U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Refractory Leiomyosarcoma

MedGen UID:
1652428
•Concept ID:
C4724965
•
Neoplastic Process

Definition

Leiomyosarcoma that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Leiomyosarcoma

Professional guidelines

PubMed

A retrospective chart review of drug treatment patterns and clinical outcomes among patients with metastatic or recurrent soft tissue sarcoma refractory to one or more prior chemotherapy treatments.
Wagner MJ, Amodu LI, Duh MS, Korves C, Solleza F, Manson SC, Diaz J, Neary MP, Demetri GD
BMC Cancer 2015 Mar 25;15:175. doi: 10.1186/s12885-015-1182-4. PMID: 25885530Free PMC Article
Amplitude-modulated electromagnetic fields for the treatment of cancer: discovery of tumor-specific frequencies and assessment of a novel therapeutic approach.
Barbault A, Costa FP, Bottger B, Munden RF, Bomholt F, Kuster N, Pasche B
J Exp Clin Cancer Res 2009 Apr 14;28(1):51. doi: 10.1186/1756-9966-28-51. PMID: 19366446Free PMC Article
Gemcitabine in the treatment of soft tissue sarcomas.
Bauer S, Seeber S, Schütte J
Onkologie 2004 Apr;27(2):180-6. doi: 10.1159/000076910. PMID: 15138353

Recent clinical studies

Etiology

Phase I Study of mTORC1/2 Inhibitor Sapanisertib (CB-228/TAK-228) in Combination with Metformin in Patients with mTOR/AKT/PI3K Pathway Alterations and Advanced Solid Malignancies.
Subbiah V, Coleman N, Piha-Paul SA, Tsimberidou AM, Janku F, Rodon J, Pant S, Dumbrava EEI, Fu S, Hong DS, Zhang S, Sun M, Jiang Y, Roszik J, Song J, Yuan Y, Meric-Bernstam F, Naing A
Cancer Res Commun 2024 Feb 12;4(2):378-387. doi: 10.1158/2767-9764.CRC-22-0260. PMID: 38126764Free PMC Article
Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts.
Stacchiotti S, Miah AB, Frezza AM, Messiou C, Morosi C, Caraceni A, Antonescu CR, Bajpai J, Baldini E, Bauer S, Biagini R, Bielack S, Blay JY, Bonvalot S, Boukovinas I, Bovee JVMG, Boye K, Brodowicz T, Callegaro D, De Alava E, Deoras-Sutliff M, Dufresne A, Eriksson M, Errani C, Fedenko A, Ferraresi V, Ferrari A, Fletcher CDM, Garcia Del Muro X, Gelderblom H, Gladdy RA, Gouin F, Grignani G, Gutkovich J, Haas R, Hindi N, Hohenberger P, Huang P, Joensuu H, Jones RL, Jungels C, Kasper B, Kawai A, Le Cesne A, Le Grange F, Leithner A, Leonard H, Lopez Pousa A, Martin Broto J, Merimsky O, Merriam P, Miceli R, Mir O, Molinari M, Montemurro M, Oldani G, Palmerini E, Pantaleo MA, Patel S, Piperno-Neumann S, Raut CP, Ravi V, Razak ARA, Reichardt P, Rubin BP, Rutkowski P, Safwat AA, Sangalli C, Sapisochin G, Sbaraglia M, Scheipl S, Schöffski P, Strauss D, Strauss SJ, Sundby Hall K, Tap WD, Trama A, Tweddle A, van der Graaf WTA, Van De Sande MAJ, Van Houdt W, van Oortmerssen G, Wagner AJ, Wartenberg M, Wood J, Zaffaroni N, Zimmermann C, Casali PG, Dei Tos AP, Gronchi A
ESMO Open 2021 Jun;6(3):100170. Epub 2021 Jun 2 doi: 10.1016/j.esmoop.2021.100170. PMID: 34090171Free PMC Article
Soft tissue sarcomas, a look into the future: different treatments for different subtypes.
Reichardt P
Future Oncol 2014 Jun;10(8 Suppl):s19-27. doi: 10.2217/fon.14.116. PMID: 25048045
Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent histologies: leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma.
Mahmood ST, Agresta S, Vigil CE, Zhao X, Han G, D'Amato G, Calitri CE, Dean M, Garrett C, Schell MJ, Antonia S, Chiappori A
Int J Cancer 2011 Oct 15;129(8):1963-9. Epub 2011 Mar 25 doi: 10.1002/ijc.25843. PMID: 21154746Free PMC Article
New therapeutic strategies for soft tissue sarcomas.
von Mehren M
Curr Treat Options Oncol 2003 Dec;4(6):441-51. doi: 10.1007/s11864-003-0045-4. PMID: 14585225

Diagnosis

Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts.
Stacchiotti S, Miah AB, Frezza AM, Messiou C, Morosi C, Caraceni A, Antonescu CR, Bajpai J, Baldini E, Bauer S, Biagini R, Bielack S, Blay JY, Bonvalot S, Boukovinas I, Bovee JVMG, Boye K, Brodowicz T, Callegaro D, De Alava E, Deoras-Sutliff M, Dufresne A, Eriksson M, Errani C, Fedenko A, Ferraresi V, Ferrari A, Fletcher CDM, Garcia Del Muro X, Gelderblom H, Gladdy RA, Gouin F, Grignani G, Gutkovich J, Haas R, Hindi N, Hohenberger P, Huang P, Joensuu H, Jones RL, Jungels C, Kasper B, Kawai A, Le Cesne A, Le Grange F, Leithner A, Leonard H, Lopez Pousa A, Martin Broto J, Merimsky O, Merriam P, Miceli R, Mir O, Molinari M, Montemurro M, Oldani G, Palmerini E, Pantaleo MA, Patel S, Piperno-Neumann S, Raut CP, Ravi V, Razak ARA, Reichardt P, Rubin BP, Rutkowski P, Safwat AA, Sangalli C, Sapisochin G, Sbaraglia M, Scheipl S, Schöffski P, Strauss D, Strauss SJ, Sundby Hall K, Tap WD, Trama A, Tweddle A, van der Graaf WTA, Van De Sande MAJ, Van Houdt W, van Oortmerssen G, Wagner AJ, Wartenberg M, Wood J, Zaffaroni N, Zimmermann C, Casali PG, Dei Tos AP, Gronchi A
ESMO Open 2021 Jun;6(3):100170. Epub 2021 Jun 2 doi: 10.1016/j.esmoop.2021.100170. PMID: 34090171Free PMC Article
Soft tissue sarcomas, a look into the future: different treatments for different subtypes.
Reichardt P
Future Oncol 2014 Jun;10(8 Suppl):s19-27. doi: 10.2217/fon.14.116. PMID: 25048045
Primary leiomyosarcoma of saphenous vein presenting as deep venous thrombosis.
Fremed DI, Faries PL, Schanzer HR, Marin ML, Ting W
Vascular 2014 Dec;22(6):450-3. Epub 2013 Dec 17 doi: 10.1177/1708538113516446. PMID: 24347138
Diagnosis of gastrointestinal stromal tumors from minute specimens: cytomorphology, immunohistochemistry, and molecular diagnostic findings.
Layfield LJ, Wallander ML
Diagn Cytopathol 2012 Jun;40(6):484-90. Epub 2012 Feb 20 doi: 10.1002/dc.22838. PMID: 22351482
New therapeutic strategies for soft tissue sarcomas.
von Mehren M
Curr Treat Options Oncol 2003 Dec;4(6):441-51. doi: 10.1007/s11864-003-0045-4. PMID: 14585225

Therapy

Regorafenib in advanced solitary fibrous tumour: Results from an exploratory phase II clinical study.
Stacchiotti S, Baldi GG, Frezza AM, Morosi C, Greco FG, Collini P, Barisella M, Dagrada GP, Zaffaroni N, Pasquali S, Gronchi A, Huang P, Ingrosso M, Tinè G, Miceli R, Casali PG
Eur J Cancer 2023 Dec;195:113391. Epub 2023 Oct 18 doi: 10.1016/j.ejca.2023.113391. PMID: 37918286
Molecular analysis for refractory rare cancers: Sequencing battle continues - learnings for the MOSCATO-01 study.
Debien V, Vignot S, Massard C, Malouf G, Hollebecque A, Scoazec JY, Michiels S, Verlingue L
Crit Rev Oncol Hematol 2023 Jan;181:103888. Epub 2022 Nov 29 doi: 10.1016/j.critrevonc.2022.103888. PMID: 36460264
Effect of Capivasertib in Patients With an AKT1 E17K-Mutated Tumor: NCI-MATCH Subprotocol EAY131-Y Nonrandomized Trial.
Kalinsky K, Hong F, McCourt CK, Sachdev JC, Mitchell EP, Zwiebel JA, Doyle LA, McShane LM, Li S, Gray RJ, Rubinstein LV, Patton D, Williams PM, Hamilton SR, Conley BA, O'Dwyer PJ, Harris LN, Arteaga CL, Chen AP, Flaherty KT
JAMA Oncol 2021 Feb 1;7(2):271-278. doi: 10.1001/jamaoncol.2020.6741. PMID: 33377972Free PMC Article
Ultrasonic therapy for gynecologic tumors.
Yu T, Zhou S, Zhang J
J Minim Invasive Gynecol 2008 Nov-Dec;15(6):667-72. Epub 2008 Sep 6 doi: 10.1016/j.jmig.2008.07.018. PMID: 18774758
Gemcitabine in the treatment of soft tissue sarcomas.
Bauer S, Seeber S, Schütte J
Onkologie 2004 Apr;27(2):180-6. doi: 10.1159/000076910. PMID: 15138353

Prognosis

Safety and Efficacy of Anlotinib, a Multikinase Angiogenesis Inhibitor, in Patients with Refractory Metastatic Soft-Tissue Sarcoma.
Chi Y, Fang Z, Hong X, Yao Y, Sun P, Wang G, Du F, Sun Y, Wu Q, Qu G, Wang S, Song J, Yu J, Lu Y, Zhu X, Niu X, He Z, Wang J, Yu H, Cai J
Clin Cancer Res 2018 Nov 1;24(21):5233-5238. Epub 2018 Jun 12 doi: 10.1158/1078-0432.CCR-17-3766. PMID: 29895706
Diagnosis of gastrointestinal stromal tumors from minute specimens: cytomorphology, immunohistochemistry, and molecular diagnostic findings.
Layfield LJ, Wallander ML
Diagn Cytopathol 2012 Jun;40(6):484-90. Epub 2012 Feb 20 doi: 10.1002/dc.22838. PMID: 22351482
Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent histologies: leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma.
Mahmood ST, Agresta S, Vigil CE, Zhao X, Han G, D'Amato G, Calitri CE, Dean M, Garrett C, Schell MJ, Antonia S, Chiappori A
Int J Cancer 2011 Oct 15;129(8):1963-9. Epub 2011 Mar 25 doi: 10.1002/ijc.25843. PMID: 21154746Free PMC Article
Gemcitabine in the treatment of soft tissue sarcomas.
Bauer S, Seeber S, Schütte J
Onkologie 2004 Apr;27(2):180-6. doi: 10.1159/000076910. PMID: 15138353
New therapeutic strategies for soft tissue sarcomas.
von Mehren M
Curr Treat Options Oncol 2003 Dec;4(6):441-51. doi: 10.1007/s11864-003-0045-4. PMID: 14585225

Clinical prediction guides

Phase I Study of mTORC1/2 Inhibitor Sapanisertib (CB-228/TAK-228) in Combination with Metformin in Patients with mTOR/AKT/PI3K Pathway Alterations and Advanced Solid Malignancies.
Subbiah V, Coleman N, Piha-Paul SA, Tsimberidou AM, Janku F, Rodon J, Pant S, Dumbrava EEI, Fu S, Hong DS, Zhang S, Sun M, Jiang Y, Roszik J, Song J, Yuan Y, Meric-Bernstam F, Naing A
Cancer Res Commun 2024 Feb 12;4(2):378-387. doi: 10.1158/2767-9764.CRC-22-0260. PMID: 38126764Free PMC Article
Regorafenib in advanced solitary fibrous tumour: Results from an exploratory phase II clinical study.
Stacchiotti S, Baldi GG, Frezza AM, Morosi C, Greco FG, Collini P, Barisella M, Dagrada GP, Zaffaroni N, Pasquali S, Gronchi A, Huang P, Ingrosso M, Tinè G, Miceli R, Casali PG
Eur J Cancer 2023 Dec;195:113391. Epub 2023 Oct 18 doi: 10.1016/j.ejca.2023.113391. PMID: 37918286
Efficacy of Pazopanib With or Without Gemcitabine in Patients With Anthracycline- and/or Ifosfamide-Refractory Soft Tissue Sarcoma: Final Results of the PAPAGEMO Phase 2 Randomized Clinical Trial.
Schmoll HJ, Lindner LH, Reichardt P, Heißner K, Kopp HG, Kessler T, Mayer-Steinacker R, Rüssel J, Egerer G, Crysandt M, Kasper B, Niederwieser D, Kunitz A, Eigendorff E, Petersen I, Steighardt J, Cygon F, Meinert F, Stein A
JAMA Oncol 2021 Feb 1;7(2):255-262. doi: 10.1001/jamaoncol.2020.6564. PMID: 33355646Free PMC Article
Gemcitabine in the treatment of soft tissue sarcomas.
Bauer S, Seeber S, Schütte J
Onkologie 2004 Apr;27(2):180-6. doi: 10.1159/000076910. PMID: 15138353
Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignancies.
Senderowicz AM
Leukemia 2001 Jan;15(1):1-9. doi: 10.1038/sj.leu.2401994. PMID: 11243375

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...