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Moderate Hepatic Insufficiency

MedGen UID:
1653680
•Concept ID:
C4725020
•
Disease or Syndrome
Synonym: Moderate Hepatic Impairment

Definition

Findings indicating moderate impairment of liver function. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVModerate Hepatic Insufficiency

Professional guidelines

PubMed

Rifaximin for prevention and treatment of hepatic encephalopathy in people with cirrhosis.
Zacharias HD, Kamel F, Tan J, Kimer N, Gluud LL, Morgan MY
Cochrane Database Syst Rev 2023 Jul 19;7(7):CD011585. doi: 10.1002/14651858.CD011585.pub2. PMID: 37467180Free PMC Article
Guidelines for the Acute Treatment of Cerebral Edema in Neurocritical Care Patients.
Cook AM, Morgan Jones G, Hawryluk GWJ, Mailloux P, McLaughlin D, Papangelou A, Samuel S, Tokumaru S, Venkatasubramanian C, Zacko C, Zimmermann LL, Hirsch K, Shutter L
Neurocrit Care 2020 Jun;32(3):647-666. doi: 10.1007/s12028-020-00959-7. PMID: 32227294Free PMC Article
Pathophysiology, diagnosis and treatment of ascites in cirrhosis.
Arroyo V
Ann Hepatol 2002 Apr-Jun;1(2):72-9. PMID: 15115971

Recent clinical studies

Etiology

A Phase I Clinical Study of the Pharmacokinetics and Safety of Prusogliptin Tablets in Subjects with Mild to Moderate Hepatic Insufficiency and Normal Liver Function.
Zhang H, Bian Y, Zhao W, Miao L, Zhang H, Cui J, Zhang X, Zhang X, Cai W
Curr Drug Metab 2024;25(2):140-151. doi: 10.2174/0113892002288120240221111336. PMID: 38454771
Physiologically based pharmacokinetic model combined with reverse dose method to study the nephrotoxic tolerance dose of tacrolimus.
Cai L, Ke M, Wang H, Wu W, Lin R, Huang P, Lin C
Arch Toxicol 2023 Oct;97(10):2659-2673. Epub 2023 Aug 12 doi: 10.1007/s00204-023-03576-3. PMID: 37572130
Influence of renal and hepatic impairment on the pharmacokinetics of anacetrapib.
Lauring B, Li XS, Liu Y, Corr C, Lazarus N, Cote J, Larson P, Levonas AO, Lasseter KC, Preston RA, Smith WB, Lai E, Wagner JA
J Clin Pharmacol 2014 Nov;54(11):1247-55. Epub 2014 Jun 6 doi: 10.1002/jcph.320. PMID: 24782116
Influence of hepatic impairment on the pharmacokinetics of the dopamine agonist rotigotine.
Cawello W, Fichtner A, Boekens H, Braun M
Eur J Drug Metab Pharmacokinet 2014 Sep;39(3):155-63. Epub 2013 Sep 20 doi: 10.1007/s13318-013-0153-x. PMID: 24052490
The effect of hepatic insufficiency on the safety and pharmacokinetics of paricalcitol (Zemplar).
Carr RA, André AK, Chen P, Grabowski BA, Chang MS, Locke CS, Williams LA, Chojkier M
Nephron Clin Pract 2006;103(3):c100-5. Epub 2006 Mar 13 doi: 10.1159/000092018. PMID: 16534233

Diagnosis

Influence of hepatic impairment on the pharmacokinetics of the dopamine agonist rotigotine.
Cawello W, Fichtner A, Boekens H, Braun M
Eur J Drug Metab Pharmacokinet 2014 Sep;39(3):155-63. Epub 2013 Sep 20 doi: 10.1007/s13318-013-0153-x. PMID: 24052490
No influence of moderate hepatic impairment on the pharmacokinetics of lumiracoxib, an oral COX-2 selective inhibitor.
Kalbag J, Yeh CM, Milosavljev S, Lasseter K, Oberstein S, Rordorf C
Pharmacol Res 2004 Aug;50(2):181-6. doi: 10.1016/j.phrs.2004.03.002. PMID: 15177307

Therapy

Influence of renal and hepatic impairment on the pharmacokinetics of anacetrapib.
Lauring B, Li XS, Liu Y, Corr C, Lazarus N, Cote J, Larson P, Levonas AO, Lasseter KC, Preston RA, Smith WB, Lai E, Wagner JA
J Clin Pharmacol 2014 Nov;54(11):1247-55. Epub 2014 Jun 6 doi: 10.1002/jcph.320. PMID: 24782116
Effect of moderate hepatic insufficiency on the pharmacokinetics of sitagliptin.
Migoya EM, Stevens CH, Bergman AJ, Luo WL, Lasseter KC, Dilzer SC, Davies MJ, Wagner JA, Herman GA
Can J Clin Pharmacol 2009 Winter;16(1):e165-70. Epub 2009 Feb 16 PMID: 19221403
The effect of hepatic insufficiency on the safety and pharmacokinetics of paricalcitol (Zemplar).
Carr RA, André AK, Chen P, Grabowski BA, Chang MS, Locke CS, Williams LA, Chojkier M
Nephron Clin Pract 2006;103(3):c100-5. Epub 2006 Mar 13 doi: 10.1159/000092018. PMID: 16534233
Caspofungin: an echinocandin antifungal agent.
Stone EA, Fung HB, Kirschenbaum HL
Clin Ther 2002 Mar;24(3):351-77; discussion 329. doi: 10.1016/s0149-2918(02)85039-1. PMID: 11952021
Moxifloxacin in uncomplicated skin and skin structure infections.
Muijsers RB, Jarvis B
Drugs 2002;62(6):967-73; discussion 974-5. doi: 10.2165/00003495-200262060-00008. PMID: 11929342

Prognosis

Physiologically based pharmacokinetic model combined with reverse dose method to study the nephrotoxic tolerance dose of tacrolimus.
Cai L, Ke M, Wang H, Wu W, Lin R, Huang P, Lin C
Arch Toxicol 2023 Oct;97(10):2659-2673. Epub 2023 Aug 12 doi: 10.1007/s00204-023-03576-3. PMID: 37572130

Clinical prediction guides

Physiologically based pharmacokinetic model combined with reverse dose method to study the nephrotoxic tolerance dose of tacrolimus.
Cai L, Ke M, Wang H, Wu W, Lin R, Huang P, Lin C
Arch Toxicol 2023 Oct;97(10):2659-2673. Epub 2023 Aug 12 doi: 10.1007/s00204-023-03576-3. PMID: 37572130
Influence of hepatic impairment on the pharmacokinetics of the dopamine agonist rotigotine.
Cawello W, Fichtner A, Boekens H, Braun M
Eur J Drug Metab Pharmacokinet 2014 Sep;39(3):155-63. Epub 2013 Sep 20 doi: 10.1007/s13318-013-0153-x. PMID: 24052490
Effect of moderate hepatic insufficiency on the pharmacokinetics of sitagliptin.
Migoya EM, Stevens CH, Bergman AJ, Luo WL, Lasseter KC, Dilzer SC, Davies MJ, Wagner JA, Herman GA
Can J Clin Pharmacol 2009 Winter;16(1):e165-70. Epub 2009 Feb 16 PMID: 19221403
Olmesartan medoxomil: an angiotensin II-receptor blocker.
Brousil JA, Burke JM
Clin Ther 2003 Apr;25(4):1041-55. doi: 10.1016/s0149-2918(03)80066-8. PMID: 12809956
Caspofungin: an echinocandin antifungal agent.
Stone EA, Fung HB, Kirschenbaum HL
Clin Ther 2002 Mar;24(3):351-77; discussion 329. doi: 10.1016/s0149-2918(02)85039-1. PMID: 11952021

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