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Grade 2 Carbon Monoxide Diffusing Capacity Decreased, CTCAE

MedGen UID:
1632763
•Concept ID:
C4685555
•
Finding

Definition

6-8 units below LLN; for follow-up, an asymptomatic decrease of >5-8 units (ml/min/mm Hg) below the baseline value; symptomatic and intervention not indicated [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 2 Carbon Monoxide Diffusing Capacity Decreased, CTCAE

Recent clinical studies

Etiology

Abnormal pulmonary function tests predict the development of radiation-induced pneumonitis in advanced non-small cell lung Cancer.
Torre-Bouscoulet L, Muñoz-Montaño WR, Martínez-Briseño D, Lozano-Ruiz FJ, Fernández-Plata R, Beck-Magaña JA, García-Sancho C, Guzmán-Barragán A, Vergara E, Blake-Cerda M, Gochicoa-Rangel L, Maldonado F, Arroyo-Hernández M, Arrieta O
Respir Res 2018 Apr 24;19(1):72. doi: 10.1186/s12931-018-0775-2. PMID: 29690880Free PMC Article
Mature results of an individualized radiation dose prescription study based on normal tissue constraints in stages I to III non-small-cell lung cancer.
van Baardwijk A, Wanders S, Boersma L, Borger J, Ollers M, Dingemans AM, Bootsma G, Geraedts W, Pitz C, Lunde R, Lambin P, De Ruysscher D
J Clin Oncol 2010 Mar 10;28(8):1380-6. Epub 2010 Feb 8 doi: 10.1200/JCO.2009.24.7221. PMID: 20142596

Diagnosis

Abnormal pulmonary function tests predict the development of radiation-induced pneumonitis in advanced non-small cell lung Cancer.
Torre-Bouscoulet L, Muñoz-Montaño WR, Martínez-Briseño D, Lozano-Ruiz FJ, Fernández-Plata R, Beck-Magaña JA, García-Sancho C, Guzmán-Barragán A, Vergara E, Blake-Cerda M, Gochicoa-Rangel L, Maldonado F, Arroyo-Hernández M, Arrieta O
Respir Res 2018 Apr 24;19(1):72. doi: 10.1186/s12931-018-0775-2. PMID: 29690880Free PMC Article

Therapy

Mature results of an individualized radiation dose prescription study based on normal tissue constraints in stages I to III non-small-cell lung cancer.
van Baardwijk A, Wanders S, Boersma L, Borger J, Ollers M, Dingemans AM, Bootsma G, Geraedts W, Pitz C, Lunde R, Lambin P, De Ruysscher D
J Clin Oncol 2010 Mar 10;28(8):1380-6. Epub 2010 Feb 8 doi: 10.1200/JCO.2009.24.7221. PMID: 20142596

Prognosis

Abnormal pulmonary function tests predict the development of radiation-induced pneumonitis in advanced non-small cell lung Cancer.
Torre-Bouscoulet L, Muñoz-Montaño WR, Martínez-Briseño D, Lozano-Ruiz FJ, Fernández-Plata R, Beck-Magaña JA, García-Sancho C, Guzmán-Barragán A, Vergara E, Blake-Cerda M, Gochicoa-Rangel L, Maldonado F, Arroyo-Hernández M, Arrieta O
Respir Res 2018 Apr 24;19(1):72. doi: 10.1186/s12931-018-0775-2. PMID: 29690880Free PMC Article

Clinical prediction guides

Abnormal pulmonary function tests predict the development of radiation-induced pneumonitis in advanced non-small cell lung Cancer.
Torre-Bouscoulet L, Muñoz-Montaño WR, Martínez-Briseño D, Lozano-Ruiz FJ, Fernández-Plata R, Beck-Magaña JA, García-Sancho C, Guzmán-Barragán A, Vergara E, Blake-Cerda M, Gochicoa-Rangel L, Maldonado F, Arroyo-Hernández M, Arrieta O
Respir Res 2018 Apr 24;19(1):72. doi: 10.1186/s12931-018-0775-2. PMID: 29690880Free PMC Article

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