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Refractory Malignant Thymoma

MedGen UID:
1644175
Concept ID:
C4688372
Neoplastic Process

Definition

Malignant thymoma that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Malignant Thymoma

Professional guidelines

PubMed

Tannemaat MR, Huijbers MG, Verschuuren JJGM
Handb Clin Neurol 2024;200:283-305. doi: 10.1016/B978-0-12-823912-4.00026-8. PMID: 38494283
Merveilleux du Vignaux C, Maury JM, Girard N
Curr Treat Options Oncol 2017 Aug 10;18(9):52. doi: 10.1007/s11864-017-0495-8. PMID: 28795288
Tüzün E, Dalmau J
Neurologist 2007 Sep;13(5):261-71. doi: 10.1097/NRL.0b013e31813e34a5. PMID: 17848866

Recent clinical studies

Etiology

Piehl F, Eriksson-Dufva A, Budzianowska A, Feresiadou A, Hansson W, Hietala MA, Håkansson I, Johansson R, Jons D, Kmezic I, Lindberg C, Lindh J, Lundin F, Nygren I, Punga AR, Press R, Samuelsson K, Sundström P, Wickberg O, Brauner S, Frisell T
JAMA Neurol 2022 Nov 1;79(11):1105-1112. doi: 10.1001/jamaneurol.2022.2887. PMID: 36121672Free PMC Article
Álvarez-Velasco R, Gutiérrez-Gutiérrez G, Trujillo JC, Martínez E, Segovia S, Arribas-Velasco M, Fernández G, Paradas C, Vélez-Gómez B, Casasnovas C, Nedkova V, Guerrero-Sola A, Ramos-Fransi A, Martínez-Piñeiro A, Pardo J, Sevilla T, Gómez-Caravaca MT, López de Munain A, Jericó I, Pelayo-Negro AL, Martín MA, Morgado Y, Mendoza MD, Pérez-Pérez H, Rojas-García R, Turon-Sans J, Querol L, Gallardo E, Illa I, Cortés-Vicente E
Eur J Neurol 2021 Jun;28(6):2083-2091. Epub 2021 Mar 30 doi: 10.1111/ene.14820. PMID: 33721382
Cortés-Vicente E, Álvarez-Velasco R, Segovia S, Paradas C, Casasnovas C, Guerrero-Sola A, Pardo J, Ramos-Fransi A, Sevilla T, López de Munain A, Gómez MT, Jericó I, Gutiérrez-Gutiérrez G, Pelayo-Negro AL, Martín MA, Mendoza MD, Morís G, Rojas-Garcia R, Díaz-Manera J, Querol L, Gallardo E, Vélez B, Albertí MA, Galán L, García-Sobrino T, Martínez-Piñeiro A, Lozano-Veintimilla A, Fernández-Torrón R, Cano-Abascal Á, Illa I
Neurology 2020 Mar 17;94(11):e1171-e1180. Epub 2020 Feb 18 doi: 10.1212/WNL.0000000000008903. PMID: 32071167Free PMC Article
Lippner EA, Lewis DB, Robinson WH, Katsumoto TR
Curr Treat Options Oncol 2019 Jun 22;20(7):62. doi: 10.1007/s11864-019-0661-2. PMID: 31227926
Howard JF Jr, Utsugisawa K, Benatar M, Murai H, Barohn RJ, Illa I, Jacob S, Vissing J, Burns TM, Kissel JT, Muppidi S, Nowak RJ, O'Brien F, Wang JJ, Mantegazza R; REGAIN Study Group
Lancet Neurol 2017 Dec;16(12):976-986. Epub 2017 Oct 20 doi: 10.1016/S1474-4422(17)30369-1. PMID: 29066163

Diagnosis

Tannemaat MR, Huijbers MG, Verschuuren JJGM
Handb Clin Neurol 2024;200:283-305. doi: 10.1016/B978-0-12-823912-4.00026-8. PMID: 38494283
Lippner EA, Lewis DB, Robinson WH, Katsumoto TR
Curr Treat Options Oncol 2019 Jun 22;20(7):62. doi: 10.1007/s11864-019-0661-2. PMID: 31227926
Howard JF Jr, Utsugisawa K, Benatar M, Murai H, Barohn RJ, Illa I, Jacob S, Vissing J, Burns TM, Kissel JT, Muppidi S, Nowak RJ, O'Brien F, Wang JJ, Mantegazza R; REGAIN Study Group
Lancet Neurol 2017 Dec;16(12):976-986. Epub 2017 Oct 20 doi: 10.1016/S1474-4422(17)30369-1. PMID: 29066163
Merveilleux du Vignaux C, Maury JM, Girard N
Curr Treat Options Oncol 2017 Aug 10;18(9):52. doi: 10.1007/s11864-017-0495-8. PMID: 28795288
Tüzün E, Dalmau J
Neurologist 2007 Sep;13(5):261-71. doi: 10.1097/NRL.0b013e31813e34a5. PMID: 17848866

Therapy

Piehl F, Eriksson-Dufva A, Budzianowska A, Feresiadou A, Hansson W, Hietala MA, Håkansson I, Johansson R, Jons D, Kmezic I, Lindberg C, Lindh J, Lundin F, Nygren I, Punga AR, Press R, Samuelsson K, Sundström P, Wickberg O, Brauner S, Frisell T
JAMA Neurol 2022 Nov 1;79(11):1105-1112. doi: 10.1001/jamaneurol.2022.2887. PMID: 36121672Free PMC Article
Girard N
Curr Opin Oncol 2019 Sep;31(5):454-460. doi: 10.1097/CCO.0000000000000564. PMID: 31394557
Chen F, Zou Z, Du J, Su S, Shao J, Meng F, Yang J, Xu Q, Ding N, Yang Y, Liu Q, Wang Q, Sun Z, Zhou S, Du S, Wei J, Liu B
J Clin Invest 2019 May 1;129(5):2056-2070. Epub 2019 Mar 5 doi: 10.1172/JCI99538. PMID: 30835255Free PMC Article
Howard JF Jr, Utsugisawa K, Benatar M, Murai H, Barohn RJ, Illa I, Jacob S, Vissing J, Burns TM, Kissel JT, Muppidi S, Nowak RJ, O'Brien F, Wang JJ, Mantegazza R; REGAIN Study Group
Lancet Neurol 2017 Dec;16(12):976-986. Epub 2017 Oct 20 doi: 10.1016/S1474-4422(17)30369-1. PMID: 29066163
Merveilleux du Vignaux C, Maury JM, Girard N
Curr Treat Options Oncol 2017 Aug 10;18(9):52. doi: 10.1007/s11864-017-0495-8. PMID: 28795288

Prognosis

Uzawa A, Suzuki S, Kuwabara S, Akamine H, Onishi Y, Yasuda M, Ozawa Y, Kawaguchi N, Kubota T, Takahashi MP, Suzuki Y, Watanabe G, Kimura T, Sugimoto T, Samukawa M, Minami N, Masuda M, Konno S, Nagane Y, Utsugisawa K
BMC Neurol 2024 Apr 25;24(1):139. doi: 10.1186/s12883-024-03644-w. PMID: 38664714Free PMC Article
Mizrahi N, Kugler E, Hayman L, Yeshurun M, Grossman A, Raanani P, Wolach O
Acta Haematol 2022;145(1):106-111. Epub 2021 Sep 17 doi: 10.1159/000519033. PMID: 34537764
Álvarez-Velasco R, Gutiérrez-Gutiérrez G, Trujillo JC, Martínez E, Segovia S, Arribas-Velasco M, Fernández G, Paradas C, Vélez-Gómez B, Casasnovas C, Nedkova V, Guerrero-Sola A, Ramos-Fransi A, Martínez-Piñeiro A, Pardo J, Sevilla T, Gómez-Caravaca MT, López de Munain A, Jericó I, Pelayo-Negro AL, Martín MA, Morgado Y, Mendoza MD, Pérez-Pérez H, Rojas-García R, Turon-Sans J, Querol L, Gallardo E, Illa I, Cortés-Vicente E
Eur J Neurol 2021 Jun;28(6):2083-2091. Epub 2021 Mar 30 doi: 10.1111/ene.14820. PMID: 33721382
Chen F, Zou Z, Du J, Su S, Shao J, Meng F, Yang J, Xu Q, Ding N, Yang Y, Liu Q, Wang Q, Sun Z, Zhou S, Du S, Wei J, Liu B
J Clin Invest 2019 May 1;129(5):2056-2070. Epub 2019 Mar 5 doi: 10.1172/JCI99538. PMID: 30835255Free PMC Article
Thomas A, Rajan A, Berman A, Tomita Y, Brzezniak C, Lee MJ, Lee S, Ling A, Spittler AJ, Carter CA, Guha U, Wang Y, Szabo E, Meltzer P, Steinberg SM, Trepel JB, Loehrer PJ, Giaccone G
Lancet Oncol 2015 Feb;16(2):177-86. Epub 2015 Jan 13 doi: 10.1016/S1470-2045(14)71181-7. PMID: 25592632Free PMC Article

Clinical prediction guides

Uzawa A, Suzuki S, Kuwabara S, Akamine H, Onishi Y, Yasuda M, Ozawa Y, Kawaguchi N, Kubota T, Takahashi MP, Suzuki Y, Watanabe G, Kimura T, Sugimoto T, Samukawa M, Minami N, Masuda M, Konno S, Nagane Y, Utsugisawa K
BMC Neurol 2024 Apr 25;24(1):139. doi: 10.1186/s12883-024-03644-w. PMID: 38664714Free PMC Article
Tannemaat MR, Huijbers MG, Verschuuren JJGM
Handb Clin Neurol 2024;200:283-305. doi: 10.1016/B978-0-12-823912-4.00026-8. PMID: 38494283
Piehl F, Eriksson-Dufva A, Budzianowska A, Feresiadou A, Hansson W, Hietala MA, Håkansson I, Johansson R, Jons D, Kmezic I, Lindberg C, Lindh J, Lundin F, Nygren I, Punga AR, Press R, Samuelsson K, Sundström P, Wickberg O, Brauner S, Frisell T
JAMA Neurol 2022 Nov 1;79(11):1105-1112. doi: 10.1001/jamaneurol.2022.2887. PMID: 36121672Free PMC Article
Chen F, Zou Z, Du J, Su S, Shao J, Meng F, Yang J, Xu Q, Ding N, Yang Y, Liu Q, Wang Q, Sun Z, Zhou S, Du S, Wei J, Liu B
J Clin Invest 2019 May 1;129(5):2056-2070. Epub 2019 Mar 5 doi: 10.1172/JCI99538. PMID: 30835255Free PMC Article
Howard JF Jr, Utsugisawa K, Benatar M, Murai H, Barohn RJ, Illa I, Jacob S, Vissing J, Burns TM, Kissel JT, Muppidi S, Nowak RJ, O'Brien F, Wang JJ, Mantegazza R; REGAIN Study Group
Lancet Neurol 2017 Dec;16(12):976-986. Epub 2017 Oct 20 doi: 10.1016/S1474-4422(17)30369-1. PMID: 29066163

Recent systematic reviews

Arunachalam A, Zhang I, Zhao B, Frederickson AM, Catherine Pietanza M
Lung Cancer 2023 Feb;176:132-139. Epub 2023 Jan 2 doi: 10.1016/j.lungcan.2023.01.003. PMID: 36638588
Boyko M, Au KLK, Casault C, de Robles P, Pfeffer G
J Neurol 2020 Apr;267(4):1137-1146. Epub 2020 Jan 7 doi: 10.1007/s00415-019-09686-2. PMID: 31912210

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