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Refractory Multiple Myeloma

MedGen UID:
1636255
Concept ID:
C4551538
Neoplastic Process
Synonym: Refractory Plasma Cell Myeloma

Definition

Multiple myeloma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Multiple Myeloma

Professional guidelines

PubMed

Kumar SK, Callander NS, Adekola K, Anderson LD Jr, Baljevic M, Baz R, Campagnaro E, Castillo JJ, Costello C, D'Angelo C, Devarakonda S, Elsedawy N, Garfall A, Godby K, Hillengass J, Holmberg L, Htut M, Huff CA, Hultcrantz M, Kang Y, Larson S, Lee HC, Liedtke M, Martin T, Omel J, Robinson T, Rosenberg A, Sborov D, Schroeder MA, Sherbenou D, Suvannasankha A, Valent J, Varshavsky-Yanovsky AN, Kumar R, Snedeker J
J Natl Compr Canc Netw 2023 Dec;21(12):1281-1301. doi: 10.6004/jnccn.2023.0061. PMID: 38081133
Shen F, Shen W
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221106563. doi: 10.1177/15330338221106563. PMID: 35903924Free PMC Article
Moreau P, Kumar SK, San Miguel J, Davies F, Zamagni E, Bahlis N, Ludwig H, Mikhael J, Terpos E, Schjesvold F, Martin T, Yong K, Durie BGM, Facon T, Jurczyszyn A, Sidana S, Raje N, van de Donk N, Lonial S, Cavo M, Kristinsson SY, Lentzsch S, Hajek R, Anderson KC, João C, Einsele H, Sonneveld P, Engelhardt M, Fonseca R, Vangsted A, Weisel K, Baz R, Hungria V, Berdeja JG, Leal da Costa F, Maiolino A, Waage A, Vesole DH, Ocio EM, Quach H, Driessen C, Bladé J, Leleu X, Riva E, Bergsagel PL, Hou J, Chng WJ, Mellqvist UH, Dytfeld D, Harousseau JL, Goldschmidt H, Laubach J, Munshi NC, Gay F, Beksac M, Costa LJ, Kaiser M, Hari P, Boccadoro M, Usmani SZ, Zweegman S, Holstein S, Sezer O, Harrison S, Nahi H, Cook G, Mateos MV, Rajkumar SV, Dimopoulos MA, Richardson PG
Lancet Oncol 2021 Mar;22(3):e105-e118. doi: 10.1016/S1470-2045(20)30756-7. PMID: 33662288

Recent clinical studies

Etiology

San-Miguel J, Dhakal B, Yong K, Spencer A, Anguille S, Mateos MV, Fernández de Larrea C, Martínez-López J, Moreau P, Touzeau C, Leleu X, Avivi I, Cavo M, Ishida T, Kim SJ, Roeloffzen W, van de Donk NWCJ, Dytfeld D, Sidana S, Costa LJ, Oriol A, Popat R, Khan AM, Cohen YC, Ho PJ, Griffin J, Lendvai N, Lonardi C, Slaughter A, Schecter JM, Jackson CC, Connors K, Li K, Zudaire E, Chen D, Gilbert J, Yeh TM, Nagle S, Florendo E, Pacaud L, Patel N, Harrison SJ, Einsele H
N Engl J Med 2023 Jul 27;389(4):335-347. Epub 2023 Jun 5 doi: 10.1056/NEJMoa2303379. PMID: 37272512
Bhatt P, Kloock C, Comenzo R
Curr Oncol 2023 Feb 15;30(2):2322-2347. doi: 10.3390/curroncol30020179. PMID: 36826140Free PMC Article
Rodriguez-Otero P, Ailawadhi S, Arnulf B, Patel K, Cavo M, Nooka AK, Manier S, Callander N, Costa LJ, Vij R, Bahlis NJ, Moreau P, Solomon SR, Delforge M, Berdeja J, Truppel-Hartmann A, Yang Z, Favre-Kontula L, Wu F, Piasecki J, Cook M, Giralt S
N Engl J Med 2023 Mar 16;388(11):1002-1014. Epub 2023 Feb 10 doi: 10.1056/NEJMoa2213614. PMID: 36762851
Martin T, Usmani SZ, Berdeja JG, Agha M, Cohen AD, Hari P, Avigan D, Deol A, Htut M, Lesokhin A, Munshi NC, O'Donnell E, Stewart AK, Schecter JM, Goldberg JD, Jackson CC, Yeh TM, Banerjee A, Allred A, Zudaire E, Deraedt W, Olyslager Y, Zhou C, Pacaud L, Madduri D, Jakubowiak A, Lin Y, Jagannath S
J Clin Oncol 2023 Feb 20;41(6):1265-1274. Epub 2022 Jun 4 doi: 10.1200/JCO.22.00842. PMID: 35658469Free PMC Article
Moreau P, Kumar SK, San Miguel J, Davies F, Zamagni E, Bahlis N, Ludwig H, Mikhael J, Terpos E, Schjesvold F, Martin T, Yong K, Durie BGM, Facon T, Jurczyszyn A, Sidana S, Raje N, van de Donk N, Lonial S, Cavo M, Kristinsson SY, Lentzsch S, Hajek R, Anderson KC, João C, Einsele H, Sonneveld P, Engelhardt M, Fonseca R, Vangsted A, Weisel K, Baz R, Hungria V, Berdeja JG, Leal da Costa F, Maiolino A, Waage A, Vesole DH, Ocio EM, Quach H, Driessen C, Bladé J, Leleu X, Riva E, Bergsagel PL, Hou J, Chng WJ, Mellqvist UH, Dytfeld D, Harousseau JL, Goldschmidt H, Laubach J, Munshi NC, Gay F, Beksac M, Costa LJ, Kaiser M, Hari P, Boccadoro M, Usmani SZ, Zweegman S, Holstein S, Sezer O, Harrison S, Nahi H, Cook G, Mateos MV, Rajkumar SV, Dimopoulos MA, Richardson PG
Lancet Oncol 2021 Mar;22(3):e105-e118. doi: 10.1016/S1470-2045(20)30756-7. PMID: 33662288

Diagnosis

Kumar SK, Callander NS, Adekola K, Anderson LD Jr, Baljevic M, Baz R, Campagnaro E, Castillo JJ, Costello C, D'Angelo C, Devarakonda S, Elsedawy N, Garfall A, Godby K, Hillengass J, Holmberg L, Htut M, Huff CA, Hultcrantz M, Kang Y, Larson S, Lee HC, Liedtke M, Martin T, Omel J, Robinson T, Rosenberg A, Sborov D, Schroeder MA, Sherbenou D, Suvannasankha A, Valent J, Varshavsky-Yanovsky AN, Kumar R, Snedeker J
J Natl Compr Canc Netw 2023 Dec;21(12):1281-1301. doi: 10.6004/jnccn.2023.0061. PMID: 38081133
Shen F, Shen W
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221106563. doi: 10.1177/15330338221106563. PMID: 35903924Free PMC Article
Berdeja JG, Madduri D, Usmani SZ, Jakubowiak A, Agha M, Cohen AD, Stewart AK, Hari P, Htut M, Lesokhin A, Deol A, Munshi NC, O'Donnell E, Avigan D, Singh I, Zudaire E, Yeh TM, Allred AJ, Olyslager Y, Banerjee A, Jackson CC, Goldberg JD, Schecter JM, Deraedt W, Zhuang SH, Infante J, Geng D, Wu X, Carrasco-Alfonso MJ, Akram M, Hossain F, Rizvi S, Fan F, Lin Y, Martin T, Jagannath S
Lancet 2021 Jul 24;398(10297):314-324. Epub 2021 Jun 24 doi: 10.1016/S0140-6736(21)00933-8. PMID: 34175021
Richardson PG, Oriol A, Beksac M, Liberati AM, Galli M, Schjesvold F, Lindsay J, Weisel K, White D, Facon T, San Miguel J, Sunami K, O'Gorman P, Sonneveld P, Robak P, Semochkin S, Schey S, Yu X, Doerr T, Bensmaine A, Biyukov T, Peluso T, Zaki M, Anderson K, Dimopoulos M; OPTIMISMM trial investigators
Lancet Oncol 2019 Jun;20(6):781-794. Epub 2019 May 13 doi: 10.1016/S1470-2045(19)30152-4. PMID: 31097405
Palumbo A, Chanan-Khan A, Weisel K, Nooka AK, Masszi T, Beksac M, Spicka I, Hungria V, Munder M, Mateos MV, Mark TM, Qi M, Schecter J, Amin H, Qin X, Deraedt W, Ahmadi T, Spencer A, Sonneveld P; CASTOR Investigators
N Engl J Med 2016 Aug 25;375(8):754-66. doi: 10.1056/NEJMoa1606038. PMID: 27557302

Therapy

Rodriguez-Otero P, Ailawadhi S, Arnulf B, Patel K, Cavo M, Nooka AK, Manier S, Callander N, Costa LJ, Vij R, Bahlis NJ, Moreau P, Solomon SR, Delforge M, Berdeja J, Truppel-Hartmann A, Yang Z, Favre-Kontula L, Wu F, Piasecki J, Cook M, Giralt S
N Engl J Med 2023 Mar 16;388(11):1002-1014. Epub 2023 Feb 10 doi: 10.1056/NEJMoa2213614. PMID: 36762851
Hansen DK, Sidana S, Peres LC, Colin Leitzinger C, Shune L, Shrewsbury A, Gonzalez R, Sborov DW, Wagner C, Dima D, Hashmi H, Kocoglu MH, Atrash S, Simmons G, Kalariya N, Ferreri C, Afrough A, Kansagra A, Voorhees P, Baz R, Khouri J, Alsina M, McGuirk J, Locke FL, Patel KK
J Clin Oncol 2023 Apr 10;41(11):2087-2097. Epub 2023 Jan 9 doi: 10.1200/JCO.22.01365. PMID: 36623248Free PMC Article
Tanenbaum B, Miett T, Patel SA
Ann Hematol 2023 Jan;102(1):1-11. Epub 2022 Dec 3 doi: 10.1007/s00277-022-05058-5. PMID: 36462062Free PMC Article
Kang C
Drugs 2022 Nov;82(16):1613-1619. doi: 10.1007/s40265-022-01793-1. PMID: 36352205Free PMC Article
Usmani SZ, Quach H, Mateos MV, Landgren O, Leleu X, Siegel D, Weisel K, Gavriatopoulou M, Oriol A, Rabin N, Nooka A, Qi M, Beksac M, Jakubowiak A, Ding B, Zahlten-Kumeli A, Yusuf A, Dimopoulos M
Lancet Oncol 2022 Jan;23(1):65-76. Epub 2021 Dec 3 doi: 10.1016/S1470-2045(21)00579-9. PMID: 34871550

Prognosis

Martin TG, Mateos MV, Nooka A, Banerjee A, Kobos R, Pei L, Qi M, Verona R, Doyle M, Smit J, Sun W, Trancucci D, Uhlar C, van de Donk NWCJ, Rodriguez C
Cancer 2023 Jul 1;129(13):2035-2046. Epub 2023 Mar 29 doi: 10.1002/cncr.34756. PMID: 36991547
Bhatt P, Kloock C, Comenzo R
Curr Oncol 2023 Feb 15;30(2):2322-2347. doi: 10.3390/curroncol30020179. PMID: 36826140Free PMC Article
Martin T, Usmani SZ, Berdeja JG, Agha M, Cohen AD, Hari P, Avigan D, Deol A, Htut M, Lesokhin A, Munshi NC, O'Donnell E, Stewart AK, Schecter JM, Goldberg JD, Jackson CC, Yeh TM, Banerjee A, Allred A, Zudaire E, Deraedt W, Olyslager Y, Zhou C, Pacaud L, Madduri D, Jakubowiak A, Lin Y, Jagannath S
J Clin Oncol 2023 Feb 20;41(6):1265-1274. Epub 2022 Jun 4 doi: 10.1200/JCO.22.00842. PMID: 35658469Free PMC Article
Berdeja JG, Madduri D, Usmani SZ, Jakubowiak A, Agha M, Cohen AD, Stewart AK, Hari P, Htut M, Lesokhin A, Deol A, Munshi NC, O'Donnell E, Avigan D, Singh I, Zudaire E, Yeh TM, Allred AJ, Olyslager Y, Banerjee A, Jackson CC, Goldberg JD, Schecter JM, Deraedt W, Zhuang SH, Infante J, Geng D, Wu X, Carrasco-Alfonso MJ, Akram M, Hossain F, Rizvi S, Fan F, Lin Y, Martin T, Jagannath S
Lancet 2021 Jul 24;398(10297):314-324. Epub 2021 Jun 24 doi: 10.1016/S0140-6736(21)00933-8. PMID: 34175021
Richardson PG, Oriol A, Beksac M, Liberati AM, Galli M, Schjesvold F, Lindsay J, Weisel K, White D, Facon T, San Miguel J, Sunami K, O'Gorman P, Sonneveld P, Robak P, Semochkin S, Schey S, Yu X, Doerr T, Bensmaine A, Biyukov T, Peluso T, Zaki M, Anderson K, Dimopoulos M; OPTIMISMM trial investigators
Lancet Oncol 2019 Jun;20(6):781-794. Epub 2019 May 13 doi: 10.1016/S1470-2045(19)30152-4. PMID: 31097405

Clinical prediction guides

Martin TG, Mateos MV, Nooka A, Banerjee A, Kobos R, Pei L, Qi M, Verona R, Doyle M, Smit J, Sun W, Trancucci D, Uhlar C, van de Donk NWCJ, Rodriguez C
Cancer 2023 Jul 1;129(13):2035-2046. Epub 2023 Mar 29 doi: 10.1002/cncr.34756. PMID: 36991547
Minakata D, Fujiwara SI, Yokoyama D, Noguchi A, Aoe S, Oyama T, Koyama S, Murahashi R, Nakashima H, Hyodo K, Ikeda T, Kawaguchi SI, Toda Y, Ito S, Nagayama T, Mashima K, Umino K, Morita K, Ashizawa M, Yamamoto C, Hatano K, Sato K, Ohmine K, Kanda Y
Br J Haematol 2023 Mar;200(6):694-703. Epub 2023 Jan 20 doi: 10.1111/bjh.18654. PMID: 36661264
Dimopoulos MA, Dytfeld D, Grosicki S, Moreau P, Takezako N, Hori M, Leleu X, LeBlanc R, Suzuki K, Raab MS, Richardson PG, Popa McKiver M, Jou YM, Yao D, Das P, San-Miguel J
J Clin Oncol 2023 Jan 20;41(3):568-578. Epub 2022 Aug 12 doi: 10.1200/JCO.21.02815. PMID: 35960908Free PMC Article
Martin T, Usmani SZ, Berdeja JG, Agha M, Cohen AD, Hari P, Avigan D, Deol A, Htut M, Lesokhin A, Munshi NC, O'Donnell E, Stewart AK, Schecter JM, Goldberg JD, Jackson CC, Yeh TM, Banerjee A, Allred A, Zudaire E, Deraedt W, Olyslager Y, Zhou C, Pacaud L, Madduri D, Jakubowiak A, Lin Y, Jagannath S
J Clin Oncol 2023 Feb 20;41(6):1265-1274. Epub 2022 Jun 4 doi: 10.1200/JCO.22.00842. PMID: 35658469Free PMC Article
Berdeja JG, Madduri D, Usmani SZ, Jakubowiak A, Agha M, Cohen AD, Stewart AK, Hari P, Htut M, Lesokhin A, Deol A, Munshi NC, O'Donnell E, Avigan D, Singh I, Zudaire E, Yeh TM, Allred AJ, Olyslager Y, Banerjee A, Jackson CC, Goldberg JD, Schecter JM, Deraedt W, Zhuang SH, Infante J, Geng D, Wu X, Carrasco-Alfonso MJ, Akram M, Hossain F, Rizvi S, Fan F, Lin Y, Martin T, Jagannath S
Lancet 2021 Jul 24;398(10297):314-324. Epub 2021 Jun 24 doi: 10.1016/S0140-6736(21)00933-8. PMID: 34175021

Recent systematic reviews

Minakata D, Fujiwara SI, Yokoyama D, Noguchi A, Aoe S, Oyama T, Koyama S, Murahashi R, Nakashima H, Hyodo K, Ikeda T, Kawaguchi SI, Toda Y, Ito S, Nagayama T, Mashima K, Umino K, Morita K, Ashizawa M, Yamamoto C, Hatano K, Sato K, Ohmine K, Kanda Y
Br J Haematol 2023 Mar;200(6):694-703. Epub 2023 Jan 20 doi: 10.1111/bjh.18654. PMID: 36661264
George LL, Deshpande SR, Cortese MJ, Kendall EK, Chattaraj A, Shah Z, Zhao J, Anwer F
Clin Lymphoma Myeloma Leuk 2021 Nov;21(11):741-751. Epub 2021 Jun 15 doi: 10.1016/j.clml.2021.06.003. PMID: 34253497
Yang Q, Li X, Zhang F, Yang Q, Zhou W, Liu J
Int J Med Sci 2021;18(8):1786-1797. Epub 2021 Feb 18 doi: 10.7150/ijms.46811. PMID: 33746596Free PMC Article
Sparano F, Cavo M, Niscola P, Caravita T, Efficace F
Support Care Cancer 2018 Jul;26(7):2075-2090. Epub 2018 Mar 20 doi: 10.1007/s00520-018-4137-x. PMID: 29560502
Ying L, YinHui T, Yunliang Z, Sun H
Oncotarget 2017 Jul 11;8(28):46593-46600. doi: 10.18632/oncotarget.16235. PMID: 28423741Free PMC Article

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