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Grade 4 Infant Irritability, AE

MedGen UID:
1648773
•Concept ID:
C4743837
•
Finding
Synonym: Grade 4 Infant Irritability, Adverse Event

Definition

An adverse event in a newborn characterized by life threatening irritability, with loss of autonomic control of temperature or heart rate; requiring urgent care change. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 4 Infant Irritability, AE

Recent clinical studies

Etiology

Reduced reactogenicity of primary vaccination with DT3aP-HBV-IPV/Hib compared with DT2aP-HBV-IPV-Hib among infants: Mathematical projections in six countries.
George M, Pérez Martin J, AbdelGhany M, Gkalapi F, Jamet N, Kosse RC, Ruiz García Y, Turriani E, Berlaimont V
Hum Vaccin Immunother 2023 Dec 31;19(1):2202124. Epub 2023 Apr 27 doi: 10.1080/21645515.2023.2202124. PMID: 37102330Free PMC Article
Prophylactic intravenous calcium therapy for exchange blood transfusion in the newborn.
Ogunlesi TA, Lesi FE, Oduwole O
Cochrane Database Syst Rev 2017 Oct 12;10(10):CD011048. doi: 10.1002/14651858.CD011048.pub2. PMID: 29022989Free PMC Article
Atypical antipsychotics for disruptive behaviour disorders in children and youths.
Loy JH, Merry SN, Hetrick SE, Stasiak K
Cochrane Database Syst Rev 2017 Aug 9;8(8):CD008559. doi: 10.1002/14651858.CD008559.pub3. PMID: 28791693Free PMC Article
Safety and reactogenicity of primary vaccination with the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine in Vietnamese infants: a randomised, controlled trial.
Huu TN, Toan NT, Tuan HM, Viet HL, Le Thanh Binh P, Yu TW, Shafi F, Habib A, Borys D
BMC Infect Dis 2013 Feb 21;13:95. doi: 10.1186/1471-2334-13-95. PMID: 23432812Free PMC Article
Safety and reactogenicity of the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) when coadministered with routine childhood vaccines.
Chevallier B, Vesikari T, Brzostek J, Knuf M, Bermal N, Aristegui J, Borys D, Cleerbout J, Lommel P, Schuerman L
Pediatr Infect Dis J 2009 Apr;28(4 Suppl):S109-18. doi: 10.1097/INF.0b013e318199f62d. PMID: 19325447

Diagnosis

Atypical antipsychotics for disruptive behaviour disorders in children and youths.
Loy JH, Merry SN, Hetrick SE, Stasiak K
Cochrane Database Syst Rev 2017 Aug 9;8(8):CD008559. doi: 10.1002/14651858.CD008559.pub3. PMID: 28791693Free PMC Article
Hyperthyroidism in children: an Indian experience.
Menon PS, Singh GR
J Pediatr Endocrinol Metab 1996 Jul-Aug;9(4):441-6. doi: 10.1515/jpem.1996.9.4.441. PMID: 8910812
Postpericardiotomy syndrome in pediatric heart transplant recipients. Immunologic characteristics.
Cabalka AK, Rosenblatt HM, Towbin JA, Price JK, Windsor NT, Martin AB, Louis PT, Frazier OH, Bricker JT
Tex Heart Inst J 1995;22(2):170-6. PMID: 7647601Free PMC Article

Therapy

Reduced reactogenicity of primary vaccination with DT3aP-HBV-IPV/Hib compared with DT2aP-HBV-IPV-Hib among infants: Mathematical projections in six countries.
George M, Pérez Martin J, AbdelGhany M, Gkalapi F, Jamet N, Kosse RC, Ruiz García Y, Turriani E, Berlaimont V
Hum Vaccin Immunother 2023 Dec 31;19(1):2202124. Epub 2023 Apr 27 doi: 10.1080/21645515.2023.2202124. PMID: 37102330Free PMC Article
Prophylactic intravenous calcium therapy for exchange blood transfusion in the newborn.
Ogunlesi TA, Lesi FE, Oduwole O
Cochrane Database Syst Rev 2017 Oct 12;10(10):CD011048. doi: 10.1002/14651858.CD011048.pub2. PMID: 29022989Free PMC Article
Atypical antipsychotics for disruptive behaviour disorders in children and youths.
Loy JH, Merry SN, Hetrick SE, Stasiak K
Cochrane Database Syst Rev 2017 Aug 9;8(8):CD008559. doi: 10.1002/14651858.CD008559.pub3. PMID: 28791693Free PMC Article
Safety and reactogenicity of primary vaccination with the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine in Vietnamese infants: a randomised, controlled trial.
Huu TN, Toan NT, Tuan HM, Viet HL, Le Thanh Binh P, Yu TW, Shafi F, Habib A, Borys D
BMC Infect Dis 2013 Feb 21;13:95. doi: 10.1186/1471-2334-13-95. PMID: 23432812Free PMC Article
Safety and reactogenicity of the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) when coadministered with routine childhood vaccines.
Chevallier B, Vesikari T, Brzostek J, Knuf M, Bermal N, Aristegui J, Borys D, Cleerbout J, Lommel P, Schuerman L
Pediatr Infect Dis J 2009 Apr;28(4 Suppl):S109-18. doi: 10.1097/INF.0b013e318199f62d. PMID: 19325447

Prognosis

Reduced reactogenicity of primary vaccination with DT3aP-HBV-IPV/Hib compared with DT2aP-HBV-IPV-Hib among infants: Mathematical projections in six countries.
George M, Pérez Martin J, AbdelGhany M, Gkalapi F, Jamet N, Kosse RC, Ruiz García Y, Turriani E, Berlaimont V
Hum Vaccin Immunother 2023 Dec 31;19(1):2202124. Epub 2023 Apr 27 doi: 10.1080/21645515.2023.2202124. PMID: 37102330Free PMC Article
Safety and reactogenicity of primary vaccination with the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine in Vietnamese infants: a randomised, controlled trial.
Huu TN, Toan NT, Tuan HM, Viet HL, Le Thanh Binh P, Yu TW, Shafi F, Habib A, Borys D
BMC Infect Dis 2013 Feb 21;13:95. doi: 10.1186/1471-2334-13-95. PMID: 23432812Free PMC Article

Clinical prediction guides

Atypical antipsychotics for disruptive behaviour disorders in children and youths.
Loy JH, Merry SN, Hetrick SE, Stasiak K
Cochrane Database Syst Rev 2017 Aug 9;8(8):CD008559. doi: 10.1002/14651858.CD008559.pub3. PMID: 28791693Free PMC Article
Safety and reactogenicity of primary vaccination with the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine in Vietnamese infants: a randomised, controlled trial.
Huu TN, Toan NT, Tuan HM, Viet HL, Le Thanh Binh P, Yu TW, Shafi F, Habib A, Borys D
BMC Infect Dis 2013 Feb 21;13:95. doi: 10.1186/1471-2334-13-95. PMID: 23432812Free PMC Article
Safety and reactogenicity of the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) when coadministered with routine childhood vaccines.
Chevallier B, Vesikari T, Brzostek J, Knuf M, Bermal N, Aristegui J, Borys D, Cleerbout J, Lommel P, Schuerman L
Pediatr Infect Dis J 2009 Apr;28(4 Suppl):S109-18. doi: 10.1097/INF.0b013e318199f62d. PMID: 19325447
Humidification reduces coughing and breath-holding during inhalation induction with isoflurane in children.
Cregg N, Wall C, Green D, Mannion D, Casey W
Can J Anaesth 1996 Nov;43(11):1090-4. doi: 10.1007/BF03011833. PMID: 8922762

Recent systematic reviews

Prophylactic intravenous calcium therapy for exchange blood transfusion in the newborn.
Ogunlesi TA, Lesi FE, Oduwole O
Cochrane Database Syst Rev 2017 Oct 12;10(10):CD011048. doi: 10.1002/14651858.CD011048.pub2. PMID: 29022989Free PMC Article
Atypical antipsychotics for disruptive behaviour disorders in children and youths.
Loy JH, Merry SN, Hetrick SE, Stasiak K
Cochrane Database Syst Rev 2017 Aug 9;8(8):CD008559. doi: 10.1002/14651858.CD008559.pub3. PMID: 28791693Free PMC Article

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