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Increased serum leptin

MedGen UID:
1634154
•Concept ID:
C4703541
•
Finding
Synonym: Elevated circulating leptin level
 
HPO: HP:0031793

Definition

An increased concentration of leptin in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased serum leptin

Conditions with this feature

BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 19
MedGen UID:
1638030
•Concept ID:
C4693522
•
Finding
Patients with biallelic mutations in the ADCY3 gene show hyperphagia within the first 2 years of life and develop severe obesity. Other features include hyposmia or anosmia, and some patients exhibit mild to moderate intellectual disability (Saeed et al., 2018).
See: Condition Record
BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 19

Professional guidelines

PubMed

Short-term effects of gonadotropin-releasing hormone analogue treatment on leptin, ghrelin and peptide YY in girls with central precocious puberty.
Wijarn P, Poomthavorn P, Khlairit P, Pongratanakul S, Chailurkit L, Mahachoklertwattana P
J Pediatr Endocrinol Metab 2021 Apr 27;34(4):479-484. Epub 2021 Mar 1 doi: 10.1515/jpem-2020-0470. PMID: 33655737
Treatment with teriparatide might be associated with cardiometabolic changes in postmenopausal severe osteoporotic women.
Passeri E, Dozio E, Mendola M, Costa E, Bandera F, Corsi Romanelli MM, Corbetta S
J Biol Regul Homeost Agents 2015 Oct-Dec;29(4):931-40. PMID: 26753658

Recent clinical studies

Etiology

Cluster analysis identifies a pathophysiologically distinct subpopulation with increased serum leptin levels and severe obstructive sleep apnea.
Kozu Y, Kurosawa Y, Yamada S, Fukuda A, Hikichi M, Hiranuma H, Akahoshi T, Gon Y
Sleep Breath 2021 Jun;25(2):767-776. Epub 2020 Sep 4 doi: 10.1007/s11325-020-02160-8. PMID: 32886313Free PMC Article
Serum inhibin and leptin: Risk factors for pre-eclampsia?
Chrelias G, Makris GM, Papanota AM, Spathis A, Salamalekis G, Sergentanis TN, Rizos D, Karakitsos P, Chrelias C
Clin Chim Acta 2016 Dec 1;463:84-87. Epub 2016 Oct 11 doi: 10.1016/j.cca.2016.10.013. PMID: 27737735
Association of Increased Serum Leptin with Ameliorated Anemia and Malnutrition in Stage 5 Chronic Kidney Disease Patients after Parathyroidectomy.
Jiang Y, Zhang J, Yuan Y, Zha X, Xing C, Shen C, Shen Z, Qin C, Zeng M, Yang G, Mao H, Zhang B, Yu X, Sun B, Ouyang C, Xu X, Ge Y, Wang J, Zhang L, Cheng C, Yin C, Zhang J, Chen H, Ma H, Wang N
Sci Rep 2016 Jun 16;6:27918. doi: 10.1038/srep27918. PMID: 27307101Free PMC Article
Serum leptin and loss of control eating in children and adolescents.
Miller R, Tanofsky-Kraff M, Shomaker LB, Field SE, Hannallah L, Reina SA, Mooreville M, Sedaka N, Brady SM, Condarco T, Reynolds JC, Yanovski SZ, Yanovski JA
Int J Obes (Lond) 2014 Mar;38(3):397-403. Epub 2013 Jul 9 doi: 10.1038/ijo.2013.126. PMID: 23835660Free PMC Article
Molecular pathways: adiponectin and leptin signaling in cancer.
Vansaun MN
Clin Cancer Res 2013 Apr 15;19(8):1926-32. Epub 2013 Jan 25 doi: 10.1158/1078-0432.CCR-12-0930. PMID: 23355630Free PMC Article

Diagnosis

Elafin inhibits obesity, hyperglycemia, and liver steatosis in high-fat diet-treated male mice.
Wang J, Ortiz C, Fontenot L, Mukhopadhyay R, Xie Y, Law IKM, Shih DQ, Mattai SA, Li Z, Koon HW
Sci Rep 2020 Jul 30;10(1):12785. doi: 10.1038/s41598-020-69634-3. PMID: 32733043Free PMC Article
Leptin gene polymorphism affects leptin level in childhood asthma.
Szczepankiewicz D, Sobkowiak P, Narożna B, Wojsyk-Banaszak I, Bręborowicz A, Szczepankiewicz A
World J Pediatr 2018 Dec;14(6):601-606. Epub 2018 Sep 10 doi: 10.1007/s12519-018-0182-2. PMID: 30203371Free PMC Article
Increased serum leptin levels are associated with metabolic syndrome and carotid intima media thickness in premenopausal systemic lupus erythematosus patients without clinical atherosclerotic vascular events.
Demir S, Erten G, Artım-Esen B, Şahinkaya Y, Pehlivan Ö, Alpay-Kanıtez N, Deniz G, Inanç M
Lupus 2018 Aug;27(9):1509-1516. Epub 2018 Jun 28 doi: 10.1177/0961203318782424. PMID: 29954279
Serum inhibin and leptin: Risk factors for pre-eclampsia?
Chrelias G, Makris GM, Papanota AM, Spathis A, Salamalekis G, Sergentanis TN, Rizos D, Karakitsos P, Chrelias C
Clin Chim Acta 2016 Dec 1;463:84-87. Epub 2016 Oct 11 doi: 10.1016/j.cca.2016.10.013. PMID: 27737735
Increased serum leptin concentrations in patients with chronic stable angina pectoris and ST-elevated myocardial infarction.
Taneli F, Yegane S, Ulman C, Tikiz H, Bilge AR, Ari Z, Uyanik BS
Angiology 2006 May-Jun;57(3):267-72. doi: 10.1177/000331970605700302. PMID: 16703186

Therapy

Leptin regulates the expression of angiopoietin-like 6.
Kim MJ, Namkung J, Chang JS, Kim SJ, Park KS, Kong ID
Biochem Biophys Res Commun 2018 Jul 20;502(3):397-402. Epub 2018 May 30 doi: 10.1016/j.bbrc.2018.05.180. PMID: 29852166
Association of Increased Serum Leptin with Ameliorated Anemia and Malnutrition in Stage 5 Chronic Kidney Disease Patients after Parathyroidectomy.
Jiang Y, Zhang J, Yuan Y, Zha X, Xing C, Shen C, Shen Z, Qin C, Zeng M, Yang G, Mao H, Zhang B, Yu X, Sun B, Ouyang C, Xu X, Ge Y, Wang J, Zhang L, Cheng C, Yin C, Zhang J, Chen H, Ma H, Wang N
Sci Rep 2016 Jun 16;6:27918. doi: 10.1038/srep27918. PMID: 27307101Free PMC Article
Increased serum leptin and resistin levels and increased carotid intima-media wall thickness in patients with psoriasis: is psoriasis associated with atherosclerosis?
Robati RM, Partovi-Kia M, Haghighatkhah HR, Younespour S, Abdollahimajd F
J Am Acad Dermatol 2014 Oct;71(4):642-8. Epub 2014 Jul 16 doi: 10.1016/j.jaad.2014.06.006. PMID: 25043845
Serum leptin and ghrelin in chronic hepatitis C patients with steatosis.
Pavlidis C, Panoutsopoulos GI, Tiniakos D, Koutsounas S, Vlachogiannakos J, Zouboulis-Vafiadis I
World J Gastroenterol 2011 Dec 14;17(46):5097-104. doi: 10.3748/wjg.v17.i46.5097. PMID: 22171144Free PMC Article
Increased serum leptin concentrations in patients with chronic stable angina pectoris and ST-elevated myocardial infarction.
Taneli F, Yegane S, Ulman C, Tikiz H, Bilge AR, Ari Z, Uyanik BS
Angiology 2006 May-Jun;57(3):267-72. doi: 10.1177/000331970605700302. PMID: 16703186

Prognosis

Leptin gene polymorphism affects leptin level in childhood asthma.
Szczepankiewicz D, Sobkowiak P, Narożna B, Wojsyk-Banaszak I, Bręborowicz A, Szczepankiewicz A
World J Pediatr 2018 Dec;14(6):601-606. Epub 2018 Sep 10 doi: 10.1007/s12519-018-0182-2. PMID: 30203371Free PMC Article
Polymorphism in Leptin and Leptin Receptor Genes May Modify Leptin Levels and Represent Risk Factors for Multiple Sclerosis.
Farrokhi M, Dabirzadeh M, Fadaee E, Beni AA, Saadatpour Z, Rezaei A, Heidari Z
Immunol Invest 2016 May;45(4):328-35. Epub 2016 Apr 22 doi: 10.3109/08820139.2016.1157811. PMID: 27105071
Increased serum leptin and resistin levels and increased carotid intima-media wall thickness in patients with psoriasis: is psoriasis associated with atherosclerosis?
Robati RM, Partovi-Kia M, Haghighatkhah HR, Younespour S, Abdollahimajd F
J Am Acad Dermatol 2014 Oct;71(4):642-8. Epub 2014 Jul 16 doi: 10.1016/j.jaad.2014.06.006. PMID: 25043845
Serum leptin and loss of control eating in children and adolescents.
Miller R, Tanofsky-Kraff M, Shomaker LB, Field SE, Hannallah L, Reina SA, Mooreville M, Sedaka N, Brady SM, Condarco T, Reynolds JC, Yanovski SZ, Yanovski JA
Int J Obes (Lond) 2014 Mar;38(3):397-403. Epub 2013 Jul 9 doi: 10.1038/ijo.2013.126. PMID: 23835660Free PMC Article
Serum leptin and ghrelin in chronic hepatitis C patients with steatosis.
Pavlidis C, Panoutsopoulos GI, Tiniakos D, Koutsounas S, Vlachogiannakos J, Zouboulis-Vafiadis I
World J Gastroenterol 2011 Dec 14;17(46):5097-104. doi: 10.3748/wjg.v17.i46.5097. PMID: 22171144Free PMC Article

Clinical prediction guides

Elevated serum leptin may be associated with disease activity and secondary osteoporosis in Chinese patients with rheumatoid arthritis.
Gong X, Tang Y, Yu SS, Shi W, Wang YR, Deng JL, Rui JB, Qiu YY
Clin Rheumatol 2023 Dec;42(12):3333-3340. Epub 2023 Aug 30 doi: 10.1007/s10067-023-06725-2. PMID: 37646860
Increased serum leptin levels are associated with metabolic syndrome and carotid intima media thickness in premenopausal systemic lupus erythematosus patients without clinical atherosclerotic vascular events.
Demir S, Erten G, Artım-Esen B, Şahinkaya Y, Pehlivan Ö, Alpay-Kanıtez N, Deniz G, Inanç M
Lupus 2018 Aug;27(9):1509-1516. Epub 2018 Jun 28 doi: 10.1177/0961203318782424. PMID: 29954279
Serum leptin levels and GHR-d3/fl gene polymorphism in acromegalic patients with thyroid nodules.
Topsakal S, Akin F, Turgut S, Yerlikaya E, Yaylali GF
Adv Clin Exp Med 2017 Mar-Apr;26(2):281-286. doi: 10.17219/acem/34793. PMID: 28791847
Serum leptin and loss of control eating in children and adolescents.
Miller R, Tanofsky-Kraff M, Shomaker LB, Field SE, Hannallah L, Reina SA, Mooreville M, Sedaka N, Brady SM, Condarco T, Reynolds JC, Yanovski SZ, Yanovski JA
Int J Obes (Lond) 2014 Mar;38(3):397-403. Epub 2013 Jul 9 doi: 10.1038/ijo.2013.126. PMID: 23835660Free PMC Article
Serum leptin and ghrelin in chronic hepatitis C patients with steatosis.
Pavlidis C, Panoutsopoulos GI, Tiniakos D, Koutsounas S, Vlachogiannakos J, Zouboulis-Vafiadis I
World J Gastroenterol 2011 Dec 14;17(46):5097-104. doi: 10.3748/wjg.v17.i46.5097. PMID: 22171144Free PMC Article

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