, Chervin RD
J Clin Sleep Med 2015 Mar 15;11(3):293-310. doi: 10.5664/jcsm.4550. PMID: 25700882Free PMC Article
Integrative "omic" analysis of experimental bacteremia identifies a metabolic signature that distinguishes human sepsis from systemic inflammatory response syndromes.
Langley RJ, Tipper JL, Bruse S, Baron RM, Tsalik EL, Huntley J, Rogers AJ, Jaramillo RJ, O'Donnell D, Mega WM, Keaton M, Kensicki E, Gazourian L, Fredenburgh LE, Massaro AF, Otero RM, Fowler VG Jr, Rivers EP, Woods CW, Kingsmore SF, Sopori ML, Perrella MA, Choi AM, Harrod KS
Am J Respir Crit Care Med 2014 Aug 15;190(4):445-55. doi: 10.1164/rccm.201404-0624OC. PMID: 25054455Free PMC Article

Diagnosis

Use of Actigraphy for the Evaluation of Sleep Disorders and Circadian Rhythm Sleep-Wake Disorders: An American Academy of Sleep Medicine Clinical Practice Guideline.
Smith MT, McCrae CS, Cheung J, Martin JL, Harrod CG, Heald JL, Carden KA
J Clin Sleep Med 2018 Jul 15;14(7):1231-1237. doi: 10.5664/jcsm.7230. PMID: 29991437Free PMC Article
Renal systems biology of patients with systemic inflammatory response syndrome.
Tsalik EL, Willig LK, Rice BJ, van Velkinburgh JC, Mohney RP, McDunn JE, Dinwiddie DL, Miller NA, Mayer ES, Glickman SW, Jaehne AK, Glew RH, Sopori ML, Otero RM, Harrod KS, Cairns CB, Fowler VG, Rivers EP, Woods CW, Kingsmore SF, Langley RJ
Kidney Int 2015 Oct;88(4):804-14. Epub 2015 May 20 doi: 10.1038/ki.2015.150. PMID: 25993322Free PMC Article
Integrative "omic" analysis of experimental bacteremia identifies a metabolic signature that distinguishes human sepsis from systemic inflammatory response syndromes.
Langley RJ, Tipper JL, Bruse S, Baron RM, Tsalik EL, Huntley J, Rogers AJ, Jaramillo RJ, O'Donnell D, Mega WM, Keaton M, Kensicki E, Gazourian L, Fredenburgh LE, Massaro AF, Otero RM, Fowler VG Jr, Rivers EP, Woods CW, Kingsmore SF, Sopori ML, Perrella MA, Choi AM, Harrod KS
Am J Respir Crit Care Med 2014 Aug 15;190(4):445-55. doi: 10.1164/rccm.201404-0624OC. PMID: 25054455Free PMC Article
Further delineation of Weaver syndrome.
Ardinger HH, Hanson JW, Harrod MJ, Cohen MM Jr, Tibbles JA, Welch JP, Young-Wee T, Sommer A, Goldberg R, Shprintzen RJ
J Pediatr 1986 Feb;108(2):228-35. doi: 10.1016/s0022-3476(86)80988-x. PMID: 2418189
Congenital absence of the vagina. The Mayer-Rokitansky-Kuster-Hauser syndrome.
Griffin JE, Edwards C, Madden JD, Harrod MJ, Wilson JD
Ann Intern Med 1976 Aug;85(2):224-36. doi: 10.7326/0003-4819-85-2-224. PMID: 782313

Therapy

Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial.
RECOVERY Collaborative Group
Lancet Child Adolesc Health 2024 Mar;8(3):190-200. Epub 2024 Jan 22 doi: 10.1016/S2352-4642(23)00316-4. PMID: 38272046
Interferon-dependent signaling is critical for viral clearance in airway neutrophils.
Margaroli C, Fram T, Sharma NS, Patel SB, Tipper J, Robison SW, Russell DW, Fortmann SD, Banday MM, Soto-Vazquez Y, Abdalla T, Saitornuang S, Madison MC, Leal SM Jr, Harrod KS, Erdmann NB, Gaggar A
JCI Insight 2023 May 22;8(10) doi: 10.1172/jci.insight.167042. PMID: 37071484Free PMC Article
Characterization of the Clinical Evidence Supporting Repository Corticotropin Injection for FDA-Approved Indications: A Scoping Review.
Tran KA, Harrod C, Bourdette DN, Cohen DM, Deodhar AA, Hartung DM
JAMA Intern Med 2022 Feb 1;182(2):206-217. doi: 10.1001/jamainternmed.2021.7171. PMID: 34902005
Patients' Adaptations After Acute Respiratory Distress Syndrome: A Qualitative Study.
Hauschildt KE, Seigworth C, Kamphuis LA, Hough CL, Moss M, McPeake JM, Harrod M, Iwashyna TJ
Am J Crit Care 2021 May 1;30(3):221-229. doi: 10.4037/ajcc2021825. PMID: 34161982Free PMC Article
Verification of the fetal valproate syndrome phenotype.
Ardinger HH, Atkin JF, Blackston RD, Elsas LJ, Clarren SK, Livingstone S, Flannery DB, Pellock JM, Harrod MJ, Lammer EJ
Am J Med Genet 1988 Jan;29(1):171-85. doi: 10.1002/ajmg.1320290123. PMID: 3125743

Prognosis

Duplication 12q mosaicism in two unrelated patients with a similar syndrome.
Harrod MJ, Byrne JB, Dev VG, Francke U
Am J Med Genet 1980;7(2):123-9. doi: 10.1002/ajmg.1320070206. PMID: 7468644
A cutaneous marker in the Hunter syndrome a report of four cases.
Prystowsky SD, Maumenee IH, Freeman RG, Herndon JH Jr, Harrod MJ
Arch Dermatol 1977 May;113(5):602-5. PMID: 404968
Long-term follow-up of severe respiratory distress syndrome treated with IPPB.
Harrod JR, L'Heureux P, Wangensteen OD, Hunt CE
J Pediatr 1974 Feb;84(2):277-85. doi: 10.1016/s0022-3476(74)80623-2. PMID: 4589845

Clinical prediction guides

Congenital cataracts in mother, sister, and son of a patient with Hallermann-Streiff syndrome: coincidence or clue?
Harrod MJ, Friedman JM
Am J Med Genet 1991 Dec 15;41(4):500-2. doi: 10.1002/ajmg.1320410424. PMID: 1776644
Polycystic kidney disease in a patient with the oral-facial-digital syndrome - type I.
Harrod MJ, Stokes J, Peede LF, Goldstein JL
Clin Genet 1976 Feb;9(2):183-6. doi: 10.1111/j.1399-0004.1976.tb01565.x. PMID: 1248177

Recent systematic reviews

Use of Actigraphy for the Evaluation of Sleep Disorders and Circadian Rhythm Sleep-Wake Disorders: An American Academy of Sleep Medicine Systematic Review, Meta-Analysis, and GRADE Assessment.
Smith MT, McCrae CS, Cheung J, Martin JL, Harrod CG, Heald JL, Carden KA
J Clin Sleep Med 2018 Jul 15;14(7):1209-1230. doi: 10.5664/jcsm.7228. PMID: 29991438Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...