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Grade 3 Gastric Hemorrhage, CTCAE

MedGen UID:
1646031
•Concept ID:
C4686225
•
Finding

Definition

Transfusion indicated; invasive intervention indicated; hospitalization [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 3 Gastric Hemorrhage, CTCAE

Professional guidelines

PubMed

Correlation analyses between pre- and post-operative adverse events in gastric cancer patients receiving preoperative treatment and gastrectomy.
Li SX, Seo SH, Choi YY, Nakagawa M, An JY, Kim HI, Cheong JH, Hyung WJ, Noh SH
BMC Cancer 2016 Jan 19;16:29. doi: 10.1186/s12885-016-2066-y. PMID: 26786480Free PMC Article

Recent clinical studies

Etiology

Preoperative chemoradiation-induced hematological toxicity and related vertebral dosimetry evaluations in patients with locally advanced gastric cancer: data from a phase III clinical trial.
Wang JJ, Shao H, Zhang L, Jing M, Xu WJ, Sun HW, Zhou ZW, Zhang YJ
Radiat Oncol 2023 Jun 9;18(1):100. doi: 10.1186/s13014-023-02269-6. PMID: 37365597Free PMC Article
Safety and efficacy of S-1 plus oxaliplatin 130 mg/m(2) combination therapy in patients with previously untreated HER2-negative unresectable, advanced, or recurrent gastric/gastroesophageal junction cancer: a phase II trial (KSCC1501A).
Kashiwada T, Shinozaki K, Ueno S, Kawanaka H, Uno F, Okita Y, Fukahori M, Matsushita H, Emi Y, Shimokawa M, Makiyama A, Saeki H, Oki E, Maehara Y, Mori M, Baba E; Kyushu Study Group of Clinical Cancer (KSCC)
Int J Clin Oncol 2021 Feb;26(2):345-354. Epub 2020 Oct 21 doi: 10.1007/s10147-020-01803-w. PMID: 33085058
Influence of pretreatment with everolimus or sunitinib on the subacute hematotoxicity of (177)Lu-DOTATATE PRRT.
Medaer E, Verslype C, Van Cutsem E, Dekervel J, Clement PM, Nackaerts K, Laenen A, Gheysens O, Goffin K, Jentjens S, Van Laere K, Deroose CM
Acta Oncol 2020 Jun;59(6):644-651. Epub 2020 Feb 8 doi: 10.1080/0284186X.2020.1723161. PMID: 32036716
Dose-Volume Histogram Analysis of Stereotactic Body Radiotherapy Treatment of Pancreatic Cancer: A Focus on Duodenal Dose Constraints.
Goldsmith C, Price P, Cross T, Loughlin S, Cowley I, Plowman N
Semin Radiat Oncol 2016 Apr;26(2):149-56. Epub 2015 Dec 24 doi: 10.1016/j.semradonc.2015.12.002. PMID: 27000512
Correlation analyses between pre- and post-operative adverse events in gastric cancer patients receiving preoperative treatment and gastrectomy.
Li SX, Seo SH, Choi YY, Nakagawa M, An JY, Kim HI, Cheong JH, Hyung WJ, Noh SH
BMC Cancer 2016 Jan 19;16:29. doi: 10.1186/s12885-016-2066-y. PMID: 26786480Free PMC Article

Diagnosis

Adjuvant Treatment with S-1 in Patients after R0-Resection of Adenocarcinoma of the Stomach and Esophagogastric Junction: A Multicenter Phase I/II Feasibility Study (GMBH-STO-0114).
Heinrich K, Heinemann V, Stintzing S, Müller L, Ettrich TJ, Büchner-Steudel P, Geißler M, Trojan J, Moosmann N, Folprecht G, Schmidt J, Kanzler S, Kullmann F, Moulin JC, Werner J, Angele MK, Probst V, Held S, Schulz C, Boukovala M
Oncol Res Treat 2024;47(6):251-261. Epub 2024 Apr 2 doi: 10.1159/000538143. PMID: 38565089Free PMC Article
Gastroduodenal complications after concurrent chemoradiation therapy in patients with hepatocellular carcinoma: endoscopic findings and risk factors.
Chon YE, Seong J, Kim BK, Cha J, Kim SU, Park JY, Ahn SH, Han KH, Chon CY, Shin SK, Kim DY
Int J Radiat Oncol Biol Phys 2011 Dec 1;81(5):1343-51. Epub 2010 Oct 8 doi: 10.1016/j.ijrobp.2010.07.1986. PMID: 20934268

Therapy

Safety and efficacy of S-1 plus oxaliplatin 130 mg/m(2) combination therapy in patients with previously untreated HER2-negative unresectable, advanced, or recurrent gastric/gastroesophageal junction cancer: a phase II trial (KSCC1501A).
Kashiwada T, Shinozaki K, Ueno S, Kawanaka H, Uno F, Okita Y, Fukahori M, Matsushita H, Emi Y, Shimokawa M, Makiyama A, Saeki H, Oki E, Maehara Y, Mori M, Baba E; Kyushu Study Group of Clinical Cancer (KSCC)
Int J Clin Oncol 2021 Feb;26(2):345-354. Epub 2020 Oct 21 doi: 10.1007/s10147-020-01803-w. PMID: 33085058
Yttrium-90 radioembolization using MIRD dosimetry with resin microspheres.
Sarwar A, Kudla A, Weinstein JL, Ali A, Malik R, Bullock A, Khwaja KO, Curry M, Faintuch S, Ahmed M
Eur Radiol 2021 Mar;31(3):1316-1324. Epub 2020 Sep 8 doi: 10.1007/s00330-020-07231-8. PMID: 32901301
Influence of pretreatment with everolimus or sunitinib on the subacute hematotoxicity of (177)Lu-DOTATATE PRRT.
Medaer E, Verslype C, Van Cutsem E, Dekervel J, Clement PM, Nackaerts K, Laenen A, Gheysens O, Goffin K, Jentjens S, Van Laere K, Deroose CM
Acta Oncol 2020 Jun;59(6):644-651. Epub 2020 Feb 8 doi: 10.1080/0284186X.2020.1723161. PMID: 32036716
Bariatric Embolization of the Left Gastric Arteries for the Treatment of Obesity: 9-Month Data in 5 Patients.
Bai ZB, Qin YL, Deng G, Zhao GF, Zhong BY, Teng GJ
Obes Surg 2018 Apr;28(4):907-915. doi: 10.1007/s11695-017-2979-9. PMID: 29063494
Correlation analyses between pre- and post-operative adverse events in gastric cancer patients receiving preoperative treatment and gastrectomy.
Li SX, Seo SH, Choi YY, Nakagawa M, An JY, Kim HI, Cheong JH, Hyung WJ, Noh SH
BMC Cancer 2016 Jan 19;16:29. doi: 10.1186/s12885-016-2066-y. PMID: 26786480Free PMC Article

Prognosis

Phase I/II clinical trial of efficacy and safety of EGCG oxygen nebulization inhalation in the treatment of COVID-19 pneumonia patients with cancer.
Yin X, Zhu W, Tang X, Yang G, Zhao X, Zhao K, Jiang L, Li X, Zhao H, Wang X, Yan Y, Xing L, Yu J, Meng X, Zhao H
BMC Cancer 2024 Apr 17;24(1):486. doi: 10.1186/s12885-024-12228-3. PMID: 38632501Free PMC Article
Preoperative chemoradiation-induced hematological toxicity and related vertebral dosimetry evaluations in patients with locally advanced gastric cancer: data from a phase III clinical trial.
Wang JJ, Shao H, Zhang L, Jing M, Xu WJ, Sun HW, Zhou ZW, Zhang YJ
Radiat Oncol 2023 Jun 9;18(1):100. doi: 10.1186/s13014-023-02269-6. PMID: 37365597Free PMC Article
Effect of neoadjuvant chemotherapy combined with arterial chemoembolization on short-term clinical outcome of locally advanced gastric cancer.
Yang J, Li J, Deng Q, Chen Z, He K, Chen Y, Fu Z
BMC Cancer 2023 Mar 14;23(1):246. doi: 10.1186/s12885-023-10712-w. PMID: 36918834Free PMC Article
Multicenter phase II study of SOX plus trastuzumab for patients with HER2(+) metastatic or recurrent gastric cancer: KSCC/HGCSG/CCOG/PerSeUS 1501B.
Yuki S, Shinozaki K, Kashiwada T, Kusumoto T, Iwatsuki M, Satake H, Kobayashi K, Esaki T, Nakashima Y, Kawanaka H, Emi Y, Komatsu Y, Shimokawa M, Makiyama A, Saeki H, Oki E, Baba H, Mori M
Cancer Chemother Pharmacol 2020 Jan;85(1):217-223. Epub 2019 Nov 25 doi: 10.1007/s00280-019-03991-3. PMID: 31768696
Single-arm confirmatory trial of laparoscopy-assisted total or proximal gastrectomy with nodal dissection for clinical stage I gastric cancer: Japan Clinical Oncology Group study JCOG1401.
Katai H, Mizusawa J, Katayama H, Kunisaki C, Sakuramoto S, Inaki N, Kinoshita T, Iwasaki Y, Misawa K, Takiguchi N, Kaji M, Okitsu H, Yoshikawa T, Terashima M; Stomach Cancer Study Group of Japan Clinical Oncology Group
Gastric Cancer 2019 Sep;22(5):999-1008. Epub 2019 Feb 20 doi: 10.1007/s10120-019-00929-9. PMID: 30788750

Clinical prediction guides

Preoperative chemoradiation-induced hematological toxicity and related vertebral dosimetry evaluations in patients with locally advanced gastric cancer: data from a phase III clinical trial.
Wang JJ, Shao H, Zhang L, Jing M, Xu WJ, Sun HW, Zhou ZW, Zhang YJ
Radiat Oncol 2023 Jun 9;18(1):100. doi: 10.1186/s13014-023-02269-6. PMID: 37365597Free PMC Article
Effect of neoadjuvant chemotherapy combined with arterial chemoembolization on short-term clinical outcome of locally advanced gastric cancer.
Yang J, Li J, Deng Q, Chen Z, He K, Chen Y, Fu Z
BMC Cancer 2023 Mar 14;23(1):246. doi: 10.1186/s12885-023-10712-w. PMID: 36918834Free PMC Article
Influence of pretreatment with everolimus or sunitinib on the subacute hematotoxicity of (177)Lu-DOTATATE PRRT.
Medaer E, Verslype C, Van Cutsem E, Dekervel J, Clement PM, Nackaerts K, Laenen A, Gheysens O, Goffin K, Jentjens S, Van Laere K, Deroose CM
Acta Oncol 2020 Jun;59(6):644-651. Epub 2020 Feb 8 doi: 10.1080/0284186X.2020.1723161. PMID: 32036716
Gastroduodenal complications after concurrent chemoradiation therapy in patients with hepatocellular carcinoma: endoscopic findings and risk factors.
Chon YE, Seong J, Kim BK, Cha J, Kim SU, Park JY, Ahn SH, Han KH, Chon CY, Shin SK, Kim DY
Int J Radiat Oncol Biol Phys 2011 Dec 1;81(5):1343-51. Epub 2010 Oct 8 doi: 10.1016/j.ijrobp.2010.07.1986. PMID: 20934268
Multicentre phase II pharmacokinetic and pharmacodynamic study of OSI-7904L in previously untreated patients with advanced gastric or gastroesophageal junction adenocarcinoma.
Falk S, Anthoney A, Eatock M, Van Cutsem E, Chick J, Glen H, Valle JW, Drolet DW, Albert D, Ferry D, Ajani J
Br J Cancer 2006 Aug 21;95(4):450-6. Epub 2006 Aug 1 doi: 10.1038/sj.bjc.6603267. PMID: 16880795Free PMC Article

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