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Recurrent Acute Myeloid Leukemia Not Otherwise Specified

MedGen UID:
1656787
•Concept ID:
C4745013
•
Neoplastic Process

Definition

The reemergence of acute myeloid leukemia not otherwise specified after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Acute Myeloid Leukemia Not Otherwise Specified

Professional guidelines

PubMed

A review of treatment options employed in relapsed/refractory AML.
Mohamed Jiffry MZ, Kloss R, Ahmed-Khan M, Carmona-Pires F, Okam N, Weeraddana P, Dharmaratna D, Dandwani M, Moin K
Hematology 2023 Dec;28(1):2196482. doi: 10.1080/16078454.2023.2196482. PMID: 37036019
Treatment of Relapsed Acute Myeloid Leukemia.
Thol F, Ganser A
Curr Treat Options Oncol 2020 Jun 29;21(8):66. doi: 10.1007/s11864-020-00765-5. PMID: 32601974Free PMC Article
Management of acute promyelocytic leukemia: updated recommendations from an expert panel of the European LeukemiaNet.
Sanz MA, Fenaux P, Tallman MS, Estey EH, Löwenberg B, Naoe T, Lengfelder E, Döhner H, Burnett AK, Chen SJ, Mathews V, Iland H, Rego E, Kantarjian H, Adès L, Avvisati G, Montesinos P, Platzbecker U, Ravandi F, Russell NH, Lo-Coco F
Blood 2019 Apr 11;133(15):1630-1643. Epub 2019 Feb 25 doi: 10.1182/blood-2019-01-894980. PMID: 30803991Free PMC Article

Recent clinical studies

Etiology

Maintenance therapy in acute myeloid leukemia: advances and controversies.
Senapati J, Kadia TM, Ravandi F
Haematologica 2023 Sep 1;108(9):2289-2304. doi: 10.3324/haematol.2022.281810. PMID: 37139599Free PMC Article
A review of treatment options employed in relapsed/refractory AML.
Mohamed Jiffry MZ, Kloss R, Ahmed-Khan M, Carmona-Pires F, Okam N, Weeraddana P, Dharmaratna D, Dandwani M, Moin K
Hematology 2023 Dec;28(1):2196482. doi: 10.1080/16078454.2023.2196482. PMID: 37036019
Relapsed pediatric acute myeloid leukaemia: state-of-the-art in 2023.
Egan G, Tasian SK
Haematologica 2023 Sep 1;108(9):2275-2288. doi: 10.3324/haematol.2022.281106. PMID: 36861399Free PMC Article
Acute myeloid leukaemia.
Short NJ, Rytting ME, Cortes JE
Lancet 2018 Aug 18;392(10147):593-606. Epub 2018 Aug 2 doi: 10.1016/S0140-6736(18)31041-9. PMID: 30078459Free PMC Article
Acute myeloid leukaemia.
Khwaja A, Bjorkholm M, Gale RE, Levine RL, Jordan CT, Ehninger G, Bloomfield CD, Estey E, Burnett A, Cornelissen JJ, Scheinberg DA, Bouscary D, Linch DC
Nat Rev Dis Primers 2016 Mar 10;2:16010. doi: 10.1038/nrdp.2016.10. PMID: 27159408

Diagnosis

A longitudinal single-cell atlas of treatment response in pediatric AML.
Lambo S, Trinh DL, Ries RE, Jin D, Setiadi A, Ng M, Leblanc VG, Loken MR, Brodersen LE, Dai F, Pardo LM, Ma X, Vercauteren SM, Meshinchi S, Marra MA
Cancer Cell 2023 Dec 11;41(12):2117-2135.e12. Epub 2023 Nov 16 doi: 10.1016/j.ccell.2023.10.008. PMID: 37977148
A review of treatment options employed in relapsed/refractory AML.
Mohamed Jiffry MZ, Kloss R, Ahmed-Khan M, Carmona-Pires F, Okam N, Weeraddana P, Dharmaratna D, Dandwani M, Moin K
Hematology 2023 Dec;28(1):2196482. doi: 10.1080/16078454.2023.2196482. PMID: 37036019
Relapsed pediatric acute myeloid leukaemia: state-of-the-art in 2023.
Egan G, Tasian SK
Haematologica 2023 Sep 1;108(9):2275-2288. doi: 10.3324/haematol.2022.281106. PMID: 36861399Free PMC Article
Acute Myeloid Leukemia: A Review.
Pelcovits A, Niroula R
R I Med J (2013) 2020 Apr 1;103(3):38-40. PMID: 32236160
Acute myeloid leukaemia.
Short NJ, Rytting ME, Cortes JE
Lancet 2018 Aug 18;392(10147):593-606. Epub 2018 Aug 2 doi: 10.1016/S0140-6736(18)31041-9. PMID: 30078459Free PMC Article

Therapy

Maintenance therapy in acute myeloid leukemia: advances and controversies.
Senapati J, Kadia TM, Ravandi F
Haematologica 2023 Sep 1;108(9):2289-2304. doi: 10.3324/haematol.2022.281810. PMID: 37139599Free PMC Article
A review of treatment options employed in relapsed/refractory AML.
Mohamed Jiffry MZ, Kloss R, Ahmed-Khan M, Carmona-Pires F, Okam N, Weeraddana P, Dharmaratna D, Dandwani M, Moin K
Hematology 2023 Dec;28(1):2196482. doi: 10.1080/16078454.2023.2196482. PMID: 37036019
Treatment of Relapsed Acute Myeloid Leukemia.
Thol F, Ganser A
Curr Treat Options Oncol 2020 Jun 29;21(8):66. doi: 10.1007/s11864-020-00765-5. PMID: 32601974Free PMC Article
Acute Myeloid Leukemia: A Review.
Pelcovits A, Niroula R
R I Med J (2013) 2020 Apr 1;103(3):38-40. PMID: 32236160
Acute myeloid leukaemia.
Short NJ, Rytting ME, Cortes JE
Lancet 2018 Aug 18;392(10147):593-606. Epub 2018 Aug 2 doi: 10.1016/S0140-6736(18)31041-9. PMID: 30078459Free PMC Article

Prognosis

Minimal Residual Disease in Acute Myeloid Leukemia: Old and New Concepts.
Chea M, Rigolot L, Canali A, Vergez F
Int J Mol Sci 2024 Feb 10;25(4) doi: 10.3390/ijms25042150. PMID: 38396825Free PMC Article
A longitudinal single-cell atlas of treatment response in pediatric AML.
Lambo S, Trinh DL, Ries RE, Jin D, Setiadi A, Ng M, Leblanc VG, Loken MR, Brodersen LE, Dai F, Pardo LM, Ma X, Vercauteren SM, Meshinchi S, Marra MA
Cancer Cell 2023 Dec 11;41(12):2117-2135.e12. Epub 2023 Nov 16 doi: 10.1016/j.ccell.2023.10.008. PMID: 37977148
Relapsed acute myeloid leukemia in children and adolescents: current treatment options and future strategies.
Zarnegar-Lumley S, Caldwell KJ, Rubnitz JE
Leukemia 2022 Aug;36(8):1951-1960. Epub 2022 Jun 6 doi: 10.1038/s41375-022-01619-9. PMID: 35668109
Follow-up of patients with R/R FLT3-mutation-positive AML treated with gilteritinib in the phase 3 ADMIRAL trial.
Perl AE, Larson RA, Podoltsev NA, Strickland S, Wang ES, Atallah E, Schiller GJ, Martinelli G, Neubauer A, Sierra J, Montesinos P, Récher C, Yoon SS, Hosono N, Onozawa M, Chiba S, Kim HJ, Hasabou N, Lu Q, Tiu R, Levis MJ
Blood 2022 Jun 9;139(23):3366-3375. doi: 10.1182/blood.2021011583. PMID: 35081255Free PMC Article
Treatment of Relapsed Acute Myeloid Leukemia.
Thol F, Ganser A
Curr Treat Options Oncol 2020 Jun 29;21(8):66. doi: 10.1007/s11864-020-00765-5. PMID: 32601974Free PMC Article

Clinical prediction guides

Minimal Residual Disease in Acute Myeloid Leukemia: Old and New Concepts.
Chea M, Rigolot L, Canali A, Vergez F
Int J Mol Sci 2024 Feb 10;25(4) doi: 10.3390/ijms25042150. PMID: 38396825Free PMC Article
Longitudinal single-cell profiling of chemotherapy response in acute myeloid leukemia.
Naldini MM, Casirati G, Barcella M, Rancoita PMV, Cosentino A, Caserta C, Pavesi F, Zonari E, Desantis G, Gilioli D, Carrabba MG, Vago L, Bernardi M, Di Micco R, Di Serio C, Merelli I, Volpin M, Montini E, Ciceri F, Gentner B
Nat Commun 2023 Mar 8;14(1):1285. doi: 10.1038/s41467-023-36969-0. PMID: 36890137Free PMC Article
DNA Sequencing to Detect Residual Disease in Adults With Acute Myeloid Leukemia Prior to Hematopoietic Cell Transplant.
Dillon LW, Gui G, Page KM, Ravindra N, Wong ZC, Andrew G, Mukherjee D, Zeger SL, El Chaer F, Spellman S, Howard A, Chen K, Auletta J, Devine SM, Jimenez Jimenez AM, De Lima MJG, Litzow MR, Kebriaei P, Saber W, Weisdorf DJ, Hourigan CS
JAMA 2023 Mar 7;329(9):745-755. doi: 10.1001/jama.2023.1363. PMID: 36881031Free PMC Article
Allogeneic Hematopoietic Cell Transplantation vs Standard Consolidation Chemotherapy in Patients With Intermediate-Risk Acute Myeloid Leukemia: A Randomized Clinical Trial.
Bornhäuser M, Schliemann C, Schetelig J, Röllig C, Kramer M, Glass B, Platzbecker U, Burchert A, Hänel M, Müller LP, Klein S, Bug G, Beelen D, Rösler W, Schäfer-Eckart K, Schmid C, Jost E, Lenz G, Tischer J, Spiekermann K, Pfirrmann M, Serve H, Stölzel F, Alakel N, Middeke JM, Thiede C, Ehninger G, Berdel WE, Stelljes M
JAMA Oncol 2023 Apr 1;9(4):519-526. doi: 10.1001/jamaoncol.2022.7605. PMID: 36757706Free PMC Article
Updates on targeted therapies for acute myeloid leukaemia.
Kayser S, Levis MJ
Br J Haematol 2022 Jan;196(2):316-328. Epub 2021 Aug 4 doi: 10.1111/bjh.17746. PMID: 34350585

Recent systematic reviews

Patient-Level Meta-analysis of Clofarabine in Acute Lymphoblastic Leukemia.
Jeha S, Goto H, Baruchel A, Boëlle-Le Corfec E, Geffriaud-Ricouard C, Pieters R, Shin HY
Adv Ther 2023 Dec;40(12):5447-5463. Epub 2023 Oct 11 doi: 10.1007/s12325-023-02696-7. PMID: 37819554Free PMC Article
Myeloablative conditioning regimens in adult patients with acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation in complete remission: a systematic review and network meta-analysis.
Luo C, Wu G, Huang X, Ding Y, Huang Y, Song Q, Hou Y, Chen J, Li X, Xu S
Bone Marrow Transplant 2023 Feb;58(2):175-185. Epub 2022 Nov 10 doi: 10.1038/s41409-022-01865-6. PMID: 36357773
Measurable residual disease in pediatric acute myeloid leukemia: a systematic review.
Segerink WH, de Haas V, Kaspers GJL
Expert Rev Anticancer Ther 2021 Apr;21(4):451-459. Epub 2021 Mar 11 doi: 10.1080/14737140.2021.1860763. PMID: 33706635
Pediatric relapsed acute myeloid leukemia: a systematic review.
Hoffman AE, Schoonmade LJ, Kaspers GJ
Expert Rev Anticancer Ther 2021 Jan;21(1):45-52. Epub 2020 Nov 8 doi: 10.1080/14737140.2021.1841640. PMID: 33111585
Treatment of venous thromboembolism in acute leukemia: A systematic review.
Ahrari A, Al-Ani F, Wang YP, Lazo-Langner A
Thromb Res 2019 Jun;178:1-6. Epub 2019 Mar 20 doi: 10.1016/j.thromres.2019.03.014. PMID: 30921533

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