U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Grade 2 Alanine Aminotransferase Increased, CTCAE

MedGen UID:
1647234
•Concept ID:
C4685494
•
Finding

Definition

>3.0-5.0 x ULN if baseline was normal; >3.0-5.0 x baseline if baseline was abnormal [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 2 Alanine Aminotransferase Increased, CTCAE

Professional guidelines

PubMed

Hepatic Arterial Infusion Chemotherapy with Modified FOLFOX as an Alternative Treatment Option in Advanced Hepatocellular Carcinoma Patients with Failed or Unsuitability for Transarterial Chemoembolization.
Hsu SJ, Xu X, Chen MP, Zhao ZY, Wang Y, Yin X, Zhang L, Ge NL, Chen Y, Wang YH, Luo JF, Ren ZG, Chen RX
Acad Radiol 2021 Nov;28 Suppl 1:S157-S166. Epub 2021 Feb 27 doi: 10.1016/j.acra.2021.01.024. PMID: 33653656
Toward consensus reporting of radiation-induced liver toxicity in the treatment of primary liver malignancies: Defining clinically relevant endpoints.
Chapman TR, Bowen SR, Schaub SK, Yeung RH, Kwan SW, Park JO, Yu L, Harris WP, Johnson GE, Liou IW, Nyflot MJ, Apisarnthanarax S
Pract Radiat Oncol 2018 May-Jun;8(3):157-166. Epub 2017 Nov 4 doi: 10.1016/j.prro.2017.10.013. PMID: 29426691
Transarterial chemoembolization with cisplatin as second-line treatment for hepatocellular carcinoma unresponsive to chemoembolization with epirubicin-Lipiodol emulsion.
Maeda N, Osuga K, Higashihara H, Tomoda K, Mikami K, Nakazawa T, Nakamura H, Tomiyama N
Cardiovasc Intervent Radiol 2012 Feb;35(1):82-9. Epub 2011 Jan 4 doi: 10.1007/s00270-010-0086-6. PMID: 21203761

Recent clinical studies

Etiology

Elevated posaconazole trough concentrations are not associated with increased risk for posaconazole toxicity in lung transplant recipients.
Sabatino DC, Lange NW, Salerno DM, Scheffert J
Clin Transplant 2023 Jan;37(1):e14826. Epub 2022 Oct 26 doi: 10.1111/ctr.14826. PMID: 36205935
Hepatic safety and tolerability of cipargamin (KAE609), in adult patients with Plasmodium falciparum malaria: a randomized, phase II, controlled, dose-escalation trial in sub-Saharan Africa.
Ndayisaba G, Yeka A, Asante KP, Grobusch MP, Karita E, Mugerwa H, Asiimwe S, Oduro A, Fofana B, Doumbia S, Jain JP, Barsainya S, Kullak-Ublick GA, Su G, Schmitt EK, Csermak K, Gandhi P, Hughes D
Malar J 2021 Dec 20;20(1):478. doi: 10.1186/s12936-021-04009-1. PMID: 34930267Free PMC Article
Hepatic Arterial Infusion Chemotherapy with Modified FOLFOX as an Alternative Treatment Option in Advanced Hepatocellular Carcinoma Patients with Failed or Unsuitability for Transarterial Chemoembolization.
Hsu SJ, Xu X, Chen MP, Zhao ZY, Wang Y, Yin X, Zhang L, Ge NL, Chen Y, Wang YH, Luo JF, Ren ZG, Chen RX
Acad Radiol 2021 Nov;28 Suppl 1:S157-S166. Epub 2021 Feb 27 doi: 10.1016/j.acra.2021.01.024. PMID: 33653656
Low body surface area predicts hepatotoxicity of nintedanib in patients with idiopathic pulmonary fibrosis.
Ikeda S, Sekine A, Baba T, Yamanaka Y, Sadoyama S, Yamakawa H, Oda T, Okuda R, Kitamura H, Okudela K, Iwasawa T, Ohashi K, Takemura T, Ogura T
Sci Rep 2017 Sep 7;7(1):10811. doi: 10.1038/s41598-017-11321-x. PMID: 28883482Free PMC Article
Transarterial chemoembolization with cisplatin as second-line treatment for hepatocellular carcinoma unresponsive to chemoembolization with epirubicin-Lipiodol emulsion.
Maeda N, Osuga K, Higashihara H, Tomoda K, Mikami K, Nakazawa T, Nakamura H, Tomiyama N
Cardiovasc Intervent Radiol 2012 Feb;35(1):82-9. Epub 2011 Jan 4 doi: 10.1007/s00270-010-0086-6. PMID: 21203761

Therapy

Pooled Safety Analysis of Single-Agent Lurbinectedin in Patients With Advanced Solid Tumours.
Leary A, Oaknin A, Trigo JM, Moreno V, Delord JP, Boni V, Braña I, Fernández C, Kahatt C, Nieto A, Cullell-Young M, Zeaiter A, Subbiah V
Eur J Cancer 2023 Oct;192:113259. Epub 2023 Jul 28 doi: 10.1016/j.ejca.2023.113259. PMID: 37634282
Hepatic Arterial Infusion Chemotherapy with Modified FOLFOX as an Alternative Treatment Option in Advanced Hepatocellular Carcinoma Patients with Failed or Unsuitability for Transarterial Chemoembolization.
Hsu SJ, Xu X, Chen MP, Zhao ZY, Wang Y, Yin X, Zhang L, Ge NL, Chen Y, Wang YH, Luo JF, Ren ZG, Chen RX
Acad Radiol 2021 Nov;28 Suppl 1:S157-S166. Epub 2021 Feb 27 doi: 10.1016/j.acra.2021.01.024. PMID: 33653656
Adjuvant Trastuzumab Emtansine (T-DM1) and Concurrent Radiotherapy for Residual Invasive HER2-positive Breast Cancer: Single-center Preliminary Results.
Zolcsák Z, Loirat D, Fourquet A, Kirova YM
Am J Clin Oncol 2020 Dec 1;43(12):895-901. doi: 10.1097/COC.0000000000000769. PMID: 33027084
Safety and efficacy of anti-PD-1 therapy for metastatic melanoma and non-small-cell lung cancer in patients with viral hepatitis: a case series.
Kothapalli A, Khattak MA
Melanoma Res 2018 Apr;28(2):155-158. doi: 10.1097/CMR.0000000000000434. PMID: 29406396
Low body surface area predicts hepatotoxicity of nintedanib in patients with idiopathic pulmonary fibrosis.
Ikeda S, Sekine A, Baba T, Yamanaka Y, Sadoyama S, Yamakawa H, Oda T, Okuda R, Kitamura H, Okudela K, Iwasawa T, Ohashi K, Takemura T, Ogura T
Sci Rep 2017 Sep 7;7(1):10811. doi: 10.1038/s41598-017-11321-x. PMID: 28883482Free PMC Article

Prognosis

Rates of laboratory adverse events by course in paediatric leukaemia ascertained with automated electronic health record extraction: a retrospective cohort study from the Children's Oncology Group.
Miller TP, Getz KD, Li Y, Demissei BG, Adamson PC, Alonzo TA, Burrows E, Cao L, Castellino SM, Daves MH, Fisher BT, Gerbing R, Grundmeier RW, Krause EM, Lee J, Lupo PJ, Rabin KR, Ramos M, Scheurer ME, Wilkes JJ, Winestone LE, Hawkins DS, Gramatges MM, Aplenc R
Lancet Haematol 2022 Sep;9(9):e678-e688. Epub 2022 Jul 20 doi: 10.1016/S2352-3026(22)00168-5. PMID: 35870472Free PMC Article
Hepatic Arterial Infusion Chemotherapy with Modified FOLFOX as an Alternative Treatment Option in Advanced Hepatocellular Carcinoma Patients with Failed or Unsuitability for Transarterial Chemoembolization.
Hsu SJ, Xu X, Chen MP, Zhao ZY, Wang Y, Yin X, Zhang L, Ge NL, Chen Y, Wang YH, Luo JF, Ren ZG, Chen RX
Acad Radiol 2021 Nov;28 Suppl 1:S157-S166. Epub 2021 Feb 27 doi: 10.1016/j.acra.2021.01.024. PMID: 33653656
Toward consensus reporting of radiation-induced liver toxicity in the treatment of primary liver malignancies: Defining clinically relevant endpoints.
Chapman TR, Bowen SR, Schaub SK, Yeung RH, Kwan SW, Park JO, Yu L, Harris WP, Johnson GE, Liou IW, Nyflot MJ, Apisarnthanarax S
Pract Radiat Oncol 2018 May-Jun;8(3):157-166. Epub 2017 Nov 4 doi: 10.1016/j.prro.2017.10.013. PMID: 29426691
Low body surface area predicts hepatotoxicity of nintedanib in patients with idiopathic pulmonary fibrosis.
Ikeda S, Sekine A, Baba T, Yamanaka Y, Sadoyama S, Yamakawa H, Oda T, Okuda R, Kitamura H, Okudela K, Iwasawa T, Ohashi K, Takemura T, Ogura T
Sci Rep 2017 Sep 7;7(1):10811. doi: 10.1038/s41598-017-11321-x. PMID: 28883482Free PMC Article
Transarterial chemoembolization with cisplatin as second-line treatment for hepatocellular carcinoma unresponsive to chemoembolization with epirubicin-Lipiodol emulsion.
Maeda N, Osuga K, Higashihara H, Tomoda K, Mikami K, Nakazawa T, Nakamura H, Tomiyama N
Cardiovasc Intervent Radiol 2012 Feb;35(1):82-9. Epub 2011 Jan 4 doi: 10.1007/s00270-010-0086-6. PMID: 21203761

Clinical prediction guides

Elevated posaconazole trough concentrations are not associated with increased risk for posaconazole toxicity in lung transplant recipients.
Sabatino DC, Lange NW, Salerno DM, Scheffert J
Clin Transplant 2023 Jan;37(1):e14826. Epub 2022 Oct 26 doi: 10.1111/ctr.14826. PMID: 36205935
Hepatic safety and tolerability of cipargamin (KAE609), in adult patients with Plasmodium falciparum malaria: a randomized, phase II, controlled, dose-escalation trial in sub-Saharan Africa.
Ndayisaba G, Yeka A, Asante KP, Grobusch MP, Karita E, Mugerwa H, Asiimwe S, Oduro A, Fofana B, Doumbia S, Jain JP, Barsainya S, Kullak-Ublick GA, Su G, Schmitt EK, Csermak K, Gandhi P, Hughes D
Malar J 2021 Dec 20;20(1):478. doi: 10.1186/s12936-021-04009-1. PMID: 34930267Free PMC Article
Hepatic Arterial Infusion Chemotherapy with Modified FOLFOX as an Alternative Treatment Option in Advanced Hepatocellular Carcinoma Patients with Failed or Unsuitability for Transarterial Chemoembolization.
Hsu SJ, Xu X, Chen MP, Zhao ZY, Wang Y, Yin X, Zhang L, Ge NL, Chen Y, Wang YH, Luo JF, Ren ZG, Chen RX
Acad Radiol 2021 Nov;28 Suppl 1:S157-S166. Epub 2021 Feb 27 doi: 10.1016/j.acra.2021.01.024. PMID: 33653656
Low body surface area predicts hepatotoxicity of nintedanib in patients with idiopathic pulmonary fibrosis.
Ikeda S, Sekine A, Baba T, Yamanaka Y, Sadoyama S, Yamakawa H, Oda T, Okuda R, Kitamura H, Okudela K, Iwasawa T, Ohashi K, Takemura T, Ogura T
Sci Rep 2017 Sep 7;7(1):10811. doi: 10.1038/s41598-017-11321-x. PMID: 28883482Free PMC Article
Transarterial chemoembolization with cisplatin as second-line treatment for hepatocellular carcinoma unresponsive to chemoembolization with epirubicin-Lipiodol emulsion.
Maeda N, Osuga K, Higashihara H, Tomoda K, Mikami K, Nakazawa T, Nakamura H, Tomiyama N
Cardiovasc Intervent Radiol 2012 Feb;35(1):82-9. Epub 2011 Jan 4 doi: 10.1007/s00270-010-0086-6. PMID: 21203761

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...