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Infusion Related Reaction, CTCAE

MedGen UID:
1633178
•Concept ID:
C4552999
•
Finding

Definition

A disorder characterized by adverse reaction to the infusion of pharmacological or biological substances. [from NCI]

Professional guidelines

PubMed

Plasmafiltration as an effective method in the removal of circulating pegylated liposomal doxorubicin (PLD) and the reduction of mucocutaneous toxicity during the treatment of advanced platinum-resistant ovarian cancer.
Kubeček O, Martínková J, Chládek J, Bláha M, Maláková J, Hodek M, Špaček J, Filip S
Cancer Chemother Pharmacol 2020 Feb;85(2):353-365. Epub 2019 Nov 14 doi: 10.1007/s00280-019-03976-2. PMID: 31728628
Standardizing assessment and reporting of adverse effects in rheumatology clinical trials II: the Rheumatology Common Toxicity Criteria v.2.0.
Woodworth T, Furst DE, Alten R, Bingham CO 3rd, Yocum D, Sloan V, Tsuji W, Stevens R, Fries J, Witter J, Johnson K, Lassere M, Brooks P
J Rheumatol 2007 Jun;34(6):1401-14. PMID: 17552067

Recent clinical studies

Etiology

Extent of extravasation: Patients on parenteral plant alkaloids.
Somayaji S, Reddy SS, Murthy MK, Maka VV
J Cancer Res Ther 2023 Jan 1;19(Suppl 2):S841-S844. Epub 2023 Dec 15 doi: 10.4103/jcrt.JCRT_457_19. PMID: 38384064
Adverse events caused by cord blood infusion in Japan during a 5-year period.
Hashimoto S, Kato K, Kai S, Sekimoto T, Minemoto M, Ishii H, Mori T, Azuma F, Ishimaru F, Kimura T, Miyata S, Satake M, Takanashi M
Vox Sang 2023 Jan;118(1):84-92. Epub 2022 Dec 1 doi: 10.1111/vox.13379. PMID: 36454585
Risk factors for and prognosis of carboplatin-related hypersensitivity in patients with epithelial ovarian cancer.
Hwang WY, Lee M, Suh DH, Kim K, No JH, Kim YB, Kim JH
Arch Gynecol Obstet 2022 Aug;306(2):443-449. Epub 2022 Jan 19 doi: 10.1007/s00404-022-06403-9. PMID: 35044514
Retrospective review of accelerated daratumumab administration.
Patel A, Clark S, Espiritu J, Dechen T, Tran Q
J Oncol Pharm Pract 2022 Jun;28(4):816-821. Epub 2021 Apr 17 doi: 10.1177/10781552211009967. PMID: 33866892
Phase I study of CT-2103, a polymer-conjugated paclitaxel, and carboplatin in patients with advanced solid tumors.
Nemunaitis J, Cunningham C, Senzer N, Gray M, Oldham F, Pippen J, Mennel R, Eisenfeld A
Cancer Invest 2005;23(8):671-6. doi: 10.1080/07357900500359935. PMID: 16377585

Diagnosis

Infusion reactions are common after high-dose carmustine in BEAM chemotherapy and are not reduced by lengthening the time of administration.
Perreault S, Baker J, Medoff E, Pratt K, Foss F, Isufi I, Seropian S, Cooper DL
Support Care Cancer 2017 Jan;25(1):205-208. Epub 2016 Sep 10 doi: 10.1007/s00520-016-3399-4. PMID: 27614867
Complete response and long-term survival (>20 years) of a child with tectal glioma: a case report.
Burzynski SR, Burzynski GS, Janicki TJ, Marszalek A
Pediatr Neurosurg 2015;50(2):99-103. Epub 2015 Apr 22 doi: 10.1159/000369907. PMID: 25926271
Standardizing assessment and reporting of adverse effects in rheumatology clinical trials II: the Rheumatology Common Toxicity Criteria v.2.0.
Woodworth T, Furst DE, Alten R, Bingham CO 3rd, Yocum D, Sloan V, Tsuji W, Stevens R, Fries J, Witter J, Johnson K, Lassere M, Brooks P
J Rheumatol 2007 Jun;34(6):1401-14. PMID: 17552067

Therapy

Extent of extravasation: Patients on parenteral plant alkaloids.
Somayaji S, Reddy SS, Murthy MK, Maka VV
J Cancer Res Ther 2023 Jan 1;19(Suppl 2):S841-S844. Epub 2023 Dec 15 doi: 10.4103/jcrt.JCRT_457_19. PMID: 38384064
Phase 1 pilot study of RRx-001 + nivolumab in patients with advanced metastatic cancer (PRIMETIME).
Reid T, Oronsky B, Caroen S, Quinn M, Williams J, Cabrales P, Abrouk N
Front Immunol 2023;14:1104753. Epub 2023 Mar 7 doi: 10.3389/fimmu.2023.1104753. PMID: 36960054Free PMC Article
Adverse events caused by cord blood infusion in Japan during a 5-year period.
Hashimoto S, Kato K, Kai S, Sekimoto T, Minemoto M, Ishii H, Mori T, Azuma F, Ishimaru F, Kimura T, Miyata S, Satake M, Takanashi M
Vox Sang 2023 Jan;118(1):84-92. Epub 2022 Dec 1 doi: 10.1111/vox.13379. PMID: 36454585
Risk factors for and prognosis of carboplatin-related hypersensitivity in patients with epithelial ovarian cancer.
Hwang WY, Lee M, Suh DH, Kim K, No JH, Kim YB, Kim JH
Arch Gynecol Obstet 2022 Aug;306(2):443-449. Epub 2022 Jan 19 doi: 10.1007/s00404-022-06403-9. PMID: 35044514
Retrospective review of accelerated daratumumab administration.
Patel A, Clark S, Espiritu J, Dechen T, Tran Q
J Oncol Pharm Pract 2022 Jun;28(4):816-821. Epub 2021 Apr 17 doi: 10.1177/10781552211009967. PMID: 33866892

Prognosis

Extent of extravasation: Patients on parenteral plant alkaloids.
Somayaji S, Reddy SS, Murthy MK, Maka VV
J Cancer Res Ther 2023 Jan 1;19(Suppl 2):S841-S844. Epub 2023 Dec 15 doi: 10.4103/jcrt.JCRT_457_19. PMID: 38384064
Risk factors for and prognosis of carboplatin-related hypersensitivity in patients with epithelial ovarian cancer.
Hwang WY, Lee M, Suh DH, Kim K, No JH, Kim YB, Kim JH
Arch Gynecol Obstet 2022 Aug;306(2):443-449. Epub 2022 Jan 19 doi: 10.1007/s00404-022-06403-9. PMID: 35044514
Complete response and long-term survival (>20 years) of a child with tectal glioma: a case report.
Burzynski SR, Burzynski GS, Janicki TJ, Marszalek A
Pediatr Neurosurg 2015;50(2):99-103. Epub 2015 Apr 22 doi: 10.1159/000369907. PMID: 25926271
Accelerated infusion rates of rituximab are well tolerated and safe in rheumatology practice: a single-centre experience.
Can M, Alibaz-Öner F, Yılmaz-Öner S, Atagündüz P, İnanç N, Direskeneli H
Clin Rheumatol 2013 Jan;32(1):87-90. Epub 2012 Oct 11 doi: 10.1007/s10067-012-2094-1. PMID: 23053686
Phase I study of CT-2103, a polymer-conjugated paclitaxel, and carboplatin in patients with advanced solid tumors.
Nemunaitis J, Cunningham C, Senzer N, Gray M, Oldham F, Pippen J, Mennel R, Eisenfeld A
Cancer Invest 2005;23(8):671-6. doi: 10.1080/07357900500359935. PMID: 16377585

Clinical prediction guides

Extent of extravasation: Patients on parenteral plant alkaloids.
Somayaji S, Reddy SS, Murthy MK, Maka VV
J Cancer Res Ther 2023 Jan 1;19(Suppl 2):S841-S844. Epub 2023 Dec 15 doi: 10.4103/jcrt.JCRT_457_19. PMID: 38384064
Phase 1 pilot study of RRx-001 + nivolumab in patients with advanced metastatic cancer (PRIMETIME).
Reid T, Oronsky B, Caroen S, Quinn M, Williams J, Cabrales P, Abrouk N
Front Immunol 2023;14:1104753. Epub 2023 Mar 7 doi: 10.3389/fimmu.2023.1104753. PMID: 36960054Free PMC Article
Risk factors for and prognosis of carboplatin-related hypersensitivity in patients with epithelial ovarian cancer.
Hwang WY, Lee M, Suh DH, Kim K, No JH, Kim YB, Kim JH
Arch Gynecol Obstet 2022 Aug;306(2):443-449. Epub 2022 Jan 19 doi: 10.1007/s00404-022-06403-9. PMID: 35044514
Infusion reactions are common after high-dose carmustine in BEAM chemotherapy and are not reduced by lengthening the time of administration.
Perreault S, Baker J, Medoff E, Pratt K, Foss F, Isufi I, Seropian S, Cooper DL
Support Care Cancer 2017 Jan;25(1):205-208. Epub 2016 Sep 10 doi: 10.1007/s00520-016-3399-4. PMID: 27614867
Standardizing assessment and reporting of adverse effects in rheumatology clinical trials II: the Rheumatology Common Toxicity Criteria v.2.0.
Woodworth T, Furst DE, Alten R, Bingham CO 3rd, Yocum D, Sloan V, Tsuji W, Stevens R, Fries J, Witter J, Johnson K, Lassere M, Brooks P
J Rheumatol 2007 Jun;34(6):1401-14. PMID: 17552067

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