U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Grade 3 Necrotizing Enterocolitis, AE

MedGen UID:
1659724
•Concept ID:
C4743914
•
Finding
Synonym: Grade 3 Necrotizing Enterocolitis, Adverse Event

Definition

An adverse event in a newborn characterized by confirmed necrotizing enterocolitis; major care change indicated (e.g. NPO, antibiotics, non-urgent surgery). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 3 Necrotizing Enterocolitis, AE

Professional guidelines

PubMed

Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants.
Ohlsson A, Walia R, Shah SS
Cochrane Database Syst Rev 2020 Feb 11;2(2):CD003481. doi: 10.1002/14651858.CD003481.pub8. PMID: 32045960Free PMC Article
Bronchodilators for the prevention and treatment of chronic lung disease in preterm infants.
Ng G, da Silva O, Ohlsson A
Cochrane Database Syst Rev 2016 Dec 14;12(12):CD003214. doi: 10.1002/14651858.CD003214.pub3. PMID: 27960245Free PMC Article
Bronchodilators for the prevention and treatment of chronic lung disease in preterm infants.
Ng G, da Silva O, Ohlsson A
Cochrane Database Syst Rev 2012 Jun 13;(6):CD003214. doi: 10.1002/14651858.CD003214.pub2. PMID: 22696334

Recent clinical studies

Etiology

Interventions for patent ductus arteriosus (PDA) in preterm infants: an overview of Cochrane Systematic Reviews.
Mitra S, de Boode WP, Weisz DE, Shah PS
Cochrane Database Syst Rev 2023 Apr 11;4(4):CD013588. doi: 10.1002/14651858.CD013588.pub2. PMID: 37039501Free PMC Article
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Early full enteral feeding for preterm or low birth weight infants.
Walsh V, Brown JVE, Copperthwaite BR, Oddie SJ, McGuire W
Cochrane Database Syst Rev 2020 Dec 27;12(12):CD013542. doi: 10.1002/14651858.CD013542.pub2. PMID: 33368149Free PMC Article
Continuous positive airway pressure (CPAP) for respiratory distress in preterm infants.
Ho JJ, Subramaniam P, Davis PG
Cochrane Database Syst Rev 2020 Oct 15;10(10):CD002271. doi: 10.1002/14651858.CD002271.pub3. PMID: 33058208Free PMC Article
Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.
Roberts D, Brown J, Medley N, Dalziel SR
Cochrane Database Syst Rev 2017 Mar 21;3(3):CD004454. doi: 10.1002/14651858.CD004454.pub3. PMID: 28321847Free PMC Article

Diagnosis

Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants.
Jasani B, Mitra S, Shah PS
Cochrane Database Syst Rev 2022 Dec 15;12:CD010061. doi: 10.1002/14651858.CD010061.pub5. PMID: 36519620
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
The future of Cochrane Neonatal.
Soll RF, Ovelman C, McGuire W
Early Hum Dev 2020 Nov;150:105191. Epub 2020 Sep 12 doi: 10.1016/j.earlhumdev.2020.105191. PMID: 33036834
Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants.
Pammi M, Suresh G
Cochrane Database Syst Rev 2020 Mar 31;3(3):CD007137. doi: 10.1002/14651858.CD007137.pub6. PMID: 32232984Free PMC Article
Protein supplementation of human milk for promoting growth in preterm infants.
Amissah EA, Brown J, Harding JE
Cochrane Database Syst Rev 2018 Jun 22;6(6):CD000433. doi: 10.1002/14651858.CD000433.pub2. PMID: 29931679Free PMC Article

Therapy

Interventions for patent ductus arteriosus (PDA) in preterm infants: an overview of Cochrane Systematic Reviews.
Mitra S, de Boode WP, Weisz DE, Shah PS
Cochrane Database Syst Rev 2023 Apr 11;4(4):CD013588. doi: 10.1002/14651858.CD013588.pub2. PMID: 37039501Free PMC Article
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Early full enteral feeding for preterm or low birth weight infants.
Walsh V, Brown JVE, Copperthwaite BR, Oddie SJ, McGuire W
Cochrane Database Syst Rev 2020 Dec 27;12(12):CD013542. doi: 10.1002/14651858.CD013542.pub2. PMID: 33368149Free PMC Article
Continuous positive airway pressure (CPAP) for respiratory distress in preterm infants.
Ho JJ, Subramaniam P, Davis PG
Cochrane Database Syst Rev 2020 Oct 15;10(10):CD002271. doi: 10.1002/14651858.CD002271.pub3. PMID: 33058208Free PMC Article
Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.
Roberts D, Brown J, Medley N, Dalziel SR
Cochrane Database Syst Rev 2017 Mar 21;3(3):CD004454. doi: 10.1002/14651858.CD004454.pub3. PMID: 28321847Free PMC Article

Prognosis

Interventions for patent ductus arteriosus (PDA) in preterm infants: an overview of Cochrane Systematic Reviews.
Mitra S, de Boode WP, Weisz DE, Shah PS
Cochrane Database Syst Rev 2023 Apr 11;4(4):CD013588. doi: 10.1002/14651858.CD013588.pub2. PMID: 37039501Free PMC Article
Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants.
Jasani B, Mitra S, Shah PS
Cochrane Database Syst Rev 2022 Dec 15;12:CD010061. doi: 10.1002/14651858.CD010061.pub5. PMID: 36519620
Continuous positive airway pressure (CPAP) for respiratory distress in preterm infants.
Ho JJ, Subramaniam P, Davis PG
Cochrane Database Syst Rev 2020 Oct 15;10(10):CD002271. doi: 10.1002/14651858.CD002271.pub3. PMID: 33058208Free PMC Article
Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants.
Pammi M, Suresh G
Cochrane Database Syst Rev 2020 Mar 31;3(3):CD007137. doi: 10.1002/14651858.CD007137.pub6. PMID: 32232984Free PMC Article
Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.
Roberts D, Brown J, Medley N, Dalziel SR
Cochrane Database Syst Rev 2017 Mar 21;3(3):CD004454. doi: 10.1002/14651858.CD004454.pub3. PMID: 28321847Free PMC Article

Clinical prediction guides

Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Early full enteral feeding for preterm or low birth weight infants.
Walsh V, Brown JVE, Copperthwaite BR, Oddie SJ, McGuire W
Cochrane Database Syst Rev 2020 Dec 27;12(12):CD013542. doi: 10.1002/14651858.CD013542.pub2. PMID: 33368149Free PMC Article
Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.
Roberts D, Brown J, Medley N, Dalziel SR
Cochrane Database Syst Rev 2017 Mar 21;3(3):CD004454. doi: 10.1002/14651858.CD004454.pub3. PMID: 28321847Free PMC Article
Should we believe in transfusion-associated enterocolitis? Applying a GRADE to the literature.
Hay S, Zupancic JA, Flannery DD, Kirpalani H, Dukhovny D
Semin Perinatol 2017 Feb;41(1):80-91. Epub 2016 Nov 17 doi: 10.1053/j.semperi.2016.09.021. PMID: 27866662
Prophylactic indomethacin: systematic review and meta-analysis.
Fowlie PW
Arch Dis Child Fetal Neonatal Ed 1996 Mar;74(2):F81-7. doi: 10.1136/fn.74.2.f81. PMID: 8777672Free PMC Article

Recent systematic reviews

Interventions for patent ductus arteriosus (PDA) in preterm infants: an overview of Cochrane Systematic Reviews.
Mitra S, de Boode WP, Weisz DE, Shah PS
Cochrane Database Syst Rev 2023 Apr 11;4(4):CD013588. doi: 10.1002/14651858.CD013588.pub2. PMID: 37039501Free PMC Article
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Early full enteral feeding for preterm or low birth weight infants.
Walsh V, Brown JVE, Copperthwaite BR, Oddie SJ, McGuire W
Cochrane Database Syst Rev 2020 Dec 27;12(12):CD013542. doi: 10.1002/14651858.CD013542.pub2. PMID: 33368149Free PMC Article
Continuous positive airway pressure (CPAP) for respiratory distress in preterm infants.
Ho JJ, Subramaniam P, Davis PG
Cochrane Database Syst Rev 2020 Oct 15;10(10):CD002271. doi: 10.1002/14651858.CD002271.pub3. PMID: 33058208Free PMC Article
Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.
Roberts D, Brown J, Medley N, Dalziel SR
Cochrane Database Syst Rev 2017 Mar 21;3(3):CD004454. doi: 10.1002/14651858.CD004454.pub3. PMID: 28321847Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...