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Childhood Anaplastic Astrocytoma

MedGen UID:
1635918
•Concept ID:
C4551548
•
Neoplastic Process
Synonyms: Anaplastic Childhood Astrocytoma; Anaplastic Pediatric Astrocytoma; Grade 3 Childhood Astrocytic Neoplasm; Grade 3 Childhood Astrocytic Tumor; Grade 3 Childhood Astrocytoma; Grade 3 Pediatric Astrocytic Neoplasm; Grade 3 Pediatric Astrocytic Tumor; Grade 3 Pediatric Astrocytoma; Grade III Childhood Astrocytic Neoplasm; Grade III Childhood Astrocytic Tumor; Grade III Childhood Astrocytoma; Grade III Pediatric Astrocytic Neoplasm; Grade III Pediatric Astrocytic Tumor; Grade III Pediatric Astrocytoma; Undifferentiated Childhood Astrocytoma; Undifferentiated Pediatric Astrocytoma

Definition

An anaplastic astrocytoma that arises from the central nervous system and occurs during childhood. [from NCI]

Professional guidelines

PubMed

The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen.
Malta TM, Sabedot TS, Morosini NS, Datta I, Garofano L, Vallentgoed W, Varn FS, Aldape K, D'Angelo F, Bakas S, Barnholtz-Sloan JS, Gan HK, Hasanain M, Hau AC, Johnson KC, Cazacu S, deCarvalho AC, Khasraw M, Kocakavuk E, Kouwenhoven MCM, Migliozzi S, Niclou SP, Niers JM, Ormond DR, Paek SH, Reifenberger G, Sillevis Smitt PA, Smits M, Stead LF, van den Bent MJ, Van Meir EG, Walenkamp A, Weiss T, Weller M, Westerman BA, Ylstra B, Wesseling P, Lasorella A, French PJ, Poisson LM; Consortium The GLASS, Verhaak RGW, Iavarone A, Noushmehr H
Cancer Res 2024 Mar 4;84(5):741-756. doi: 10.1158/0008-5472.CAN-23-2093. PMID: 38117484Free PMC Article
Clinical Features, Treatment and Outcome of Childhood Glial Tumors.
Kara B, Ertan K, Karabagli P, Karabagli H, Yavas G, Caglayan AO, Koksal Y
Turk Neurosurg 2022;32(1):135-142. doi: 10.5137/1019-5149.JTN.34801-21.2. PMID: 34751424
Childhood brain tumors: current management, biological insights, and future directions.
Pollack IF, Agnihotri S, Broniscer A
J Neurosurg Pediatr 2019 Mar 1;23(3):261-273. doi: 10.3171/2018.10.PEDS18377. PMID: 30835699Free PMC Article

Recent clinical studies

Etiology

Phase II study of 6-thioguanine, procarbazine, dibromodulcitol, lomustine, and vincristine chemotherapy with radiotherapy for treating malignant glioma in children.
Levin VA, Lamborn K, Wara W, Davis R, Edwards M, Rabbitt J, Malec M, Prados MD
Neuro Oncol 2000 Jan;2(1):22-8. doi: 10.1093/neuonc/2.1.22. PMID: 11302250Free PMC Article

Therapy

Phase II study of 6-thioguanine, procarbazine, dibromodulcitol, lomustine, and vincristine chemotherapy with radiotherapy for treating malignant glioma in children.
Levin VA, Lamborn K, Wara W, Davis R, Edwards M, Rabbitt J, Malec M, Prados MD
Neuro Oncol 2000 Jan;2(1):22-8. doi: 10.1093/neuonc/2.1.22. PMID: 11302250Free PMC Article

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