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Grade 4 Hypoxic Ischemic Encephalopathy, AE

MedGen UID:
1660927
•Concept ID:
C4743830
•
Finding
Synonyms: Grade 4 HIE, AE; Grade 4 Hypoxic Ischemic Encephalopathy, Adverse Event

Definition

An adverse event in a newborn characterized by severe clinical signs (see Sarnat stages for further guidance on mild, moderate and severe clinical signs of encephalopathy) of encephalopathy resulting from a perinatal asphyxia event with life-threatening consequences (e.g. respiratory depression, refractory seizures). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 4 Hypoxic Ischemic Encephalopathy, AE

Professional guidelines

PubMed

Safety and efficacy of intravenous lacosamide for adjunctive treatment of refractory status epilepticus: a comparative cohort study.
Sutter R, Marsch S, Rüegg S
CNS Drugs 2013 Apr;27(4):321-9. doi: 10.1007/s40263-013-0049-y. PMID: 23533010

Recent clinical studies

Etiology

The Frequency and Severity of Magnetic Resonance Imaging Abnormalities in Infants with Mild Neonatal Encephalopathy.
Walsh BH, Neil J, Morey J, Yang E, Silvera MV, Inder TE, Ortinau C
J Pediatr 2017 Aug;187:26-33.e1. Epub 2017 May 4 doi: 10.1016/j.jpeds.2017.03.065. PMID: 28479101Free PMC Article
Safety and efficacy of intravenous lacosamide for adjunctive treatment of refractory status epilepticus: a comparative cohort study.
Sutter R, Marsch S, Rüegg S
CNS Drugs 2013 Apr;27(4):321-9. doi: 10.1007/s40263-013-0049-y. PMID: 23533010
Risk factors for intracranial hemorrhage among full-term infants: a case-control study.
Jhawar BS, Ranger A, Steven D, Del Maestro RF
Neurosurgery 2003 Mar;52(3):581-90; discussion 588-90. doi: 10.1227/01.neu.0000047819.33177.72. PMID: 12590682
Effect of extreme hypercapnia on hypoxic-ischemic brain damage in the immature rat.
Vannucci RC, Towfighi J, Brucklacher RM, Vannucci SJ
Pediatr Res 2001 Jun;49(6):799-803. doi: 10.1203/00006450-200106000-00015. PMID: 11385141
Resuscitation of asphyxiated newborn infants with room air or oxygen: an international controlled trial: the Resair 2 study.
Saugstad OD, Rootwelt T, Aalen O
Pediatrics 1998 Jul;102(1):e1. doi: 10.1542/peds.102.1.e1. PMID: 9651453

Diagnosis

The Frequency and Severity of Magnetic Resonance Imaging Abnormalities in Infants with Mild Neonatal Encephalopathy.
Walsh BH, Neil J, Morey J, Yang E, Silvera MV, Inder TE, Ortinau C
J Pediatr 2017 Aug;187:26-33.e1. Epub 2017 May 4 doi: 10.1016/j.jpeds.2017.03.065. PMID: 28479101Free PMC Article
Safety and efficacy of intravenous lacosamide for adjunctive treatment of refractory status epilepticus: a comparative cohort study.
Sutter R, Marsch S, Rüegg S
CNS Drugs 2013 Apr;27(4):321-9. doi: 10.1007/s40263-013-0049-y. PMID: 23533010
Risk factors for intracranial hemorrhage among full-term infants: a case-control study.
Jhawar BS, Ranger A, Steven D, Del Maestro RF
Neurosurgery 2003 Mar;52(3):581-90; discussion 588-90. doi: 10.1227/01.neu.0000047819.33177.72. PMID: 12590682

Therapy

Safety and dose-finding trial of tadalafil administered for fetus in labor: A phase I clinical study.
Tamaishi Y, Tanaka H, Hirai T, Hiramatsu SI, Takakura S, Magawa S, Tanaka K, Kondo E, Iwamoto T, Ikeda T
J Obstet Gynaecol Res 2024 Mar;50(3):448-455. Epub 2024 Jan 2 doi: 10.1111/jog.15871. PMID: 38165071
The Frequency and Severity of Magnetic Resonance Imaging Abnormalities in Infants with Mild Neonatal Encephalopathy.
Walsh BH, Neil J, Morey J, Yang E, Silvera MV, Inder TE, Ortinau C
J Pediatr 2017 Aug;187:26-33.e1. Epub 2017 May 4 doi: 10.1016/j.jpeds.2017.03.065. PMID: 28479101Free PMC Article
Safety and efficacy of intravenous lacosamide for adjunctive treatment of refractory status epilepticus: a comparative cohort study.
Sutter R, Marsch S, Rüegg S
CNS Drugs 2013 Apr;27(4):321-9. doi: 10.1007/s40263-013-0049-y. PMID: 23533010
Neurodevelopmental outcome of infants with birth asphyxia treated with magnesium sulfate.
Ichiba H, Yokoi T, Tamai H, Ueda T, Kim TJ, Yamano T
Pediatr Int 2006 Feb;48(1):70-5. doi: 10.1111/j.1442-200X.2006.02167.x. PMID: 16490075
Effect of extreme hypercapnia on hypoxic-ischemic brain damage in the immature rat.
Vannucci RC, Towfighi J, Brucklacher RM, Vannucci SJ
Pediatr Res 2001 Jun;49(6):799-803. doi: 10.1203/00006450-200106000-00015. PMID: 11385141

Prognosis

Neurodevelopmental outcome of infants with birth asphyxia treated with magnesium sulfate.
Ichiba H, Yokoi T, Tamai H, Ueda T, Kim TJ, Yamano T
Pediatr Int 2006 Feb;48(1):70-5. doi: 10.1111/j.1442-200X.2006.02167.x. PMID: 16490075
Resuscitation of asphyxiated newborn infants with room air or oxygen: an international controlled trial: the Resair 2 study.
Saugstad OD, Rootwelt T, Aalen O
Pediatrics 1998 Jul;102(1):e1. doi: 10.1542/peds.102.1.e1. PMID: 9651453

Clinical prediction guides

Neurodevelopmental outcome of infants with birth asphyxia treated with magnesium sulfate.
Ichiba H, Yokoi T, Tamai H, Ueda T, Kim TJ, Yamano T
Pediatr Int 2006 Feb;48(1):70-5. doi: 10.1111/j.1442-200X.2006.02167.x. PMID: 16490075
Risk factors for intracranial hemorrhage among full-term infants: a case-control study.
Jhawar BS, Ranger A, Steven D, Del Maestro RF
Neurosurgery 2003 Mar;52(3):581-90; discussion 588-90. doi: 10.1227/01.neu.0000047819.33177.72. PMID: 12590682
Effect of extreme hypercapnia on hypoxic-ischemic brain damage in the immature rat.
Vannucci RC, Towfighi J, Brucklacher RM, Vannucci SJ
Pediatr Res 2001 Jun;49(6):799-803. doi: 10.1203/00006450-200106000-00015. PMID: 11385141
Resuscitation of asphyxiated newborn infants with room air or oxygen: an international controlled trial: the Resair 2 study.
Saugstad OD, Rootwelt T, Aalen O
Pediatrics 1998 Jul;102(1):e1. doi: 10.1542/peds.102.1.e1. PMID: 9651453

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