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FGFR Gene Rearrangement

MedGen UID:
1653698
Concept ID:
C4727114
Cell or Molecular Dysfunction
Synonyms: FGF Receptor Gene Family Rearrangement; FGF Receptor Gene Rearrangement; FGFR Family Gene Rearrangement; FGFR Family Rearrangement; Fibroblast Growth Factor Receptor Family Gene Rearrangement; Fibroblast Growth Factor Receptor Gene Rearrangement

Definition

A molecular abnormality indicating rearrangement of an FGFR family gene. [from NCI]

Professional guidelines

PubMed

Beri N
Future Oncol 2022 Apr;18(11):1391-1402. Epub 2022 Jan 27 doi: 10.2217/fon-2021-1089. PMID: 35081733
Braun S, McSheehy P, Litherland K, McKernan P, Forster-Gross N, Bachmann F, El-Shemerly M, Dimova-Dobreva M, Polyakova I, Häckl M, Zhou P, Lane H, Kellenberger L, Engelhardt M
Expert Opin Investig Drugs 2021 Nov;30(11):1071-1080. Epub 2021 Nov 9 doi: 10.1080/13543784.2021.1995355. PMID: 34698609
King G, Javle M
Curr Oncol Rep 2021 Jul 16;23(9):108. doi: 10.1007/s11912-021-01100-3. PMID: 34269915

Recent clinical studies

Etiology

Silverman IM, Hollebecque A, Friboulet L, Owens S, Newton RC, Zhen H, Féliz L, Zecchetto C, Melisi D, Burn TC
Cancer Discov 2021 Feb;11(2):326-339. Epub 2020 Nov 20 doi: 10.1158/2159-8290.CD-20-0766. PMID: 33218975
Pederzoli F, Bandini M, Marandino L, Ali SM, Madison R, Chung J, Ross JS, Necchi A
Nat Rev Urol 2020 Nov;17(11):613-625. Epub 2020 Oct 12 doi: 10.1038/s41585-020-00379-4. PMID: 33046892
Gobbini E, Galetta D, Tiseo M, Graziano P, Rossi A, Bria E, Di Maio M, Rossi G, Gregorc V, Riccardi F, Scotti V, Ceribelli A, Buffoni L, Delmonte A, Franchina T, Migliorino MR, Cortinovis D, Pisconti S, Bordi P, Catino A, Maiello E, Arizio F, Novello S; other Co-Authors
Lung Cancer 2017 Sep;111:30-37. Epub 2017 Jun 16 doi: 10.1016/j.lungcan.2017.06.009. PMID: 28838394
Wu YM, Su F, Kalyana-Sundaram S, Khazanov N, Ateeq B, Cao X, Lonigro RJ, Vats P, Wang R, Lin SF, Cheng AJ, Kunju LP, Siddiqui J, Tomlins SA, Wyngaard P, Sadis S, Roychowdhury S, Hussain MH, Feng FY, Zalupski MM, Talpaz M, Pienta KJ, Rhodes DR, Robinson DR, Chinnaiyan AM
Cancer Discov 2013 Jun;3(6):636-47. Epub 2013 Apr 4 doi: 10.1158/2159-8290.CD-13-0050. PMID: 23558953Free PMC Article

Diagnosis

Frampton JE
Target Oncol 2024 Jan;19(1):107-114. Epub 2024 Jan 11 doi: 10.1007/s11523-023-01024-x. PMID: 38206555
Wang R, Zhong J, Pan X, Su Z, Xu Y, Zhang M, Chen X, Chen N, Yu T, Zhou Q
J Transl Med 2023 Nov 22;21(1):840. doi: 10.1186/s12967-023-04718-y. PMID: 37993879Free PMC Article
Phan T, Tong J, Krivanek M, Graf N, Dexter M, Tumuluri K
Ophthalmic Plast Reconstr Surg 2023 May-Jun 01;39(3):206-210. Epub 2022 Oct 20 doi: 10.1097/IOP.0000000000002287. PMID: 36356178
Sadeghi S
Drugs Today (Barc) 2022 Jul;58(7):327-334. doi: 10.1358/dot.2022.58.7.3408813. PMID: 35851868
Bekaii-Saab TS, Valle JW, Van Cutsem E, Rimassa L, Furuse J, Ioka T, Melisi D, Macarulla T, Bridgewater J, Wasan H, Borad MJ, Abou-Alfa GK, Jiang P, Lihou CF, Zhen H, Asatiani E, Féliz L, Vogel A
Future Oncol 2020 Oct;16(30):2385-2399. Epub 2020 Jul 17 doi: 10.2217/fon-2020-0429. PMID: 32677452Free PMC Article

Therapy

Frampton JE
Target Oncol 2024 Jan;19(1):107-114. Epub 2024 Jan 11 doi: 10.1007/s11523-023-01024-x. PMID: 38206555
Sadeghi S
Drugs Today (Barc) 2022 Jul;58(7):327-334. doi: 10.1358/dot.2022.58.7.3408813. PMID: 35851868
Rizzo A, Ricci AD, Frega G, Di Federico A, Brandi G
Expert Rev Gastroenterol Hepatol 2021 May;15(5):567-574. Epub 2021 Apr 5 doi: 10.1080/17474124.2021.1911646. PMID: 33787429
Silverman IM, Hollebecque A, Friboulet L, Owens S, Newton RC, Zhen H, Féliz L, Zecchetto C, Melisi D, Burn TC
Cancer Discov 2021 Feb;11(2):326-339. Epub 2020 Nov 20 doi: 10.1158/2159-8290.CD-20-0766. PMID: 33218975
Bekaii-Saab TS, Valle JW, Van Cutsem E, Rimassa L, Furuse J, Ioka T, Melisi D, Macarulla T, Bridgewater J, Wasan H, Borad MJ, Abou-Alfa GK, Jiang P, Lihou CF, Zhen H, Asatiani E, Féliz L, Vogel A
Future Oncol 2020 Oct;16(30):2385-2399. Epub 2020 Jul 17 doi: 10.2217/fon-2020-0429. PMID: 32677452Free PMC Article

Prognosis

Frampton JE
Target Oncol 2024 Jan;19(1):107-114. Epub 2024 Jan 11 doi: 10.1007/s11523-023-01024-x. PMID: 38206555
Wang R, Zhong J, Pan X, Su Z, Xu Y, Zhang M, Chen X, Chen N, Yu T, Zhou Q
J Transl Med 2023 Nov 22;21(1):840. doi: 10.1186/s12967-023-04718-y. PMID: 37993879Free PMC Article
Sadeghi S
Drugs Today (Barc) 2022 Jul;58(7):327-334. doi: 10.1358/dot.2022.58.7.3408813. PMID: 35851868
Rizzo A, Ricci AD, Frega G, Di Federico A, Brandi G
Expert Rev Gastroenterol Hepatol 2021 May;15(5):567-574. Epub 2021 Apr 5 doi: 10.1080/17474124.2021.1911646. PMID: 33787429
Yoshihara K, Wang Q, Torres-Garcia W, Zheng S, Vegesna R, Kim H, Verhaak RG
Oncogene 2015 Sep 10;34(37):4845-54. Epub 2014 Dec 15 doi: 10.1038/onc.2014.406. PMID: 25500544Free PMC Article

Clinical prediction guides

Frampton JE
Target Oncol 2024 Jan;19(1):107-114. Epub 2024 Jan 11 doi: 10.1007/s11523-023-01024-x. PMID: 38206555
Wang R, Zhong J, Pan X, Su Z, Xu Y, Zhang M, Chen X, Chen N, Yu T, Zhou Q
J Transl Med 2023 Nov 22;21(1):840. doi: 10.1186/s12967-023-04718-y. PMID: 37993879Free PMC Article
Wang Z, Anderson KS
Cancer J 2022 Sep-Oct 01;28(5):354-362. doi: 10.1097/PPO.0000000000000615. PMID: 36165723Free PMC Article
Kang CW, Jang KW, Sohn J, Kim SM, Pyo KH, Kim H, Yun MR, Kang HN, Kim HR, Lim SM, Moon YW, Paik S, Kim DJ, Kim JH, Cho BC
Mol Cancer Ther 2015 Oct;14(10):2238-48. Epub 2015 Jul 24 doi: 10.1158/1535-7163.MCT-15-0350. PMID: 26208525
Yoshihara K, Wang Q, Torres-Garcia W, Zheng S, Vegesna R, Kim H, Verhaak RG
Oncogene 2015 Sep 10;34(37):4845-54. Epub 2014 Dec 15 doi: 10.1038/onc.2014.406. PMID: 25500544Free PMC Article

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