U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Grade 2 Neonatal Coagulation Disorder, AE

MedGen UID:
1662323
•Concept ID:
C4743877
•
Finding
Synonym: Grade 2 Neonatal Coagulation Disorder, Adverse Event

Definition

An adverse event in a newborn characterized by biochemical coagulation abnormalities with clinical signs; requiring increased monitoring. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 2 Neonatal Coagulation Disorder, AE

Professional guidelines

PubMed

Treatment of immune thrombocytopenia during pregnancy with thrombopoietin receptor agonists.
Rottenstreich A, Bussel JB
Br J Haematol 2023 Dec;203(5):872-885. Epub 2023 Oct 13 doi: 10.1111/bjh.19161. PMID: 37830251
Practice guidelines for the therapy of essential thrombocythemia. A statement from the Italian Society of Hematology, the Italian Society of Experimental Hematology and the Italian Group for Bone Marrow Transplantation.
Barbui T, Barosi G, Grossi A, Gugliotta L, Liberato LN, Marchetti M, Mazzucconi MG, Rodeghiero F, Tura S
Haematologica 2004 Feb;89(2):215-32. PMID: 15003898

Recent clinical studies

Etiology

Emicizumab prophylaxis in infants with hemophilia A (HAVEN 7): primary analysis of a phase 3b open-label trial.
Pipe SW, Collins P, Dhalluin C, Kenet G, Schmitt C, Buri M, Jiménez-Yuste V, Peyvandi F, Young G, Oldenburg J, Mancuso ME, Kavakli K, Kiialainen A, Deb S, Niggli M, Chang T, Lehle M, Fijnvandraat K
Blood 2024 Apr 4;143(14):1355-1364. doi: 10.1182/blood.2023021832. PMID: 38127586Free PMC Article
Practice guidelines for the therapy of essential thrombocythemia. A statement from the Italian Society of Hematology, the Italian Society of Experimental Hematology and the Italian Group for Bone Marrow Transplantation.
Barbui T, Barosi G, Grossi A, Gugliotta L, Liberato LN, Marchetti M, Mazzucconi MG, Rodeghiero F, Tura S
Haematologica 2004 Feb;89(2):215-32. PMID: 15003898
Corticosteroid prophylaxis for neurologic complications of intravenous immunoglobulin G therapy in childhood immune thrombocytopenic purpura.
Jayabose S, Mahmoud M, Levendoglu-Tugal O, Sandoval C, Ozkaynak F, Giamelli J Jr, Visintainer P
J Pediatr Hematol Oncol 1999 Nov-Dec;21(6):514-7. PMID: 10598663

Diagnosis

Outcome of unrelated umbilical cord blood transplantation in 88 patients with primary immunodeficiency in Japan.
Morio T, Atsuta Y, Tomizawa D, Nagamura-Inoue T, Kato K, Ariga T, Kawa K, Koike K, Tauchi H, Kajiwara M, Hara T, Kato S; Japanese Cord Blood Bank Network
Br J Haematol 2011 Aug;154(3):363-72. Epub 2011 May 14 doi: 10.1111/j.1365-2141.2011.08735.x. PMID: 21569009

Therapy

Emicizumab prophylaxis in infants with hemophilia A (HAVEN 7): primary analysis of a phase 3b open-label trial.
Pipe SW, Collins P, Dhalluin C, Kenet G, Schmitt C, Buri M, Jiménez-Yuste V, Peyvandi F, Young G, Oldenburg J, Mancuso ME, Kavakli K, Kiialainen A, Deb S, Niggli M, Chang T, Lehle M, Fijnvandraat K
Blood 2024 Apr 4;143(14):1355-1364. doi: 10.1182/blood.2023021832. PMID: 38127586Free PMC Article
Treatment of immune thrombocytopenia during pregnancy with thrombopoietin receptor agonists.
Rottenstreich A, Bussel JB
Br J Haematol 2023 Dec;203(5):872-885. Epub 2023 Oct 13 doi: 10.1111/bjh.19161. PMID: 37830251
Outcome of unrelated umbilical cord blood transplantation in 88 patients with primary immunodeficiency in Japan.
Morio T, Atsuta Y, Tomizawa D, Nagamura-Inoue T, Kato K, Ariga T, Kawa K, Koike K, Tauchi H, Kajiwara M, Hara T, Kato S; Japanese Cord Blood Bank Network
Br J Haematol 2011 Aug;154(3):363-72. Epub 2011 May 14 doi: 10.1111/j.1365-2141.2011.08735.x. PMID: 21569009
Practice guidelines for the therapy of essential thrombocythemia. A statement from the Italian Society of Hematology, the Italian Society of Experimental Hematology and the Italian Group for Bone Marrow Transplantation.
Barbui T, Barosi G, Grossi A, Gugliotta L, Liberato LN, Marchetti M, Mazzucconi MG, Rodeghiero F, Tura S
Haematologica 2004 Feb;89(2):215-32. PMID: 15003898
Analysis of engraftment, graft-versus-host disease, and immune recovery following unrelated donor cord blood transplantation.
Thomson BG, Robertson KA, Gowan D, Heilman D, Broxmeyer HE, Emanuel D, Kotylo P, Brahmi Z, Smith FO
Blood 2000 Oct 15;96(8):2703-11. PMID: 11023501

Prognosis

Outcome of unrelated umbilical cord blood transplantation in 88 patients with primary immunodeficiency in Japan.
Morio T, Atsuta Y, Tomizawa D, Nagamura-Inoue T, Kato K, Ariga T, Kawa K, Koike K, Tauchi H, Kajiwara M, Hara T, Kato S; Japanese Cord Blood Bank Network
Br J Haematol 2011 Aug;154(3):363-72. Epub 2011 May 14 doi: 10.1111/j.1365-2141.2011.08735.x. PMID: 21569009
Analysis of engraftment, graft-versus-host disease, and immune recovery following unrelated donor cord blood transplantation.
Thomson BG, Robertson KA, Gowan D, Heilman D, Broxmeyer HE, Emanuel D, Kotylo P, Brahmi Z, Smith FO
Blood 2000 Oct 15;96(8):2703-11. PMID: 11023501
Corticosteroid prophylaxis for neurologic complications of intravenous immunoglobulin G therapy in childhood immune thrombocytopenic purpura.
Jayabose S, Mahmoud M, Levendoglu-Tugal O, Sandoval C, Ozkaynak F, Giamelli J Jr, Visintainer P
J Pediatr Hematol Oncol 1999 Nov-Dec;21(6):514-7. PMID: 10598663

Clinical prediction guides

Treatment of immune thrombocytopenia during pregnancy with thrombopoietin receptor agonists.
Rottenstreich A, Bussel JB
Br J Haematol 2023 Dec;203(5):872-885. Epub 2023 Oct 13 doi: 10.1111/bjh.19161. PMID: 37830251

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...