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Recurrent Sarcoma of the Extremity

MedGen UID:
1650115
•Concept ID:
C4744308
•
Neoplastic Process
Synonym: Recurrent Extremity Sarcoma

Definition

A sarcoma of the soft tissues or bones of the upper or lower extremity that has recurred after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Sarcoma of the Extremity

Professional guidelines

PubMed

Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142Free PMC Article
Radiation Therapy for Treatment of Soft Tissue Sarcoma in Adults: Executive Summary of an ASTRO Clinical Practice Guideline.
Salerno KE, Alektiar KM, Baldini EH, Bedi M, Bishop AJ, Bradfield L, Chung P, DeLaney TF, Folpe A, Kane JM, Li XA, Petersen I, Powell J, Stolten M, Thorpe S, Trent JC, Voermans M, Guadagnolo BA
Pract Radiat Oncol 2021 Sep-Oct;11(5):339-351. Epub 2021 Jul 26 doi: 10.1016/j.prro.2021.04.005. PMID: 34326023
Management of Breast Sarcoma.
Hsu C, McCloskey SA, Peddi PF
Surg Clin North Am 2016 Oct;96(5):1047-58. doi: 10.1016/j.suc.2016.05.004. PMID: 27542642

Recent clinical studies

Etiology

Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142Free PMC Article
What is the standard indication of adjuvant or neoadjuvant chemotherapy in localized soft-tissue sarcoma?
Hindi N, Martin-Broto J
Curr Opin Oncol 2021 Jul 1;33(4):329-335. doi: 10.1097/CCO.0000000000000742. PMID: 33973551
The management of deep-seated, lowgrade lipomatous lesions.
Al-Ani Z, Fernando M, Wilkinson V, Kotnis N
Br J Radiol 2018 Jun;91(1086):20170725. Epub 2018 Jan 17 doi: 10.1259/bjr.20170725. PMID: 29303371
Neo-adjuvant chemotherapy for primary high-grade extremity soft tissue sarcoma.
Grobmyer SR, Maki RG, Demetri GD, Mazumdar M, Riedel E, Brennan MF, Singer S
Ann Oncol 2004 Nov;15(11):1667-72. doi: 10.1093/annonc/mdh431. PMID: 15520069
Soft tissue sarcomas.
Lewis JJ, Brennan MF
Curr Probl Surg 1996 Oct;33(10):817-72. PMID: 8885853

Diagnosis

Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142Free PMC Article
Soft Tissue Tumors of the Extremity.
Roland CL
Surg Clin North Am 2020 Jun;100(3):669-680. Epub 2020 Apr 13 doi: 10.1016/j.suc.2020.02.015. PMID: 32402308
Well-differentiated liposarcoma and dedifferentiated liposarcoma: An updated review.
Thway K
Semin Diagn Pathol 2019 Mar;36(2):112-121. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.006. PMID: 30852045
Chondrosarcoma of bone.
Leddy LR, Holmes RE
Cancer Treat Res 2014;162:117-30. doi: 10.1007/978-3-319-07323-1_6. PMID: 25070233
Soft tissue sarcomas.
Lewis JJ, Brennan MF
Curr Probl Surg 1996 Oct;33(10):817-72. PMID: 8885853

Therapy

Preoperative radiotherapy plus surgery versus surgery alone for patients with primary retroperitoneal sarcoma (EORTC-62092: STRASS): a multicentre, open-label, randomised, phase 3 trial.
Bonvalot S, Gronchi A, Le Péchoux C, Swallow CJ, Strauss D, Meeus P, van Coevorden F, Stoldt S, Stoeckle E, Rutkowski P, Rastrelli M, Raut CP, Hompes D, De Paoli A, Sangalli C, Honoré C, Chung P, Miah A, Blay JY, Fiore M, Stelmes JJ, Dei Tos AP, Baldini EH, Litière S, Marreaud S, Gelderblom H, Haas RL
Lancet Oncol 2020 Oct;21(10):1366-1377. Epub 2020 Sep 14 doi: 10.1016/S1470-2045(20)30446-0. PMID: 32941794
Significant Reduction of Late Toxicities in Patients With Extremity Sarcoma Treated With Image-Guided Radiation Therapy to a Reduced Target Volume: Results of Radiation Therapy Oncology Group RTOG-0630 Trial.
Wang D, Zhang Q, Eisenberg BL, Kane JM, Li XA, Lucas D, Petersen IA, DeLaney TF, Freeman CR, Finkelstein SE, Hitchcock YJ, Bedi M, Singh AK, Dundas G, Kirsch DG
J Clin Oncol 2015 Jul 10;33(20):2231-8. Epub 2015 Feb 9 doi: 10.1200/JCO.2014.58.5828. PMID: 25667281Free PMC Article
Neo-adjuvant chemotherapy for primary high-grade extremity soft tissue sarcoma.
Grobmyer SR, Maki RG, Demetri GD, Mazumdar M, Riedel E, Brennan MF, Singer S
Ann Oncol 2004 Nov;15(11):1667-72. doi: 10.1093/annonc/mdh431. PMID: 15520069
Adjuvant chemotherapy for adult soft tissue sarcomas of the extremities and girdles: results of the Italian randomized cooperative trial.
Frustaci S, Gherlinzoni F, De Paoli A, Bonetti M, Azzarelli A, Comandone A, Olmi P, Buonadonna A, Pignatti G, Barbieri E, Apice G, Zmerly H, Serraino D, Picci P
J Clin Oncol 2001 Mar 1;19(5):1238-47. doi: 10.1200/JCO.2001.19.5.1238. PMID: 11230464
Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: meta-analysis of individual data. Sarcoma Meta-analysis Collaboration.
Lancet 1997 Dec 6;350(9092):1647-54. PMID: 9400508

Prognosis

Soft Tissue Tumors of the Extremity.
Roland CL
Surg Clin North Am 2020 Jun;100(3):669-680. Epub 2020 Apr 13 doi: 10.1016/j.suc.2020.02.015. PMID: 32402308
Soft tissue sarcoma of the extremities: pending questions on surgery and radiotherapy.
Hoefkens F, Dehandschutter C, Somville J, Meijnders P, Van Gestel D
Radiat Oncol 2016 Oct 12;11(1):136. doi: 10.1186/s13014-016-0668-9. PMID: 27733179Free PMC Article
Extremity Soft Tissue Sarcoma: Tailoring Resection to Histologic Subtype.
Cable MG, Randall RL
Surg Oncol Clin N Am 2016 Oct;25(4):677-95. Epub 2016 Aug 5 doi: 10.1016/j.soc.2016.05.014. PMID: 27591492
Leiomyosarcoma of the hand.
Angelini A, Barastegui D, Gambarotti M, Ruggieri P
Handchir Mikrochir Plast Chir 2015 Apr;47(2):139-41. Epub 2015 Apr 21 doi: 10.1055/s-0034-1395605. PMID: 25897583
Soft tissue sarcomas.
Cormier JN, Pollock RE
CA Cancer J Clin 2004 Mar-Apr;54(2):94-109. doi: 10.3322/canjclin.54.2.94. PMID: 15061599

Clinical prediction guides

Popliteal Fossa Sarcomas.
Erdogan O, Çeli K A, Yildirim ANT, Tekçe E, Altun G, Demi Röz S, Güler Y, Ozkan K, Gurkan V
Acta Chir Orthop Traumatol Cech 2023;90(3):181-187. PMID: 37395425
Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142Free PMC Article
Chondrosarcoma of the hands and feet.
Kask G, Laitinen MK, Stevenson J, Evans S, Jeys LM, Parry MC
Bone Joint J 2021 Mar;103-B(3):562-568. doi: 10.1302/0301-620X.103B3.BJJ-2020-1337.R1. PMID: 33641425
Clinical Outcome of Surgically Treated Leiomyosarcoma of the Extremities: A Retrospective Overview.
VAN Beeck A, VAN DE Sande M, VAN Praag V, Dammerer D, Michielsen J, Schubert T, Kapanci B, Shumelinsky F, Somville J, Dijkstra S
Anticancer Res 2020 Sep;40(9):5319-5325. doi: 10.21873/anticanres.14539. PMID: 32878824
The management of deep-seated, lowgrade lipomatous lesions.
Al-Ani Z, Fernando M, Wilkinson V, Kotnis N
Br J Radiol 2018 Jun;91(1086):20170725. Epub 2018 Jan 17 doi: 10.1259/bjr.20170725. PMID: 29303371

Recent systematic reviews

A systematic review of undifferentiated pleomorphic sarcoma of the chest wall.
Bennett C, Bharadwaj S, Arndt A, Chawla A
Chin Clin Oncol 2023 Dec;12(6):66. Epub 2023 Nov 28 doi: 10.21037/cco-23-71. PMID: 38073309
Soft tissue sarcomas of the buttock: A systematic review and meta-analysis.
Sacco R, Lalevée M, Pellegrino P, Ferro A, Yasmine B, André G, Matthieu G, Hamza A, Piana R, Dujardin F
Surg Oncol 2022 Dec;45:101883. Epub 2022 Nov 7 doi: 10.1016/j.suronc.2022.101883. PMID: 36371906
Hemipelvectomy hernia: case series and literature review.
Hope WC, Ferro LC, Snyder JA, Procter LD, Salluzzo JL
Hernia 2021 Oct;25(5):1159-1167. Epub 2020 Jul 22 doi: 10.1007/s10029-020-02258-8. PMID: 32700157
Liposarcoma of Hypopharynx and Esophagus: a Unique Entity?
Riva G, Sensini M, Corvino A, Garzaro M, Pecorari G
J Gastrointest Cancer 2016 Jun;47(2):135-42. doi: 10.1007/s12029-016-9808-6. PMID: 26875081
Pediatric lower extremity sarcoma reconstruction: A review of limb salvage procedures and outcomes.
Piper M, Irwin C, Sbitany H
J Plast Reconstr Aesthet Surg 2016 Jan;69(1):91-6. Epub 2015 Sep 5 doi: 10.1016/j.bjps.2015.08.035. PMID: 26601876

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