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Peripheral primitive neuroectodermal tumor of bone

MedGen UID:
163179
•Concept ID:
C0855009
•
Neoplastic Process
Synonyms: Bone Peripheral Neuroepithelioma; bone peripheral neuroepithelioma; bone tissue peripheral primitive neuroectodermal tumor; bone tissue peripheral primitive neuroectodermal tumour; Osseous Peripheral Neuroepithelioma; osseous peripheral neuroepithelioma; Peripheral Neuroectodermal Tumor of Bone; peripheral neuroectodermal tumor of bone; Peripheral Neuroectodermal Tumor of the Bone; peripheral neuroectodermal tumor of the bone; peripheral neuroectodermal tumour of bone; peripheral neuroectodermal tumour of the bone; Peripheral Neuroepithelioma of Bone; peripheral neuroepithelioma of bone; Peripheral Neuroepithelioma of the Bone; peripheral neuroepithelioma of the bone; Peripheral Primitive Neuroectodermal Tumor of Bone; peripheral primitive neuroectodermal tumor of bone; peripheral primitive neuroectodermal tumor of bone tissue; peripheral primitive neuroectodermal tumour of bone tissue
 
Monarch Initiative: MONDO:0002981

Definition

A small round cell tumor with neural differentiation arising from the bone. It may be associated with pain. [from NCI]

Professional guidelines

PubMed

Revisions to the International Neuroblastoma Response Criteria: A Consensus Statement From the National Cancer Institute Clinical Trials Planning Meeting.
Park JR, Bagatell R, Cohn SL, Pearson AD, Villablanca JG, Berthold F, Burchill S, Boubaker A, McHugh K, Nuchtern JG, London WB, Seibel NL, Lindwasser OW, Maris JM, Brock P, Schleiermacher G, Ladenstein R, Matthay KK, Valteau-Couanet D
J Clin Oncol 2017 Aug 1;35(22):2580-2587. Epub 2017 May 4 doi: 10.1200/JCO.2016.72.0177. PMID: 28471719Free PMC Article
Management of Neuroblastoma: ICMR Consensus Document.
Bansal D, Totadri S, Chinnaswamy G, Agarwala S, Vora T, Arora B, Prasad M, Kapoor G, Radhakrishnan V, Laskar S, Kaur T, Rath GK, Bakhshi S
Indian J Pediatr 2017 Jun;84(6):446-455. Epub 2017 Apr 3 doi: 10.1007/s12098-017-2298-0. PMID: 28367616
Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment.
Brodeur GM, Pritchard J, Berthold F, Carlsen NL, Castel V, Castelberry RP, De Bernardi B, Evans AE, Favrot M, Hedborg F
J Clin Oncol 1993 Aug;11(8):1466-77. doi: 10.1200/JCO.1993.11.8.1466. PMID: 8336186

Recent clinical studies

Etiology

Considerations for the Use of SH-SY5Y Neuroblastoma Cells in Neurobiology.
Kovalevich J, Santerre M, Langford D
Methods Mol Biol 2021;2311:9-23. doi: 10.1007/978-1-0716-1437-2_2. PMID: 34033074
Revisions to the International Neuroblastoma Response Criteria: A Consensus Statement From the National Cancer Institute Clinical Trials Planning Meeting.
Park JR, Bagatell R, Cohn SL, Pearson AD, Villablanca JG, Berthold F, Burchill S, Boubaker A, McHugh K, Nuchtern JG, London WB, Seibel NL, Lindwasser OW, Maris JM, Brock P, Schleiermacher G, Ladenstein R, Matthay KK, Valteau-Couanet D
J Clin Oncol 2017 Aug 1;35(22):2580-2587. Epub 2017 May 4 doi: 10.1200/JCO.2016.72.0177. PMID: 28471719Free PMC Article
The International Neuroblastoma Risk Group (INRG) staging system: an INRG Task Force report.
Monclair T, Brodeur GM, Ambros PF, Brisse HJ, Cecchetto G, Holmes K, Kaneko M, London WB, Matthay KK, Nuchtern JG, von Schweinitz D, Simon T, Cohn SL, Pearson AD; INRG Task Force
J Clin Oncol 2009 Jan 10;27(2):298-303. Epub 2008 Dec 1 doi: 10.1200/JCO.2008.16.6876. PMID: 19047290Free PMC Article
Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation.
Lonergan GJ, Schwab CM, Suarez ES, Carlson CL
Radiographics 2002 Jul-Aug;22(4):911-34. doi: 10.1148/radiographics.22.4.g02jl15911. PMID: 12110723
Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment.
Brodeur GM, Pritchard J, Berthold F, Carlsen NL, Castel V, Castelberry RP, De Bernardi B, Evans AE, Favrot M, Hedborg F
J Clin Oncol 1993 Aug;11(8):1466-77. doi: 10.1200/JCO.1993.11.8.1466. PMID: 8336186

Diagnosis

Neuroblastoma (Peripheral neuroblastic tumours).
Luksch R, Castellani MR, Collini P, De Bernardi B, Conte M, Gambini C, Gandola L, Garaventa A, Biasoni D, Podda M, Sementa AR, Gatta G, Tonini GP
Crit Rev Oncol Hematol 2016 Nov;107:163-181. Epub 2016 Oct 6 doi: 10.1016/j.critrevonc.2016.10.001. PMID: 27823645
Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Kidney: A Rare and Lethal Entity.
Celli R, Cai G
Arch Pathol Lab Med 2016 Mar;140(3):281-5. doi: 10.5858/arpa.2014-0367-RS. PMID: 26927724
Pediatrics: diagnosis of neuroblastoma.
Sharp SE, Gelfand MJ, Shulkin BL
Semin Nucl Med 2011 Sep;41(5):345-53. doi: 10.1053/j.semnuclmed.2011.05.001. PMID: 21803184
Neuroblastoma.
Humpl T
World J Urol 1995;13(4):233-9. doi: 10.1007/BF00182969. PMID: 8528298
Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment.
Brodeur GM, Pritchard J, Berthold F, Carlsen NL, Castel V, Castelberry RP, De Bernardi B, Evans AE, Favrot M, Hedborg F
J Clin Oncol 1993 Aug;11(8):1466-77. doi: 10.1200/JCO.1993.11.8.1466. PMID: 8336186

Therapy

Anti-GD2 CAR-NKT cells in patients with relapsed or refractory neuroblastoma: an interim analysis.
Heczey A, Courtney AN, Montalbano A, Robinson S, Liu K, Li M, Ghatwai N, Dakhova O, Liu B, Raveh-Sadka T, Chauvin-Fleurence CN, Xu X, Ngai H, Di Pierro EJ, Savoldo B, Dotti G, Metelitsa LS
Nat Med 2020 Nov;26(11):1686-1690. Epub 2020 Oct 12 doi: 10.1038/s41591-020-1074-2. PMID: 33046868
Effect of Tandem Autologous Stem Cell Transplant vs Single Transplant on Event-Free Survival in Patients With High-Risk Neuroblastoma: A Randomized Clinical Trial.
Park JR, Kreissman SG, London WB, Naranjo A, Cohn SL, Hogarty MD, Tenney SC, Haas-Kogan D, Shaw PJ, Kraveka JM, Roberts SS, Geiger JD, Doski JJ, Voss SD, Maris JM, Grupp SA, Diller L
JAMA 2019 Aug 27;322(8):746-755. doi: 10.1001/jama.2019.11642. PMID: 31454045Free PMC Article
Patient-derived xenografts as preclinical neuroblastoma models.
Braekeveldt N, Bexell D
Cell Tissue Res 2018 May;372(2):233-243. Epub 2017 Sep 19 doi: 10.1007/s00441-017-2687-8. PMID: 28924803Free PMC Article
Revisions to the International Neuroblastoma Response Criteria: A Consensus Statement From the National Cancer Institute Clinical Trials Planning Meeting.
Park JR, Bagatell R, Cohn SL, Pearson AD, Villablanca JG, Berthold F, Burchill S, Boubaker A, McHugh K, Nuchtern JG, London WB, Seibel NL, Lindwasser OW, Maris JM, Brock P, Schleiermacher G, Ladenstein R, Matthay KK, Valteau-Couanet D
J Clin Oncol 2017 Aug 1;35(22):2580-2587. Epub 2017 May 4 doi: 10.1200/JCO.2016.72.0177. PMID: 28471719Free PMC Article
Post-laminectomy kyphosis.
Lonstein JE
Clin Orthop Relat Res 1977 Oct;(128):93-100. PMID: 598179

Prognosis

Neuroblastoma (Peripheral neuroblastic tumours).
Luksch R, Castellani MR, Collini P, De Bernardi B, Conte M, Gambini C, Gandola L, Garaventa A, Biasoni D, Podda M, Sementa AR, Gatta G, Tonini GP
Crit Rev Oncol Hematol 2016 Nov;107:163-181. Epub 2016 Oct 6 doi: 10.1016/j.critrevonc.2016.10.001. PMID: 27823645
The International Neuroblastoma Risk Group (INRG) staging system: an INRG Task Force report.
Monclair T, Brodeur GM, Ambros PF, Brisse HJ, Cecchetto G, Holmes K, Kaneko M, London WB, Matthay KK, Nuchtern JG, von Schweinitz D, Simon T, Cohn SL, Pearson AD; INRG Task Force
J Clin Oncol 2009 Jan 10;27(2):298-303. Epub 2008 Dec 1 doi: 10.1200/JCO.2008.16.6876. PMID: 19047290Free PMC Article
Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation.
Lonergan GJ, Schwab CM, Suarez ES, Carlson CL
Radiographics 2002 Jul-Aug;22(4):911-34. doi: 10.1148/radiographics.22.4.g02jl15911. PMID: 12110723
Neuroblastoma.
Humpl T
World J Urol 1995;13(4):233-9. doi: 10.1007/BF00182969. PMID: 8528298
Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment.
Brodeur GM, Pritchard J, Berthold F, Carlsen NL, Castel V, Castelberry RP, De Bernardi B, Evans AE, Favrot M, Hedborg F
J Clin Oncol 1993 Aug;11(8):1466-77. doi: 10.1200/JCO.1993.11.8.1466. PMID: 8336186

Clinical prediction guides

Single-cell analyses of metastatic bone marrow in human neuroblastoma reveals microenvironmental remodeling and metastatic signature.
Mei S, Alchahin AM, Embaie BT, Gavriliuc IM, Verhoeven BM, Zhao T, Li X, Jeffries NE, Pepich A, Sarkar H, Olsen TK, Wickström M, Stenman J, Reina-Bedoya O, Kharchenko PV, Saylor PJ, Johnsen JI, Sykes DB, Kogner P, Baryawno N
JCI Insight 2024 Feb 15;9(6) doi: 10.1172/jci.insight.173337. PMID: 38358826Free PMC Article
Anti-GD2 CAR-NKT cells in patients with relapsed or refractory neuroblastoma: an interim analysis.
Heczey A, Courtney AN, Montalbano A, Robinson S, Liu K, Li M, Ghatwai N, Dakhova O, Liu B, Raveh-Sadka T, Chauvin-Fleurence CN, Xu X, Ngai H, Di Pierro EJ, Savoldo B, Dotti G, Metelitsa LS
Nat Med 2020 Nov;26(11):1686-1690. Epub 2020 Oct 12 doi: 10.1038/s41591-020-1074-2. PMID: 33046868
Patient-derived xenografts as preclinical neuroblastoma models.
Braekeveldt N, Bexell D
Cell Tissue Res 2018 May;372(2):233-243. Epub 2017 Sep 19 doi: 10.1007/s00441-017-2687-8. PMID: 28924803Free PMC Article
Functional-metabolic imaging of neuroblastoma.
Sharp SE, Parisi MT, Gelfand MJ, Yanik GA, Shulkin BL
Q J Nucl Med Mol Imaging 2013 Mar;57(1):6-20. PMID: 23474631
Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment.
Brodeur GM, Pritchard J, Berthold F, Carlsen NL, Castel V, Castelberry RP, De Bernardi B, Evans AE, Favrot M, Hedborg F
J Clin Oncol 1993 Aug;11(8):1466-77. doi: 10.1200/JCO.1993.11.8.1466. PMID: 8336186

Recent systematic reviews

Diagnostic Performance of (18)F-FDG PET(CT) in Bone-Bone Marrow Involvement in Pediatric Neuroblastoma: A Systemic Review and Meta-Analysis.
Sun L, Zhang B, Peng R
Contrast Media Mol Imaging 2021;2021:8125373. Epub 2021 Jun 16 doi: 10.1155/2021/8125373. PMID: 34220381Free PMC Article
The Diagnostic Accuracy of PET(CT) in Patients With Neuroblastoma: A Meta-Analysis and Systematic Review.
Li HF, Mao HJ, Zhao L, Guo DL, Chen B, Yang JF
J Comput Assist Tomogr 2020 Jan/Feb;44(1):111-117. doi: 10.1097/RCT.0000000000000973. PMID: 31939891
Primary Intracranial pPNET/Ewing Sarcoma: Diagnosis, Management, and Prognostic Factors Dilemma-A Systematic Review of the Literature.
Cherif El Asri A, Benzagmout M, Chakour K, Chaoui MF, Laaguili J, Chahdi H, Gazzaz M, El Mostarchid B
World Neurosurg 2018 Jul;115:346-356. Epub 2018 May 3 doi: 10.1016/j.wneu.2018.04.164. PMID: 29729469
Iodine-131-meta-iodobenzylguanidine therapy for patients with newly diagnosed high-risk neuroblastoma.
Kraal KC, van Dalen EC, Tytgat GA, Van Eck-Smit BL
Cochrane Database Syst Rev 2017 Apr 21;4(4):CD010349. doi: 10.1002/14651858.CD010349.pub2. PMID: 28429876Free PMC Article
Endoscopic Endonasal Anterior Skull Base Surgery: A Systematic Review of Complications During the Past 65 Years.
Borg A, Kirkman MA, Choi D
World Neurosurg 2016 Nov;95:383-391. Epub 2016 Mar 4 doi: 10.1016/j.wneu.2015.12.105. PMID: 26960277

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