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Grade 2 Dry Mouth, CTCAE

MedGen UID:
1639775
•Concept ID:
C4685596
•
Finding

Definition

Moderate symptoms; oral intake alterations (e.g., copious water, other lubricants, diet limited to purees and/or soft, moist foods); unstimulated saliva 0.1 to 0.2 ml/min [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 2 Dry Mouth, CTCAE

Professional guidelines

PubMed

Mid-treatment 18F-FDG PET imaging changes in parotid gland correlates to radiation-induced xerostomia.
Trada Y, Lee MT, Jameson MG, Chlap P, Keall P, Moses D, Lin P, Fowler A
Radiother Oncol 2023 Sep;186:109745. Epub 2023 Jun 15 doi: 10.1016/j.radonc.2023.109745. PMID: 37330056
Taste disorders following cancer treatment: report of a case series.
Epstein JB, de Andrade E Silva SM, Epstein GL, Leal JHS, Barasch A, Smutzer G
Support Care Cancer 2019 Dec;27(12):4587-4595. Epub 2019 Mar 29 doi: 10.1007/s00520-019-04758-5. PMID: 30927113
Effects of treatment intensification on acute local toxicity during radiotherapy for head and neck cancer: prospective observational study validating CTCAE, version 3.0, scoring system.
Palazzi M, Tomatis S, Orlandi E, Guzzo M, Sangalli C, Potepan P, Fantini S, Bergamini C, Gavazzi C, Licitra L, Scaramellini G, Cantu' G, Olmi P
Int J Radiat Oncol Biol Phys 2008 Feb 1;70(2):330-7. Epub 2007 Sep 19 doi: 10.1016/j.ijrobp.2007.06.022. PMID: 17881148

Recent clinical studies

Etiology

Administering [(177)Lu]Lu-PSMA-617 Prior to Radical Prostatectomy in Men with High-risk Localised Prostate Cancer (LuTectomy): A Single-centre, Single-arm, Phase 1/2 Study.
Eapen RS, Buteau JP, Jackson P, Mitchell C, Oon SF, Alghazo O, McIntosh L, Dhiantravan N, Scalzo MJ, O'Brien J, Sandhu S, Azad AA, Williams SG, Sharma G, Haskali MB, Bressel M, Chen K, Jenjitranant P, McVey A, Moon D, Lawrentschuk N, Neeson PJ, Murphy DG, Hofman MS
Eur Urol 2024 Mar;85(3):217-226. Epub 2023 Oct 26 doi: 10.1016/j.eururo.2023.08.026. PMID: 37891072
Mid-treatment 18F-FDG PET imaging changes in parotid gland correlates to radiation-induced xerostomia.
Trada Y, Lee MT, Jameson MG, Chlap P, Keall P, Moses D, Lin P, Fowler A
Radiother Oncol 2023 Sep;186:109745. Epub 2023 Jun 15 doi: 10.1016/j.radonc.2023.109745. PMID: 37330056
Xerostomia: an immunotherapy-related adverse effect in cancer patients.
Bustillos H, Indorf A, Alwan L, Thompson J, Jung L
Support Care Cancer 2022 Feb;30(2):1681-1687. Epub 2021 Sep 25 doi: 10.1007/s00520-021-06535-9. PMID: 34562169
Taste disorders following cancer treatment: report of a case series.
Epstein JB, de Andrade E Silva SM, Epstein GL, Leal JHS, Barasch A, Smutzer G
Support Care Cancer 2019 Dec;27(12):4587-4595. Epub 2019 Mar 29 doi: 10.1007/s00520-019-04758-5. PMID: 30927113
[(177)Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study.
Hofman MS, Violet J, Hicks RJ, Ferdinandus J, Thang SP, Akhurst T, Iravani A, Kong G, Ravi Kumar A, Murphy DG, Eu P, Jackson P, Scalzo M, Williams SG, Sandhu S
Lancet Oncol 2018 Jun;19(6):825-833. Epub 2018 May 8 doi: 10.1016/S1470-2045(18)30198-0. PMID: 29752180

Diagnosis

Oral Risk Factors in Patients with Cancer Undergoing Chemotherapy - A Pilot Study.
Aradya A, Kiran PK, Raghavendra Swamy KN, Doddawad VG, Ranganatha N, Sravani K
Indian J Dent Res 2024 Apr 1;35(2):126-130. Epub 2024 Aug 22 doi: 10.4103/ijdr.ijdr_516_23. PMID: 39171581
Primary and adjuvant intensity-modulated radiotherapy in oropharyngeal carcinoma patients from a single institution.
Hauswald H, Petrow E, Roeder F, Debus J, Zwicker F, Huber PE
J Cancer Res Ther 2024 Jan 1;20(1):375-382. Epub 2023 Apr 4 doi: 10.4103/jcrt.jcrt_2178_22. PMID: 38554349
Predicting acute radiation induced xerostomia in head and neck Cancer using MR and CT Radiomics of parotid and submandibular glands.
Sheikh K, Lee SH, Cheng Z, Lakshminarayanan P, Peng L, Han P, McNutt TR, Quon H, Lee J
Radiat Oncol 2019 Jul 29;14(1):131. doi: 10.1186/s13014-019-1339-4. PMID: 31358029Free PMC Article
Definitive radiotherapy vs. postoperative radiotherapy for lower gingival carcinomas of the mandible : A single-center report about outcome and toxicity.
Lang K, Akbaba S, Held T, Kargus S, Horn D, Bougatf N, Bernhardt D, Freier K, Rieken S, Debus J, Adeberg S
Strahlenther Onkol 2019 Sep;195(9):819-829. Epub 2019 Jul 2 doi: 10.1007/s00066-019-01484-z. PMID: 31267170
A randomized phase II/III study of adverse events between sequential (SEQ) versus simultaneous integrated boost (SIB) intensity modulated radiation therapy (IMRT) in nasopharyngeal carcinoma; preliminary result on acute adverse events.
Songthong AP, Kannarunimit D, Chakkabat C, Lertbutsayanukul C
Radiat Oncol 2015 Aug 8;10:166. doi: 10.1186/s13014-015-0472-y. PMID: 26253488Free PMC Article

Therapy

Administering [(177)Lu]Lu-PSMA-617 Prior to Radical Prostatectomy in Men with High-risk Localised Prostate Cancer (LuTectomy): A Single-centre, Single-arm, Phase 1/2 Study.
Eapen RS, Buteau JP, Jackson P, Mitchell C, Oon SF, Alghazo O, McIntosh L, Dhiantravan N, Scalzo MJ, O'Brien J, Sandhu S, Azad AA, Williams SG, Sharma G, Haskali MB, Bressel M, Chen K, Jenjitranant P, McVey A, Moon D, Lawrentschuk N, Neeson PJ, Murphy DG, Hofman MS
Eur Urol 2024 Mar;85(3):217-226. Epub 2023 Oct 26 doi: 10.1016/j.eururo.2023.08.026. PMID: 37891072
Patient-reported Adverse Events During Neoadjuvant Therapy in a Phase 2 Borderline Resectable Pancreatic Cancer Clinical Trial (Alliance A021501).
Snyder RA, Dueck AC, Fruth B, Shi Q, Hubbard JM, Herman JM, O'Reilly EM, Katz MHG
Ann Surg 2023 Oct 1;278(4):598-608. Epub 2023 Jun 19 doi: 10.1097/SLA.0000000000005958. PMID: 37334719Free PMC Article
The efficacy and safety of intravenous chlorpromazine treatment for sleep disturbance in patients with incurable cancer, with oral administration difficulty: a 1-week, prospective observational study.
Fujii R, Hasuo H, Sakuma H, Okada M, Uchitani K
Ann Palliat Med 2021 Aug;10(8):8547-8556. Epub 2021 Jul 14 doi: 10.21037/apm-21-948. PMID: 34263621
[(177)Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study.
Hofman MS, Violet J, Hicks RJ, Ferdinandus J, Thang SP, Akhurst T, Iravani A, Kong G, Ravi Kumar A, Murphy DG, Eu P, Jackson P, Scalzo M, Williams SG, Sandhu S
Lancet Oncol 2018 Jun;19(6):825-833. Epub 2018 May 8 doi: 10.1016/S1470-2045(18)30198-0. PMID: 29752180
Phase 2 Trial of De-intensified Chemoradiation Therapy for Favorable-Risk Human Papillomavirus-Associated Oropharyngeal Squamous Cell Carcinoma.
Chera BS, Amdur RJ, Tepper J, Qaqish B, Green R, Aumer SL, Hayes N, Weiss J, Grilley-Olson J, Zanation A, Hackman T, Funkhouser W, Sheets N, Weissler M, Mendenhall W
Int J Radiat Oncol Biol Phys 2015 Dec 1;93(5):976-85. Epub 2015 Aug 22 doi: 10.1016/j.ijrobp.2015.08.033. PMID: 26581135

Prognosis

Mid-treatment 18F-FDG PET imaging changes in parotid gland correlates to radiation-induced xerostomia.
Trada Y, Lee MT, Jameson MG, Chlap P, Keall P, Moses D, Lin P, Fowler A
Radiother Oncol 2023 Sep;186:109745. Epub 2023 Jun 15 doi: 10.1016/j.radonc.2023.109745. PMID: 37330056
Xerostomia: an immunotherapy-related adverse effect in cancer patients.
Bustillos H, Indorf A, Alwan L, Thompson J, Jung L
Support Care Cancer 2022 Feb;30(2):1681-1687. Epub 2021 Sep 25 doi: 10.1007/s00520-021-06535-9. PMID: 34562169
Predicting acute radiation induced xerostomia in head and neck Cancer using MR and CT Radiomics of parotid and submandibular glands.
Sheikh K, Lee SH, Cheng Z, Lakshminarayanan P, Peng L, Han P, McNutt TR, Quon H, Lee J
Radiat Oncol 2019 Jul 29;14(1):131. doi: 10.1186/s13014-019-1339-4. PMID: 31358029Free PMC Article
Mature results of a prospective study of deintensified chemoradiotherapy for low-risk human papillomavirus-associated oropharyngeal squamous cell carcinoma.
Chera BS, Amdur RJ, Tepper JE, Tan X, Weiss J, Grilley-Olson JE, Hayes DN, Zanation A, Hackman TG, Patel S, Sheets N, Weissler MC, Mendenhall WM
Cancer 2018 Jun 1;124(11):2347-2354. Epub 2018 Mar 26 doi: 10.1002/cncr.31338. PMID: 29579339
Neoadjuvant chemotherapy followed by concurrent chemoradiation for locally advanced nasopharyngeal carcinoma.
Kong L, Zhang YW, Hu CS, Guo Y
Chin J Cancer 2010 May;29(5):551-5. doi: 10.5732/cjc.009.10518. PMID: 20426907

Clinical prediction guides

Patient-reported Adverse Events During Neoadjuvant Therapy in a Phase 2 Borderline Resectable Pancreatic Cancer Clinical Trial (Alliance A021501).
Snyder RA, Dueck AC, Fruth B, Shi Q, Hubbard JM, Herman JM, O'Reilly EM, Katz MHG
Ann Surg 2023 Oct 1;278(4):598-608. Epub 2023 Jun 19 doi: 10.1097/SLA.0000000000005958. PMID: 37334719Free PMC Article
Mid-treatment 18F-FDG PET imaging changes in parotid gland correlates to radiation-induced xerostomia.
Trada Y, Lee MT, Jameson MG, Chlap P, Keall P, Moses D, Lin P, Fowler A
Radiother Oncol 2023 Sep;186:109745. Epub 2023 Jun 15 doi: 10.1016/j.radonc.2023.109745. PMID: 37330056
Predicting acute radiation induced xerostomia in head and neck Cancer using MR and CT Radiomics of parotid and submandibular glands.
Sheikh K, Lee SH, Cheng Z, Lakshminarayanan P, Peng L, Han P, McNutt TR, Quon H, Lee J
Radiat Oncol 2019 Jul 29;14(1):131. doi: 10.1186/s13014-019-1339-4. PMID: 31358029Free PMC Article
Radiotherapy for cutaneous head and neck cancer and parotid tumours: a prospective investigation of treatment-related acute swallowing and toxicity patterns.
Moroney LB, Helios J, Ward EC, Crombie J, Burns CL, Yeo SQ, Pelecanos A, Spurgin AL, Blake C, Kenny L, Chua B, Hughes BGM
Support Care Cancer 2019 Feb;27(2):573-581. Epub 2018 Jul 17 doi: 10.1007/s00520-018-4352-5. PMID: 30019149
[(177)Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study.
Hofman MS, Violet J, Hicks RJ, Ferdinandus J, Thang SP, Akhurst T, Iravani A, Kong G, Ravi Kumar A, Murphy DG, Eu P, Jackson P, Scalzo M, Williams SG, Sandhu S
Lancet Oncol 2018 Jun;19(6):825-833. Epub 2018 May 8 doi: 10.1016/S1470-2045(18)30198-0. PMID: 29752180

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