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Blasts 30 Percent or Less of Bone Marrow Nucleated Cells

MedGen UID:
1636039
•Concept ID:
C4683694
•
Finding
Synonyms: Blasts Less than or Equal to 30 Percent of Bone Marrow Nucleated Cells; Blasts Under 31 Percent of Bone Marrow Nucleated Cells

Definition

A semi-quantitative microscopic finding indicating that 30 percent or less of the nucleated cells in a bone marrow sample are immature mononuclear cells. [from NCI]

Professional guidelines

PubMed

Management of postoperative pseudomeningoceles: an international survey study.
Tu A, Tamburrini G, Steinbok P
Childs Nerv Syst 2014 Nov;30(11):1791-801. Epub 2014 Oct 9 doi: 10.1007/s00381-014-2501-9. PMID: 25296539
Management of head trauma due to landmine explosions: from battle field to operation room.
Atabey C, Asir A, Ersoy T
Br J Neurosurg 2012 Apr;26(2):208-11. Epub 2011 Nov 11 doi: 10.3109/02688697.2011.626875. PMID: 22077586
Prevalence and treatment of headaches in veterans with mild traumatic brain injury.
Patil VK, St Andre JR, Crisan E, Smith BM, Evans CT, Steiner ML, Pape TL
Headache 2011 Jul-Aug;51(7):1112-21. doi: 10.1111/j.1526-4610.2011.01946.x. PMID: 21762135

Recent clinical studies

Therapy

Decitabine Versus Hydroxyurea for Advanced Proliferative Chronic Myelomonocytic Leukemia: Results of a Randomized Phase III Trial Within the EMSCO Network.
Itzykson R, Santini V, Thepot S, Ades L, Chaffaut C, Giagounidis A, Morabito M, Droin N, Lübbert M, Sapena R, Nimubona S, Goasguen J, Wattel E, Zini G, Torregrosa Diaz JM, Germing U, Pelizzari AM, Park S, Jaekel N, Metzgeroth G, Onida F, Navarro R, Patriarca A, Stamatoullas A, Götze K, Puttrich M, Mossuto S, Solary E, Gloaguen S, Chevret S, Chermat F, Platzbecker U, Fenaux P
J Clin Oncol 2023 Apr 1;41(10):1888-1897. Epub 2022 Dec 1 doi: 10.1200/JCO.22.00437. PMID: 36455187
Safety and efficacy of avalglucosidase alfa versus alglucosidase alfa in patients with late-onset Pompe disease (COMET): a phase 3, randomised, multicentre trial.
Diaz-Manera J, Kishnani PS, Kushlaf H, Ladha S, Mozaffar T, Straub V, Toscano A, van der Ploeg AT, Berger KI, Clemens PR, Chien YH, Day JW, Illarioshkin S, Roberts M, Attarian S, Borges JL, Bouhour F, Choi YC, Erdem-Ozdamar S, Goker-Alpan O, Kostera-Pruszczyk A, Haack KA, Hug C, Huynh-Ba O, Johnson J, Thibault N, Zhou T, Dimachkie MM, Schoser B; COMET Investigator Group
Lancet Neurol 2021 Dec;20(12):1012-1026. doi: 10.1016/S1474-4422(21)00241-6. PMID: 34800399
Multiple Autologous Bone Marrow-Derived CD271(+) Mesenchymal Stem Cell Transplantation Overcomes Drug-Resistant Epilepsy in Children.
Milczarek O, Jarocha D, Starowicz-Filip A, Kwiatkowski S, Badyra B, Majka M
Stem Cells Transl Med 2018 Jan;7(1):20-33. Epub 2017 Dec 10 doi: 10.1002/sctm.17-0041. PMID: 29224250Free PMC Article
Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia.
Rocha V, Labopin M, Sanz G, Arcese W, Schwerdtfeger R, Bosi A, Jacobsen N, Ruutu T, de Lima M, Finke J, Frassoni F, Gluckman E; Acute Leukemia Working Party of European Blood and Marrow Transplant Group; Eurocord-Netcord Registry
N Engl J Med 2004 Nov 25;351(22):2276-85. doi: 10.1056/NEJMoa041469. PMID: 15564544
A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811.
Larson RA, Dodge RK, Burns CP, Lee EJ, Stone RM, Schulman P, Duggan D, Davey FR, Sobol RE, Frankel SR
Blood 1995 Apr 15;85(8):2025-37. PMID: 7718875

Prognosis

Decitabine Versus Hydroxyurea for Advanced Proliferative Chronic Myelomonocytic Leukemia: Results of a Randomized Phase III Trial Within the EMSCO Network.
Itzykson R, Santini V, Thepot S, Ades L, Chaffaut C, Giagounidis A, Morabito M, Droin N, Lübbert M, Sapena R, Nimubona S, Goasguen J, Wattel E, Zini G, Torregrosa Diaz JM, Germing U, Pelizzari AM, Park S, Jaekel N, Metzgeroth G, Onida F, Navarro R, Patriarca A, Stamatoullas A, Götze K, Puttrich M, Mossuto S, Solary E, Gloaguen S, Chevret S, Chermat F, Platzbecker U, Fenaux P
J Clin Oncol 2023 Apr 1;41(10):1888-1897. Epub 2022 Dec 1 doi: 10.1200/JCO.22.00437. PMID: 36455187
Safety and efficacy of avalglucosidase alfa versus alglucosidase alfa in patients with late-onset Pompe disease (COMET): a phase 3, randomised, multicentre trial.
Diaz-Manera J, Kishnani PS, Kushlaf H, Ladha S, Mozaffar T, Straub V, Toscano A, van der Ploeg AT, Berger KI, Clemens PR, Chien YH, Day JW, Illarioshkin S, Roberts M, Attarian S, Borges JL, Bouhour F, Choi YC, Erdem-Ozdamar S, Goker-Alpan O, Kostera-Pruszczyk A, Haack KA, Hug C, Huynh-Ba O, Johnson J, Thibault N, Zhou T, Dimachkie MM, Schoser B; COMET Investigator Group
Lancet Neurol 2021 Dec;20(12):1012-1026. doi: 10.1016/S1474-4422(21)00241-6. PMID: 34800399
Bioengineered Exosomal Extracellular Vesicles in Cancer Therapeutics.
Miles J, Andre M, Caobi A, Ruiz M, Nair M, Raymond AD
Crit Rev Biomed Eng 2020;48(3):177-187. doi: 10.1615/CritRevBiomedEng.2020034847. PMID: 33389895Free PMC Article
The challenging task of enumerating blasts in the bone marrow.
Hodes A, Calvo KR, Dulau A, Maric I, Sun J, Braylan R
Semin Hematol 2019 Jan;56(1):58-64. Epub 2018 Aug 16 doi: 10.1053/j.seminhematol.2018.07.001. PMID: 30573046
A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811.
Larson RA, Dodge RK, Burns CP, Lee EJ, Stone RM, Schulman P, Duggan D, Davey FR, Sobol RE, Frankel SR
Blood 1995 Apr 15;85(8):2025-37. PMID: 7718875

Clinical prediction guides

Down-regulation of A20 mRNA expression in peripheral blood mononuclear cells from MDS patients.
Wang K, Si T, Wei C, Hu Q, Zhou Y, Bao J
Hematology 2024 Dec;29(1):2330851. Epub 2024 Mar 21 doi: 10.1080/16078454.2024.2330851. PMID: 38511647
Decitabine Versus Hydroxyurea for Advanced Proliferative Chronic Myelomonocytic Leukemia: Results of a Randomized Phase III Trial Within the EMSCO Network.
Itzykson R, Santini V, Thepot S, Ades L, Chaffaut C, Giagounidis A, Morabito M, Droin N, Lübbert M, Sapena R, Nimubona S, Goasguen J, Wattel E, Zini G, Torregrosa Diaz JM, Germing U, Pelizzari AM, Park S, Jaekel N, Metzgeroth G, Onida F, Navarro R, Patriarca A, Stamatoullas A, Götze K, Puttrich M, Mossuto S, Solary E, Gloaguen S, Chevret S, Chermat F, Platzbecker U, Fenaux P
J Clin Oncol 2023 Apr 1;41(10):1888-1897. Epub 2022 Dec 1 doi: 10.1200/JCO.22.00437. PMID: 36455187
Safety and efficacy of avalglucosidase alfa versus alglucosidase alfa in patients with late-onset Pompe disease (COMET): a phase 3, randomised, multicentre trial.
Diaz-Manera J, Kishnani PS, Kushlaf H, Ladha S, Mozaffar T, Straub V, Toscano A, van der Ploeg AT, Berger KI, Clemens PR, Chien YH, Day JW, Illarioshkin S, Roberts M, Attarian S, Borges JL, Bouhour F, Choi YC, Erdem-Ozdamar S, Goker-Alpan O, Kostera-Pruszczyk A, Haack KA, Hug C, Huynh-Ba O, Johnson J, Thibault N, Zhou T, Dimachkie MM, Schoser B; COMET Investigator Group
Lancet Neurol 2021 Dec;20(12):1012-1026. doi: 10.1016/S1474-4422(21)00241-6. PMID: 34800399
The challenging task of enumerating blasts in the bone marrow.
Hodes A, Calvo KR, Dulau A, Maric I, Sun J, Braylan R
Semin Hematol 2019 Jan;56(1):58-64. Epub 2018 Aug 16 doi: 10.1053/j.seminhematol.2018.07.001. PMID: 30573046
A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811.
Larson RA, Dodge RK, Burns CP, Lee EJ, Stone RM, Schulman P, Duggan D, Davey FR, Sobol RE, Frankel SR
Blood 1995 Apr 15;85(8):2025-37. PMID: 7718875

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