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Grade 3 Rectal Pain, CTCAE

MedGen UID:
1641143
•Concept ID:
C4686475
•
Finding

Definition

Severe pain; limiting self care ADL [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 3 Rectal Pain, CTCAE

Professional guidelines

PubMed

Evaluating the safety of high-intensity focused ultrasound treatment for rectal endometriosis: results from a French prospective multicentre study including 60 patients.
Dubernard G, Maissiat E, Legendre G, Dennis T, Capmas P, Warembourg S, Descamps P, Chavrier F, Roman H, Fernandez H, Nguyen-Ba E, Merlot B, Rousset P, Lafon C, Philip CA
Hum Reprod 2024 Aug 1;39(8):1673-1683. doi: 10.1093/humrep/deae127. PMID: 38914481Free PMC Article

Recent clinical studies

Etiology

Evaluating the safety of high-intensity focused ultrasound treatment for rectal endometriosis: results from a French prospective multicentre study including 60 patients.
Dubernard G, Maissiat E, Legendre G, Dennis T, Capmas P, Warembourg S, Descamps P, Chavrier F, Roman H, Fernandez H, Nguyen-Ba E, Merlot B, Rousset P, Lafon C, Philip CA
Hum Reprod 2024 Aug 1;39(8):1673-1683. doi: 10.1093/humrep/deae127. PMID: 38914481Free PMC Article
Timing of High-Dose-Rate Brachytherapy With External Beam Radiation Therapy in Patients With Intermediate- and High-Risk Localized Prostate Cancer and Its Effects on Toxicity and Quality of Life: A Randomized Controlled Trial (THEPCA).
Choudhury M, Thomas SS, Cain A, Palvai S, Nageshwaran S, Zhang J, Hayden K, Cain A, Hoskin P, Ahmed I
Int J Radiat Oncol Biol Phys 2024 May 1;119(1):90-99. Epub 2023 Dec 30 doi: 10.1016/j.ijrobp.2023.11.011. PMID: 38163520
Prostate hypofractionated radiotherapy (62Gy at 3.1Gy per fraction) with injection of hyaluronic acid: final results of the RPAH1 study.
Chapet O, Udrescu C, Bin S, Decullier E, Fenoglietto P, Beneux A, Segui B, Enachescu C, Gaudioz S, Ruffion A, Azria D
Br J Radiol 2021 Aug 1;94(1124):20210242. doi: 10.1259/bjr.20210242. PMID: 34282946Free PMC Article
Irreversible Electroporation to Treat Malignant Tumor Recurrences Within the Pelvic Cavity: A Case Series.
Vroomen LGPH, Scheffer HJ, Melenhorst MCAM, van Grieken N, van den Tol MP, Meijerink MR
Cardiovasc Intervent Radiol 2017 Oct;40(10):1631-1640. Epub 2017 May 3 doi: 10.1007/s00270-017-1657-6. PMID: 28470395Free PMC Article
Rectal toxicity profile after transperineal interstitial permanent prostate brachytherapy: use of a comprehensive toxicity scoring system and identification of rectal dosimetric toxicity predictors.
Shah JN, Ennis RD
Int J Radiat Oncol Biol Phys 2006 Mar 1;64(3):817-24. Epub 2005 Nov 16 doi: 10.1016/j.ijrobp.2005.08.042. PMID: 16297567

Diagnosis

Quantitative Sensory Testing at Baseline and During Cycle 1 Oxaliplatin Infusion Detects Subclinical Peripheral Neuropathy and Predicts Clinically Overt Chronic Neuropathy in Gastrointestinal Malignancies.
Reddy SM, Vergo MT, Paice JA, Kwon N, Helenowski IB, Benson AB, Mulcahy MF, Nimeiri HS, Harden RN
Clin Colorectal Cancer 2016 Mar;15(1):37-46. Epub 2015 Jul 26 doi: 10.1016/j.clcc.2015.07.001. PMID: 26337211
Rectal toxicity profile after transperineal interstitial permanent prostate brachytherapy: use of a comprehensive toxicity scoring system and identification of rectal dosimetric toxicity predictors.
Shah JN, Ennis RD
Int J Radiat Oncol Biol Phys 2006 Mar 1;64(3):817-24. Epub 2005 Nov 16 doi: 10.1016/j.ijrobp.2005.08.042. PMID: 16297567

Therapy

Evaluating the safety of high-intensity focused ultrasound treatment for rectal endometriosis: results from a French prospective multicentre study including 60 patients.
Dubernard G, Maissiat E, Legendre G, Dennis T, Capmas P, Warembourg S, Descamps P, Chavrier F, Roman H, Fernandez H, Nguyen-Ba E, Merlot B, Rousset P, Lafon C, Philip CA
Hum Reprod 2024 Aug 1;39(8):1673-1683. doi: 10.1093/humrep/deae127. PMID: 38914481Free PMC Article
Timing of High-Dose-Rate Brachytherapy With External Beam Radiation Therapy in Patients With Intermediate- and High-Risk Localized Prostate Cancer and Its Effects on Toxicity and Quality of Life: A Randomized Controlled Trial (THEPCA).
Choudhury M, Thomas SS, Cain A, Palvai S, Nageshwaran S, Zhang J, Hayden K, Cain A, Hoskin P, Ahmed I
Int J Radiat Oncol Biol Phys 2024 May 1;119(1):90-99. Epub 2023 Dec 30 doi: 10.1016/j.ijrobp.2023.11.011. PMID: 38163520
Prostate hypofractionated radiotherapy (62Gy at 3.1Gy per fraction) with injection of hyaluronic acid: final results of the RPAH1 study.
Chapet O, Udrescu C, Bin S, Decullier E, Fenoglietto P, Beneux A, Segui B, Enachescu C, Gaudioz S, Ruffion A, Azria D
Br J Radiol 2021 Aug 1;94(1124):20210242. doi: 10.1259/bjr.20210242. PMID: 34282946Free PMC Article
Quantitative Sensory Testing at Baseline and During Cycle 1 Oxaliplatin Infusion Detects Subclinical Peripheral Neuropathy and Predicts Clinically Overt Chronic Neuropathy in Gastrointestinal Malignancies.
Reddy SM, Vergo MT, Paice JA, Kwon N, Helenowski IB, Benson AB, Mulcahy MF, Nimeiri HS, Harden RN
Clin Colorectal Cancer 2016 Mar;15(1):37-46. Epub 2015 Jul 26 doi: 10.1016/j.clcc.2015.07.001. PMID: 26337211
Rectal toxicity profile after transperineal interstitial permanent prostate brachytherapy: use of a comprehensive toxicity scoring system and identification of rectal dosimetric toxicity predictors.
Shah JN, Ennis RD
Int J Radiat Oncol Biol Phys 2006 Mar 1;64(3):817-24. Epub 2005 Nov 16 doi: 10.1016/j.ijrobp.2005.08.042. PMID: 16297567

Prognosis

Irreversible Electroporation to Treat Malignant Tumor Recurrences Within the Pelvic Cavity: A Case Series.
Vroomen LGPH, Scheffer HJ, Melenhorst MCAM, van Grieken N, van den Tol MP, Meijerink MR
Cardiovasc Intervent Radiol 2017 Oct;40(10):1631-1640. Epub 2017 May 3 doi: 10.1007/s00270-017-1657-6. PMID: 28470395Free PMC Article
Quantitative Sensory Testing at Baseline and During Cycle 1 Oxaliplatin Infusion Detects Subclinical Peripheral Neuropathy and Predicts Clinically Overt Chronic Neuropathy in Gastrointestinal Malignancies.
Reddy SM, Vergo MT, Paice JA, Kwon N, Helenowski IB, Benson AB, Mulcahy MF, Nimeiri HS, Harden RN
Clin Colorectal Cancer 2016 Mar;15(1):37-46. Epub 2015 Jul 26 doi: 10.1016/j.clcc.2015.07.001. PMID: 26337211
Rectal toxicity profile after transperineal interstitial permanent prostate brachytherapy: use of a comprehensive toxicity scoring system and identification of rectal dosimetric toxicity predictors.
Shah JN, Ennis RD
Int J Radiat Oncol Biol Phys 2006 Mar 1;64(3):817-24. Epub 2005 Nov 16 doi: 10.1016/j.ijrobp.2005.08.042. PMID: 16297567

Clinical prediction guides

Timing of High-Dose-Rate Brachytherapy With External Beam Radiation Therapy in Patients With Intermediate- and High-Risk Localized Prostate Cancer and Its Effects on Toxicity and Quality of Life: A Randomized Controlled Trial (THEPCA).
Choudhury M, Thomas SS, Cain A, Palvai S, Nageshwaran S, Zhang J, Hayden K, Cain A, Hoskin P, Ahmed I
Int J Radiat Oncol Biol Phys 2024 May 1;119(1):90-99. Epub 2023 Dec 30 doi: 10.1016/j.ijrobp.2023.11.011. PMID: 38163520
Prostate hypofractionated radiotherapy (62Gy at 3.1Gy per fraction) with injection of hyaluronic acid: final results of the RPAH1 study.
Chapet O, Udrescu C, Bin S, Decullier E, Fenoglietto P, Beneux A, Segui B, Enachescu C, Gaudioz S, Ruffion A, Azria D
Br J Radiol 2021 Aug 1;94(1124):20210242. doi: 10.1259/bjr.20210242. PMID: 34282946Free PMC Article
Irreversible Electroporation to Treat Malignant Tumor Recurrences Within the Pelvic Cavity: A Case Series.
Vroomen LGPH, Scheffer HJ, Melenhorst MCAM, van Grieken N, van den Tol MP, Meijerink MR
Cardiovasc Intervent Radiol 2017 Oct;40(10):1631-1640. Epub 2017 May 3 doi: 10.1007/s00270-017-1657-6. PMID: 28470395Free PMC Article
Quantitative Sensory Testing at Baseline and During Cycle 1 Oxaliplatin Infusion Detects Subclinical Peripheral Neuropathy and Predicts Clinically Overt Chronic Neuropathy in Gastrointestinal Malignancies.
Reddy SM, Vergo MT, Paice JA, Kwon N, Helenowski IB, Benson AB, Mulcahy MF, Nimeiri HS, Harden RN
Clin Colorectal Cancer 2016 Mar;15(1):37-46. Epub 2015 Jul 26 doi: 10.1016/j.clcc.2015.07.001. PMID: 26337211
Rectal toxicity profile after transperineal interstitial permanent prostate brachytherapy: use of a comprehensive toxicity scoring system and identification of rectal dosimetric toxicity predictors.
Shah JN, Ennis RD
Int J Radiat Oncol Biol Phys 2006 Mar 1;64(3):817-24. Epub 2005 Nov 16 doi: 10.1016/j.ijrobp.2005.08.042. PMID: 16297567

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